STEM CELL BIOLOGY
COURSE INFO:
Medical school: G16.4413/GSAS: G23.2128
Course Organizer: E. Jane Hubbard, Associate Professor jane.hubbard@med.nyu.edu
COURSE GOALS:
Stem cell biology lies at the intersection of developmental/cell biology and medicine. It has direct relevance to cancer and holds promise for regenerative medicine. One challenge in the field is the background required to stay abreast of progress is being made in divergent organisms and organ systems using a host of techniques. This course - in its breadth and emphasis on molecular underpinnings and rigorous data interpretation - aims to meet this challenge.
COURSE DESCRIPTION:
This course will cover a broad range of topics relevant to stem cell biology. This fast-moving field brings together many aspects of basic and applied biology and medicine including development, regeneration/repair, and cancer. The course will cover these topics in four parts: concepts and themes (including adult, embryonic, germline stem cells, general molecular themes), stem cell biology relevant to specific organ systems, stem cells and cancer, and therapeutics and ethics. The lecture/discussion format will give students both a broad background and the opportunity to apply critical thinking skills to recent data in the field.
COURSE LOGISTICS:
6 credits. Prerequisites: Completion of first three semesters of graduate curriculum of the Sackler graduate program, Biology graduate program, or equivalent. Permission of instructor required for non-Sackler students.
GRADING:
Will be based on active participation in discussion sessions and on a final paper. Final paper will be in the format of an original short proposal describing 1-2 follow-up experiments that derive from the class discussion sessions. Papers must be written independently and in your own words, but you may discuss the proposed experiment(s) with faculty and/or classmates. Papers are due the at the last class meeting. Limit is 5 pages; include a clear statement of the question, relevant background, experimental design and methods, expected results and interpretation, alternative possible results and interpretation, and references.
Relevant programs: Cellular and Molecular Biology, Developmental Genetics, Molecular Oncology and Immunology, Molecular Pharmacology, Pathobiology, Neuroscience and Physiology; other GSAS programs: Department of Biology
Format: spring semester – 5-7pm Tuesdays and Thursdays, beginning January 27, 2009. 4th floor conference room, Skirball Institute building)
2-hr Lecture (usually team of 2 lecturers)
2-hr Discussion (current primary literature-based; may include presentations; students will be graded on preparation and participation)
Resources: No textbook is available, as can be expected in this very new, fast-moving field. As the course progresses, lecturers will compile and update a set of useful comprehensive high-quality review articles (e.g, from Cell, Nature and Science, and other journals including “special issues” or special sections on stem cell biology). Future: a web-based stem cell information resource as a bi-product of the course.
Week 1:
Introduction and concepts in Stem cell biology
Jane Hubbard and Lyn Wilson
Assigned primary papers for week 1:
(1) Ohlstein et al. The adult Drosophila posterior midgut is maintained by
pluripotent stem cells. Nature (2006) vol. 439 (7075) pp. 470-474.
(2) Hanna et al. Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin. Science (2007) vol. 318 (5858) pp. 1920-1923
Week 2
Germline stem cells and germline-derived pluripotent cells
Jane Hubbard and Ruth Lehmann
Assigned papers for week 2:
Week 3
Embryonic Stem cells
Lisa Dailey and Chris Hansis
Assigned papers for week 3:
Week 4:
Induced Pluripotent Stem cells
Lisa Dailey and Jane Hubbard
Assigned papers for week 4:
Week 5
Neuronal stem cells
Gord Fishell and Jeremy Dasen
Assigned papers for week 5:
Week 6
Telomeres & Chromatin
Susan Smith and Danny Reinberg
Assigned papers for week 6:
Medical school: G16.4413/GSAS: G23.2128
Course Organizer: E. Jane Hubbard, Associate Professor jane.hubbard@med.nyu.edu
COURSE GOALS:
Stem cell biology lies at the intersection of developmental/cell biology and medicine. It has direct relevance to cancer and holds promise for regenerative medicine. One challenge in the field is the background required to stay abreast of progress is being made in divergent organisms and organ systems using a host of techniques. This course - in its breadth and emphasis on molecular underpinnings and rigorous data interpretation - aims to meet this challenge.
COURSE DESCRIPTION:
This course will cover a broad range of topics relevant to stem cell biology. This fast-moving field brings together many aspects of basic and applied biology and medicine including development, regeneration/repair, and cancer. The course will cover these topics in four parts: concepts and themes (including adult, embryonic, germline stem cells, general molecular themes), stem cell biology relevant to specific organ systems, stem cells and cancer, and therapeutics and ethics. The lecture/discussion format will give students both a broad background and the opportunity to apply critical thinking skills to recent data in the field.
COURSE LOGISTICS:
6 credits. Prerequisites: Completion of first three semesters of graduate curriculum of the Sackler graduate program, Biology graduate program, or equivalent. Permission of instructor required for non-Sackler students.
GRADING:
Will be based on active participation in discussion sessions and on a final paper. Final paper will be in the format of an original short proposal describing 1-2 follow-up experiments that derive from the class discussion sessions. Papers must be written independently and in your own words, but you may discuss the proposed experiment(s) with faculty and/or classmates. Papers are due the at the last class meeting. Limit is 5 pages; include a clear statement of the question, relevant background, experimental design and methods, expected results and interpretation, alternative possible results and interpretation, and references.
Relevant programs: Cellular and Molecular Biology, Developmental Genetics, Molecular Oncology and Immunology, Molecular Pharmacology, Pathobiology, Neuroscience and Physiology; other GSAS programs: Department of Biology
Format: spring semester – 5-7pm Tuesdays and Thursdays, beginning January 27, 2009. 4th floor conference room, Skirball Institute building)
2-hr Lecture (usually team of 2 lecturers)
2-hr Discussion (current primary literature-based; may include presentations; students will be graded on preparation and participation)
Resources: No textbook is available, as can be expected in this very new, fast-moving field. As the course progresses, lecturers will compile and update a set of useful comprehensive high-quality review articles (e.g, from Cell, Nature and Science, and other journals including “special issues” or special sections on stem cell biology). Future: a web-based stem cell information resource as a bi-product of the course.
Week 1
Introduction and concepts in Stem cell biology
Jane Hubbard and Lyn Wilson
Assigned primary papers for week 1:
(1) Ohlstein et al. The adult Drosophila posterior midgut is maintained by
pluripotent stem cells. Nature (2006) vol. 439 (7075) pp. 470-474.
(2) Hanna et al. Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin. Science (2007) vol. 318 (5858) pp. 1920-1923
Week 2
Germline stem cells and germline-derived pluripotent cells
Jane Hubbard and Ruth Lehmann
Assigned papers for week 2:
Week 3
Embryonic Stem cells
Lisa Dailey and Chris Hansis
Assigned papers for week 3:
Week 4
Induced Pluripotent Stem cells
Lisa Dailey and Jane Hubbard
Assigned papers for week 4:
Week 5
Neuronal stem cells
Gord Fishell and Jeremy Dasen
Assigned papers for week 5:
Week 6
Telomeres & Chromatin
Susan Smith and Danny Reinberg
Assigned papers for week 6:
Week 7
Breast and Prostate Stem Cells
Pam Cowin and Lyn Wilson
Assigned papers for week 7:
No class March 17 & 19
Week 8
Mesenchymal and Cardiac Stem cells
Eva Hernando and Debbie Yelon
Assigned papers for week 8:
Week 9
Hematopoietic Stem Cells
Iannis Aifantis
Assigned papers for week 9:
Week 10
Skin and Intestine Stem Cells
Ram DasGupta and Pam Cowin
Assigned papers for week 10:
Week 11
Cancer Stem Cells
Eva Hernando, Iannis Aifantis
Assigned papers for week 11:
Week 12
Cancer Stem Cells II
Iannis Aifantis
Assigned papers for week 12
Week 13A:
Stem Cells and Therapeutics
Shahin Rafii (Cornell Medical Center)
Assigned papers for week 13A:
Week 13B:
Stem Cells and Ethics
William Ruddick (NYU Department of Philosophy)
Assigned papers for week 13B:
Breast and Prostate Stem Cells
Pam Cowin and Lyn Wilson
Assigned papers for week 7:
No class March 17 & 19
Week 8
Mesenchymal and Cardiac Stem cells
Eva Hernando and Debbie Yelon
Assigned papers for week 8:
Week 9
Hematopoietic Stem Cells
Iannis Aifantis
Assigned papers for week 9:
Week 10
Skin and Intestine Stem Cells
Ram DasGupta and Pam Cowin
Assigned papers for week 10:
Week 11
Cancer Stem Cells
Eva Hernando, Iannis Aifantis
Assigned papers for week 11:
Week 12
Cancer Stem Cells II
Iannis Aifantis
Assigned papers for week 12
Week 13A:
Stem Cells and Therapeutics
Shahin Rafii (Cornell Medical Center)
Assigned papers for week 13A:
Week 13B:
Stem Cells and Ethics
William Ruddick (NYU Department of Philosophy)
Assigned papers for week 13B: