Research

The Dynlacht laboratory uses a combination of biochemical, genomic, and computational methods to dissect the role that the retinoblastoma tumor suppressor protein (pRb) family plays in effecting chromatin modifications that underlie gene repression during cell cycle progression and myogenic differentiation. The laboratory also focuses on understanding the molecular controls that govern centrosome duplication, which plays a pivotal role in cell cycle progression and mitosis.

Transcriptional Regulation

The Dynlacht laboratory uses a combination of biochemical, genomic, and computational methods to dissect the role that the retinoblastoma tumor suppressor protein (pRb) family plays in effecting chromatin modifications that underlie gene repression during cell cycle progression and myogenic differentiation. (more)

Myogenesis

Myogenesis is orchestrated through a series of transcriptional controls governed by myogenic regulatory factors (MRFs). MyoD, a basic helix-loop-helix (bHLH) transcription factor that binds sequence elements termed E-boxes, is the founding member of the MRF family which includes the closely related Myf5, myogenin, and MRF4 proteins (more)

Centrosome biology

Centrioles are required to fulfill a number of important roles during the cell cycle, establishing a microtubule organizing center in interphase and ensuring high fidelity chromosome separation in mitosis. In addition, centrioles have the capacity to act as basal bodies that nucleate the assembly of cilia (more)