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Gordon Fishell, Ph.D.
Professor of Cell Biology

Contact Information

Phone: 1-212-263-7691
Fax: 1-212-263-2248
fishell@saturn.med.nyu.edu


Education and Training

Undergraduate/Graduate
1984 – Diploma (B.Sc.) in Physiology & Biophysics, University of Toronto.

1989 – Ph.D. in Neurobiology, University of Toronto-Neurobiology Research Group.


Postdoctoral Training
1990-1992 – Postdoctoral Research Fellow, Department of Pathology, Laboratory of Mary E. Hatten at Columbia University.

Acedemic Appointments

1989-1992 – Research Developmental Neurobiologist, Columbia University

1992-1994 – Assistant Professor, Rockefeller University

1994-1999 – Assistant Professor, Developmental Genetics Program, Skirball Institute and Dept. of Cell Biology, NYU School of Medicine

1999 –2005 Associate Professor, Developmental Genetics Program, Skirball Institute and Dept. of Cell Biology, NYU School of Medicine

2005- Professor, Developmental Genetics Program, Skirball Institute and Dept. of Cell Biology, NYU School of Medicine

2006- Professor and Director of the Smilow Neuroscience Program, NYU School of Medicine

2011-Associate Director of the NYU Neuroscience Institute.

Memberships

1984 – Member of the Society for Neuroscience

Editorial Boards

Highlight Editor, Nature Reviews (Neuroscience)

Associate Editor Neurosignals

Faculty of 1000 Developmental Neurobiology section

Associate Editor The Journal of Neuroscience

Associate Editor Developmental Neuroscience.

Associate Editor Genes and Development

Major Research Interests

Molecular Genetics of Regional Patterning in the Mammalian Telencephalon

Molecular Control of Neural Stem Cell Proliferation and Specification


Bibliography

Original reports
van der Kooy D, Fishell G. Neuronal birthdate underlies the development of striatal compartments. Brain Res 1987; 401: 155-161.

Fishell G, van der Kooy D. Pattern formation in the striatum: developmental changes in the distribution of striatonigral neurons. J Neurosci 1987; 7: 1969-1978.

Takada M, Fishell G, Li ZK, van der Kooy D, Hattori T. The development of laterality in the forebrain projections of midline thalamic cell groups in the rat. Brain Res 1987; 432: 275-282.

Fishell G, van der Kooy D. Pattern formation in the striatum: developmental changes in the distribution of striatonigral projections. Dev Brain Res 1989; 45: 239-255.

Fishell G, Rossant J, van der Kooy D. Neuronal lineages in chimeric mouse forebrain are segregated between compartments and in the rostrocaudal and radial planes. Dev Biol 1990; 141: 70-83.

Fishell G, van der Kooy D. Pattern formation in the striatum: neurons with early projections to the substantia nigra survive the cell death period. J Comp Neurol 1991; 312: 33-42.

Fishell G, Hatten ME. Astrotactin provides a receptor system for CNS neuronal migration. Development 1991; 113: 755-765.

van der Kooy D, Fishell G. Embryonic lesions of the substantia nigra prevent the patchy expression of opiate receptors, but not the segregation of patch and matrix compartment neurons, in the developing rat striatum. Dev Brain Res 1992; 66: 141-145.

Krushel LA, Johnston JG, Fishell G, Tibshirani R, van der Kooy D. Spatially localized neuronal cell lineages in the developing mammalian forebrain. Neuroscience 1993; 53: 1035-1047.

Fishell G, Mason CA, Hatten ME. Dispersion of neural progenitors within the germinal zones of the forebrain Nature 1993; 362: 636-638.

Fishell G, Blazeski R, Godement P, Rivas R, Wang LC, Mason CA. Optical microscopy. Tracking fluorescently labeled neurons in developing brain. FASEB J 1995; 9: 324-334.

Fishell G. Striatal precursors adopt cortical identities in response to local cues. Development 1995; 121: 803-812.

Krushel LA, Fishell G, van der Kooy D. Pattern formation in the mammalian forebrain: striatal patch and matrix neurons intermix prior to compartment formation. Eur J Neurosci 1995; 7: 1210-1219.

Chen J, Chang S, Duncan SA, Okano HJ, Fishell G, Aderem A. Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly. Proc Natl Acad Sci USA, 1996; 93: 6275-6279.

Neyt C, Welch M, Langston A, Kohtz J, Fishell G. A short-range signal restricts cell movement between telencephalic proliferative zones. J Neurosci 1997; 17: 9194-9203.

Lim DA, Fishell G, Alvarez-Buylla A. Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis. Proc Natl Acad Sci USA 1997; 94: 14832-14836.

Nothias F, Fishell G, Ruiz i Altaba A. Cooperation of intrinsic and extrinsic signals in the elaboration of regional identity in the posterior cerebral cortex. Curr Biol 1998; 8: 459-462.

Na E, McCarthy M, Neyt C, Lai E, Fishell G. Telencephalic progenitors maintain anteroposterior identities cell autonomously. Curr Biol 1998; 8: 987-990.

Friedlander DR, Brittis PA, Sakurai T, Shif B, Wirchansky W, Fishell G, Grumet M. Generation of a radial-like glial cell line. J Neurobiol 1998; 37: 291-304.

Kohtz JD, Baker DP, Corte G, Fishell G. Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog. Development 1998; 125: 5079-5089.

Gaiano N, Kohtz JD, Turnbull DH, Fishell G. A method for rapid gain-of-function studies in the mouse embryonic nervous system. Nature Neurosci 1999; 2: 812-819.

Gaiano N, Nye J, Fishell G. Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron 2000; 26: 395-404.

Corbin J, Gaiano N, Machold RP, Langston A, Fishell G. Multiple defects in telencephalic development associated with the loss of Gsh2 homeodomain gene. Development 2000; 127: 5007-5020.

McCarthy M, Na E, Neyt C, Fishell G. Calcium independent adhesion is necessary for the maintenance of Prosomeres. Dev Biol 2001; 233: 80-94.

Nery S, Wichterle, H, Fishell G. Sonic hedgehog contributes to oligodendrocyte specification in the mammalian telencephalon. Development 2001; 128: 527-540.

Chambers CB, Hoang Nguyen Y-P, Gaiano N, Fishell G, Nye JS. Notch1 Signals Alter the Potential of Neural Precursor Cells in the Mammalian Forebrain. Development 2001; 128: 689-702.

Hormigo A, McCarthy M, Nothias JM, Hasegawa K, Huang W, Friedlander D, Fischer I, Fishell G, Grumet G. Radial Glial Cell Line C6-R Integrates Preferentially in Adult White Matter and Facilitates Migration of Co-implanted Neurons In Vivo. J Expt Neurol 2001; 168: 310-322.

Lee JD, Kraus P, Gaiano N, Nery S, Kohtz J, Fishell G, Loomis CA, Treisman JE. An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development. Dev Biol 2001; 233: 122-136.

Kohtz JD, Lee H-Y, Gaiano N, Segal J, Ng E, Larson T, Baker D, Garber EA, Williams KP, Fishell G. N-terminal fatty acylation of Sonic Hedgehog enhances the induction of rodent ventral forebrain neurons. Development 2001; 128: 2351-2363.

Wichterle H, Turnbull D, Nery S, Fishell G, Alvarez-Buylla A. Distinct migratory pathways of neuronal precursors originating in medial and lateral ganglionic eminences revealed by in vivo fate map analysis Development 2001, 128,3759-3771.

McCarthy M, Walsh CA, Turnbull D, Fishell G. Telencephalic Neural Progenitors are Regionally and Glial Restricted Prior to the Onset of Neurogenesis Journal of Neuroscience 2001; 21: 6772-6781.

Rallu M, Machold R, Gaiano N, Corbin J., Fishell G. Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Development 2002 129, 4963-4974.

Nery S, , Fishell G., Corbin J. The caudal ganglionic eminence is a novel source of distinct cortical and subcortical cell populations. Nat. Neurosci. 2002, 12, 1279-1287.

Nery S, Corbin J, and Fishell G.,. Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon. Cerebral Cortex,2003, 13: 895-903.

Corbin, J., Rutlin, M and Fishell G. Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning. Development, 2003, 130: 4895-4906.

Machold, R., Hayashi, S., Rutlin, M., Muzumdar, M.D., Nery, S., Corbin, J.G., Gritli-Linde, A., Dellovade, T., Porter, J.A., Rubin, L.L., Dudek, H, McMahon, A.P. and Fishell, G. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron, 2003, 39: 937–950.

Hanashima, C., Li, S.C., Shen, L., Lai, E., and Fishell, G. Foxg1 suppresses early cortical
cell fate. Science, 2004, 303: 56-59.


Anthony, T. A., Klein, C., Fishell, G. and Heintz, N. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron, 2004, 41: 881-890.

Kohtz, J.D. and Fishell, G. Developmental regulation of EVF-1, a novel non-coding RNA transcribed upstream of the mouse Dlx6 gene. Gene Express. Patterns , 2004, 4: 407-412.

Fuccillo, M., Rallu, M., McMahon A.P. and Fishell, G. Temporal requirement for hedgehog signaling in ventral telencephalic patterning, 2004, 131: 5031-5040.

Keejung, Y., Nery, S., Rutlin, M.L., Radtke, F., Fishell, G. and Gaiano, N. Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with notch1 signaling in telencephalic progenitors, Journal of Neuroscience, 2004, 24, 9497–9506.

Anthony, T. A., Mason, H.A., Gridley, T., Fishell, G. and Heintz, N. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes and Development, 2005, 19: 1028-1033.

Mason, H.A., Rakowiecki, S.M., Raftopoulou, M., Nery, S., Huang YY., Gridley,T. and Fishell, G. Notch signaling coordinates the patterning of striatal compartments. Development, 2005, 132: 4247-4258.

Klein, C., Butt, S.J.B., Machold, R.P., Johnson, J.E. and Fishell, G. Cerebellum- and forebrain-derived stem cells possess intrinsic regional character. Development, 2005, 132: 4497-4508.

Machold, R.P. and Fishell, G. Math1 is expressed in temporally discrete pools of cerebellar rhombic lip neural progenitors. Neuron, 2005, 48:17-24.

Butt, S., J., B., Fuccillo, M., Nery, S., Noctor, S., Kriegstein, A., Corbin, J., G. and Fishell, G. The Temporal and Spatial Origins of Cortical Interneurons predicts their Physiological Subtype. Neuron, 2005, 48:591-604.

Mason, H.A., Rakowiecki, S., M., Gridley, T., and Fishell, G. Loss of Notch activity in the developing central nervous system leads to increased cell death. Development Neuroscience 2006, 28:49-57.

Fuccillo, M ., Rutlin, M. and Fishell, G. Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice . Cerebral Cortex, 2006, 16:96-102.

Balordi, F. and Fishell, G.Hedgehog Signaling in the Subventricular Zone Is Required
for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons. Journal of Neuroscience, 2007, 27:5936 –5947.

Miyoshi, G., Butt, S.J.B., Takebayashi, H. and Fishell, G. Physiologically Distinct Temporal Cohorts of Cortical Interneurons arise from Telencephalic Olig2-expressing Precursors. Journal of Neuroscience, 2007, 27:7786 –7987.

Hanashima, C., Fernandes, M., Hebert, J.M. and Fishell, G. The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes . Journal of Neuroscience, 2007, 11103 –11111.

Balordi, F. and Fishell, G. Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal. Journal of Neuroscience, 2007, 27:14248–14259.

Batista-Brito, R., Machold, R., Klein, K. and Fishell, G. Gene expression in cortical interneuron precursors is prescient of their mature function. Cerebral Cortex , 2008, February E-pub.

Batista-Brito, R., Close, J., Machold, R. and Fishell, G. The distinct temporal origins of olfactory bulb interneuron subtypes. Journal of Neuroscience, 2008, 28: 3966-3975.

Butt, S., J., Sousa, V.H., Fuccillo, M., Hjerling-Leffler, J., Miyoshi, G., Kimura, S. and Fishell, G. The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes. Neuron, 2008, 59: 722-732.

Sousa VH, Miyoshi G, Hjerling-Leffler J, Karayannis T, Fishell G. Characterization of Nkx6-2-Derived neocortical interneuron lineages. Characterization of Nkx6-2-derived neocorticali interneuron lineages. Cereb Cortex. 2009 Apr 10. [Epub ahead of print]

Cocas, L.A., Miyoshi, G., Carney, R.S.E., Sousa, V.H. Hirata, T., Jones, K.R.,
Fishell,G.,Huntsman, M.M. and Corbin, J.G.. Emx1-Lineage Progenitors Differentially Contribute to
Neural Diversity in the Striatum and Amygdala Journal of Neuroscience, 2009, 29: 15933-15946.

Batista-Brito, R., Rossignol,E., Hjerling-Leffler, J., Denaxa, M., Wegner, M., Lefebvre, V., Pachnis, V. and Fishell, G. The cell -intrinsic requirement of Sox6 for cortical interneuron development. Neuron, 2009, 63: 466-481.

Carney R.S., Alfonso T.B., Cohen D., Dai H., Nery S., Stoica B., Slotkin J., Bregman B.S., Fishell G. and Corbin J.G. Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system. Journal of Neuroscience , 2006, 26:11562-11574.

Machold, R.P., Kittell-Jones, D, and Fishell, G. Antagonism between Notch and BMP receptor signaling regulates neurogenesis in the cerebellar rhombic lip. Neural Development 2007, 2:5.

Gleiberman, A.S., Michurina, R., Encinas, J.M., Roig, J.L. Krasnov. P.< Balordi., F., Fishell, G. Rosenfeld, M.G. and Enikolopov, G., Genetic approaches identity adult pituitary stem cells. PNAS 2008, 105: 6332-6337.

Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V.H., Butt, S.J.B., Battiste, J., Johnson, J.E., Machold, R.P. and Fishell, G. Genetic fate mapping reveals that the caudal ganglionic
eminence produces a large and diverse population of superficial cortical interneurons. Journal of Neuroscience, 2010, 30: 1582-1594.

Rudy, B., Fishell, G., Lee, S-H., and Hjerling-Leffler, J. Three groups of Interneurons account for nearly 100% of neocortical GABAergic neurons. Journal of Neuroscience, 2010, 71: 45-61.

Carney, R.S.E., Mangin, J-M., Hayes, L., Mansfield, K., Sousa, V.H., Fishell, G., Machold., R.P., Ahn, S-H., Gallo, V., and Corbin, C.G. Sonic hedgeho expressing and responding cells generate neuronal diversity in the medial amygdala. Neural Development, 2010, 5: 14-31.

Tricoire, L., Pelkey, K.A., Daw, M.L., Miyoshi, G., Sousa, V.H., Miyoshi, G., Jefferies, B., Caulli, B., Fishell, G. and McBain, C.J. Common origins of hippocampal ivy and nitric oxide synthase expressing neurogliaform cells. Journal of Neuroscience, 2010, 30: 2165-2176.

Lee, S-H., Hjerling-Leffler, J., Zagha, E., Fishell, G. and Rudy, B. The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors. Journal of Neuroscience, 2010, 30: 16796-16808.

Machold, R., Klein, C. and Fishell, G. and McBain, C.J. Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene expression patterns, 2011, (epub ahead of print).

De Marco-Garcia, N.V., Karayannis, T., and Fishell, G. Neuronal activity is required for the development of specific cortical interneuron subtypes. Nature, 2011 (epub ahead of print).


Reviews
Fishell G. Regionalization in the mammalian telencephalon. Curr Opin Neurobiol 1997; 7: 62-69.

Gaiano N, Fishell G. Transplantation as a tool to study progenitors within the vertebrate nervous system. J Neurobiol 1998; 36: 152-161.

Fishell G. BMPs: time to murder and create? Nature Neurosci 1999; 2: 301-303.

Corbin J, Nery, S, Fishell G. Taking a tangent: the molecular and cellular basis of non-radial migration in the mammalian telencephalon. Nature Neuroscience supp. 2001 4: 1177-1182 Machold, R, Fishell G Sonic Hedgehog: patterns midbrain ARC-itecture. TINS 2002 25: 10-11.

Gaiano, N. Fishell G. Notch functions in glial specification and differentiation., Annual Review of Neuroscience Annu. Rev. Neurosci. 2002. 25:471490.

Rallu, M., Corbin, J., and Fishell G. Parsing the Prosencephalon. Nature Neuroscience Reviews 2002, 12, 943-951.

Fishell G, and Kriegstein AR. Neurons from radial glia: the consequences of asymmetric inheritance. Curr Opin Neurobiol. 13, 34-41.

Hanashima, C., Molnár, Z., Fishell G. Building bridges to the Cortex. Cell , 2006, 7:24-27.

Chambers, D., Fishell G. Functional genomics of early cortical patterning Genome Biology , 2006, 7:202.

Au, E., Fishell G. Adult corticcal neurogenesis: nuanced, negligible or nonexistent? Nature Neuroscience , 2006, 9:1086-1088.

Miyoshi, G., Fishell, G. Directing neuron-specific transgene expression in the mouse CNS. Current Opinion in Neurobiology , 2006, 9:1086-1088.

Fuccillo, M., Joyner, A.L. and Fishell, G. Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nature Neuroscience Review , 2006, 7:772-783.

Fishell, G. Perspectives on the developmental origins of cortical interneurons. In: Cortical development: Genes and genetic abnormalities, Novartis Foundation Symposium 288, 2007(eds. John Wiley & Sons Lmd) pp.21-35.

Au, E., and Fishell, G. Cortex shatters the glass ceiling, Cell Stem Cell, 2008, 3:472-474.

The Petilla Interneuron Nomenclature Group. Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nature Reviews Neuroscience, 2008, 9:257-268.

Hebért, J.M. and Fishell, G. The genetics of early telencephalic patterning. Nature Reviews Neuroscience, 2008, 9:678-685.

Fishell, G. and Hanashima, C. Pyramidal neurons grow up and change their mind. Neuron, 2008, 77:532-537.

Batista-Brito R and Fishell G. The developmental integration of cortical interneurons into a functional network.Curr Top Dev Biol. 2009;87:81-118.

Machold, R.P. and Fishell G Math1: Waiting to inhale. Neuron 2010; 64:293-294.

Fishell G and Goldman, J.E. A silver lining to stroke: does ischemia generate new
cortical interneurons? Nature Neuroscience 2010; 13:145-146.

Karayannis, T. and Fishell G Inhibition as a Transplant-Mediated Therapy: A New Paradigm for Treating Parkinson’s? Cell Stem Cell 2010; 6:184-185.

Sousa, V. and Fishell G Sonic hedgehog functions through dynamic changes in temporal
competence in the developing forebrain. Current Opinion in Genetics and Development, 2010; 20:1-9.

Fishell G. and Rudy, B. Mechanisms of Inhibition within the Telencephalon:
"Where the Wild Things Are". Annu. Rev. Neurosci. 2011; 34:535–567.


Books
Fishell G. Community Living in Forebrain: Neural Precursors Modify their Regional Specificity after Heterotopic Transplantation within the Telencephalon. Neural Cell Specification: molecular mechanisms and neurotherapeutic implications; eds K Juurlink BHJ., PH Kulyk, WM, VMK Verge and RJ Doucette New York and London: Plenum Press 1995; 189-194.

Gao W-Q, Fishell G, Kuhar S, Feng L, Heintz M, Hatten ME. Control of Granule Cell Neurogenesis and Migration in Developing Cerebellar Cortex. Cell-Cell Signaling in Vertebrate Development. ed E Robertson New York: Academic Press. 1993; 9-31.

Hatten ME, Fishell G, Stitt TN, Mason CA. Astroglia as a Scaffold for Development of the CNS. Seminars in the Neurosciences, ed RMAK Jessen Vol. 2. New York WB Saunders. 1990; 455-465.

Johnston JG, Fishell G, Krushel LA, van der Kooy D. The Development of Striatal Compartmentalization: The Role of Mitotic and Postmitotic Events. Basal Ganglia-Structure and Function, ed MBCAR. Jayaraman. Vol. 2. New York: Plenum. 1990; 34-56.

van der Kooy D, Fishell G, Krushel L, Johnston J. The Development of Striatal Compartments: from Proliferation to Patches. Basal Ganglia-Structure and Function, ed MB Carpenter and R Jayaraman. New York: Plenum Press. 1987; 81-98.