Research

Clinical observations and laboratory data are continually recorded so that a data bank of information is accumulated. This aids in periodic review and analysis of data to determine incidence of particular problems, effectiveness of therapy and long term sequelae of FD and the other HSAN types while maintaining patient confidentiality. In addition, patients may be given the opportunity to participate in clinical studies.

Clinical research studies at the Dysautonomia Center include developing better treatment of various problems. For example, to better control centrally induced nausea and vomiting, patients have found diazepam and clonidine helpful and for orthostatic hypotension, there have been trials of Florinef and a new alpha agonist, midodrine.

In addition, collaboration with basic science research in FD has aided in identification of the FD gene (March 2001). The Center will be participating in research to understand the role of the FD gene and its protein product in the development and maintenance of sensory and autonomic neurons, as well as more definitive treatment trials.

Research in HSAN is ongoing in order to better understand the various distinctions and relationships between genetic error and clinical expression.