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Youssef Zaim WadghiriAssociate Professor, Department of Radiology
660 First Avenue
New York, NY 10016
Research SummaryMicro-MRI of Small Animal Models of Human Diseases: To date all identified human disease associated genes can find their homologues in mice. It is these homologies that have made mouse models of disease the prevalent mammalian model of choice to study gene function and human disease. The research activities of the Wadghiri Lab are devoted to the development of non-invasive MRI strategies to facilitate the collection of anatomical and functional data of mouse models of human disease. The lab has established extensive interdisciplinary collaborations to enhance the depth of this work. The lab is also applying existing clinical protocols to the mouse in the areas of cancer and neurodegenerative diseases where MRI can be optimized and validated through a more precise correlation with histological data. Molecular MRI Mapping of Disease Biomarkers: Non-invasive MRI of molecular markers distinct to a disease would provide critical information on the location and extent of the pathology in the organ examined. A diagnosis at the initial stage would both facilitate intervention prior to any irreversible damage and monitor the efficacy and specificity of current and new therapies being tested in mice. Our broad interests are aimed at developing high field MRI methods in combination with cellular and molecular targeting techniques to better understand human diseases and validate small animal imaging protocols that will be transferable to humans. Dr. Zaim Wadghiri's latest work has lead to two significant contributions using targeted labeling techniques: the first in vivo observation of Alzheimer's plaques in transgenic mouse models of Alzheimer's disease and the first MRI study to report detection of early prion infection in the spleen as a method to identify asymptomatic carriers in an infection mouse model of prion diseases. Cellular MRI of Invasive Cell fate: The Wadghiri Lab is currently developing i n vivo 3D MRI methods for tracking individual cell invasion in order to study the role of specific molecular signaling and their effect on the distribution and interaction of tumor and stem cells in tissues.
Research InterestsMRI, Molecular and Cellular imaging, contrast agent, animal models of human diseases, micro-MRI.
3D mapping of neuronal migration in the embryonic mouse brain with magnetic resonance microimaging
Deans, Abby E; Wadghiri, Youssef Zaim; Aristizabal, Orlando; Turnbull, Daniel H. 3D mapping of neuronal migration in the embryonic mouse brain with magnetic resonance microimaging. Neuroimage. 2015 Apr 11;114:303-310 (1532932)
Towards An Advanced Graphene-Based Magnetic Resonance Imaging Contrast Agent: Sub-acute Toxicity and Efficacy Studies in Small Animals
Kanakia, Shruti; Toussaint, Jimmy; Hoang, Dung Minh; Mullick Chowdhury, Sayan; Lee, Stephen; Shroyer, Kenneth R; Moore, William; Wadghiri, Youssef Z; Sitharaman, Balaji. Towards An Advanced Graphene-Based Magnetic Resonance Imaging Contrast Agent: Sub-acute Toxicity and Efficacy Studies in Small Animals. Scientific reports. 2015 Dec 2;5:17182-17182 (1863412)
Surface-to-volume ratio mapping of tumor microstructure using oscillating gradient diffusion weighted imaging
Reynaud, Olivier; Winters, Kerryanne Veronica; Hoang, Dung Minh; Wadghiri, Youssef Zaim; Novikov, Dmitry S; Kim, Sungheon Gene. Surface-to-volume ratio mapping of tumor microstructure using oscillating gradient diffusion weighted imaging. Magnetic resonance in medicine. 2015 Jul 24;:?-? (1684152)
Evaluation of coils for imaging histological slides: Signal-to-noise ratio and filling factor
Hoang, Dung Minh; Voura, Evelyn B; Zhang, Chao; Fakri-Bouchet, Latifa; Wadghiri, Youssef Zaim. Evaluation of coils for imaging histological slides: Signal-to-noise ratio and filling factor. Magnetic resonance in medicine. 2013 Jul 15;71(5):1932-1943 (898972)
Development and characterization of a clinically relevant mouse model of melanoma brain metastasis
Morsi, Amr; Gaziel-Sovran, Avital; Cruz-Munoz, William; Kerbel, Robert S; Golfinos, John G; Hernando, Eva; Wadghiri, Youssef Z. Development and characterization of a clinically relevant mouse model of melanoma brain metastasis. Pigment cell & melanoma research. 2013 Jun 4;26(5):743-745 (512832)