Core Facilities by Research Center
- Clinical and Translational Science Institute (CTSI)
- Center for AIDS Research
- Skirball Institute of Biomolecular Medicine
- NYU Cancer Institute
- NYU RNAi Core Facility
Clinical and Translational Science Institute (CTSI)
CTSI Core Lab
Molecular biology support for CTSI clinical research protocols,
training of clinical research fellows and medical students
in the laboratory methods of patient-oriented research.
CTSI Center for Health & Bioinformatics
CTSI Study Design, Biostatistics & Ethics
Statistical consultation and collaboration to CTSI investigators
in all stages of the clinical research process for approved
protocols. Protocol development and review through conduct,
analysis, and reporting of results.
CTSI Population Health Resource
The CTSI’s PHR initiative is thus focused on the interface of the delivery
of clinical care by urban healthcare delivery systems such as ours and the
health of the clinical and community populations served.
CTSI Community Engagement
The Community Engagement Core of the NYU-HHC CTSI is a campus-community
partnership among New York University (NYU), the New York City Health
and Hospitals Corporation (HHC), and community and government partners
serving New York City’s diverse communities. Community-based research
principles (CBPR) guide the work of the Community Engagement Core.
CTSI Bench to Bedside Consultation
CTSI Research
Subject Safety Office
Ensurance of safety and ethical conduct, with protection of human subjects accorded
the highest priority.
The
Translational Research Education and Careers (TREC) Core
TREC prepares health professionals for careers as clinical
translational scientists. TREC programs provide training and
mentoring for learners from predoctoral students through junior
faculty. Current programs include a Masters of Science in Clinical
Investigation (Translational), funding/mentoring opportunities
for pre- and post-doctoral trainees through T32 and K12 programs,
and the Physician Scientist Training Program, which supports
physicians in training for an extra year of research. We plan
to soon bring online a number of other educational initiatives,
including seminar series and on-line learning tools for clinical
research.
Translational
Research and Novel Technologies
Center for AIDS Research
Clinical
Core: Biostatistics and Epidemiology
Patient-based research: epidemiological and biostatistical
consultation, biomathematical modeling, and data management.
Clinical
Core: Specimen Management
Processing and storage of biological samples from HIV-infected
patients and uninfected controls, cataloging and distribution
of information on stored specimens, procurement of fresh biological
samples for HIV/AIDS studies.
Flow
Cytometry
Innovative flow measurements, 3-color surface phenotyping of
lymphocytes, training and consultation on phenotyping methods.
Immunology
Core
Immunologic assays; testing of polyclonal sera as well as human,
primate and rodent anti-HIV mAbs for neutralizing activity
against HIV primary isolates and for their ability to bind
to intact virions and to infected cells; provision of human
anti-HIV mAbs; frozen stocks of more than 70 mycoplasma-free
cell lines producing human anti-HIV mAbs.
Virology
Core
Bulk and quantitative HIV culture, measurement, resistance
testing, phenotype analysis , and genotype analysis using heteroduplex
mobility assay and sequencing; HIV RNA in plasma or culture
fluids by the Roche RT-PCR method; and a licensed virology
lab which detects the presence of herpes viruses (HSV, CMV,
HHV6, VZV, and EBV) by culture and/or PCR, as well as other
viruses such as HCV and JC by PCR.
Skirball Institute of Biomolecular Medicine
DNA Sequencing
Facility
DNA sequencing performed with Applied Boisystems 3730 DNA Analyzer;
in-person consulting for sequencing strategy planning and troubleshooting.
Image Core Facility
Wide spectrum of microscopy equipment, technical assistance
in sample preparation and image acquisition. CM 12 transmission
electron microscope, CM 200 transmission electron microscope
with cryo holder, Leica Ultracut UCT ultramicrotome, Sorvall
ultramicrotome, Leica glass knife-makers, Denton Vacuum carbon
coating unit, Carl Zeiss inverted microscope, Zeiss light microscope.
Instruction, consultation, assistance and collaboration for
the research involving electron microscopy. Sample preparation,
ultramicrotomy, staining, and immuno-gold electron microscopy.
Information Technologies
Digital Media
Services
Professional quality large format posters, digital prints,
digital production services, fabric poster printing.
Protein Analysis Lab
ALDI-TOF mass spectrometry, Q-TOF mass spectrometry (MS/MS
peptide sequencing), Ion Trap mass spectrometry (MS/MS peptide
sequencing), proteolysis and identification of proteins
from SDS-PAGE gels.
Washington Square Advanced
Media Studio
Archival printing, laser cutting, rapid prototyping, and other
advanced media services to the NYU community.
X-Ray Diffraction Lab
Two Rigaku X-ray systems for collecting macromolecular single-crystal
diffraction data.
NYU Cancer Institute
Analytical
Chemistry
Combined mass spectrometry and metals analysis laboratories.
Mass spectrometry (MS) and atomic absorption (AA) spectroscopy;
consultative services to NYU investigators in physical and
inorganic chemistry, separations science, and spectral interpretation
(MS, NMR, UV); training of students and researchers in the
use of MS, NMR, and AA.
Biostatistics
Statistical collaboration and consultation in clinical and
translational oncology, basic science, cancer epidemiology
and prevention, and the core research services. Statistical
expertise in research study design, conduct, analysis, interpretation,
and reporting of results for clinical trials, laboratory experiments,
and observational studies.
Core Clinical
Laboratory
Support of immune-modulating antineoplastic agents and cytotoxic
therapies, specialized clinical correlates to monitor novel
approaches to cancer treatment. Laboratory support for institutional
cancer clinical trials, logistical support for trials
that require specimen collection and assessment of multiple
parameters ranging from specialized tests for patient eligibility
to quality control of specialized therapeutic modalities.
Experimental Animal
and Exposure Core
Facilities, animal care, technical assistance for experiments
with rodent species involving delivery of carcinogenic
and toxic chemicals, infectious agents, or intervention compounds,
using inhalation, systemic, dermal, and oral administration
routes of exposure; experimental design and conduct for cancer-related
animal studies; segregated housing and health monitoring of
animals; necropsy services for animal experiments.
Experimental
Pathology
Anatomic pathology: tissues acquisition and banking, histopathology,
acquisition of human pathological specimens, processing of
human and murine tissues; resources and guidance for investigators;
access to immunohistochemistry, murine cytogenetics,
laser capture, quantitative morphometry, and the preparation
of tissue arrays.
Flow Cytometry & Cell
Sorting
DakoCytomation MoFlo, Becton Dickinson LSR system, Becton Dickinson
FACScan.
Genomics Facility
Affymetrix Genechip system for gene expression and DNA genotyping
analyses, manufacturing of spotted DNA arrays, pyrosequencing
and high-throughput quantitative PCR. Experimental designs,
standards for DNA array procedures, guidance in data
management and analysis.
Histopathology
Histology and comparative pathology service: paraffin, plastic,
and cryostat sectioning, preparation of slides for conventional
and specialized staining, immunohistochemistry, and in situ
hybridization; conventional and specialized slide staining
and immunohistochemistry; necropsy services including appropriate
tissue fixation required for animal experiments; comprehensive
consultation and collaboration on comparative and experimental
pathology; basic photomicroscopy services.
Immunohistochemistry
State-of-the-art computer-controlled immunohistochemical system,
extensive menu of antibodies (Angiogenesis - CD34, CD31,
Factor VIII, FAK, VEGF, HIF-1 alpha; apoptosis - bcl-2, CD30,
MDM2, TUNEL, activated caspase 3; cell cycle and related -
cyclins D1, E, p16, p21, p27, p53, p57; hematopoietic - CD1a,
CD3, CD4, CD8, CD5, CD61, CD99, TIA-1, CD117; hormone and related
- estrogen, progesterone, erb-B2, MIB-1; thymidine phosphorylase,
CD44, cytokeratins 7, 19, 17, E-cadherin, FHIT, Cox-2, TTF-1,
TGF-b, MDR, EGF-R, green fluorescent protein). Development
of preliminary data as well as staining of funded research.
Mouse Imaging
Magnetic resonance micro-imaging (µMRI) and ultrasound
biomicroscopy (UBM) services to detect and follow tumor progression
in mouse models.
NYUCI Proteomics
Core Facility
Assists scientists at NYU with their research by helping them
to characterize proteins of interest.
Tissue
Acquisition & Banking Services
Human tissue sample procurement (collected from excess surgical
material) and tissue banking for investigators involved in
peer-reviewed grants or institutionally funded projects.
Transgenic Mouse/ES
Cell Chimera Facility
Production of transgenic (Tg) mice by zygote injection, production
of embryonic stem (ES) cell chimeras, and rederivation of mouse
strains.
Vaccine & Cell
Therapy Laboratory
Production and monitoring of experimental immunotherapies for
patients with cancer or chronic viral infections.
NYU RNAi Core Facility
NYU RNAi Core Facility
The NYU RNAi Core Facility provides an integrated, state-of-the-art,
RNA interference (RNAi) based high-throughput screening (HTS)
facility at the NYU Langone Medical Center. The facility
is committed to offering siRNA/dsRNA screening libraries
for the cross-species functional characterization of whole
genomes in a systematic, comprehensive, and cost effective
manner. In addition, the facility may also provide logistic,
technical, and bioinformatic support in order to assist screeners
in performing and interpreting their genome scale RNAi screens.
Importantly, we are strongly committed to making the NYU
RNAi Core Facility fully accessible to the entire academic
community**, both at the national and international level,
in order to facilitate inter-disciplinary and multi-institutional
collaborations.
