Derkatch Lab
Research Interests
Figure 1. Experimental system. Schematic representation (top) of the synthesis on the ribosome of the Ade1 protein from the transcript containing a premature stop codon (star). In a [PSI+] strain, Sup35 (circle) is prionized (square) and doesn't bind Sup45 (triangle) to form release factor. This leads to a frequent read-through of the stop codon and to the synthesis of full-length Ade1, that can be detected as growth on adenineless media and white color on YPD medium (bottom).
Research Interests
Figure 1. Experimental system. Schematic representation (top) of the synthesis on the ribosome of the Ade1 protein from the transcript containing a premature stop codon (star). In a [PSI+] strain, Sup35 (circle) is prionized (square) and doesn't bind Sup45 (triangle) to form release factor. This leads to a frequent read-through of the stop codon and to the synthesis of full-length Ade1, that can be detected as growth on adenineless media and white color on YPD medium (bottom).