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Youssef Zaim WadghiriAssociate Professor, Department of Radiology
550 First Avenue
New York, NY 10016
Research SummaryMicro-MRI of Small Animal Models of Human Diseases: To date all identified human disease associated genes can find their homologues in mice. It is these homologies that have made mouse models of disease the prevalent mammalian model of choice to study gene function and human disease. The research activities of the Wadghiri Lab are devoted to the development of non-invasive MRI strategies to facilitate the collection of anatomical and functional data of mouse models of human disease. The lab has established extensive interdisciplinary collaborations to enhance the depth of this work. The lab is also applying existing clinical protocols to the mouse in the areas of cancer and neurodegenerative diseases where MRI can be optimized and validated through a more precise correlation with histological data. Molecular MRI Mapping of Disease Biomarkers: Non-invasive MRI of molecular markers distinct to a disease would provide critical information on the location and extent of the pathology in the organ examined. A diagnosis at the initial stage would both facilitate intervention prior to any irreversible damage and monitor the efficacy and specificity of current and new therapies being tested in mice. Our broad interests are aimed at developing high field MRI methods in combination with cellular and molecular targeting techniques to better understand human diseases and validate small animal imaging protocols that will be transferable to humans. Dr. Zaim Wadghiri's latest work has lead to two significant contributions using targeted labeling techniques: the first in vivo observation of Alzheimer's plaques in transgenic mouse models of Alzheimer's disease and the first MRI study to report detection of early prion infection in the spleen as a method to identify asymptomatic carriers in an infection mouse model of prion diseases. Cellular MRI of Invasive Cell fate: The Wadghiri Lab is currently developing i n vivo 3D MRI methods for tracking individual cell invasion in order to study the role of specific molecular signaling and their effect on the distribution and interaction of tumor and stem cells in tissues.
Research InterestsMRI, Molecular and Cellular imaging, contrast agent, animal models of human diseases, micro-MRI.
Neurovascular analysis of the aging murine brain using 3D in vivo gadolinium micelle-enhanced magnetic resonance angiography
Hill, L K; Hoang, D M; Briley, K; Sadowski, M; Wadghiri, Y Z. Neurovascular analysis of the aging murine brain using 3D in vivo gadolinium micelle-enhanced magnetic resonance angiography [Meeting Abstract]. Molecular imaging & biology. 2016 July 2016;18(1):S1772-S1774 (2161262)
Myeloperoxidase activity assessment in human brain vascular pathology using fluorescent and micro-MR Imaging
Hoang, D M; Wadghiri, Y Z; Gounis, M J; Caravan, P; Bogdanov, A A. Myeloperoxidase activity assessment in human brain vascular pathology using fluorescent and micro-MR Imaging [Meeting Abstract]. Molecular imaging & biology. 2016 July 2016;18(1):S1828-S1829 (2161252)
Optimal target VOI size for accurate 4D coregistration of DCE-MRI
Park, Brian; Mikheev, Artem; Wadghiri, Youssef Zaim; Bertrand, Anne; Novikov, Dmitry; Chandarana, Hersh; Rusinek, Henry. Optimal target VOI size for accurate 4D coregistration of DCE-MRI [Meeting Abstract]. Proceedings of SPIE (The International Society for Optical Engineering). 2016 ;9788:?-? (2228152)
Pulsed and oscillating gradient MRI for assessment of cell size and extracellular space (POMACE) in mouse gliomas
Reynaud, Olivier; Winters, Kerryanne Veronica; Hoang, Dung Minh; Wadghiri, Youssef Zaim; Novikov, Dmitry S; Kim, Sungheon Gene. Pulsed and oscillating gradient MRI for assessment of cell size and extracellular space (POMACE) in mouse gliomas. NMR in biomedicine. 2016 Oct;29(10):1350-1363 (2261502)
3D mapping of neuronal migration in the embryonic mouse brain with magnetic resonance microimaging
Deans, Abby E; Wadghiri, Youssef Zaim; Aristizabal, Orlando; Turnbull, Daniel H. 3D mapping of neuronal migration in the embryonic mouse brain with magnetic resonance microimaging. Neuroimage. 2015 Apr 11;114:303-310 (1532932)