Mohr Lab
Research Interests
Figure 2. Upon binding the 7-methyl guanine cap (7m) at the 5’ end of the mRNA, eIF4E (open crescent) recruits eIF4G and eIF4A to assemble the eIF4F complex. The 40S ribosome is recruited through its association with eIF3. eIF4G also interacts with the eIF4E kinase mnk-1, which phosphorylates eIF4E (depicted as a P), and the polyA binding protein, via Paip-1, bound to the 3’ end of the mRNA.
Research Interests
Figure 2. Upon binding the 7-methyl guanine cap (7m) at the 5’ end of the mRNA, eIF4E (open crescent) recruits eIF4G and eIF4A to assemble the eIF4F complex. The 40S ribosome is recruited through its association with eIF3. eIF4G also interacts with the eIF4E kinase mnk-1, which phosphorylates eIF4E (depicted as a P), and the polyA binding protein, via Paip-1, bound to the 3’ end of the mRNA.