the philips lab
departments of medicine, cell biology and pharmacology, NYU cancer institute, Division of Rheumatology, NYU School of Medicine
CAAX Processing
CAAX Processing
CAAX processing pathway showing iCMT as the third of the three enzymes that covalently modify the C-terminus of Ras and other CAAX proteins. more detail
CAAX Processing
Localization of GFP-tagged iCMT exclusively in the endoplasmic reticulum of a CHO cell. more detail

We are interested in the post-translational modification of small GTPases such as Ras, γ subnits of heterotrimeric G proteins and other CAAX proteins.