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Silvia G. Priori , M.D., Ph.D.

Dr. Priori is Director of the new Cardiovascular Genetics Program in the Leon H. Charney Division of Cardiology.  Her groundbreaking studies have used genetic techniques to identify new genes responsible for various forms of inherited arrhythmias.

Prior to joining NYU in 2008, Dr. Priori had established the world's largest genetics screening laboratory, database and clinic dedicated to genetics of arrhythmias at the University of Pavia, Italy.  There, her research focused on unraveling how mutations lead to disease, enabling the screening of individuals and families at risk of sudden cardiac death to target treatment and prevent cardiac arrest.  Dr. Priori is the recipient of numerous grants, with support from the European Union, the Italian Government, the Telethon Foundation and the Leducq Foundation.

Dr Priori has served in leadership positions in many international organizations and scientific societies, including being the Chairperson of the Committee for Clinical Practice Guidelines of the European Society of Cardiology and the President of the European Heart Rhythm Society.  She has been named to the editorial board of many major cardiovascular journals.  She is the recipient of many major awards, including the Outstanding Research Award in Pediatric Cardiology from the American Heart Association.

Selected publications

  1. Priori SG, Schwartz PJ, Napolitano C, Bloise R, Grillo M, Vicentini A, Spazzolini C, Ronchetti E, Cappelletti D, Nastoli J, Bottelli G, Folli R. Risk stratification in the Long-QT Syndrome. N Engl J Med 2003;348:1866-1874.
  2. Priori SG, Napolitano C, Schwartz PJ, Grillo M, Bloise R, Ronchetti E, Moncalvo C, Tulipani C, Veia A, Bottelli G, Nastoli J. Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers. JAMA 2004;292:1341-1344.
  3. Napolitano C, Priori SG, Schwartz PJ, Bloise R, Ronchetti E, Nastoli J, Bottelli G, Cerrone M, Leonardi S. Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice. JAMA 2005;294:2975-2980.
  4. Cerrone M, Colombi B, Santoro M, Raffaele di Barletta M, Scelsi M, Villani L, Napolitano C, Priori SG. Bidirectional Ventricular Tachycardia and Fibrillation Elicited in a Knock-In Mouse Model Carrier of a Mutation in the Cardiac Ryanodine Receptor (RyR2). Circ Res 2005;96:e77-82.
  5. Priori SG, Napolitano C. Should patients with an asymptomatic Brugada electrocardiogram undergo pharmacological and electrophysiological testing? Circulation 2005;112:279-292;
  6. Liu N, Colombi B, Memmi M, Zissimopoulos S, Rizzi N, Negri S, Imbriani M, Napolitano C, Lai FA, Priori SG. Arrhythmogenesis in Catecholaminergic Polymorphic Ventricular Tachycardia: insights from a RyR2 R4496C knock-in mouse model. Circ Res 2006;99:292-298.
  7. Raffaele di Barletta M, Viatchenko-Karpinski S, Nori A, Memmi M, Terentyev D, Turcato F, Valle G, Napoltitano C, Gyorke S, Volpe P, Priori SG. Clinical phenotype and functional characterization of CASQ2 mutations associated with Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation 2006;114:1012-1019.
  8. Ruan Y, Liu N, Bloise R, Napolitano C, Priori SG. Gating Properties of SCN5A Mutations and the Response to Mexiletine in Long-QT Syndrome Type 3 Patients. Circulation 2007;116(10):1137-44.
  9. Cerrone M, Noujaim SF, Tolkacheva EG, Talkachou A, O'connell R, Berenfeld O, Anumonwo J, Pandit SV, Vikstrom K, Napolitano C, Priori SG, Jalife J. Arrhythmogenic Mechanisms in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res 2007;101(10):1039-48.
  10. Liu N, Priori SG. Disruption of calcium homeostasis and arrhythmogenesis induced by mutations in the cardiac ryanodine receptor and calsequestrin. Cardiovasc Res 2008;77(2):293-301.
  11. Qin J, Valle G, Nani A, Nori A, Rizzi N, Priori SG, Volpe P, Fill M. Luminal Ca2+ regulation of single cardiac ryanodine receptors: insights provided by calsequestrin and its mutants.J Gen Physiol 2008;131(4):325-34. Epub 2008 Mar 17.
  12. Chen PS, Priori SG. The Brugada syndrome. J Am Coll Cardiol. 2008;51(12):1176-80.
  13. Valle G, Galla D, Nori A, Priori SG, Gyorke S, De Filippis V, Volpe P. Catecholaminergic polymorphic ventricular tachycardia-related mutations R33Q and L167H alter calcium sensitivity of human cardiac calsequestrin. Biochem J. 2008 Jul 15;413(2):291-303 Epub Apr 9.
  14. Rizzi N, Liu N, Napolitano C, Nori A, Turcato F, Colombi B, Bicciato S, Arcelli D, Spedito A, Scelsi M, Villani L, Esposito G, Boncompagni S, Protasi F, Volpe P, Priori SG. Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin: a complex arrhythmogenic cascade in a knock in mouse model. Circ Res. 2008;103(3):298-306.
  15. Priori SG, Auricchio A, Nisam S, Yong P.To Replace or Not to Replace: A Systematic Approach to Respond to Device Advisories. J Cardiovasc Electrophysiol. 2008 Sep 17 [Epub ahead of print]
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