Edward Ziff

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Edward Ziff

Professor, Department of Biochemistry and Molecular Pharmacology
Biochemistry and Molecular Pharmacology

Contact Info

540-562 First Avenue
New York, NY 10016



— Princeton University, Graduate Education
1969-1973 — Princeton University, PostDoctoral Training
1970-1973 — NIH Postdoctoral Fellowship at the MRC, Cambridge, UK with Dr. F. Sanger, PostDoctoral Training

Research Summary

Our lab studies the molecular mechanisms which regulate synaptic transmission at excitatory synapses. We focus on two ion channels, the AMPA and the NMDA type glutamate receptors. These receptors are multisubunited pores that admit cations into the postsynaptic cell when stimulated by glutamate. AMPA receptors function in fast excitatory transmission while NMDA receptors function in altering synaptic architecture and transmission strength. Both receptor types are composed of integral membrane protein subunits that project domains outside the cell and into the cytoplasm. The cytoplasmic domains associate with binding proteins that serve as attachment sites to the cytoskeleton or to regulatory proteins (such as kinase or phosphatases) that modify receptor activity. We have cloned proteins which associate with the cytoplasmic tail of the GluR2 AMPA type glutamate receptor subunit and are studying the role of these binding factors in receptor control. One protein that binds to GluR2 is the chaperone, NSF. A second protein is AMPA Receptor Binding Protein (ABP). ABP may form a cytoplasmic scaffold that binds receptors at the synapse. We are testing a model that NSF regulates the attachment of GluR2 to ABP and other cytoplasmic factors. We are studying the role of the NMDA receptor in the control of the AMPA receptor. Our goal is to obtain a molecular view of changes in synaptic signaling induced by neuron activity.

Research Interests

Molecular Mechanisms of Synaptic Regulation

Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors
Kim, Seonil; Titcombe, Roseann F; Zhang, Hong; Khatri, Latika; Girma, Hiwot K; Hofmann, Franz; Arancio, Ottavio; Ziff, Edward B
2015-03-01; 0027-8424,Proceedings of the National Academy of Sciences of the United States of America (PNAS) - id: 1473812, year: 2015 JOURNAL ARTICLE

Episodic sucrose intake during food restriction increases synaptic abundance of AMPA receptors in nucleus accumbens and augments intake of sucrose following restoration of ad libitum feeding
Peng, X-X; Lister, A; Rabinowitsch, A; Kolaric, R; Cabeza de Vaca, S; Ziff, E B; Carr, K D
2015-04-27; 1873-7544,Neuroscience - id: 1544082, year: 2015 Journal Article

Animal Models for Depression Associated with HIV-1 Infection
Barreto, Isabella Cristina Gomes; Viegas, Patricia; Ziff, Edward B; Konkiewitz, Elisabete Castelon
2014-04-22; 1557-1890,Journal of neuroimmune pharmacology - id: 882942, year: 2014 Journal Article

Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors
Kim, Seonil; Ziff, Edward B
2014-11-03; 1544-9173,PLoS biology - id: 1323312, year: 2014 Journal Article; Research Support, N.I.H., Extramural

Trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) receptor subunit GluA2 from the endoplasmic reticulum is stimulated by a complex containing Ca2+/calmodulin-activated kinase II (CaMKII) and PICK1 protein and by release of Ca2+ from internal stores
Lu, Wei; Khatri, Latika; Ziff, Edward B
2014-09-15; 0021-9258,Journal of biological chemistry - id: 1186542, year: 2014 Journal Article; Research Support, N.I.H., Extramural