Publications
Wu, L., Fan, J., and J. G. Belasco. (2006) "MicroRNAs direct rapid deadenylation of mRNA." Proc. Natl. Acad. Sci. USA, 103: 4034-4039.
Deana, A., and J. G. Belasco. (2005) "Lost in translation: the influence of ribosomes on bacterial mRNA decay." Genes Dev., 19: 2526-2533.
Wu, L., and J. G. Belasco. (2005) "Micro-RNA Regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells." Mol. Cell. Biol., 25: 9198-9208.
Jiang, X., and J. G. Belasco. (2004) "Catalytic activation of multimeric RNase E and RNase G by 5'-monophosphorylated RNA." Proc. Natl. Acad. Sci. USA, 101: 9211-9216.
Deana A; and J. G. Belasco (2004) "The function of RNase G in Escherichia coli is constrained by its amino and carboxyl termini".Molecular microbiology.,51:1205
Diwa AA; Jiang X; Schapira M; Belasco JG. (2002) "Two distinct regions on the surface of an RNA-binding domain are crucial for RNase E function".Molecular microbiology. 46:959
Diwa AA; Belasco JG. (2002) "Critical features of a conserved RNA stem-loop important for feedback regulation of RNase E synthesis".Journal of biological chemistry.277:20415
Feldbrugge, M; Arizti, P; Sullivan, ML; Zamore, PD; Belasco, JG; Green, PJ. (2002) "Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells".Plant molecular biology. 49:215
Jain, C., A. Deana, and J.G. Belasco. (2002) "Consequences of RNase E scarcity in Escherichia coli." Molecular Microbiology, in press.
Danner, S., and J.G. Belasco. (2001) "T7 phage display: a novel genetic selection system for cloning RNA-binding proteins from cDNA libraries." Proc. Natl. Acad. Sci. USA 98:12954-12959.
Jain, C., and J.G. Belasco. (2001) "Structural model for the cooperative assembly of HIV-1 Rev multimers on the RRE as deduced from analysis of assembly-defective mutants." Mol. Cell 7:603-614.
Diwa, A., A.L. Bricker, C. Jain, and J.G. Belasco. (2000) "An evolutionarily conserved RNA stem-loop functions as a sensor that directs feedback regulation of RNase E gene expression." Genes Dev. 14:1249-1260.
Jiang, X., A. Diwa, and J.G. Belasco. (2000) "Regions of RNase E important for 5'-end-dependent RNA cleavage and autoregulated synthesis." J. Bacteriol. 182:2468-2475.
Jain, C., and J.G. Belasco. (2000) "Rapid genetic analysis of RNA-protein interactions by translational repression in E. coli." Methods Enzymol. 318:309-332.
Bricker, A.L., and J.G. Belasco. (1999) "Importance of a 5' stem-loop for longevity of papA mRNA in Escherichia coli." J. Bacteriol. 181:3587-90.
Rimmele, M.E., and J.G. Belasco. (1998) "Target discrimination by RNA-binding proteins: role of the ancillary protein U2A' and a critical leucine residue in differentiating the RNA-binding specificity of spliceosomal proteins U1A and U2B." RNA 4:1386-1396.
Arnold, T.E., J. Yu, and J.G. Belasco. (1998) "mRNA stabilization by the ompA 5' untranslated region: two protective elements hinder distinct pathways for mRNA degradation." RNA 4:319-330.
Laird-Offringa, I.A., and J.G. Belasco. (1998) "RNA-binding proteins tamed." Nature Struct. Biol. 5:665-668.
Bouvet, P., Jain C., J.G. Belasco, F. Amalric, and M. Erard. (1997) "RNA recognition by the joint action of two nucleolin RNA-binding domains:genetic analysis and structural modeling." EMBO J. 16:5235-5246.
Jain, C., and Belasco J.G. (1997) "A rapid genetic method for the study of RNA binding proteins." In:Richter JD, ed., mRNA Formation and Function. Academic Press, 263-284.
Jain, C., and J.G. Belasco. (1996) "A structural model for the HIV-1 Rev-RRE complex deduced from altered-specificity rev variants isolated by a rapid genetic strategy." Cell 87:115-125.
Aristarkhov, A., A. Mikulskis, J.G. Belasco, and E.C.C. Lin. (1996) "Translation of the adhE transcript to produce ethanol dehydrogenase requires RNase III cleavage in Escherichia coli." J. Bacteriol. 178:4327-4332.
Laird-Offringa, I.A., and J.G. Belasco. (1996) "In vitro genetic analysis of RNA-binding proteins using phage display libraries." Methods Enzymol. 267:149-168.
Laird-Offringa, I.A., and J.G. Belasco. (1995) "Analysis of RNA-binding proteins by in vitro genetic selection: identification of an amino acid residue important for locking U1A onto its RNA target." Proc. Natl. Acad. Sci. USA 92:11859-11863.
Zubiaga, A.M., J.G. Belasco, and M.E. Greenberg. (1995) "The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation." Mol. Cell. Biol. 15:2219-2230.
Jain, C., and J.G. Belasco. (1995) "Autoregulation of RNase E synthesis in Escherichia coli." Nucleic Acids Symp. Ser. 33:85-88.
Jain, C., and J.G. Belasco. (1995) "RNase E autoregulates its synthesis by controlling the degradation rate of its own mRNA in Escherichia coli: unusual sensitivity of the rne transcript to RNase E activity." Genes Dev. 9:84-96.
Hansen, M.J., L.H. Chen, M.L. Fejzo, and J.G. Belasco. (1994) "The ompA 5' untranslated region impedes a major pathway for mRNA degradation in Escherichia coli." Mol Microbiol. 12:707-716.
Schiavi, S.C., C.L. Wellington, A.B. Shyu, C.Y. Chen, M.E. Greenberg, and J.G. Belasco. (1994) "Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation." J. Biol. Chem. 269:3441-3448 .
Wellington, C.L., M.E. Greenberg, and J.G. Belasco. (1993) "The destabilizing elements in the coding region of c-fos mRNA are recognized as RNA." Mol. Cell. Biol. :5034-5042.
Schiavi, S.C., J.G. Belasco, and M.E. Greenberg. (1992) "Regulation of proto-oncogene mRNA stability." Biochim. Biophys. Acta 1114 :95-106.
Bouvet, P., and J.G. Belasco. (1992) "Control of RNase E-mediated RNA degradation by 5'-terminal base pairing in E. coli." Nature 360:488-491.
Emory, S.A., P. Bouvet, and J.G. Belasco. (1992) "A 5'-terminal stem-loop structure can stabilize mRNA in Escherichia coli." Genes Dev. 6:135-148.
Chen, L.H., S.A. Emory, A.L. Bricker, P. Bouvet, and J.G. Belasco. (1991) "Structure and function of a bacterial mRNA stabilizer: analysis of the 5' untranslated region of ompA mRNA." J. Bacteriol. 173:4758-4586.
Shyu, A.B., J.G. Belasco, and M.E. Greenberg. (1991) "Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay." Genes Dev. 5:221-231.
Chen, C.Y., and J.G. Belasco. (1990) "Degradation of pufLMX mRNA in Rhodobacter capsulatus is initiated by nonrandom endonucleolytic cleavage." J. Bacteriol. 172:4578-4586.
Emory, S.A., and J.G. Belasco. (1990) "The ompA 5' untranslated RNA segment functions in Escherichia coli as a growth-rate-regulated mRNA stabilizer whose activity is unrelated to translational efficiency." J. Bacteriol. 172:4472-4481.
Greenberg, M.E., A.B. Shyu, and J.G. Belasco. (1990) "Deadenylylation: a mechanism controlling c-fos mRNA decay." Enzyme 44:181-192.
Shyu, A.B., M.E. Greenberg, and J.G. Belasco. (1989) "The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways." Genes Dev. 3:60-72.
Belasco, J.G., and C.Y. Chen. (1988) "Mechanism of puf mRNA degradation: the role of an intercistronic stem-loop structure." Genes Dev. 72:109-117.
Belasco, J.G., and C.F. Higgins. (1988) "Mechanisms of mRNA decay in bacteria: a perspective." Gene 72:15-23.
Chen, C.Y., J.T. Beatty, S.N. Cohen, and J.G. Belasco. (1988) "An intercistronic stem-loop structure functions as an mRNA decay terminator necessary but insufficient for puf mRNA stability." Cell 52:609-619.
Nilsson, G., J.G. Belasco, S.N. Cohen, and A. von Gabain. (1987) "Effect of premature termination of translation on mRNA stability depends on the site of ribosome release." Proc. Natl. Acad. Sci. USA 84:4890-4894.
Belasco, J.G., G. Nilsson, A. von Gabain, and S.N. Cohen. (1986) "The stability of E. coli gene transcripts is dependent on determinants localized to specific mRNA segments." Cell 46:245-251.
Belasco, J.G., T.W. Bruice, L.M. Fisher, W.J. Albery, and J.R. Knowles. (1986) "Energetics of proline racemase: rates, fractionation factors, and buffer catalysis in the oversaturated region. Nature of the interconversion of the two forms of free enzyme. Biochemistry 25:2564-2571.
Belasco, J.G., T.W. Bruice, W.J. Albery, and J.R. Knowles. (1986) "Energetics of proline racemase: fractionation factors for the essential catalytic groups in the enzyme-substrate complexes." Biochemistry 25:2558-2564.
Belasco, J.G., W.J. Albery, and J.R. Knowles. (1986) "Energetics of proline racemase: double fractionation experiment, a test for concertedness and for transition-state dominance." Biochemistry 25:2552-2558.
Fisher, L.M., J.G. Belasco, T.W. Bruice, W.J. Albery, and J.R. Knowles. (1986) "Energetics of proline racemase: transition-state fractionation factors for the two protons involved in the catalytic steps." Biochemistry 25:2543-2551.
Belasco, J.G., J.T. Beatty, C.W. Adams, A. von Gabain, and S.N. Cohen. (1985) "Differential expression of photosynthesis genes in R. capsulata results from segmental differences in stability within the polycistronic rxcA transcript." Cell 40:171-181.
Nilsson, G., J.G. Belasco, S.N. Cohen, and A. von Gabain. (1984) "Growth-rate dependent regulation of mRNA stability in Escherichia coli." Nature 312:75-77
von Gabain, A., J.G. Belasco, J.L. Schottel, A.C. Chang, and S.N. Cohen. (1983) "Decay of mRNA in Escherichia coli: investigation of the fate of specific segments of transcripts." Proc. Natl. Acad. Sci. USA 80:653-657.
Belasco, J.G., and J.R. Knowles. (1983) "Polarization of substrate carbonyl groups by yeast aldolase: investigation by Fourier transform infrared spectroscopy." Biochemistry 22:122-129.
Fisher, J., J.G. Belasco, S. Khosla, and J.R. Knowles. (1980) "Beta-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin." Biochemistry 19:2859-2901.
Fisher, J., J.G. Belasco, R.L. Charnas, S. Khosla, and J.R. Knowles. (1980) "Beta-lactamase inactivation by mechanism-based reagents." Philos. Trans. R. Soc. Lond. B. Biol. Sci. 289:309-319.
Belasco, J.G., and J.R. Knowles. (1980) "Direct observation of substrate distortion by triosephosphate isomerase using Fourier transform infrared spectroscopy." Biochemistry 19:472-477.
Belasco, J.G., J.M. Herlihy, and J.R. Knowles. (1978) "Critical ionization states in the reaction catalyzed by triosephosphate isomerase." Biochemistry 17:2971-2978.