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Schizophrenia is a chronic, severe, and progressively disabling disease of the brain. People with schizophrenia often suffer terrifying symptoms such as hearing voices not heard by others, or believing that other people are reading their minds, controlling their thoughts, or plotting to harm them. These symptoms may leave them fearful and withdrawn. Their speech and behavior can be so disorganized that they may be incomprehensible or frightening to others.

The combination of severe symptoms and chronic course of illness can cause a high degree of disability for those who suffer from schizophrenia. Approximately 1% of the population develops schizophrenia during their lifetime. More than 2 million Americans suffer from the illness. Although schizophrenia affects men and women with equal frequency, the disorder often appears earlier in men. Men are usually affected in their late teens or early twenties. Women are generally affected in their twenties to early thirties.

Researchers are not sure what causes schizophrenia. Problems with brain structure and chemistry are thought to play a role. There also appears to be a genetic component. Some have theorized that a viral infection in infancy and/or severe first trimester stress may increase the risk of schizophrenia in people who are more likely to develop the disease.

Schizophrenia increases a person’s risk of suicide, self-mutilation, substance abuse, and other social problems such as being unemployed, homeless, and incarcerated. Obsessive-compulsive disorder affects a significant number of people with schizophrenia.