Dr. Fishman is Director of the Leon H. Charney Division of Cardiology and the NYU Program in Cardiovascular Biology. His laboratory is broadly interested in understanding cardiovascular development and disease. A major focus of the laboratory is elucidating the nature of cardiac excitability, including the molecular genetic basis of conduction system development and function, as well as the molecular pathophysiology of cardiac arrhythmias. The laboratory utilizes a multi-disciplinary approach, combining molecular and cellular biology, biochemistry, electrophysiology, together with genetically modified mouse model systems.

Selected Publications:

1. Fishman, G.I., D.C. Spray, and L.A. Leinwand. (1990) Molecular characterization and functional expression of the human cardiac gap junction channel. J. Cell Biol. 111: 589-598.
2. Fishman, G.I., A.P. Moreno, D.C. Spray and L.A. Leinwand. (1991) Functional analysis of human cardiac gap junction channel mutants. Proc. Natl Acad. Sci. USA 88: 3525-3529.
3. De Leon, J.R., H.J. Federoff, K. Vickstrom, D.W. Dickson and G.I. Fishman. (1994) Cardiac and Skeletal Myopathy in MHCbeta-tsA58 transgenic mice. Proc. Natl. Acad. Sci, USA. 91: 519-523.
4. Fishman, G.I., M.L. Kaplan and P.M. Buttrick. (1994) Tetracycline-regulated cardiac gene expression in vivo. J. Clin. Invest. 93: 1864-1868.
5. Passman, R. and G. I. Fishman. (1994) Regulated Expression of Foreign Genes in Vivo After Germline Transfer. J. Clin. Invest. 94: 2421-2425.
6. Meyers, M.B., S-S. Sheu, V.L. Sharma, V.M. Pickel, K.W. Scotto and G.I. Fishman. (1995) Association of sorcin with the cardiac ryanodine receptor. J. Biol. Chem. 270(4): 26411-26418.
7. Yu, Z., C. Redfern and G.I. Fishman. (1996) Conditional transgene expression in the heart. Circ. Res.79: 691-697.
8. McDonald, T.V., Z. Yu, Z. Ming, E. Palma, M.B. Meyers, K-W Wang, S.N.A. Goldstein and G.I. Fishman. (1997) A minK-HERG complex regulates the cardiac potassium current I KrNature 388: 289-292.
9. Meyers M.B., T.S. Puri, A.J. Chien, T. Gao, P-H Hsu, M.M. Hosey and G.I. Fishman (1998) Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca 2+ channels. J Biol Chem 273(30):18930-5.
10. Lee, P., G. Morley, Q. Huang, A. Fischer, S. Seiler, J.W. Horner, S.M. Factor, V. Dhananjay, J. Jalife and G.I. Fishman (1998) Conditional lineage ablation to model human diseases. Proc. Natl. Acad. Sci, USA. 95: 11371-11376.
11. Ai, Z, A. Fischer, D.C. Spray, A.M.C. Brown and G.I. Fishman (2000). Wnt-1 Regulation of Connexin43 in Cardiac Myocytes. J. Clin Invest. 105:161-171.
12. Gutstein, D.E., G.E. Morley, H. Tamaddon, D. Vaidya, M.D. Schneider, J. Chen, K.R. Chien, H. Stuhlmann and G.I. Fishman. (2001). Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of Connexin43. Circulation Research 88: 333 - 339.
13. Rentschler, S., H. Tamaddon, K. Degenhardt, D. Sassoon, G.E. Morley and G.I. Fishman. (2001) Visualization and Functional Characterization of the Developing Murine Cardiac Conduction System. Development 128, 1785-1792.
14. Gutstein, D.E., Morley, G., Vaidya, D., Liu, F., Chen, F.L., Stuhlmann, H., and G.I. Fishman. (2001). Heterogeneous expression of gap junction channels in the heart leads to conduction defects and ventricular dysfunction. Circulation 104(10):1194-9.
15. Rentschler, S., Zander, J., Burns, K., France, D., Levine, R., Porter, G., Rivkees, S.A., Morley, G.E. and G.I. Fishman. (2002). Neuregulin-1 Promotes Formation of the Murine Cardiac Conduction System. Proc. Natl. Acad. Sci. USA 99: 10464-10469.
16. Gutstein, D.E., Danik, S.B., Sereysky, J., Morley G.E. and G.I. Fishman. (2003). Subdiaphragmatic murine electrophysiologic studies: sequential determination of ventricular refractoriness and induction of lethal arrhythmias. Am J Physiol Heart Circ Physiol. 285(3):H1091-6.
17. Meyers, M.B., A. Fischer, Y-J Sun, C. Lopes, TY Nakamura, Y.Y. Zhou, P. Lee, R.A. Altschuld, S.A. McCune, W.A. Coetzee, G.I. Fishman. (2003). Sorcin regulates excitation-contraction coupling in the heart. J Biol Chem. 278(31):28865-71.
18. Danik, S.B., Liu, F., Zhang, J., Suk, H.J., Morley, G.E., Fishman, G.I. D.E. Gutstein. (2004). Modulation of cardiac gap junction expression and arrhythmic susceptibility Circulation Research 95(10);1035-41.
19. Morley GE, Danik SB, Bernstein S, Sun Y, Rosner G, Gutstein DE, Fishman, GI. (2005) Reduced intercellular coupling leads to paradoxical propagation across the Purkinje-ventricular junction and aberrant myocardial activation. Proc Natl Acad Sci U S A. 102(11):4126-9.
20. Gutstein, D.E., Danik, SB, France, D., Liu, F, Chen, FL, Zhang, J., Ghodsi, N., Morley, GE and Fishman G.I. (2005) Focal Gap Junction Uncoupling and Spontaneous Ventricular Ectopy. Am J Physiol Heart Circ Physiol 289(3):H1091-8.