For the first time, detailed speciation and metagenomic characterization of the microbiome of various niches in the human body are now possible using medium-high throughput techniques. Many retained solutes in renal failure and putative uremic toxins are metabolic byproducts of gut bacteria. In collaboration with Dr. Martin Blaser's lab (Medicine and Microbiology), we are investigating the host-microbiome interaction in uremia.

Manish Ponda, MD, Publications:

Ponda MP, Barash I. Lipid Metabolism in Dialysis Patients – The Story Gets More Complicated. Semin Dial. In Press.

Raff AC, Lieu S, Melamed ML, Quan Z, Ponda M, Meyer TW, Hostetter TH.  Relationship of Impaired Olfactory Function in ESRD to Malnutrition and Retained Uremic Molecules. Am J Kidney Dis. 2008 Apr 17.

Niranjan T, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K.  The Notch pathway in podocytes plays a role in the development of glomerular disease.  Nat Med. 2008 Mar;14(3):290-8.

Ponda MP, Hostetter TH.  Aldosterone antagonism in chronic kidney disease. Clin J Am Soc Nephrol. 2006 Jul;1(4):668-77.

Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S.  Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase.  J Biol Chem. 2001 Jun 15;276(24):21737-44.