Laura Senatus, PhD, Postdoctoral Fellow
As a member of the Diabetes Research Program, Laura is studying regression of atherosclerosis in diabetes. While focusing on macrophages, a major question addressed is whether high glucose levels impair regression. If so, does the RAGE knockout model reverse this? In various in vivo and in vitro experiments she is elucidating the role of RAGE/mDia1 interaction in regression and investigating macrophage properties in atherosclerotic lesions (migration, influx, egress patterns).
In September 2016, Laura successfully defended her PhD thesis titled “Receptor for Advanced Glycation End Products (Ager) and Diaphanous-1 (Drf1) Suppress Regression of Diabetic Atherosclerosis”.