Lawrence Gardner, MD | Gardner Lab | NYU School of Medicine, Department of Medicine

Lawrence B. Gardner, MD

Lawrence Gardner, MD Prinicpal Investigator

Assistant Professor of Medicine and Pharmacology

Departments of Medicine (Hematology) and Pharmacology, and the NYU Cancer Institute

Laboratory of Tumor Hypoxia

Many tumors are hypoxic, and hypoxic tumors are more aggressive than non-hypoxic tumors. The goal of our laboratory is to determine how cellular proliferation and differentiation are regulated in hypoxic cells, and how this may affect tumor progression. We use a variety of molecular biology, cell biology, and biochemical techniques to explore how cell cycle checkpoints are regulated in hypoxic cells (and how this regulation may be aberrant in tumor cells) and how gene expression is regulated in hypoxic cells (and the significance of this hypoxic regulation). Although we study basic cellular processes, our ultimate goal is to better understand and treat human cancers.

Education/Training:

Medical Education

Yale University School of Medicine

Residency Training

Johns Hopkins Hospital (Medicine)

Clinical Fellowships

Johns Hopkins Hospital (Hematology and Medical Oncology)

Medical Interests

Anemias, Myeloproliferative Disorders, Coagulation Disordersy

Selected Publications:

Peer Reviewed Research

1.	Tang L., Cheng T., Kehr A., Kim J., Gardner L., Silvern L., Tsang L., Lai G., Chung C., Pakrash E., Levandowsky M. Chemosensory Responses to Amino Acids and Certain Amines by the Ciliate Tetrahmena; a Flat Capillary Assay. Biological Bulletin 167:322, 1984
2.	Gardner L.B., Liu Z., Barrett E.J. The Role of Glucose-6-Phosphatase in the Action of Insulin on Hepatic Glucose Production in the Rat. Diabetes 42:1614 1993.
3.	Liu Z., Gardner L.B., Barret E.J. Insulin and Glucose Suppress Hepatic Glycogenolysis by Distinct Enzymatic Mechanisms. Metabolism 42:1546, 1993
4.	Liu Z., Gardner L.B., Barrett E.J. An Endogenous Glycogen Associated Compound Modulates Glucose-6-Phosphatase Activity in Rat Liver Microsome. Biochem Biophys Res Commun 195:173, 1993
5.	Gardner L.B., Li, Q., Park M.S., Flanagan W.M., Semenza G.L., Dang C.V. Hypoxia Activates a G1/S Checpoint Through Regulation of p27 Expression. J Biol Chem 276:79199, 2001
6.	Gardner L.B., Li F., Yang X., Dang C. Anoxic Fibroblasts Activate an S phase Checkpoint that is Bypassed By E1a. Molecular and Cellular Biology23:9032, 2003
7.	Toonkel R, Levine M, Gardner L. Erythropoietin-deficient anemia associated with autoimmune polyglandular syndrome type I. Am J Hematol. 75:84, 2004
8.	Allen A, Zheng Y, Gardner L, Safford M, Horton MR, Powell JD. The Novel Cyclophilin Binding Compound, Sanglifehrin A, Disassociates G(1) Cell Cycle Arrest From Tolerance Induction. J Immunol. 172:4797-803. 2004
9.	Dang D.T., Chen, F., Gardner, L.B., Rago C., Cummins, J.M., Bunz, F., Kantsevoy S.V., Dang, L.H. Hypoxia-Inducible Factor-1a Promotes Nonhypoxia-Mediated Proliferation in Colon Cancer Cells and Xenografts. Cancer Research 66:1684, 2006
10.	S. Maureen Nemetski and Lawrence B. Gardner, Hypoxic Suppression of Id-1 via Activation of theUnfolded Protein Response is Aberrant in Neuroblastoma J Biol Chem. 282:240, 2007
11.	Asmis L.M., Segal J.B., Plantinga, L.C., Fink, N.E., Kerman J.S., Kickler, TS, Coresh J., Gardner, L.B., Heparin-Induced Antibodies and Cardiovascular Risk in Patients on Dialysis, submitted
1.	Gardner L.B., Benz E.J. The Anemia of Chronic Disease. In Hematology; Basic Practice and Principles 3ed Edition Churchill Livingston 1999
2.	Dang C.V. and Gardner L.B.,Transient Global Amnesia After Sex. Lancet 352:397, 1998
3.	Gardner L.B., Lee L.A., Dang C.V. c-myc Protooncogene in Encyclopedia of Cancer, 2nd edition
4.	Gardner L.B., Dang C.V. Myelodysplasia in The Oxford Textbook of Medicine, 4th edition
5.	Lee S., Diaz L., Gardner L. Thrombocytopenia in The Osler Medical Handbook, Mosby 2003
6.	Gardner L.B., Blood Smear and Bone Marrow Review, in The Johns Hopkins Internal Medicine Review, Miller, Sisson, Ashar editors. 1st edition, 2004
7.	Gardner L.B., Benz E.J. The Anemia of Chronic Disease. In Hematology; Basic Practice and Principles 4th Edition. Churchill Livingston 2005.
8.	Kim, J, Gardner, L.B., Dang, C.V. Oncogenic Alterations of Metabolism and the Warburg Effect Drug Discovery Today: Disease Mechanisms 2:233-238 2005
9.	Gardner, L.B. Hypoxia in Tumor Physiology. Encyclopedia of Cancer, 2nd edition (2007).
10.	Gardner L.B., Benz E.J. The Anemia of Chronic Disease. In Hematology; Basic Practice and Principles 4th Edition. Churchill Livingston in press.
11.	Gardner, L. B. Blood Smear and Bone Marrow Review, in The Johns Hopkins Internal Medicine Board Review, 2nd Edition, in press.

Chapters and Reviews

Email:

Lawrence Gardner, MD

The Gardner Lab