Representative
Publications:
Kim, N. and Burden, S.J. 2008. MuSK controls where motor axons grow and form synapses. Nature Neuroscience 11:19-27.
Friese, M.B., Blagden, C.S. and Burden, S.J. 2007. Synaptic differentiation is defective in mice lacking acetylcholine receptor beta subunit tyrosine phosphorylation. Development 134:4167-4176.
Jaworski, A., Smith, C.L. and Burden, S.J. 2007. GABP is dispensable for neuromuscular synapse formation and synapse-specific gene expression. Mol. Cell. Biol. 27:5040-5046.
Jevsek, M., Jaworski, A., Polo-Parada, L., Kim, N., Fan, J., Landmesser, L.T. and Burden, S.J. 2006. CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission. Proc. Natl. Acad. Sci. USA, 103:6374-6379.
Jaworski, A. and Burden, S.J. 2006. Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1. J. Neurosci. 26:655-661.
Wang, X., Blagden, C., Fan, J. Nowak, S., Taniuchi, I., Littman, D.R. and Burden, S.J. 2005. Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes and Development 19:1715-1722.
Herbst, R., Avetisova, E. and Burden, S.J. 2002. Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Development 129:5449-5460.
Yang, X., Arber, S., William, C., Li, L., Tanable,
Y., Jessell, T.M., Birchmeier, C. and Burden, S.J. (2001). Patterning
of muscle acetylcholine receptor gene expression in the absence of
motor innervation. Neuron 30:399-410.
Yang, X., Li, W., Prescott, E.D., Burden, S.J., and Wang, J.C. (2000).
DNA topoisomerase II beta and neural development. Science 287:131-134.
Herbst, R. and Burden, S.J. (2000). The juxtamembrane region of MuSK
has a critical role in agrin-mediated signaling. EMBO J. 19:67-77.
Watty, A., Neubauer, G., Dreger, M., Zimmer, M., Wilm, M. and Burden,
S.J. (2000). The in vitro and in vivo phosphotyrosine map of activated
MuSK. Proc. Natl. Acad. Sci. USA 97:4585-4590.
Fromm, L. and S.J. Burden. (1998). Synapse-specific and neuregulin-induced
transcription require an Ets site that binds GABPa/GABPb. Genes
and Development 12:3074-3083.
DeChiara, T.M., Bowen, D.C., Valenzuela, D.M., Simmons, M.V., Poueymirou,
W.T., Thomas, S., Kinetz, E., Compton, D.L., Park, J.S., Smith, C.,
DiStefano, P.S., Glass, D.J., Burden, S.J. and Yancopoulos, G.D. (1996).
The receptor tyrosine kinase, MuSK, is required for neuromuscular
junction formation in vivo. Cell 85:501-512.
Glass, D.J., Bowen, D.C., Radziejewski, C., Bruno. J., Stitt, T.N.,
Ryan, T.E., Gies, D.R., Mattsson, K., Shah, S., Burden, S.J., Valenzuela,
D.M., DeChiara, T.M., and Yancopoulos, G.D. (1996). Agrin acts vis
a MuSK receptor complex. Cell 85:513-523.
Zhu, X., Lai, C., Thomas, S. and Burden, S.J. (1995). Neuregulin receptors,
erbB3 and erbB4, are localized at neuromuscular synapses. EMBO
J. 14:5842-5848.
Jo, S.A., Zhu, X., Marchionni, M. A. and Burden, S.J. (1995). Neuregulins
are concentrated at nerve-muscle synapses and activate ACh-receptor
gene expression. Nature 373:158-161.
Research is supported by the National Institutes of Health. |
