6/03-present - Medical Student, NYU School
9/98-6/02 - A.B. in Molecular Biology from Princeton University.
Undergraduate thesis in the laboratory of Dr. Virginia Zakian:
"Mutagenesis of Rrm3p, a helicase involved in telomere
and rDNA replication."
Sonic Hedgehog (Shh) is required in the
telencephalon for the formation of the most ventral structures
as well as the dorsal midline. The role of Shh in patterning
these structures is, in large part, modulated as Shh antagonizes
the activity of two proteins: Pax6 and Gli3-repressor (Gli3-R).
Downstream of their interaction with Shh, however, it is unclear
how Pax6 and Gli3-R interact in dorsal/ventral patterning.
Since genetic analysis of this interaction in the mouse telencephalon
has been difficult, I am examining this interaction in the
mouse spinal cord, where development is analogous in many
ways to development in the telencephalon.