Ratner Lab - Microbiology
Adam J. Ratner, M.D., M.P.H.
Associate Professor of Pediatrics and Microbiology
Division Chief, Pediatric Infectious Diseases
Medical Science Building, Room 223
550 First Avenue, New York, NY 10016
Office: (646) 501-0044
Lab: (646) 501-0038
B.A., Yale University, 1993
M.P.H., Columbia University, 1997
M.D., Columbia University, 1998
Resident in Pediatrics, Columbia University, 1998-2001
Fellow in Pediatric Infectious Diseases, Children’s Hospital of Philadelphia, 2001-2004
Postdoctoral Fellow, University of Pennsylvania, 2004-2006
Associate Professor of Pediatrics and Microbiology, New York University School of Medicine (2015 – present)
Description of Ratner Lab Research:
We are a translational research group with a clear mission: to decrease morbidity and mortality of pregnant women and children by developing new knowledge, treatments, diagnostics, and vaccines for infectious diseases.
Pregnancy and early life are times of particular vulnerability to infection. Our goal is to understand the specific mechanisms by which such infections occur and to translate that knowledge into new therapies and prevention strategies. We combine bacterial and host genetics, whole-genome and whole-transcriptome profiling, new animal models of colonization/infection, and human studies in pursuit of that goal. Our recent work has focused on Streptococcus agalactiae (Group B Streptococcus) as a cause of neonatal sepsis, bacterial vaginosis as a driver of preterm birth, and pore-forming toxins as a common bacterial strategy for survival within hosts.
Selected Recent Publications:
The essential genome of Streptococcus agalactiae.
Hooven TA, Catomeris AJ, Akabas LH, Randis TM, Maskell DJ, Peters SE, Ott S, Santana-Cruz I, Tallon LJ, Tettelin H, Ratner AJ.
BMC Genomics. 2016 May 26;17(1):406. doi: 10.1186/s12864-016-2741-z.
Hyperglycemic Conditions Prime Cells for RIP1-dependent Necroptosis.
LaRocca TJ, Sosunov SA, Shakerley NL, Ten VS, Ratner AJ.
J Biol Chem. 2016 Jun 24;291(26):13753-61. doi: 10.1074/jbc.M116.716027. Epub 2016 Apr 29.
CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis.
LaRocca TJ, Stivison EA, Mal-Sarkar T, Hooven TA, Hod EA, Spitalnik SL, Ratner AJ. Cell Death Dis 2015; 6: e1773.
Group B Streptococcus -hemolysin/cytolysin breaches maternal-fetal barriers to cause preterm birth and intrauterine fetal demise in vivo.
Randis TM, Gelber SE, Hooven TA, Abellar RG, Akabas LH, Lewis EL, Walker LB, Byland LM, Nizet V, Ratner AJ.
J Infect Dis 2014; 210: 265-273.
Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes.
LaRocca TJ, Stivison EA, Hod EA, Spitalnik SL, Cowan PJ, Randis TM, Ratner AJ.
mBio 2014; 5: e01251-14.
α-Intercalated cells defend the urinary system from bacterial infection.
Paragas N, Kulkarni R, Werth M, Schmidt-Ott K, Forster C, Singer E, Klose AD, Shen TH, Reng R, Francis KP, Ray S, Vijayakumar S, Seward S, Bovino M, Xu K, Takabe Y, Amaral FE, Mohan S, Wax R, Sanna-Cherchi S, Mori K, Johnson L, Nickolas T, D'Agati V, Qiu A, Al-Awqati Q, Ratner AJ‡, Barasch J‡.
J Clin Invest 2014; 124: 2963-2976.
The role of pore-forming toxins in bacterial infectious diseases.
Los FCO, Randis TM, Aroian R, Ratner AJ.
Microbiol Mol Biol Rev 2013; 77: 173-207.
Complete genome sequence of Streptococcus agalactiae CNCTC 10/84, a hypervirulent sequence type 26 strain.
Hooven TA, Randis TM, Daugherty SC, Narechania A, Planet PJ, Tettelin H, Ratner AJ.
Genome Announc 2014; 2: e01338-14.
DNase inhibits Gardnerella vaginalis biofilms in vitro and in vivo.
Hymes SR, Randis TM, Sun TY, Ratner AJ.
J Infect Dis 2013; 207: 1491-1497.
β-Hemolysin/cytolysin of Group B Streptococcus enhances host inflammation but is dispensable for establishment of urinary tract infection.
Kulkarni R, Randis TM, Antala S, Wang A, Amaral FE, Ratner AJ.
PLOS ONE 2013; 8: e59091.
Vaginolysin drives epithelial ultrastructural responses to Gardnerella vaginalis.
Randis TM, Zaklama J, LaRocca TJ, Los FCO, Lewis EL, Desai P, Rampersaud R, Amaral FE, Ratner AJ.
Infect Immun 2013; 81: 4544-4550.
Tara Randis, M.D., M.S. – Co-investigator; Assistant Professor of Pediatrics
Jacqueline Baker, M.D. – Postdoctoral Researcher
Thomas Hooven, M.D. – Postdoctoral Researcher
Maryam Bonakdar, M.S. – Laboratory Manager
Andrew Catomeris, B.A. – Laboratory Technician
Erin Cicalese, M.D. – Neonatology Fellow (Columbia)
Geoff Rosen, B.A. – Medical Student (Columbia)