Blaser Lab Group

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'Glow' Worms

(Link to more on Cynthia Portal's research on bacterial proliferation inside the intestine of C. elegans)

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C. elegans worm subject

 

C. elegans is a small, free-living soil nematode that feeds primarily on bacteria. Its usefulness as a model organism is a result of its genetic tractability, rapid generation time, ease of propagation, a well-defined cell lineage map, and a fully sequenced genome that contains a large number of vertebrate orthologues.  Because C. elegans is genetically tractable, it has been used to study a variety of biological processes including, for example, ageing, apoptosis, chemosensation, and more recently bacterial pathogenesis and innate immunity. 
Distribution of bacterial load and location varies according to worm genotype

Dual bacterial colonization of the C. elegans gut

 

 

 

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C. elegans: wild genotype C. elegans: daf-2 mutant C. elegans: phm-2 mutant With S. typhimurium colony With E. coli colony With dual bacterial colonization