Trade Names :
Related Drugs :AminophyllinePhyllocontinSomophyllinSomophyllin-DFTruphyllineDyphyllineDilorLufyllinOxtriphyllineCholedylCholedyl-SA
Once among the most common treatments for asthma, theophylline is no longer widely used, having been replaced by drugs that cause fewer side effects.
Supplementation Possibly Helpful
Theophylline appears to impair the normal conversion of vitamin B 6 into the more active substance pyridoxal 5'-phosphate (PLP). 1–4 These findings have led some researchers to suspect that some of the many side effects of theophylline could be caused, at least in part, by interference with B 6 activity. Indeed, one study found that B 6 supplements might help reduce theophylline-induced tremors. 5
* Shimizu T, Maeda S, Mochizuki H, et al. Theophylline attenuates circulating vitamin B 6 levels in children with asthma. Pharmacology 49: 392–397, 1994.
* Martinez de Haas MG, Poels PJ, de Weert CJ, et al. Subnormal vitamin B 6 levels in theophylline users. Ned Tijdschr Geneeskd 141: 2176–2179, 1997.
* Ubbink JB, Delport R, Bissbort S, et al. Relationship between vitamin B 6 status and elevated pyridoxal kinase levels induced by theophylline therapy in humans. J Nutr 120: 1352–1359, 1990.