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About The Principle Investigators - NYU School of Medicine:

Lung Chi Chen Ph.D.
 

George D. Thurston Sc.D.

 

Associate Professor of Environmental Medicine

 
Education: Dr. Thruston Received his Sc.D. from the Harvard University School of Public Health in 1983; His M.S. fromt he Harvard University School of Public Health in 1978; and His A.B.
 
Other Responsibilities: Dr. Thurston is the Director of the Community Outreach Program for the Department of Environmental Medicines NIEHS Center
 
Research Interests:

Human health effects of inhaled air pollutants; Asthma; Aerosol science; Acidic air pollution; Air pollution meteorology and modeling; Risk analysis

Dr. Thurston´s laboratory has found associations between ambient air pollution and adverse human health effects. Analyses have considered individual subjects and their responses to ambient air pollution, as well as citywide and nationwide population health characteristics and their aggregate associations with air pollution. Our studies of individuals have included both healthy and asthmatic children at summer camps in the northeastern U.S., as these children are often outdoors and active during summertime air pollution episodes.
Our studies of aggregate populations have considered both human mortality (i.e., numbers of death per day, by-cause) and morbidity (e.g., numbers of hospital admissions per day for respiratory causes). We have found that air pollution has consistent adverse health consequences across the various populations and locations we have considered. In New York City, elevated air pollution concentrations are associated with increases in both daily respiratory hospital admissions and respiratory mortality. On a high ozone air pollution day, for example, our analyses indicate that New York City hospital admissions for respiratory causes rise approximately 20 percent above otherwise expected.

Representative Publications:
Thurston, G.D., Ito, K., Kinney, P., and Lippmann, M. (1992) A multi-year study of air pollution and respiratory hospital admissions in three New York State metropolitan areas: Results for 1988 and 1989 summers. J. Expo. Anal. Environ. Epidemiol. 2:429-450.

Thurston, G.D., Ito, K., Lippmann, M., and Bates, D.V. (1994) Respiratory hospital admissions and summertime haze air pollution in Toronto, Ontario: Consideration of the role of acid aerosols. Environ. Res. 65:271-290.

Thurston, G.D., Lippmann, M., Scott, M., and Fine, J. M. (1996) Summertime haze air pollution and children with asthma. Am. J. Respir. Crit. Care Med. 155:654-660.

Cassino, C., Ito, K., Bader, I., Ciotoli, C., Thurston, G., and Reibman, J. (In press, 1999) Cigarette smoking and ozone-associated emergency department use for asthma by adults in New York City. Am. J. Respir. Crit. Care Med.

Thurston, G.D. and Leber, M. (1999) The relationship between asthma and air pollution. In: Emergency Asthma, Brenner, B. (ed.), Marcel-Dekker, New York, NY.

Contact: E-mail: thurston@env.med.nyu.edu

Associate Professor of Environmental Medicine

Education: Dr. Lung Chi Chen received his Ph.D. in Envrionmental Health Science from New York University, NY, NY in 1983
Other Responsibilities: Dr. Chen is the Director of the Computer Facility forthe NIEHS Health Sciences Center Program. He is also the Chairman of the Computer Committee for the Department of Environmental Medicine.
Research Interests:
Inhalation Toxicology; Exposure-Response Relations; Air Pollution
Dr. Chen's primary research interest is to identify and understand the role of epithelial and inflammatory cells in the pathogenesis of the adverse pulmonary effects produced by gaseous and particulate pollutants. In vivo and in vitro techniques are applied to investigate the mechanisms of pulmonary injury. Biochemical, cellular, and molecular approaches are used to evaluate markers of cell injury such as reactive oxygen species, intracellular messengers (intracellular calcium concentration, nuclear factors NF-kB and AP-1), and extra cellular messengers (interleukins and tumor necrosis factor). The information gained from this research will be used in the design of experiments which will examine the development of tolerance and/or chronic lung injury in animals repeatedly exposed to these pollutants. Furthermore, the mechanistic results from these experiments will be applied to studies using human subjects undergoing repeated exposures to environmental agents.

Representative Publications:
Chen, L.C. and Schlesinger, R.B. (1996) Concentrations for the respiratory tract dosimetry of inhaled nitric acid vapor. Inhal. Toxicol. 8:639-654.

Chen, L.C. and Qu, Q. (1997) Formation of Intracellular hydroxyl radicals in guinea pig airway epithelium during in vitro exposure to ozone. Toxicol. Appl. Pharmacol. 143:96-101.


Jaspers, I., Flescher, E., and Chen L.C. (1997) Respiratory epithelial cells display polarity in their release of the chemokine IL-8 after exposure to ozone. Inflammation Res. 46(Suppl 2):S173-4.

Gordon, T., Gerber, H., Fang, C.P., and Chen, L.C. (1998) A centrifugal particle concentrator for use in inhalation toxicology. Inhal. Toxicol. 11:71-87.

Jaspers, I., Chen, L.C., and Flescher, E. (1998) Induction of IL-8 expression by ozone is mediated by tyrosine kinase, PKA, and MAP kinase, but not by PKC. Am. J. Cell. Physiol. 177:313-323.

Contact: E-mail: chenl@env.med.nyu.edu

   
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