Edward Ziff

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Edward Ziff

Professor, Department of Biochemistry and Molecular Pharmacology
Biochemistry and Molecular Pharmacology
Graduate Student Advisor

Contact Info

Address
540-562 First Avenue
New York, NY 10016

212/263-5774
Edward.Ziff@nyumc.org


Research Summary

Our lab studies the molecular mechanisms which regulate synaptic transmission at excitatory synapses. We focus on two ion channels, the AMPA and the NMDA type glutamate receptors. These receptors are multisubunited pores that admit cations into the postsynaptic cell when stimulated by glutamate. AMPA receptors function in fast excitatory transmission while NMDA receptors function in altering synaptic architecture and transmission strength. Both receptor types are composed of integral membrane protein subunits that project domains outside the cell and into the cytoplasm. The cytoplasmic domains associate with binding proteins that serve as attachment sites to the cytoskeleton or to regulatory proteins (such as kinase or phosphatases) that modify receptor activity. We have cloned proteins which associate with the cytoplasmic tail of the GluR2 AMPA type glutamate receptor subunit and are studying the role of these binding factors in receptor control. One protein that binds to GluR2 is the chaperone, NSF. A second protein is AMPA Receptor Binding Protein (ABP). ABP may form a cytoplasmic scaffold that binds receptors at the synapse. We are testing a model that NSF regulates the attachment of GluR2 to ABP and other cytoplasmic factors. We are studying the role of the NMDA receptor in the control of the AMPA receptor. Our goal is to obtain a molecular view of changes in synaptic signaling induced by neuron activity.

Research Interests

Molecular Mechanisms of Synaptic Regulation

Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of NF-kappaB, SOD, IL-1 beta in mice
Kassuya, C A L; Piccinelli, A C; Morato, P N; Konkiewitz, E C; Ziff, E B; Croda, J. Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of NF-kappaB, SOD, IL-1 beta in mice [Meeting Abstract]. Inflammation research. 2015 August 2015;64(2):S163-S163 (1747722)

Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors
Kim, Seonil; Titcombe, Roseann F; Zhang, Hong; Khatri, Latika; Girma, Hiwot K; Hofmann, Franz; Arancio, Ottavio; Ziff, Edward B. Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Feb;112(10):3122-3127 (1473812)

Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant
Kim, Seonil; Violette, Caroline J; Ziff, Edward B. Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant. Neurobiology of aging. 2015 Sep;:?-? (1803572)

Socioeconomic disadvantage increasing risk for depression among recently diagnosed HIV patients in an urban area in Brazil: cross-sectional study
Nomoto, Silmara Harumi; Longhi, Renata Marrona Praca; de Barros, Bruna Paes; Croda, Julio; Ziff, Edward Benjamin; Castelon Konkiewitz, Elisabete. Socioeconomic disadvantage increasing risk for depression among recently diagnosed HIV patients in an urban area in Brazil: cross-sectional study. AIDS care. 2015 Aug;27(8):979-985 (1579812)

Episodic sucrose intake during food restriction increases synaptic abundance of AMPA receptors in nucleus accumbens and augments intake of sucrose following restoration of ad libitum feeding
Peng, X-X; Lister, A; Rabinowitsch, A; Kolaric, R; Cabeza de Vaca, S; Ziff, E B; Carr, K D. Episodic sucrose intake during food restriction increases synaptic abundance of AMPA receptors in nucleus accumbens and augments intake of sucrose following restoration of ad libitum feeding. Neuroscience. 2015 Jun;295:58-71 (1544082)