David Zagzag, MD, PhD

Dr. Zagzag is Associate Professor of Pathology (Neuropathology) and Neurosurgery. His laboratory investigates molecular interactions between cells and extracellular matrix protein critical for blood vessel formation in the developing CNS that are upregulated in astrocytomas. Recent attention has focused on tenascin, an extracellular matrix protein implicated in tumor cell adhesion and migration, as well as Tie-1 and Tie-2, receptor tyrosine kinases that are essential for vasculogenesis in the developing CNS that may be involved in brain tumor angiogenesis.

Publications

• Newcomb EW, Demaria S, Lukyanov Y, Shao Y, Schnee T, Kawashima N, Lan L, Dewyngaert JK, Zagzag D, McBride WH, Formenti SC. The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas. Clin Cancer Res 12:4730-4737, 2006.
  
  
• Gagner JP, Law M, Fischer I, Newcomb EW, Zagzag D. Angiogenesis in gliomas: imaging and experimental therapeutics. Brain Pathol 15:342-363, 2005