CAAX processing pathway showing iCMT as the third of the three enzymes that covalently modify the C-terminus of Ras and other CAAX proteins. more detail
Localization of GFP-tagged iCMT exclusively in the endoplasmic reticulum of a CHO cell. more detail
We are interested in the post-translational modification of small GTPases such as Ras, γ subnits of heterotrimeric G proteins and other CAAX proteins.