Recent findings have implicated the enzymes of polyol pathway and their involvement in ischemia-reperfusion injury.
My current research interest is to investigate the underlying mechanism involved in ROS mediated myocardial injury and mitochondrial dysfunction triggered by LAD occlusion and reperfusion injury in the myocardium using murine models, both in the absence and presence of diabetes.
Our initial studies demonstrated that aldose reductase (AR) and ROS is highly upregulated in the murine heart after ischemia reperfusion injury, triggering mitochondrial dysfunction, in part through pore opening. I have over 6 years of experience in conducting studies elucidating the impact of signaling events mediated by mitochondria.
1. N. Reiniger, K. Lau, D. McCalla, B. Eby, B. Cheng, Y. Lu, W. Qu, N. Quadri, R. Ananthakrishnan, M. Furmansky, R.Rosario, F. Song, V. Rai, A. Weinberg, R. Friedman, R. Ramasamy, V. D'Agati and A. M. Schmidt. Deletion of the Receptor for Advanced Glycation Endproducts Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse. Diabetes 2010, 59: 2043-2054.
2. T.M. Ravindranath, P. Y. Mong, R. Ananthakrishnan, Q. Li, N. Quadri, A. M. Schmidt, R. Ramasamy*, Q. Wang*. Novel role for aldose reductase in mediating acute inflammatory responses in the lung. Journal of Immunology 2009, 183: 8128-8137
3. L. Shang, R. Ananthakrishnan, Q. Li, N. Quadri, M Abdillahi, Z. Zhu, W. Qu, R. Rosario, F. Touré, S.F. Yan, A. M. Schmidt, R. Ramasamy. RAGE Modulates Hypoxia/Reoxygenation Injury in Adult Murine Cardiomyocytes Via JNK and GSK-3β Signaling Pathways. PLOS One 2010, 5: e10092.
4. Radha Ananthakrishnan, Michio Kaneko, Yuying C. Hwang, Nosirudeen Quadri, Teodoro Gomez, Qing Li, Casper Casperson and Ravichandran Ramasamy. Aldose reductase mediates myocardial ischemia- reperfusion injury in part by opening mitochondrial permeability transition pore. AM J Physiol Heart Circ Physiol 296:H 333-341, 2009.