Publications
Landau, N.R., M. Warton, and D.R. Littman. (1988) "The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4." Nature, 334:159-162.
Norment, A.M., R.D. Salter, P. Parham, V. Engelhard, and D.R. Littman. (1988) "Cell-cell adhesion mediated by CD8 and MHC class I molecules." Nature, 336:79-81.
Turner, J.M., M.H. Brodsky, B.A. Irving, S.D. Levin, R.M. Perlmutter, and D.R. Littman. (1990) "Interaction of the unique amino-terminal region of the tyrosine kinase p56lck with the cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs." Cell, 60:755-765.
Page, K.A., N.R. Landau, and D.R. Littman. (1990) "Construction and use of an HIV vector for analysis of virus infectivity." J. Virol., 64:5270-5276.
Landau, N.R., K.A. Page, and D.R. Littman. (1991) "Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range." J. Virol., 65:162-169.
Glaichenhaus, N., N. Shastri, D.R. Littman, and J.M. Turner. (1991) "Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells." Cell, 64:511-520.
Sawada, S., and D.R. Littman. (1991) "Identification and characterization of a T cell specific enhancer adjacent to the murine CD4 gene." Mol. Cell. Biol., 11:5506-5515.
Killeen, N., A. Moriarty, H.-S. Teh, and D.R. Littman. (1992) "Requirement for CD8-MHC class I interaction in positive and negative selection of developing T cells." J. Exp. Med., 176:89-97.
Davis, C.B., N. Killeen, M.E.C. Crooks, D. Raulet, and D.R. Littman. (1993) "Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes." Cell, 73:237-47.
Xu, H., and D.R. Littman. (1993) "A kinase-independent function of lck in potentiating antigen-specific T cell activation." Cell, 74:633-644.
Killeen, N., and D.R. Littman. (1993) "Helper T cell development in the absence of CD4-p56lck association." Nature, 364:729-732.
Weiss, A., and D.R. Littman. (1994) "Signal transduction by lymphocyte antigen receptors." Cell, 76:263-274.
Sawada, S., J.D. Scarborough, N. Killeen, and D.R. Littman. (1994) "A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development." Cell, 77:917-929.
Crooks, C., and D.R. Littman. (1994) "Disruption of T lymphocyte positive and negative selection in mice lacking the CD8b chain." Immunity, 1:277-285.
Liao, C., and D.R. Littman. (1995) "Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk." Immunity, 3:757-769.
Deng, H.K., L. Rong, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R.E. Sutton, C.M. Hill, C.B. Davis, S.C. Peiper, T.J. Schall, D.R. Littman, N.R. Landau. (1996) "Identification of a major co-receptor for primary isolates of HIV-1." Nature, 381:661-666.
Sutton, R.E., and D.R. Littman. (1996) "Broad host range of human T-Cell leukemia virus type 1 demonstrated with an improved pseudotyping system." J. Virol., 70:7322-7326.
Hill, C.M., H.K. Deng, D. Unutmaz, V. Kewalramani, L. Bastiani, S. Zolla-Pazner, and D.R. Littman. (1997) "Envelope glycoproteins from HIV-1, HIV-2, and SIV can use human CCR5 as a cofactor for viral entry and make direct CD4-dependent interactions with this chemokine receptor." J. Virol., 71:6296-6304.
Deng, H.K., D. Unutmaz, V.N. KewalRamani, and D.R. Littman. (1997) "Expression cloning of novel receptors used by the simian and human immunodeficiency viruses." Nature, 388:296-300.
Davis, C.B., I. Dikic, D. Unutmaz, C.M. Hill, M. Siani, J. Schlessinger, and D.R. Littman. (1997) "Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5." J. Exp. Med., 186:1793-1798.
Ellmeier, W., M.J. Sunshine, K. Losos, F. Hatam, and D.R. Littman. (1997) "Identification of an enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells." Immunity, 7:537-547.
Zou, Y.R., A. Kottmann, M. Kuroda, I. Taniuchi, and D.R. Littman. (1998) "Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development." Nature, 393:595-599.
Littman, D.R. (1998) "Chemokine receptors: Keys to AIDS pathogenesis?" Cell, 93:677-680.
Rivière, I., M.J. Sunshine, and D.R. Littman. (1998) "Regulation of IL-4 expression by activation of individual alleles." Immunity, 9:217-228.
Ellmeier, W., M.J. Sunshine, K. Losos, and D.R. Littman. (1998) "Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells." Immunity, 9:485-496.
Garber, M.E., P. Wei, V.N. KewalRamani, T.P. Mayall, C. Herrmann, A. Rice, D.R. Littman, and K.A. Jones. (1998) "The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein." Genes and Dev., 12:3512-3527.
Ellmeier, W., S. Sawada, and D.R. Littman. (1999) "The regulation of CD4 and CD8 coreceptor gene expression during T cell development." Ann. Rev. Immunol., 17:523-554.
Schaeffer, E.M., J. Debnath, G. Yap, D. McVicar, X.C. Liao, D.R. Littman, A. Sher, H.E. Varmus, M.J. Lenardo, and P.L. Schwartzberg. (1999) "Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity." Science, 284:638-641.
Unutmaz, D., V.N. KewalRamani, S. Marmon, and D.R. Littman. (1999) "Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes." J. Exp. Med., 189:1735-46.
Sun, Z., C.W. Arendt, W. Ellmeier, E.M. Schaeffer, M.J. Sunshine, J. Annes, D. Petrzilka, A. Kupfer, P.L. Schwartzberg, and D.R. Littman. (2000) "PKC-q is required for TCR-induced NF-kB activation in mature but not immature T lymphocytes." Nature, 404:402-407.
Geijtenbeek, T.B.H., D.S. Kwon, R. Torensma, S.J. van Vliet, G.C.F. van Duijnhoven, J. Middel, I.L.M.H.A. Cornelisen, H.S.L.M. Nottet, V.N. KewalRamani, D.R. Littman, C.G. Figdor, and Y. van Kooyk. (2000) "DC-SIGN, a dendritic cell-specific HIV-1 binding protein that enhances trans-infection of T cells." Cell, 100:587Ñ597.
Sun, Z., D. Unutmaz, Y.R. Zou, M.J. Sunshine, A. Pierani, S. Brenner-Morton, R.E. Mebius, and D.R. Littman. (2000) "Requirement for RORg in thymocyte survival and lymphoid organ development." Science,, 288:2369-2373.
Jung, S., J. Aliberti, P. Graemmel, M.J. Sunshine, G.W. Kreutzberg, A. Sher, and D.R. Littman. (2000) "Analysis of fractalkine receptor CX3CR1 function by targeted deletion and GFP reporter gene insertion." Mol. Cell. Biol., 20:4106-14.
Ellmeier, W., M.J. Sunshine, S. Jung, F. Hatam, Y. Xu, D. Baltimore, H. Mano, and D.R. Littman. (2000). "Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk." J. Exp. Med., 192:1611-1624.