What are Febrile Seizures?
Children aged 6 months to 5-6 years may have tonic-clonic seizures when they have a high fever. These are called febrile seizures and occur in 2% to 5% of children. There is a slight familial (hereditary) tendency toward febrile seizures. In other words, the chances are slightly increased that a child will have febrile seizures if parents, brothers or sisters, or other close relatives have had them. The peak age of febrile seizures is about 18 months. The usual situation is a healthy child with normal development, who has a viral illness with high fever. As the child's temperature rapidly rises, he or she has a tonic-clonic seizure. The seizure usually involves muscles on both sides of the body. Febrile seizures can be as short as a minute or two, or as long as 30 minutes or more. They also can be repetitive. In most instances, hospitalization is not necessary, although a prompt medical consultation is essential after the first seizure.
How are Febrile Seizures Treated?
Most children with recurrent febrile seizures do not require daily antiepileptic drug therapy. Children who have had more than three febrile seizures or prolonged febrile seizures, or who have seizures when they have no fever, are usually treated with antiepileptic drugs including phenobarbital and/or valproate. Diazepam (Valium), if given by mouth or rectum at the time of fever, has been used effectively to both treat and prevent recurrent febrile seizures. However, the dose that is effective when given by mouth can cause irritability, insomnia, or other troublesome side effects that last for days.
What is the Prognosis?
The prognosis for febrile seizures is excellent. There is no reason for a child who has had a single febrile seizure to receive antiepileptic drugs unless the seizure was unusually long or other medical conditions warrant it. Recurrence rates (the chances of having another seizure) vary from 50% if the seizure occurred before age 1 year to 25% if the seizure occurred after that age. In addition, 25% to 50% of recurrent febrile seizures are not preceded by a fever. In some cases, the seizure is the first sign of an illness (usually viral) and the fever comes later. The vast majority of children with febrile seizures do not have seizures without fever after age 5.
Risk factors for later epilepsy include:
If none of these risk factors is present, the chances of later epilepsy are the same or nearly the same as in the general population; if one risk factor is present, the chances of later epilepsy are 2.5%; if two or more risk factors are present, the chances of later epilepsy range from 5% to over 10%. Rarely, febrile seizures that last more than 30 minutes may cause scar tissue in the temporal lobe and chronic epilepsy that can be effectively treated with medication or a temporal lobectomy.