Tanese Lab
Research Interests
Figure 1. Transcriptional activation of a gene. Transcriptional activators counter chromatin-mediated repression by recruiting chromatin-remodeling enzymes. In eukaryotic cells, DNA is packaged into a regular array of nucleosomes. Nucleosomes prevent RNA polymerase from accessing the transcriptional intiation site of the gene. Many activators are able to bind to their DNA target sites even in the context of chromatin and through protein-protein interactions, recruit coactivator complexes that alter ('remodel') the local nucleosomes allowing general transcription factors and RNA polymerase to assembly on the core promoter. Remodeling complexes fall into two broad classes: ATP-dependent remodeling enzymes and acetyltransferases.
Research Interests
Figure 1. Transcriptional activation of a gene. Transcriptional activators counter chromatin-mediated repression by recruiting chromatin-remodeling enzymes. In eukaryotic cells, DNA is packaged into a regular array of nucleosomes. Nucleosomes prevent RNA polymerase from accessing the transcriptional intiation site of the gene. Many activators are able to bind to their DNA target sites even in the context of chromatin and through protein-protein interactions, recruit coactivator complexes that alter ('remodel') the local nucleosomes allowing general transcription factors and RNA polymerase to assembly on the core promoter. Remodeling complexes fall into two broad classes: ATP-dependent remodeling enzymes and acetyltransferases.