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BRL Research Methods

BRL is involved in both basic and clinically applied research using a method of quantitative electroencephalography (QEEG) called Neurometrics. The focus of BRL is precise analysis of brain functions in normal subjects engaged in cognitive activity and in patients with developmental, neurological and psychiatric disorders.

Neurometric QEEG is based on our publications demonstrating that the frequency composition of the healthy, normally functioning human brain can be accurately described by a set of mathematical equations. These equations have been tested in many different countries and found to be independent of ethnic or cultural background.

A normative database has been constructed describing many hundreds of QEEG variables. In routine evaluations of recordings from individual patients, all of these quantitative descriptors of brain electrical activity are extracted by computer and compared statistically to normative data. The results are expressed as standard scores, to assess deviations from normal values.

Data from over 15,000 evaluations from normal children and adults and from large populations of psychiatric/neurological and cognitively impaired patients exists in the BRL database. This QEEG database is the largest in the world.

Using this database and multivariate statistical analyses, distinctive profiles of brain dysfunction have been demonstrated for different psychiatric/neurological and cognitive disorders, including depression, dementia, schizophrenia, OCD, drug dependence, ADHD, LD and post-concussive syndrome. The correspondence between the profile of any patient and these distinctive profiles of different disorders can serve as an adjunct to clinical diagnosis or as an aid to evaluation of treatment.

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