Associate Professor of Neurology, Neuroscience, and Oncology
Institute for Cell Engineering
Johns Hopkins University School of Medicine
733 N. Broadway / BRB Suite 711
Baltimore, MD 21205
4/02 – Left Fishell Lab.
2/97-3/02 – Postdoctoral Fellow
NYU School of Medicine / Skirball Institute, New York, NY.
Postdoctoral fellow in the laboratory of Dr. Gordon Fishell.
Studied the generation of regional and cellular diversity
in the mammalian telencephalon.
9/91-1/97 – Graduate Student
Massachusetts Institute of Technology, Cambridge, MA.
Ph.D. in Biology awarded 2/97.
9/87-5/91 – Undergraduate Student
Cornell University, Ithaca, N. Y.
B.S. in Biochemistry awarded 5/91.
Nick Gaiano joined the Department of Neurology
at Johns Hopkins Med as an Assistant Professor in 2002, and
is a member of the Graduate Program in Neuroscience. He is
also a member of the recently established Institute for Cell
Engineering (ICE) in the Program in Neurobiology. Current
studies in the lab examine the development of the mammalian
forebrain using the mouse as the model system. In particular,
the lab focuses on understanding the molecular mechanisms
that regulate neural stem cell maintenance, proliferation,
and the specification of post-mitotic cell types. Recent work
has found that the Notch and FGF signaling pathways are intimately
involved in these processes, and ongoing studies are continuing
to pursue these pathways among others. Both in vivo and in
vitro approaches are being undertaken to pursue this work.
An ultrasound image-guided injection system is used to introduce
viral vectors into the developing brain in utero prior to
the onset of neurogenesis. The fate of genetically modified
cells is then examined in vivo, or these cells are isolated
using fluorescence-activated cell sorting (FACS) for in vitro
analysis. Close coordination of both loss-of-function and
gain-of-function studies, with in vivo and in vitro assays,
should provide greater insight into the molecular and cellular
regulation of cell-fate specification during brain development.