RESEARCH MENTOR PROGRAM
- Steven Burden, Ph.D.
- Adam Carter, Ph.D.
- Alessandro Di Rocco, M.D.
- Stephen D. Ginsberg, Ph.D.
- Joseph Herbert, M.D.
- Daniel L. Labovitz, M.S., M.D.
- Juan J. Lafaille, Ph.D.
- Ruth Nass, M.D.
- Bernardo Rudy, M.D., Ph.D.
- Anuradha Singh, M.D.
- Thomas Thesen, Ph.D.
- David Zagzag, M.D., Ph.D.
Fellowship or post-doctoral training: Molecular Neurobiology
Proposed research projects for neurology residents
and medical students:
Motor neurons extend axons into target muscles that are already regionally specialized,
as acetylcholine receptors (AChRs) are preferentially expressed in the central
region of muscle prior to and independent from innervation. Importantly, this
pre-patterned region of the muscle pre-configures the region where synapses will
ultimately form. We are studying how muscle is patterned in the absence of innervation,
how innervation refines muscle pre-patterning, how MuSK, a synapse-specific muscle
receptor tyrosine kinase, establishes muscle pre-patterning and whether the pattern
of MuSK expression regulates where synapses will form. Our laboratory uses mouse
molecular genetics as well as molecular biological approaches to study how signaling
mechanisms regulate synapse formation and muscle structure.
Ideal time commitment for research assistants: negotiable
Office/lab location: Skirball Institute, 540 First Avenue, New York, NY 10016
Preferred contact: burden@saturn.med.nyu.edu
http://saturn.med.nyu.edu/research/mn/burdenlab/index.html
Selected publications:
Kim, N. and Burden, S.J. 2008. MuSK controls where motor axons grow and form
synapses. Nature Neuroscience 11:19-27.
Friese, M.B., Blagden, C.S. and Burden, S.J. 2007. Synaptic differentiation is defective in mice lacking acetylcholine receptor beta subunit tyrosine phosphorylation. Development 134:4167-76.
Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S.J., Di Lisi, R., Sandri, C., Zhao, J., Goldberg, A.L., Schiaffino, S. and Sandri, M. 2007. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metabolism 6:458-71.
Jones, N., Hardy, W.R., Friese, M.B., Jorgensen, C., Smith, M.J., Woody, N.N., Burden, S.J., and Pawson, T. 2007. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with Muscle-Specific Kinase (MuSK). Mol. Cell. Biol. 27:4759-73.
Jaworski, A., Smith, C.L. and Burden, S.J. 2007. GA-binding protein is dispensable for neuromuscular synapse formation and synapse-specific gene expression. Mol. Cell. Biol. 27:5040-46.
Stiegler, A.L., Burden, S.J., and Hubbard, S.R. 2006. Crystal structure of the Agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK. J. Mol. Biol. 364:424-33.
Jevesk, M., Jaworski, A., Polo-Parada, L., Kim, N., Fan, J., Landmesser, L.T., and Burden, S.J. 2006. CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission. Proc Natl Acad Sci USA. 103: 6374-79.
Jaworski, A. and Burden, S.J. 2006. Neuromuscular synapse formation in mice lacking neuron- and skeletal muscle-derived Neuregulin-1. J. Neurosci. 26:655-61.
Wang, X., Blagden, C., Fan, J., Nowak, S., Taniuchi, I., Littman, D.R. and Burden, S.J. 2005. Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes & Development 19:1715-22.
Mittaud, P., Camilleri, A.A., Willmann, R., Erb-Vogtli, S., Burden, S.J. and Fuhrer, C. 2004. A single pulse of agrin triggers a pathway that acts to cluster acetylcholine receptors. Mol. Cell. Biol. 24:7841-54.
Fellowship or post-doctoral training: Cellular Neurophysiology
Proposed research projects for neurology residents and medical
students:
Our
lab explores how neurons in the brain communicate with each other. We study the
physiological properties of single neurons using whole-cell recordings and 2-photon
microscopy in acute slices. These approaches allow us to examine signals within
individual dendrites and spines. We are particularly interested in neurons within
the cortex and striatum. Dysfunction of these neurons is implicated in multiple
neurological disorders, including schizophrenia and addiction. Our experiments
will ultimately help reveal the mechanisms for these diseases and develop treatments.
Ideal time commitment for research assistants: negotiable
Office/lab location: Center for Neural Science, 4 Washington Place, New York, NY 10003
Preferred contact: carter@cns.nyu.edu
http://www.cns.nyu.edu/carterlab/home.html
Selected publications:
Carter, A.G., Soler-Llavina, G.J., and Sabatini, B.L. (in press). Timing and Location of Synaptic Inputs Determine Modes of Subthreshold Integration in Striatal Medium Spiny Neurons, J. Neurosci.
Crowley, J.J., Carter, A.G., and Regehr, W.G. (2007). Fast Vesicle Replenishment and Rapid Recovery from Desensitization at a Single Synaptic Release Site, J. Neurosci. 27(20): 5448-60.
Carter, A.G., and Sabatini, B.L. (2004). State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons. Neuron 44: 483-93.
Carter, A.G., and Regehr, W.G. (2002). Quantal events shape cerebellar interneuron firing. Nature Neuroscience. 5: 1309-18.
Kreitzer, A.K., Carter, A.G., and Regehr, W.G. (2002). Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum. Neuron 34: 787-96.
Carter, A.G., Vogt, K.E., Foster, K.A., and Regehr, W.G. (2002). Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses. J. Neurosci. 22(1): 21-8.
Carter, A.G., and Regehr, W.G. (2000). Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse. J. Neurosci. 20(12): 4423-34.
Fellowship or post-doctoral training: Movement Disorders
Proposed research projects for neurology residents
and medical students:
Movement observation in Parkinson’s Disease (PD): we
will study patients at different stages of progression of
PD and and age-matched controls to evaluate their ability
to learn, retain, and consolidate simple and complex motor
behaviors, including mirror movements, using a digitized
tablet and transcranial magnetic stimulation (TMS) coupled
with high density EEG and brain navigation system. Other
studies, including clinical trials and retrospective studies,
could be of interest to students and residents with more
limited time.
Ideal time commitment for research assistants: negotiable
Office/lab location: RR 311
Preferred contact: alessandro.dirocco@med.nyu.edu
Selected publications:
Van Der Werf YD, Berendse HW, van Someren EJ, Stoffers D, Stam CJ, Wolters ECh. Observations on the cortical silent period in Parkinson's disease. J Neural Transm Suppl 2007;(72):155-8.
Epstein CM, Evatt ML, Funk A, Girard-Siqueira L, Lupei N, Slaughter L, Athar S, Green J, McDonald W, DeLong MR. An open study of repetitive transcranial magnetic stimulation in treatment-resistant depression with Parkinson's disease. Clin Neurophysiol 2007 Oct;118(10):2189-94.
Shin
HW, Kang SY, Sohn YH. Disturbed surround inhibition in
preclinical parkinsonism.
Clin Neurophysiol 2007 Oct;118(10):2176-9.
Morgante F, Espay AJ, Gunraj C, Lang AE, Chen R. Motor cortex plasticity in Parkinson's disease and levodopa-induced dyskinesias. Brain 2006 Apr;129(Pt 4):1059-69.
Fregni F, Simon DK, Wu A, Pascual-Leone A. Non-invasive brain stimulation for Parkinson's disease: a systematic review and meta-analysis of the literature. J Neurol Neurosurg Psychiatry. 2005 Dec;76(12):1614-23.
Fellowship or post-doctoral training: Molecular Neuroscience
Proposed research projects for neurology residents
and medical students:
My interests include neurodegeneration, single cell RNA analysis,
and lesion-induced synaptic plasticity. The principal
focus of the Ginsberg laboratory is to delineate cellular
and molecular mechanisms underlying synaptic and dendritic
reorganization following various brain injuries, including
excitotoxicity, specific lesions, and neurodegeneration.
The hippocampal formation, a brain region critical for learning
and memory, is the main region analyzed, with particular
emphasis on identifying mechanisms that govern synaptic reorganization
within dentate gyrus granule cells and dendrites. We conduct
experiments on animal models of synaptic plasticity and neurodegeneration.
In addition, the laboratory studies human brain tissues obtained
from patients with no cognitive impairment (NCI), mild cognitive
impairment (MCI), and Alzheimer’s disease (AD). A multidisciplinary
approach of surgical, state-of-the-art molecular biology,
immunohistochemical, and imaging techniques are utilized
as part of the experimental design.
I am happy to host residents/students interested in basic and/or translational work related to neurodegenerative disorders.
Ideal time commitment for research assistants: negotiable
Office/lab location: Center for Dementia Research, Nathan Kline Institute, 140 Old Orangeburg Road Orangeburg, NY 10962
Preferred contact: ginsberg@nki.rfmh.org
http://cdr.rfmh.org/pages/ginsbergpage.html
Selected publications:
Ginsberg, S.D., and Che, S.: Expression profile analysis within the human hippocampus: comparison of CA1 and CA3 pyramidal neurons. J. Comp. Neurol., in press.
McClain, K.L., Cai, Y-H., Hicks, J., Peterson, L.E., Yan, X-T., Che, S., and Ginsberg, S.D.: Expression profiling using human tissues in combination with RNA amplification and microarray analysis: assessment of Langerhans cell histiocytosis. Amino Acids, in press.
Che, S., and Ginsberg, S.D.: RNA amplification methodologies. In Progress in RNA Research, Nova Science Publishing, in press.
Ginsberg, S.D., Hemby, S.E., Mufson, E.J, and Martin, L.J: Cell and tissue microdissection in combination with genomic and proteomic applications. In L. Zaborszky, F. Wouterlood and J.L. Lanciego (eds); Neuroanatomical Tract Tracing 3: Molecules-Neurons-Systems, New York, Springer, in press.
Che, S., and Ginsberg, S.D.: Amplification of transcripts using terminal continuation. Lab Invest., 84: 131-137, 2004
Ginsberg, S.D., and Che, S.: Combined histochemical staining, RNA amplification, regional, and single cell analysis within the hippocampus. Lab. Invest., 84:952-962 2004.
Ginsberg, S.D., Elarova, I., Ruben, M., Tan, F., Counts, S.E., Eberwine, J.H., Trojanowski, J.Q., Hemby, S.E., Mufson, E.J., and Che, S.: Single cell gene expression analysis: implications for neurodegenerative and neuropsychiatric disorders: Neurochem. Res., 29:1053-1064, 2004.
Galvin, J.E., and Ginsberg, S.D.: Expression profiling and pharmacotherapeutic development in the central nervous system. Alzheimer Dis. Assoc. Disord., 18:264-269, 2004.
King, S.R., Ginsberg, S.D., Ishii, T., Smith, R.G., Parker, K.L., and Lamb, D.J.: The steroidogenic acute regulatory (StAR) protein is expressed in steroidogenic cells of the day-old (P1) brain. Endocrinology, 145:4775-4780, 2004.
Counts, S.E., Nadeem, M., Wuu, J., Ginsberg, S.D., Saragovi, H.U., and Mufson, E.J.: Reduction of cortical TrkA but not p75NTR NGF receptor protein levels in early stage Alzheimer’s disease. Ann. Neurol., 56:520-531, 2004.
Fellowship or post-doctoral training: Neuropathology, Multiple Sclerosis
Proposed research projects for neurology residents
and medical students:
Joseph Herbert, M.D. directs the NYU Medical Center-Hospital
for Joint Diseases Multiple Sclerosis program. Clinical studies
in Multiple Sclerosis (MS) include immunomodulation, symptom
management, rehabilitation out comes and quality of life. Dr.
Herbert's basic research interests focus on hereditary, amyloid
neuropathy, specifically the mechanisms of amyloid fibrillogenesis
and potential modulators of this process.
Ideal time commitment for research assistants: negotiable
Office/lab location: NYU Hospital for Joint Diseases, 301 East 17th Street, Suite 544, New York, NY 10003
Preferred contact: joseph.herbert@nyumc.org
Selected publications:
Inglese M, Adhya S, Johnson G, Babb JS, Miles L, Jaggi H, Herbert J, Grossman RI. Perfusion magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis. Journal of cerebral blood flow & metabolism 2008 Jan;28(1):164-71.
Ge Y, Jensen JH, Lu H, Helpern JA, Miles L, Inglese M, Babb JS, Herbert J, Grossman R I. Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imaging. American journal of neuroradiology 2007 Oct;28(9):1639-44.
Gonen O, Oberndorfer TA, Inglese M, Babb JS, Herbert J, Grossman RI. Reproducibility of three whole-brain N-acetylaspartate decline cohorts in relapsing-remitting multiple sclerosis. American journal of neuroradiology 2007 Feb;28(2):267-71.
Inglese M, Park SJ, Glyn B, James S, Miles L, Jaggi H, Herbert J, Grossman RI. Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T. Archives of neurology 2007 Feb;64(2):196-202.
Adhya S, Johnson G, Herbert J, Jaggi H, Babb JS, Grossman RI, Inglese M. Pattern of hemodynamic impairment in multiple sclerosis: dynamic susceptibility contrast perfusion MR imaging at 3.0 T. Neuroimage 2006 Dec;33(4):1029-35.
Bacon J, Fromm JT, Herbert J. Cognitive rehabilitation of memory processes and processing speed to improve daily functioning of multiple sclerosis patients [Abstract]. Multiple sclerosis 2006 Sept;12(7131):S117.
Bacon J, Riber L, Fromm JT, Safier M, Herbert J. Motivational styles as a predictor of adherence to injection therapy for multiple sclerosis [Abstract]. Multiple sclerosis 2006 Sept;12(7131):S117.
Herbert, J. Rational treatment algorithms for relapsing multiple sclerosis [Abstract]. Multiple sclerosis 2006 Sept;12(7131):S81.
Herbert, J. Rigorous definitions for "benign" and "mild" multiple sclerosis [Abstract]. Multiple sclerosis 2006 Sept;12(7131):S159-60.
Herbert J, Jakubowska-Sadowska K, Russell HK, Kasten LE, Layer N, Glueck A, Frankel M, Fromm JT, DelBene M. The timed tandem walk is a more informative measure of mild impairment in multiple sclerosis than the 25-foot walk [Abstract]. Multiple sclerosis 2006 Sept;12(7131):S87.
Fellowship or post-doctoral training: Stroke / Vascular Neurology
Proposed research projects for neurology residents
and medical students:
-Predictors of arrival with TIA
-Race-ethnic variation in arrival time after acute stroke
-Dysphagia after acute stroke
Ideal time commitment for research assistants: Project-dependent
Office/lab location: HCC 5F, Tisch Hospital
Preferred contact: daniel.labovitz@med.nyu.edu
Selected publications:
Labovitz DL. Accuracy and yield of ICD-9 codes for identifying children with ischemic stroke. Neurology. 2007 May 8;68(19):1638.
Labovitz DL, Boden-Albala B, Hauser WA, Sacco RL. Lacunar infarct or deep intracerebral hemorrhage: who gets which? The Northern Manhattan Study. Neurology. 2007 Feb 20;68(8):606-8.
Labovitz DL, Halim AX, Brent B, Boden-Albala B, Hauser WA, Sacco RL. Subarachnoid hemorrhage incidence among Whites, Blacks and Caribbean Hispanics: the Northern Manhattan Study. Neuroepidemiology. 2006;26(3):147-50.
Labovitz DL, Halim A, Boden-Albala B, Hauser WA, Sacco RL. The incidence of deep and lobar intracerebral hemorrhage in whites, blacks, and Hispanics. Neurology. 2005 Aug 23;65(4):518-22.
Labovitz DL, Hauser WA. Preventing stroke-related seizures: when should anticonvulsant drugs be started? Neurology. 2003 Feb 11;60(3):365-6.
Stapf C, Labovitz DL, Sciacca RR, Mast H, Mohr JP, Sacco RL. Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey. Cerebrovasc Dis. 2002;13(1):43-6.
Labovitz DL, Hauser WA, Sacco RL. Prevalence and predictors of early seizure and status epilepticus after first stroke. Neurology. 2001 Jul 24;57(2):200-6.
Labovitz DL, Sacco RL. Intracerebral hemorrhage: update. Curr Opin Neurol. 2001 Feb;14(1):103-8. Review.
Fellowship or post-doctoral training: Molecular pathogenesis of autoimmune and allergic diseases
Proposed research projects for neurology residents
and medical students:
Although most normal immune responses against pathogens require
the action of T-lymphocytes, their improper control lies
at the heart of two types of disease: autoimmunity and allergy.
Our laboratory uses transgenic and knockout mice to study
the molecular mechanisms responsible for the normal control
of T-lymphocyte reactivity and the changes that occur when
T-lymphocytes become either aggressive against self antigens
or inappropriately reactive against substances (allergens)
normally present in the environment. Currently, we are examining
the development of experimental autoimmune encephalomyelitis
(EAE), an animal model for multiple sclerosis, in transgenic
mice bearing antimyelin basic protein (MBP) T-lymphocytes.
Mice harboring large numbers of anti-MBP T-lymphocytes in
addition to other lymphocytes seldom develop EAE spontaneously.
However, when these mice are crossed with RAG-l KO mice,
thereby producing only anti-MBP T-lymphocytes, they all develop
spontaneous EAE. The sharp contrast in susceptibility to
EAE between the two types of anti-MBP transgenic mice, one
carrying regulatory lymphocytes and the other not, enables
us to pursue identifying and characterizating those cells.
We also focus on a transgenic mouse model for asthma to determine
in vivo the factors controlling the synthesis of important
interleukins involved in the asthmatic process such as IL-4
and IL-5 and the increased production of immunoglobulin E.
Ideal time commitment for research assistants: negotiable
Office/lab location: Skirball Institute, 540 First Avenue, New York, NY 10016
Preferred contact: lafaille@saturn.med.nyu.edu
Selected publications:
de Lafaille MAC, Kutchukhidze N, Ding Y, Shen S; Lafaille, JJ. Peripherally-induced allergen-specific Foxp3+regulatory T cells are essential for the control of chronic allergic lung inflammation. [Abstract] Journal of allergy & clinical immunology, 2007 JAN;119(1):S47-S47.
Erazo A, Kutchukhidze N, Leung M, Christ APG, Urban JF Jr, Curotto de Lafaille MA, Lafaille JJ. Unique maturation program of the IgE response in vivo. Immunity, 2007 Feb;26(2):191-203.
Maraver A, Tadokoro CE, Badura ML, Shen J, Serrano M, Lafaille JJ. Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood, 2007 Nov 1;110(9):3218-25.
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua, DJ, Littman DR. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell, 2006 Sep 22;126(6):1121-33.
Murano M, Xiong X, Murano N, Salzer JL, Lafaille JJ, Tsiagbe VK. Latent TGF-{beta}1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitis. Journal of leukocyte biology, 2006 Jan;79(1):140-6.
Tadokoro CE, Shakhar G, Shen S, Ding Y, Lino AC, Maraver A, Lafaille JJ, Dustin ML. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. Journal of experimental medicine, 2006 Mar 20;203(3):505-11.
Curotto de Lafaille MA, Shen S, Olivares-Villagomez D, Camps-Ramirez M, Lafaille JJ. Do regulatory T cells play a role in the control of homeostatic proliferation? International reviews of immunology, 2005 May-Aug;24(3-4):269-84.
Marcondes MC, Furtado GC, Wensky A, Curotto de Lafaille MA, Fox HS, Lafaille JJ. Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis. American journal of pathology, 2005 Jun;166(6):1749-60.
Mucida D; Kutchukhidze N; Erazo A; Russo M; Lafaille JJ; Curotto de Lafaille MA. Oral tolerance in the absence of naturally occurring Tregs. Journal of clinical investigation, 2005 Jul;115(7):1923-33.
Shen S, Ding Y, Tadokoro CE, Olivares-Villagomez D, Camps-Ramirez M, Curotto de Lafaille MA, Lafaille JJ. Control of homeostatic proliferation by regulatory T cells. Journal of clinical investigation, 2005 Dec;115(12):3517-26.
Fellowship or post-doctoral training: Pediatric Neurology
Proposed research projects for neurology residents
and medical students:
-Cognitive outcomes of congenital stroke
-Stereotypies versus tics – autism versus Tourette’s syndrome
-Social skills in ADHD versus autism
-Processing of emotional facial expressions using fMRI
-Bioethics – moral development during residency
-Pathophysiology of autism in tuberous sclerosis
Ideal time commitment for research assistants: 1 day/week, optimally Friday
Office/lab location: RR - 311, Tisch Hospital
Preferred contact: ruth.nass@nyumc.org
Selected publications:
Zaroff C et al. MR: relation to seizure and tuber burden in Tuberous Sclerosis. Seizure. 15,558-62, 2006.
Nass R et al. Non Verbal Learning Disabilities: Frequency in an LD school. Thalamus, 24, 17-36, 2006.
Nass R, Trauner D. Developmental Language Disorders. In: Steven Ashwal (ed), Pediatric Neurology, 2006.
Nass R. Evaluation and assessment issues in the diagnosis of ADHD. Sem Ped Neurol 12(4):200-16, 2005.
Nass R, Ross G. Disorders of Higher Cortical Function in the Preschooler. In: David R, ed, Child and Adolescent Neurology. Mosby, St Louis: MO, 2005.
Nass R, Ross G. The neurological examination in the preschooler. In: David R, ed, Child and Adolescent Neurology. Mosby, St Louis: MO, 2005.
Nass R, Ross G. CP and Mental Retardation. In: M Rizzo, P. Eslinger eds. Principles and Practice of Behavioral Neurology and Neuropsychology. New York, Saunders, 2004, 940-64.
Nass R, Leventhal F. The Autism Tourettes Spectrum. Developmental Disabilities. In: M Rizzo, P. Eslinger eds. Principles and Practice of Behavioral Neurology and Neuropsychology. New York, Saunders, 2004, 917-39.
Nass R, Trauner D. Cognitive consequences of congenital stroke. CNS Spectrum, 9:320-336, 2004.
Ross G, et al. Learning disabilities in children born of SLE pregnancy. J Child Adolescent Med, 2003.
Fellowship or post-doctoral training: Biochemistry, Neurobiology
Proposed research projects for neurology residents
and medical students:
Ion channels are membrane proteins that control cell permeability
to specific ions. In neurons, ion channels and neurotransmitter
receptors underlie the cell's excitability and are thus responsible
for signal generation and transmission. The type, properties,
number, and specific cell location of the ion channel determine
a neuron's signaling properties; the reorganization of ion
channels and receptors contributes to learning and memory
processes. Our laboratory investigates the molecular mechanisms
governing ion-channel expression in neurons. K channels regulate
the excitability level of neurons, play a major role in determining
their firing patterns, and thus significantly contribute
to neuronal integration. The K-channel family, the most diverse
of the ion channels, generates many different excitability
properties. The molecular mechanisms of this diversity are
important targets for regulating neuronal excitability. We
combine molecular biology techniques, such as molecular cloning,
in-situ hybridization, immunocytochemistry, and gene targeting,
with electrophysiological methods to determine K-channel
expression and function in the central nervous system. A
special focus of our research are ion channels expressed
in thalamic relay neurons, the cells that process all sensory
information before transmitting it to the cortex, as well
as in the cortical neurons that receive and process this
information. Modulation of ion channels by second messenger
cascades underlies changes in the thalamocortical circuit
associated with global states of awareness such as sleep,
wakefulness, arousal, coma, or changes in attention. We also
study how changes in ion channel expression and function
in thalamical and cortical neurons contributes to the establishment
and plasticity of sensory cortical maps.
Ideal time commitment for research assistants: negotiable
Office/lab location: SRB 6 605, 522 First Avenue, New York, NY 10016
Preferred contact: rudyb01@med.nyu.edu
Selected publications:
Chang SY, Zagha E, Kwon ES, Ozaita A, Bobik M, Martone ME, Ellisman MH, Heintz N, Rudy B. Distribution of Kv3.3 potassium channel subunits in distinct neuronal populations of mouse brain. Journal of comparative neurology 2007 Jun 20;502(6):953-72.
Kasten MR, Rudy B, Anderson MP. Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels. Journal of physiology 2007 Oct 15;584(2):565-82.
Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B. Differential characterization of three alternative spliced isoforms of DPPX. Brain research 2006 Jun 13;1094(1):1-12.
Song ZM, Hu J, Rudy B, Redman SJ. Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells. Neuroscience 2006 Apr;139(2):531-38.
Song, ZM; Hu, J; Rudy, B; Redman, SJ. Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells. Neuroscience, 2006 Jul;141(1):543.
Goldberg EM, Watanabe S, Chang SY, Joho RH, Huang ZJ, Leonard CS, Rudy B. Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse. Journal of neuroscience 2005 May 25;25(21):5230-5.
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X. International union of pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacological reviews 2005 Dec;57(4):473-508.
Petit-Jacques J, Volgyi B, Rudy B, Bloomfield SA. Spontaneous Oscillatory Activity of Starburst Amacrine Cells in the Mouse Retina. Journal of neurophysiology 2005 Sep;94 (3):1770-80.
Yan L, Herrington J, Goldberg E, Dulski PM, Bugianesi RM, Slaughter RS, Banerjee P, Brochu RM, Priest BT, Kaczorowski GJ, Rudy B, Garcia ML. ShK, a pharmacological tool for studying Kv3.2 channels. Molecular pharmacology 2005 May;67(5):1513-21.
Zagha E, Ozaita A, Chang SY, Nadal MS, Lin U, Saganich MJ, McCormack T, Akinsanya KO, Qi SY, Rudy B. Dipeptidyl peptidase 10 modulates Kv4-mediated A-type potassium channels. Journal of biological chemistry. 2005 May;280(19):18853-61.
Fellowship or post-doctoral training: Epilepsy
Proposed research projects for neurology residents
and medical students:
-Surgical outcome of epilepsy patients with cavernomas, DNETs
or other low grade
tumors
-Complaince to AEDs in the Latino Population
-Usefulness of EMUs in the city hospital
-Incidence of NES during EMU monitoring
-Prophylactic vitamin K for newer AEDs
-Pregnancy registry outcomes of newer AEDs
-Comparison of synthetic versus natural progesterone in patients with catamenial
epilepsy
-Seasonal variation in catamenial epilepsy
Ideal time commitment for research assistants: 1 month to 1 year
Office/lab location: 7S16, Epilepsy Unit, Bellevue Hospital
Preferred contact: anusinghus@yahoo.com
Selected publications:
Baumann C R, Acciarri N, Bertalanffy H, Devinsky O, Elger C E, Lo Russo G, Cossu M, Sure U, Singh, A, Stefan H, Hammen T, Georgiadis D, Baumgartner R W, Andermann F, Siegel A M. Seizure outcome after resection of supratentorial cavernous malformations: a study of 168 patients. Epilepsia, 2007 Mar;48(3):559-63.
Singh,
Anuradha. 100 questions & answers about epilepsy. Sudbury,
MA: Jones and Bartlett Publishers, 2006.
Singh,
Anuradha. Motor sequelae of epilepsy. In: Motor disorders. Philadelphia:
Lippincott Williams & Wilkins, 2005 2nd ed. p. 607-614.
Boylan LS, Kaley TJ, Singh A, Devinsky O. Postictal laughter following absence status epilepticus. Epilepsy & behavior, 2003 Dec;4(6):773-5.
Ritaccio AL; Singh A; Devinsky O. Cognition-induced epilepsy. Epilepsy & behavior, 2002 Dec;3(6):496-501.
Fellowship or post-doctoral training: fMRI, MEG and intracranial EEG of sensory and cognitive function, clinical neuroimaging of epilepsy, non-invasive mapping of language and memory cortex
Proposed research projects for neurology residents
and medical students:
Dr. Thesen heads the Cognitive Neurophysiology Research Group
at NYU School of Medicine. The group has a special emphasis
on cognitive and translational research: moving state-of-the-art
brain imaging techniques from the laboratory into clinical
practice, and using the clinical environment to generate
novel hypotheses about brain function that can be tested
in the laboratory. The group is also involved in the investigation
of basic neuroscience questions dealing with sensory and
cognitive processing. In order to gain a better understanding
of how the brain accomplishes these tasks, the laboratory
takes a multimodal approach by using a variety of behavioral
and neuroimaging methods, such as fMRI, MEG, intracranial
EEG, and psychophysics.
Opportunities exist for talented students and residents to participate in one of the lab’s research areas. Students will be provided with training in functional neuroimaging and are part of the research process at all levels. Students are usually integrated into an ongoing project and supervised by an advanced grad student, postdoc or faculty member. In some circumstances, it may be possible for the student to pursue their own research project.
Examples of current projects include:
-Development of non-invasive language mapping protocols for
clinical use
-Sensory and cognitive information processing in humans: intracranial
EEG
-MRI morphometry and epilepsy: post-ictal psychosis and temporal
lobe epilepsy
Ideal time commitment for research assistants: Variable between 8h/week to full-time. Summer projects availabe
Office/lab location: HCC-12
Preferred contact: thomas.thesen@med.nyu.edu
http://mmil.ucsd.edu/thomas/group
Selected publications:
Calvert GA, Thesen T. BOLD and frequency responses to multisensory
social signals: different rules for different sensory systems
[Abstract]. Annual meeting abstract program (Cognitive Neuroscience
Society) 2007;137 (#D60).
Fiebelkorn I, Sehatpour P, De Sanctis P, Thesen T, Devinsky O, Molholm S, Foxe JJ. Pre-attentive processing of auditory stimuli: a human intracranial study of generators of mismatch negativity for phonemic and non-phonemic sounds [Abstract]. Annual meeting abstract program (Cognitive Neuroscience Society) 2007;181 (#E92).
Halgren E, Thesen T, Leontiev O, Huang MX, Song T, Dehghani N, Hagler DJ, Dale AM, Buxton R. Effects of hypercapnia on evoked human brain activity measured with MEG [Abstract]. Annual meeting abstract program (Cognitive Neuroscience Society) 2007;145 (#D99).
Reale RA, Calvert GA, Thesen T, Jenison RL, Kawasaki H, Oya H, Howard MA, Brugge JF. Auditory-visual processing represented in the human superior temporal gyrus. Neuroscience 2007 Mar 2;145(1):162-84.
Sahin NT, Pinker S, Cash S, Thesen T, Wang C, Devinsky O, Kuzniecky R, Doyle W, Halgren E. Communication between Broca's and Wernicke's areas detected with intracranial electrophysiology in awake humans [Abstract]. Neuroimage 2007;36(S1) :S74.
Thesen T, McDonald CR, Carlson CE, Kuzniecky RI, Huang MX, Ahmadi HDJ, Stout JD, Nearing KI, Dale AM, Barr WB, Devinsky O, Halgren E. Non-invasive mapping of language and memory cortex with fMRI and MEG [Abstract]. Annual meeting abstract program (Cognitive Neuroscience Society) 2007;256 (#G144).
Mottonen R, Calvert GA, Jaaskelainen IP, Matthews PM, Thesen T, Tuomainen J, Sams M. Perceiving identical sounds as speech or non-speech modulates activity in the left posterior superior temporal sulcus. Neuroimage 2006 Apr 1;30(2):563-9.
Thesen T, Hansen PC, Campbell R, Osterbauer RA, Calvert GA. Event-related fMRI of auditory-visual speech processing [Abstract]. Journal of cognitive neuroscience 2005 Apr 1;30(2):216.
Calvert GA, Thesen T. Multisensory integration: methodological approaches and emerging principles in the human brain. Journal of physiology (Paris) 2004 Jan-Jun;98(1-3):191-205.
Thesen T, Vibell JF, Calvert GA, Osterbauer RA, Giard MH, Wallace M. Neuroimaging of multisensory processing in vision, audition, touch, and olfaction. Cognitive Processing 2004 Jun;5(2):84-93.
Fellowship or post-doctoral training: Neuropathology
Proposed research projects for neurology residents
and medical students:
Blood vessels are constructed by two processes: vasculogenesis,
whereby a primitive vascular network is established from
multipotential mesenchymal progenitors, and angiogenesis,
in which preexisting vessels (both in embryo and adult) send
out capillary sprouts to produce new vessels. Angiogenesis
and vasculogenesis as previously defined, are crucial process
in both neural embryogenesis and neoplasia. Several angiogenic
and vasculogenic factors and extracellular matrix (ECM) proteins
have been implicated in the development and maturation of
the central nervous system (CNS) and in the biology of brain
tumors. The interaction between ECM components and these
factors plays an important role in every step of the angiogenic
and vasculogenic cascades. Our interest is in elucidating
the expression patterns, trigger mechanisms, pathophysiological
and molecular mechanisms that are related to the expression
of both vasculogenic and angiogenic factors and ECM proteins.
Ideal time commitment for research assistants: negotiable
Office/lab location: TCH 4th Floor Tisch 411
Preferred contact: dz4@nyu.edu
Law M, Brodsky JE, Babb J, Rosenblum M, Miller DC, Zagzag D, Gruber ML, Johnson G. High cerebral blood volume in human gliomas predicts deletion of chromosome 1p: preliminary results of molecular studies in gliomas with elevated perfusion. Journal of magnetic resonance imaging 2007 Jun;25(6):1113-9.
Lui YW, Law M, Chacko-Mathew J, Babb JS, Tuvia K, Allen JC, Zagzag D, Johnson G. Brainstem corticospinal tract diffusion tensor imaging in patients with primary posterior fossa neoplasms stratified by tumor type: A study of association with motor weakness and outcome. Neurosurgery 2007;61(6):1199-1207.
Morozov A, Lee SJ, Zhang ZK, Cimica V, Zagzag D, Kalpana GV. INI1 induces interferon signaling and spindle checkpoint in rhabdoid tumors. Clinical cancer research 2007 Aug 15;13(16):4721-30.
Newcomb EW, Lukyanov Y, Schnee T, Esencay M, Fischer I, Hong D, Shao Y, Zagzag D. The geldanamycin analogue 17-allylamino-17-demethoxygeldanamycin inhibits the growth of GL261 glioma cells in vitro and in vivo. Anti-cancer drugs 2007 Sep;18(8): 875 -82.
Pivawer G, Law M, Zagzag D. Perfusion MR imaging and proton MR spectroscopic imaging in differentiating necrotizing cerebritis from glioblastoma multiforme. Magnetic resonance imaging 2007 Feb;25(2):238-43.
Arteaga C, Schnee T, Lukyanov Y, Newcomb E, Zagzag D. Stromal derived factor (SDF)-l alpha expression in glioma cells & human brain microvascular endothelial cells [Abstract]. FASEB journal 2006 Mar 6;20(4):A714.
Fischer I, Revercomb C, Elrich S, Law M, Zagzag D. Intracranial lesions mimicking neoplasia [Abstract]. Brain pathology 2006 Sept;16(11):S38-S38.
Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer research 2006 Mar 1;66(5):2725-31.
Law M, Oh S, Babb JS, Wang E, Inglese M, Zagzag D, Knopp EA, Johnson G. Low-grade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging prediction of patient clinical response. Radiology 2006 Feb;238(2):658-67.
Law M, Oh S, Johnson G, Babb JS, Zagzag D, Golfinos J, Kelly PJ. Perfusion magnetic resonance imaging predicts patient outcome as an adjunct to histopathology: a second reference standard in the surgical and nonsurgical treatment of low-grade gliomas. Neurosurgery 2006 Jun;58(6):1099-1107.
