May 2016

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Neuroscience Colloquium

Neuroscience Colloquium


Title: TBA
Jeff, Schall, PhD, Vanderbilt University 
4 Washington Place, Meyer Building, Room 815

 

Start Date:
05/02/2016 - 12:30pm
Event type:
Seminars
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Monday, May 2, 2016 - 12:30pm
 
 
Thesis Defense - Mariela Mitre (Chao/Froemke Labs)

Thesis Defense - Mariela Mitre (Chao/Froemke Labs)


Title: Oxytocin in the young and adult mouse brain: receptors and function 

PhD Candidate: Mariela Mitre

​Thesis Advisors: Moses Chao, PhD and Robert Froemke, PhD

Training Program: Neuroscience & Physiology

Room: Skirball 4th Floor Seminar Room 

Abstract:
Oxytocin is a neuropeptide important for social behaviors such as maternal care and parent-infant bonding. It is believed that oxytocin receptor signaling in the brain is critical for these behaviors, but it is unknown precisely when and where oxytocin receptors are expressed, or which neural circuits are directly sensitive to oxytocin. To overcome this challenge, we generated specific antibodies to the mouse oxytocin receptor and examined receptor expression throughout the brain. We identified a distributed network of female mouse brain regions for maternal behaviors that are especially enriched for oxytocin receptors, including the left auditory cortex, the piriform cortex, and the CA2 region of the hippocampus. Electron microscopy revealed that oxytocin receptors were mainly expressed at cortical synapses, as well as on axons and glial cells. Functionally, oxytocin transiently reduced synaptic inhibition in multiple brain regions, and enabled long-term synaptic plasticity in the auditory cortex. Thus modulation of inhibition may be a general mechanism by which oxytocin can act throughout the brain to regulate parental behaviors and social cognition. In young mice, oxytocin receptor expression in auditory cortex peaked at two weeks of postnatal life, a time period of heightened plasticity and inhibitory circuit maturation, which is promoted by BDNF. We hypothesized that oxytocin might be utilizing TrkB signaling to mediate this process and discovered that it can rapidly transactivate TrkB receptors in acute brain slices. We determined that this transactivation event occurs in cortex via the activation of CAMKII and Src kinase family members within 15-30 minutes of oxytocin treatment and it is dose-dependent. In addition, oxytocin’s TrkB transactivation is independent of BDNF release, BDNF transcription, and translation. In the long-term, oxytocin increased gephyrin clusters, suggesting an increase in inhibitory synapse number. The immediate disinhibitory effects of oxytocin lead to a temporary misbalance of excitation and inhibition. The transactivation of TrkB receptors by oxytocin may affect long-term synaptic development, particularly for inhibitory synapses, to re-balance excitation and inhibition, and maintain network stability. 

Start Date:
05/04/2016 - 10:00am
Event type:
Seminars
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Wednesday, May 4, 2016 - 10:00am
 
Neuroscience Weekly Group Meeting

Neuroscience Weekly Group Meeting


Speaker: TBA

Hosted by Niels Ringstad, PhD

12pm, Smilow Seminar Room 

Start Date:
05/04/2016 - 12:00pm
Event type:
Seminars
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Wednesday, May 4, 2016 - 12:00pm
 
 
 
 
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Neuroscience Colloquium

Neuroscience Colloquium


Neural Mechanisms for Predicting the Sensory Consequences of Behavior

Nate Sawtell, PhD, Columbia University 

12 pm, Skirball 3rd Floor Seminar Room 

Hosted by Dr. Michael Long 

Start Date:
05/09/2016 - 12:00pm
Event type:
Seminars
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Monday, May 9, 2016 - 12:00pm
 
 
Neuroscience Weekly Group Meeting

Neuroscience Weekly Group Meeting


Speaker: Makoto Kanai

Hosted by Greg Suh, PhD 

12pm, Smilow Seminar Room 

Start Date:
05/11/2016 - 12:00pm
Event type:
Seminars
More
Wednesday, May 11, 2016 - 12:00pm
 
SPiNES Seminar

SPiNES Seminar


Title: Corollary discharge promotes sustained behavior states in a neural circuit for navigation
Ni Ji, PhD, Harvard (Samuel Lab)
Alexandria East 9th Floor Conference Room
Hosted by Jung Hwan Choi, PhD, Ringstad Lab

Start Date:
05/12/2016 - 12:00pm
Event type:
Seminars
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Thursday, May 12, 2016 - 12:00pm
 
 
 
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Neuroscience Colloquium

Neuroscience Colloquium


Rich Mooney, PhD 

4 Washington Place, Meyer Building, Room 815

 

Start Date:
05/16/2016 - 12:30pm
Event type:
Seminars
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Monday, May 16, 2016 - 12:30pm
 
 
Neuroscience Weekly Group Meeting

Neuroscience Weekly Group Meeting


Speaker: Thorsten Kranz

Hosted by Dr. Moses Chao

12pm, Smilow Seminar Room 

Start Date:
05/18/2016 - 12:00pm
Event type:
Seminars
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Wednesday, May 18, 2016 - 12:00pm
 
 
 
 
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Neuroscience Colloquium

Neuroscience Colloquium


Beth Stevens, PhD, Boston Children's Hospital 

12 pm, Smilow 1st Floor Seminar Room

 

Hosted by Moses Chao, PhD

Start Date:
05/23/2016 - 12:00pm
Event type:
Seminars
More
Monday, May 23, 2016 - 12:00pm
 
 
 
 
 
 
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