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Lung Chi
Chen Ph.D. |
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Associate Professor of Environmental Medicine
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Education:
Dr. Thruston Received his Sc.D. from the Harvard
University School of Public Health in 1983; His M.S. fromt
he Harvard University School of Public Health in 1978; and
His A.B. |
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Other
Responsibilities: Dr. Thurston is the Director
of the Community Outreach Program for the Department of
Environmental Medicines NIEHS Center |
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| Research
Interests: |
Human
health effects of inhaled air pollutants; Asthma; Aerosol
science; Acidic air pollution; Air pollution meteorology
and modeling; Risk analysis |
Dr.
Thurston´s laboratory has found associations between
ambient air pollution and adverse human health effects.
Analyses have considered individual subjects and their responses
to ambient air pollution, as well as citywide and nationwide
population health characteristics and their aggregate associations
with air pollution. Our studies of individuals have included
both healthy and asthmatic children at summer camps in the
northeastern U.S., as these children are often outdoors
and active during summertime air pollution episodes.
Our studies of aggregate populations have considered both
human mortality (i.e., numbers of death per day, by-cause)
and morbidity (e.g., numbers of hospital admissions per
day for respiratory causes). We have found that air pollution
has consistent adverse health consequences across the various
populations and locations we have considered. In New York
City, elevated air pollution concentrations are associated
with increases in both daily respiratory hospital admissions
and respiratory mortality. On a high ozone air pollution
day, for example, our analyses indicate that New York City
hospital admissions for respiratory causes rise approximately
20 percent above otherwise expected. |
Representative
Publications:
Thurston, G.D., Ito, K., Kinney, P., and Lippmann, M. (1992)
A multi-year study of air pollution and respiratory hospital
admissions in three New York State metropolitan areas: Results
for 1988 and 1989 summers. J. Expo. Anal. Environ. Epidemiol.
2:429-450.
Thurston, G.D., Ito, K., Lippmann, M.,
and Bates, D.V. (1994) Respiratory hospital admissions and
summertime haze air pollution in Toronto, Ontario: Consideration
of the role of acid aerosols. Environ. Res. 65:271-290.
Thurston, G.D., Lippmann, M., Scott, M.,
and Fine, J. M. (1996) Summertime haze air pollution and
children with asthma. Am. J. Respir. Crit. Care Med. 155:654-660.
Cassino, C., Ito, K., Bader, I., Ciotoli,
C., Thurston, G., and Reibman, J. (In press, 1999) Cigarette
smoking and ozone-associated emergency department use for
asthma by adults in New York City. Am. J. Respir. Crit.
Care Med.
Thurston, G.D. and Leber, M. (1999) The
relationship between asthma and air pollution. In: Emergency
Asthma, Brenner, B. (ed.), Marcel-Dekker, New York, NY.
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| Contact:
E-mail: thurston@env.med.nyu.edu |
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Associate
Professor of Environmental Medicine |
Education:
Dr. Lung Chi Chen received his Ph.D. in Envrionmental Health Science
from New York University, NY, NY in 1983 |
Other
Responsibilities: Dr. Chen is the Director of the Computer
Facility forthe NIEHS Health Sciences Center Program. He is also
the Chairman of the Computer Committee for the Department of Environmental
Medicine. |
| Research
Interests: |
| Inhalation
Toxicology; Exposure-Response Relations; Air Pollution |
Dr.
Chen's primary research interest is to identify and understand the
role of epithelial and inflammatory cells in the pathogenesis of
the adverse pulmonary effects produced by gaseous and particulate
pollutants. In vivo and in vitro techniques are applied to investigate
the mechanisms of pulmonary injury. Biochemical, cellular, and molecular
approaches are used to evaluate markers of cell injury such as reactive
oxygen species, intracellular messengers (intracellular calcium
concentration, nuclear factors NF-kB and AP-1), and extra cellular
messengers (interleukins and tumor necrosis factor). The information
gained from this research will be used in the design of experiments
which will examine the development of tolerance and/or chronic lung
injury in animals repeatedly exposed to these pollutants. Furthermore,
the mechanistic results from these experiments will be applied to
studies using human subjects undergoing repeated exposures to environmental
agents. |
Representative
Publications:
Chen, L.C. and Schlesinger, R.B. (1996) Concentrations for the respiratory
tract dosimetry of inhaled nitric acid vapor. Inhal. Toxicol. 8:639-654.
Chen, L.C. and Qu, Q. (1997) Formation of Intracellular
hydroxyl radicals in guinea pig airway epithelium during in vitro
exposure to ozone. Toxicol. Appl. Pharmacol. 143:96-101.
Jaspers, I., Flescher, E., and Chen L.C. (1997) Respiratory epithelial
cells display polarity in their release of the chemokine IL-8 after
exposure to ozone. Inflammation Res. 46(Suppl 2):S173-4.
Gordon, T., Gerber, H., Fang, C.P., and Chen, L.C.
(1998) A centrifugal particle concentrator for use in inhalation
toxicology. Inhal. Toxicol. 11:71-87.
Jaspers, I., Chen, L.C., and Flescher, E. (1998)
Induction of IL-8 expression by ozone is mediated by tyrosine kinase,
PKA, and MAP kinase, but not by PKC. Am. J. Cell. Physiol. 177:313-323.
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| Contact:
E-mail: chenl@env.med.nyu.edu
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