Originally from Windsor, Ontario, Canada, I received my PhD from Wayne State University School of Medicine in Detroit, Michigan in Molecular Biology & Genetics where I focused my studies on the biology of myelin in the central nervous system (CNS).
Following my PhD, I completed a drug discovery postdoc at Columbia University with a team of scientists in the division of experimental therapeutics. Here, I developed a therapeutic for the US military to combat nerve agent exposure.
At the Diabetes Research Program at NYU, I am investigating the in-depth molecular and biochemical analysis of the pathways linking RAGE (receptor for advanced glycation end products) to regulation of the transcription of key genes such as glyoxalase-I, ABCG1 and Early growth response-l (Egr-l) in vascular signaling and atherosclerosis, as well as the role of RAGE and its ligands in Amyotrophic Lateral Sclerosis (ALS).
1. *Juranek J., *,Daffu G. Wojtkiewicz J., Lacomis D., Kofler J., Schmidt A.M. (2015) “Receptor for Advanced Glycation End-Products and its Ligands are Upregulated in Amyotrophic Lateral Sclerosis”. Front Cell Neurosci, 9:485. doi: 10.3389/fncel.2015.00485 *Co-first authors
2. Daffu G., Shen X., Senatus L., Abedini A., Hurtado del Pozo C., Rosario R., Song F., Friedman R., Ramasamy R., Schmidt A.M. (2015) “RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes”. Diabetes, 64 (12):4046-60.
3. Daffu G., Lopez P., Katz F., Vinogradov M., Zhan C., Landry D., Macdonald J. (2015) “Sulfhydryl-Specific PEGylation of Phosphotriesterase Cysteine Mutants for Organophosphate Detoxification”. Protein Eng Des Sel, 28(11):501-6.
4. Daffu G., Hurtado del Pozo C., O'Shea K., Ananthakrishnan R., Ramasamy R., Schmidt A.M. (2013) “Radical Roles for RAGE in the Pathogenesis of Oxidative Stress in Cardiovascular Diseases and Beyond”. Int J Mol Sci, 14:19891-19910.
5. Touré F., Fritz G., Li Q., Rai V., Daffu G., Zou Y.S., Rosario R., Ramasamy R., Alberts A., Yan S.F., Schmidt A.M. (2012) “The Formin mDia1 Mediates Vascular Remodeling via Integration of Oxidative & Signal Transduction Pathways”. Circ Res, 110(10):1279-93.
6. Daffu G., Sohi J., Kamholz J. (2012) “Proteolipid protein dimerization at cysteine 108: Implications for protein structure”. Neurosci Res, 74:144-155.