Dr. Sedlis directs the cardiac referral program at the New York Veterans Affairs Medical Center, which serves as the regional VA referral center for interventional cardiology and heart surgery. His research focuses on clinical and metabolic factors that predispose to high risk and poor outcomes in patients with advanced coronary artery disease and may impact on choice of revascularization (PCI versus CABG). He is involved in both VA and NIH sponsored randomized clinical trials in coronary artery disease (AWESOME, COURAGE, FREEDOM) and collaborates with colleagues in thrombosis research, endocrinology and cardiac surgery at the New York Veterans Affairs in studies evaluating the effect of established and novel risk factors on outcomes after coronary revascularization.

Selected Publications:

1. Sedlis SP, Sequeira JM, Altszuler HM: Coronary Sinus Lysophosphatidylcholine Accumulation During Rapid Atrial Pacing. Am J. Cardiol. 66:695-698, 1990.
2. Sedlis SP, Hom M, Sequeira JM, Esposito R. Lysophosphatidylcholine Accumulation in Ischemic Human Myocardium. J. Lab Clin Med. 121:111-117, 1993
3. Weinshel EH, Altszuler HM, Raicht RF, Sedlis SP. Beta Adrenergic Stimulation and Blockade in Cirrhosis: Effects on Azygous Vein Blood Flow and Portal Hemodynamics. Am. J. Med. Sci. 307:396-400, 1994
4. Sedlis SP, Hom M, Sequeira JM, Tritel M, Gindea A, Ladenson JH, Jaffe AS, Esposito R. Time Course of Lysophosphatidylcholine Release from Ischemic Human Myocardium Parallels the Time Course of Early Ischemic Ventricular Arrhythmia. Coronary Artery Disease. 8:19-27, 1997
5. Sedlis SP, Fisher VJ, Tice D, Esposito R, Madmon L, Steinberg EH. Racial Differences in Performance of Invasive Cardiac Procedures in a Department of Veterans Affairs Medical Center. Journal of Clinical Epidemiology. 50: 899-901, 1997.
6. Morrison DA, Sethi G, Sacks J, Henderson W, Grover F, Sedlis SP, Esposito R, Ramanathan KB, Weiman D, Saucedo J, Antakli T, Paramesh V, Pett S, Vernon S, Birjiniuk V, Welt F, Krucoff M, Wolfe W, Lucke JC, Mediratta S, Booth D, Barbiere C, Lewis D. Percutaneous Coronary Intervention versus Coronary Bypass Graft Surgery for Patients with Medically Refractory Myocardial Ischemia and Risk Factors for Adverse Outcomes with Bypass: A Multicenter Randomized Trial. J. Am Coll Cardiol. Jul; 38(1): 143-9. 2001
7. Morrison DA, Sethi G, Sacks J, Henderson W, Grover F, Sedlis SP, Esposito R, Ramanathan KB, Weiman D, Saucedo J, Antakli T, Paramesh V, Pett S, Vernon S, Birjiniuk V, Welt F, Krucoff M, Wolfe W, Lucke JC, Mediratta S, Booth D, Barbiere C, Lewis D. Percutaneous Coronary Intervention versus Coronary Bypass Graft Surgery for Patients with Medically Refractory Myocardial Ischemia and Risk Factors for Adverse Outcomes with Bypass: The VA AWESOME Multicenter Registry: Comparison with the Randomized Clinical Trial. J. Am Coll Cardiol 39:266-73. 2002
8. Sedlis SP, Morrison DA, Lorin JD, Esposito RA, Sethi G, Sacks J, Henderson W, Grover F, Ramanathan, KB, Weiman D, Saucedo J, Antakli T, Paramesh V, Pett S, Vernon S, BirjiniukV, MD, Welt F, Krucoff M, Wolfe W, Lucke JC Mediratta S, Booth D, Murphy E, Ward H, Miller L, Kies S, Barbiere C, Lewis D. Percutaneous Coronary Intervention Versus Coronary Bypass Graft Surgery for Diabetic Patients With Unstable Angina and Risk Factors for Adverse Outcomes with Bypass: Outcome of Diabetic Patients in the AWESOME Randomized Trial and Registry. J. Am Coll Cardiol. 40:1555-66. 2002
9. Lochow P, Schwartzbard A, Guest J, Ripps C, Matalon D, Gambetta R, Tunick PA, Sedlis SP. Elevated prothrombin and activated protein C resistance in patients with thoracic aortic atheroma. Angiology. 53:423-8. 2002
10. Morrison DA, Sethi G, Sacks J, Henderson W, Grover F, Sedlis SP, Esposito RA Percutaneous Coronary Intervention versus Repeat Bypass Surgery for Patients with Medically Refractory Myocardial Ischemia AWESOME Randomized Trial and Registry Experience with post-CABG Patients. J. Am Coll Cardiol. 40:1951-4. 2002
11. Sedlis SP, Ramanathan KB, Morrison DA, Sethi G, Sacks J, Henderson W. Outcome of Percutaneous Coronary Intervention Versus Coronary Bypass Grafting for Patients with Low Let Ventricular Ejection Fractions, Unstable Angina Pectoris and Risk Factors for Adverse Outcomes with Bypass (The AWESOME Randomized Trial and Registry). Am. J. Cardiol. 94:118-120, 2004
12. El-Omar M, Islam N, Broekman MJ, Drosopoulos JHF, Roa DC, Lorin JD, Sedlis SP, Olson KE and Marcus AJ. The Ratio of ADP- to ATP-Ectonucleotidase Activity is reduced in Patients with Coronary Artery Disease. Thrombosis Research; 116(3): 199-206. 2005
13. Shah B, Liou M, Grossi E, Mass H, Lorin JD, Danoff A and Sedlis SP. Relation of Elevated Periprocedural Blood Glucose to Long-Term Survival Following Percutaneous Coronary Intervention. Am. J. Cardiol 15;96(4):543-6 2005