Publications
Schneider, R.J. and I. Mohr. (2003) “Translation initiation and viral tricks.” Trends in Biochem. Sci., 3: 130-136.
Ward, S.L., D. Scheuner, J. Poppers, R.J. Kaufman, I. Mohr and D.A. Leib. (2003) “In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIFa phosphorylation.” J. Virol., 77: 4626-4634.
Benboudjema, L., M. Mulvey, Y. Gao, S.W. Pimplikar and I. Mohr. (2003) “Association of the herpes simplex virus type-1 Us11 gene product with the cellular kinesin light-chain related protein Pat1 results in the redistribution of both polypeptides.” J. Virol., 77: 9192-9203.
Mulvey, M., J. Poppers, D. Sternberg and I. Mohr. (2003) “Regulation of eIF2a phosphorylation by different functions that act during discrete phases in the HSV-1 lifecycle.” J. Virol. 77: 10917 –10928.
Mohr, I. (2004) “Neutralizing inate host defenses to control viral translation in HSV-1 infected cells.” Int. Review of Immunol. 23: 199 - 220.
Walsh, D. and I. Mohr. (2004) “Phosphorylation of eIF4E by mnk-1 enhances HSV-1 translation and replication in quiescent cells.” Genes and Development, in press.
Mulvey, M., V. Camarena, and I. Mohr. (2004) “Full resistance of HSV-1 infected primary human cells to interferon a require both the Us11 and g134.5 gene products.” J. Virol., in press.
Poppers, J., M. Mulvey, C. Perez, D. Khoo and I. Mohr. (2003) “Identification of a lytic Epstein-Barr virus gene product that can regulate PKR activation.” J. Virol., 77: 228-236.
Khoo, D., C. Perez and I. Mohr. (2002) “Characterization of RNA determinants recognize by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1 encoded double-stranded RNA binding protein that prevents PKR activation.” J. Virol., 76: 11971-11981.
Peters, G.A., D. Khoo, I. Mohr, and G. Sen. (2002) "Inhibition of PACT mediated inhibition of PKR by the herpes simplex virus type 1 Us11 protein." J. Virol. 76:11054-11064.
Taneja, S., J. MacGregor, S. Marcus, S. Ha, and I. Mohr. (2001) "Enhanced anti-tumor efficacy of a new herpes simplex virus mutant isolated by genetic selection in cancer cells." Proc. Natl. Acad. Sci USA, 98:8804-8808.
Mohr, I., D. Sternberg, S. Ward, D. Leib, M. Mulvey, and Y. Gluzman. (2001) "An HSV-1 g34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals." J. Virol., 75:5189-5196.
Poppers, J., M. Mulvey, D. Khoo, and I. Mohr. (2000) "Inhibition of PKR activation by the proline rich, RNA binding domain of the HSV-1 Us11 protein." J. Virol., 74:11215-11221.
Mulvey, M., J. Poppers, and I. Mohr. (1999) "A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function." J. Virol., 73:3375-3385.
He, B., J. Chou, R. Brandimarti, I. Mohr, Y. Gluzman, and B. Roizman. (1997) "Suppression of the phenotype of g34.5-herpes simplex virus 1: Failure of activated PKR kinase to shutoff protein synthesis is associated with a deletion in the domain of the a47 gene." J. Virol., 71:6049-6054.
Mohr, I., and Y. Gluzman (1996) "A Herpesvirus genetic element which inhibits translation in the absence of the viral GADD34 function." EMBO J., 15:4759-4766.