Thomas M. Wisniewski

Biosketch / Results /

Thomas M. Wisniewski, M.D.

Professor; Director Aging and Dementia
Departments of Neurology (Aging and Dementia Div), Pathology and Psychiatry
NYU Neurology Associates
NYU Pearl Barlow Center for Memory Evaluation and Treatment

Clinical Addresses

240 EAST 38TH STREET
20TH FLOOR
NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-263-7744
Fax: 212-263-7721

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Medical Specialties

Neurology

Medical Expertise

Memory Disorders, Dementia, Alzheimer's Disease

Clinical Responsibilities

The Memory and Dementia Disorders Center specializes in the diagnosis and manangement of age associated memory problems, mild cognitive impairment, Alzheimer's disease, vascular dementia, fronto-temporal dementia, prion disease and other neurodegenerative disorders resulting in cognitive impairment.

Director of the Memory and Dementia Disorders Center. Chief of the Division of Aging and Dementia. Director of the Neuropathology Core of the NYU Alzheimer's Disease Center. Clinical Neurologist and Staff Neurology Attending at the Manhattan VA Hospital.

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO/EPO, AFFINITY, AFFINITY EXCHANGE- ESSENTIAL, CIGNA EPO/POS, Cigna PPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS POS, EBCBS PPO, ELDERPLAN, GHI CBP, HEALTHREPUBLIC, HIP ACCESS I, HIP ACCESS II, HIP CHLD HLTH, HIP EPO/PPO, HIP HMO, HIP MEDICARE, HIP POS, LOCAL 1199 PPO, MAGNACARE PPO, MULTIPLAN/PHCS PPO, Medicare, NYS EMPIRE PLAN, OSCAR, OXFORD FREEDOM, Oxford Medicare, UHC COMMUNITY & STATE PLAN, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UPN Elite

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

1989 — Ab Psychiatry & Neurology - Neurology
1990 — Ab Pathology (Neuropathology)

Education

1983 — Univ. of London (King's College), Medical Education
1983-1984 — Kings College Hospital (Rotating Internship), Internship
1984-1985 — Univ Hosp Of Brooklyn-Suny Ctr, Internship
1985-1988 — NYU Medical Center, Residency Training
1988-1990 — Columbia Presbyterian Medical Center (Neuropathology), Clinical Fellowships

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Research Summary

Dr. Wisniewski obtained his MD at Kings College School of Medicine in the UK. He did his Neurology and Neuropathology Residencies at NYU and Columbia-Presbyterian, respectively. He is a board certified Neurologist and Neuropathologist, who runs an active research laboratory focusing on neurodegenerative disorders, in particular the mechanisms which drive amyloid deposition in Alzheimer''s and prion related diseases. This work has lead to over 210 peer-reviewed publications. An important aim of his work has been to direct this greater understanding toward therapeutic interventions. Key discoveries have included discovering the role of apolipoprotein E in driving amyloid deposition in late-onset AD. Dr. Wisniewski coined the term "pathological chaperone" to denote the role of apoE, even prior to the discovery of the linkage of apoE4 to late-onset AD. Dr. Wisniewski has also been developing strategies for the enhanced clearance of pathological conformations of both amyloid beta and tau proteins in AD using non-toxic, highly immunogenic proteins as "vaccines". This approach has been shown to be highly efficacious in several animal models of AD and prion diseases. He has also been working at using this immunomodulation approach for a broader list of neurodegenerative diseases, which are called "conformational disease". His work has shown that this approach delays the onset of disease in animal models of prion infection. Recent prion related studies have focused on testing a novel mucosal vaccine in white tailed deer to prevent chronic wasting disease (CWD). CWD is an emerging, highly infectious prion disease affecting large numbers of cervids in the USA and Canada. Recent data suggests mucosal vaccination can give partial protection from CWD.

Research Interests

Development of Treatment approaches for Alzheimer and Prion Diseases; Neuropathology of autism

Research Keywords

Alzheimer disease, amyloid beta, tau, prion disease, chronic wasting disease, apolipoprotein E, cerebral amyloidosis, presenilin, autism, Vaccination, neuropathology

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

IMMUNOTHERAPY TARGETING TAU AND AMYLOID Ab PATHOLOGY IN AD ANIMAL MODELS
Boutajangout, Allal; Al-Ahwal, Mahmoud; Habib, Hamid; Wisniewski, Thomas
2014 MAR;35(3):721-721, Neurobiology of aging
— id: 751532, year: 2014, vol: 35, page: 721, stat: Journal Article,

Tau-Based Therapeutic Approaches for Alzheimer's Disease - A Mini-Review
Boutajangout, Allal; Wisniewski, Thomas
2014 Apr;:860-872, Gerontology
— id: 878072, year: 2014, vol: , page: 860, stat: Journal Article,

Understanding the experience of caring for children with haemophilia: cross-sectional study of caregivers in the United States
Dekoven, M; Karkare, S; Kelley, L A; Cooper, D L; Pham, H; Powers, J; Lee, W C; Wisniewski, T
2014 Jan;:28-28, Haemophila
— id: 878092, year: 2014, vol: , page: 28, stat: Journal Article,

Nerve growth factor metabolic dysfunction in Down's syndrome brains
Iulita, M Florencia; Do Carmo, Sonia; Ower, Alison K; Fortress, Ashley M; Aguilar, Lisi Flores; Hanna, Michael; Wisniewski, Thomas; Granholm, Ann-Charlotte; Buhusi, Mona; Busciglio, Jorge; Cuello, A Claudio
2014 Feb;:150-150, Brain
— id: 801552, year: 2014, vol: , page: 150, stat: Journal Article,

Blocking the apolipoprotein E/Amyloid ? interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid ? and tau pathology
Liu, S; Breitbart, A; Sun, Y; Mehta, PD; Boutajangout, A; Scholtzova, H; Wisniewski, T
2014 ;128(4):577-591, Journal of neurochemistry
— id: 842142, year: 2014, vol: 128, page: 577, stat: Journal Article,

Novel immunological approaches for the treatment of Alzheimer's disease
Sabharwal, P; Wisniewski, T
2014 01 Mar 2014;14(3):139-151, Zhongguo xian dai shen jing ji bing za zhi = Chinese journal of contemporary neurology & neurosurgery
— id: 954132, year: 2014, vol: 14, page: 139, stat: Journal Article,

Amyloid beta and Tau Alzheimers disease related pathology is reduced by toll-like receptor 9 stimulation
Scholtzova, Henrieta; Chianchiano, Peter; Pan, Jason; Sun, Yanjie; Goni, Fernando; Mehta, Pankaj D; Wisniewski, Thomas
2014 Sep;2:101-101, Acta neuropathologica communications
— id: 1180662, year: 2014, vol: 2, page: 101, stat: Journal Article,

Brain-region-specific alterations of the trajectories of neuronal volume growth throughout the lifespan in autism
Wegiel, Jerzy; Flory, Michael; Kuchna, Izabela; Nowicki, Krzysztof; Ma, Shuang Yong; Imaki, Humi; Wegiel, Jarek; Cohen, Ira L; London, Eric; Brown, W Ted; Wisniewski, Thomas
2014 ;2(1):28-28, Acta neuropathologica communications
— id: 878082, year: 2014, vol: 2, page: 28, stat: Journal Article,

Immunotherapy for Alzheimer's disease
Wisniewski, Thomas; Goni, Fernando
2014 Jan;:150-150, Biochemical pharmacology
— id: 801542, year: 2014, vol: , page: 150, stat: Journal Article,

The Innate Immune System in Alzheimer's Disease
Boutajangout, Allal; Wisniewski, Thomas
2013 ;2013:576383-576383, International journal of cell biology
— id: 617502, year: 2013, vol: 2013, page: 576383, stat: Journal Article,

Health-related quality of life in haemophilia patients with inhibitors and their caregivers
Dekoven, M; Wisniewski, T; Petrilla, A; Holot, N; Lee, W C; Cooper, D L; von Mackensen, S
2013 Mar;19(2):287-293, Haemophila
— id: 878142, year: 2013, vol: 19, page: 287, stat: Journal Article,

Analysis of the South American camelids prion proteins: Possible implications for interspecies susceptibility
Elisei, Analia; Porta, Natalia G.; Pinto, Gabriel B.; Wisniewski, Thomas; Goni, Fernando; Trono, Karina G.
2013 APR-MAY;7 S S:39-39, Prion
— id: 516512, year: 2013, vol: 7 S S, page: 39, stat: Journal Article,

Immunomodulation targeting pathology-associated protein conformers in 3xtg and tgswdi mice
Goni, F; Herline, K; Peyser, D K; Wong, V; Scholtzoa, H; Ji, Y; Sun, Y; Wisniewski, T
2013 July 2013;9(4):P847-P847, Alzheimer's and dementia
— id: 953652, year: 2013, vol: 9, page: P847, stat: Journal Article,

Monoclonal antibody therapy targeting the shared pathological conformer of both beta-amyloid and hyperphosphorylated tau
Goni, F; Peyser, D K; Herline, K; Sun, Y; Wisniewski, T
2013 July 2013;9(4):P839-P839, Alzheimer's and dementia
— id: 953662, year: 2013, vol: 9, page: P839, stat: Journal Article,

Immunomodulation targeting of both Abeta and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models
Goni, Fernando; Herline, Krystal; Peyser, Daniel; Wong, Kinlung; Ji, Yong; Sun, Yanjie; Mehta, Pankaj; Wisniewski, Thomas
2013 Dec;10(1):150-150, Journal of neuroinflammation
— id: 685702, year: 2013, vol: 10, page: 150, stat: Journal Article,

Studies of chronic wasting disease transmission in cervid and non-cervid species
Hoover, Edward A.; Mathiason, Candace K.; Henderson, Davin M.; Haley, Nicholas J.; Seelig, Davis M.; Denkers, Nathaniel D.; Nalls, Amy V.; Zabe, Mark D.; Telling, Glenn C.; Goni, Fernando; Wisniewski, Thomas
2013 APR-MAY;7 S S:7-7, Prion
— id: 516522, year: 2013, vol: 7 S S, page: 7, stat: Journal Article,

Apolipoprotein Epsilon epsilon4 Frequency Is Increased among Chinese Patients with Frontotemporal Dementia and Alzheimer's Disease
Ji, Yong; Liu, Mengyuan; Huo, Ya Ruth; Liu, Shuling; Shi, Zhihong; Liu, Shuai; Wisniewski, Thomas; Wang, Jinhuan
2013 Jul;36(3-4):163-170, Dementia geriatric & cognitive disorders
— id: 458822, year: 2013, vol: 36, page: 163, stat: Journal Article,

Blocking the Apolipoprotein E/Amyloid beta Interaction in Triple Transgenic Mice Ameliorates Alzheimer's Disease Related Amyloid beta and Tau Pathology
Liu, Shan; Breitbart, Ariel; Sun, Yanjie; Mehta, Pankaj D; Boutajangout, Allal; Scholtzova, Henrieta; Wisniewski, Thomas
2013 Oct;:577-591, Journal of neurochemistry
— id: 570822, year: 2013, vol: , page: 577, stat: Journal Article,

Role of CD40 in prion disease and the immune response to recombinant PrP
Rubenstein, Richard; Chiu, Allen; Chang, Binggong; Wisniewski, Thomas
2013 Feb;:21-27, Journal of neuroimmunology
— id: 218712, year: 2013, vol: , page: 21, stat: Journal Article,

Innate immunity stimulation via TLR9 in a non-human primate model of sporadic cerebral amyloid angiopathy
Scholtzova, H; Williams, L; Nehete, P; Sabado, R; Nehete, B; Holmes, A; Wisniewski, T
2013 July 2013;9(4):P508-P508, Alzheimer's and dementia
— id: 953722, year: 2013, vol: 9, page: P508, stat: Journal Article,

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein
Um, Ji Won; Kaufman, Adam C; Kostylev, Mikhail; Heiss, Jacqueline K; Stagi, Massimiliano; Takahashi, Hideyuki; Kerrisk, Meghan E; Vortmeyer, Alexander; Wisniewski, Thomas; Koleske, Anthony J; Gunther, Erik C; Nygaard, Haakon B; Strittmatter, Stephen M
2013 Sep;79(5):887-902, Neuron
— id: 524072, year: 2013, vol: 79, page: 887, stat: Journal Article,

Detection of Amyloid Plaques Targeted by Bifunctional USPIO in Alzheimer's Disease Transgenic Mice Using Magnetic Resonance Microimaging
Wadghiri, Youssef Zaim; Li, Jialin; Wang, Jinhuan; Hoang, Dung Minh; Sun, Yanjie; Xu, Hong; Tsui, Wai; Li, Yongsheng; Boutajangout, Allal; Wang, Andrew; de Leon, Mony; Wisniewski, Thomas
2013 ;8(2):e57097-e57097 e57097, PLoS one
— id: 226992, year: 2013, vol: 8, page: e57097, stat: Journal Article,

Contribution of olivo-floccular circuitry developmental defects to atypical gaze in autism
Wegiel, Jerzy; Kuchna, Izabela; Nowicki, Krzysztof; Imaki, Humi; Wegiel, Jarek; Yong Ma, Shuang; Azmitia, Efrain C; Banerjee, Probal; Flory, Michael; Cohen, Ira L; London, Eric; Ted Brown, W; Komich Hare, Carolyn; Wisniewski, Thomas
2013 Apr;:106-122, Brain research
— id: 271672, year: 2013, vol: , page: 106, stat: Journal Article,

Mucosal immunization to prevent Chronic Wasting Disease (CWD) in deer
Wisniewski, Thomas; Mathiason, Candace; Peyser, Daniel K.; Herline, Krystal; Nalls, Amy; Anderson, Kelly; Estevez, Veronica; Yim, Lucia; Brown, David; Chabalogoity, Jose A.; Hoover, Edward A.; Goni, Fernando
2013 APR-MAY;7 S S:35-35, Prion
— id: 516502, year: 2013, vol: 7 S S, page: 35, stat: Journal Article,

Alzheimer's Disease: Brain Desmosterol Levels
Wisniewski, Thomas; Newman, Kia; Javitt, Norman B
2013 Oct;:881-888, Journal of Alzheimer's disease
— id: 180033, year: 2013, vol: , page: 881, stat: Journal Article,

Postmortem study of hippocampus subfields and layers at 7T MR
Yazdanie, M; Ge, Y; Wadghiri, Y Z; De, Leon M; Wisniewski, T
2013 July 2013;9(4):P103-P104, Alzheimer's and dementia
— id: 953812, year: 2013, vol: 9, page: P103, stat: Journal Article,

Adamts-18 is a novel candidate gene of vascular development that is related to aggravated thrombosis: Evidence from a adamts-18 knock out mice
Zhang, W; Bu, D; Dang, S; Hong, T; Wisniewski, T
2013 21 Oct 2013;122(21):-, Blood
— id: 713132, year: 2013, vol: 122, page: , stat: Journal Article,

Influence of Mabs on PrP(Sc) Formation Using In Vitro and Cell-Free Systems
Chang, Binggong; Petersen, Robert; Wisniewski, Thomas; Rubenstein, Richard
2012 ;7(7):e41626-e41626 e41626, PLoS one
— id: 174195, year: 2012, vol: 7, page: e41626, stat: Journal Article,

7 tesla mr susceptibility-contrast microscopy imaging of amyloid pathologyand the hippocampus in Alzheimer's disease
Ge, Y; Zhou, Y; Wisniewski, T; Li, Y; Newman, K; De, Leon M
2012 2012;8(4):P699-P699, Alzheimer's and dementia
— id: 178074, year: 2012, vol: 8, page: P699, stat: Journal Article,

Active immunomodulation targeting abnormal conformation for the treatment of multiple neurodegenerative diseases
Goni, F; Wong, K; Scholtzova, H; Sun, Y; Pan, J; Li, J; Ji, Y; Wisniewski, T
2012 2012;8(4):P625-P625, Alzheimer's and dementia
— id: 178077, year: 2012, vol: 8, page: P625, stat: Journal Article,

Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities
Gray, Peter M; Forrest, Gail; Wisniewski, Thomas; Porter, Gene; Freed, Daniel C; DeMartino, Julie A; Zaller, Dennis M; Guo, Zhiqiang; Leone, Joseph; Fu, Tong-Ming; Vora, Kalpit A
2012 Jul-Aug;278(1-2):113-119, Cellular immunology
— id: 458832, year: 2012, vol: 278, page: 113, stat: Journal Article,

Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Abeta metabolism
Leal, Maria C; Surace, Ezequiel I; Holgado, Maria P; Ferrari, Carina C; Tarelli, Rodolfo; Pitossi, Fernando; Wisniewski, Thomas; Castano, Eduardo M; Morelli, Laura
2012 Feb;1823(2):227-235, Biochimica & biophysica acta
— id: 163095, year: 2012, vol: 1823, page: 227, stat: Journal Article,

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Nelson, PT; Alafuzoff, I; Bigio, EH; Bouras, C; Braak, H; Cairns, NJ; Castellani, RJ; Crain, BJ; Davies, P; Tredici, KD; Duyckaerts, C; Frosch, MP; Haroutunian, V; Hof, PR; Hulette, CM; Hyman, BT; Iwatsubo, T; Jellinger, KA; Jicha, GA; Kovari, E; Kukull, WA; Leverenz, JB; Love, S; Mackenzie, IR; Mann, DM; Masliah, E; McKee, AC; Montine, TJ; Morris, JC; Schneider, JA; Sonnen, JA; Thal, DR; Trojanowski, JQ; Troncoso, JC; Wisniewski, T; Woltjer, RL; Beach, TG
2012 Apr;:362-381, Journal of neuropathology & experimental neurology
— id: 164322, year: 2012, vol: , page: 362, stat: Journal Article,

Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder
Pomara, Nunzio; Bruno, Davide; Sarreal, Antero S; Hernando, Raymundo T; Nierenberg, Jay; Petkova, Eva; Sidtis, John J; Wisniewski, Thomas M; Mehta, Pankaj D; Pratico, Domenico; Zetterberg, Henrik; Blennow, Kaj
2012 May;169(5):523-530, American journal of psychiatry
— id: 174136, year: 2012, vol: 169, page: 523, stat: Journal Article,

Apolipoprotein E: Essential Catalyst of the Alzheimer Amyloid Cascade
Potter, Huntington; Wisniewski, Thomas
2012 ;2012:489428-489428, International journal of Alzheimer's disease
— id: 174196, year: 2012, vol: 2012, page: 489428, stat: Journal Article,

Innate immunity stimulation as a novel therapeutic approach in Alzheimer's disease
Scholtzova, H; Goni, F; Pan, J; Sun, Y; Li, J; Mehta, P; Wisniewski, T
2012 2012;8(4):P392-P392, Alzheimer's and dementia
— id: 178084, year: 2012, vol: 8, page: P392, stat: Journal Article,

Alzheimer amyloid-beta oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
Um, Ji Won; Nygaard, Haakon B; Heiss, Jacqueline K; Kostylev, Mikhail A; Stagi, Massimiliano; Vortmeyer, Alexander; Wisniewski, Thomas; Gunther, Erik C; Strittmatter, Stephen M
2012 Jul;:1227-1235, Nature neuroscience
— id: 174135, year: 2012, vol: , page: 1227, stat: Journal Article,

In Vivo Magnetic Resonance Imaging of Amyloid-beta Plaques in Mice
Wadghiri, Youssef Zaim; Hoang, Dung Minh; Wisniewski, Thomas; Sigurdsson, Einar M
2012 ;849:435-451, Methods in molecular biology
— id: 165628, year: 2012, vol: 849, page: 435, stat: Journal Article,

Differences Between the Pattern of Developmental Abnormalities in Autism Associated With Duplications 15q11.2-q13 and Idiopathic Autism
Wegiel, J; Schanen, NC; Cook, EH; Sigman, M; Brown, WT; Kuchna, I; Nowicki, K; Wegiel, J; Imaki, H; Ma, SY; Marchi, E; Wierzba-Bobrowicz, T; Chauhan, A; Chauhan, V; Cohen, IL; London, E; Flory, M; Lach, B; Wisniewski, T
2012 Apr;:382-397, Journal of neuropathology & experimental neurology
— id: 164321, year: 2012, vol: , page: 382, stat: Journal Article,

Abnormal Intracellular Accumulation and Extracellular Abeta Deposition in Idiopathic and Dup15q11.2-q13 Autism Spectrum Disorders
Wegiel, Jerzy; Frackowiak, Janusz; Mazur-Kolecka, Bozena; Schanen, N Carolyn; Cook, Edwin H Jr; Sigman, Marian; Brown, W Ted; Kuchna, Izabela; Wegiel, Jarek; Nowicki, Krzysztof; Imaki, Humi; Ma, Shuang Yong; Chauhan, Abha; Chauhan, Ved; Miller, David L; Mehta, Pankaj D; Flory, Michael; Cohen, Ira L; London, Eric; Reisberg, Barry; de Leon, Mony J; Wisniewski, Thomas
2012 ;7(5):e35414-e35414 e35414, PLoS one
— id: 166779, year: 2012, vol: 7, page: e35414, stat: Journal Article,

Active immunotherapy for Alzheimer's disease
Wisniewski, T
2012 Jun;:571-572, Lancet neurology
— id: 169193, year: 2012, vol: , page: 571, stat: Journal Article,

Specific in vivo detection of amyloid plaques in transgenic mice using bifunctional uspio nanoparticles
Wisniewski, T; Li, J; Hoang, D M; Xu, H; Sun, Y; Wang, A; Wadghiri, Y Z
2012 2012;8(4):P156-P156, Alzheimer's and dementia
— id: 178090, year: 2012, vol: 8, page: P156, stat: Journal Article,

Active immune intervention for prionoses in deer
Wisniewski, T; Mathiason, C; Wong, K; Hayes-Klug, J; Nalls, A; Anderson, K; Estevez, V; Yim, L; Brown, D; Chabalgoity, J A; Hoover, E; Goni, F
2012 2012;8(4):P403-P404, Alzheimer's and dementia
— id: 178083, year: 2012, vol: 8, page: P403, stat: Journal Article,

Could immunomodulation be used to prevent prion diseases?
Wisniewski, Thomas; Goni, Fernando
2012 Mar;10(3):307-317, Expert review of anti-infective therapy
— id: 159860, year: 2012, vol: 10, page: 307, stat: Journal Article,

A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment
Zhang, Wei; Dang, Suying; Hong, Tao; Tang, Jian; Fan, Jing; Bu, Dawei; Sun, Yanjie; Wang, Zhugang; Wisniewski, Thomas
2012 Aug;:2889-2898, Blood
— id: 176970, year: 2012, vol: , page: 2889, stat: Journal Article,

Styryl-based and tricyclic compounds as potential anti-prion agents
Chung, Erika; Prelli, Frances; Dealler, Stephen; Lee, Woo Sirl; Chang, Young-Tae; Wisniewski, Thomas
2011 ;6(9):e24844-e24844, PLoS one
— id: 137851, year: 2011, vol: 6, page: e24844, stat: Journal Article,

Dissolution of Pre-Existing Platelet Thrombus by Synergistic Administration of Low Concentrations of Bifunctional Antibodies against beta3 Integrin
Dang, Suying; Hong, Tao; Wisniewski, Thomas; Zhang, Wei
2011 ;6(10):e27012-e27012, PLoS one
— id: 141502, year: 2011, vol: 6, page: e27012, stat: Journal Article,

Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists
Kandimalla, Ekambar R; Struthers, Mary; Bett, Andrew J; Wisniewski, Thomas; Dubey, Sheri A; Jiang, Weiwen; Precopio, Melissa; Sun, Zhenhua; Wang, Hao; Lan, Tao; Agrawal, Sudhir; Casimiro, Danilo R
2011 ;270(2):126-134, Cellular immunology
— id: 458842, year: 2011, vol: 270, page: 126, stat: Journal Article,

Induction of TLR9 signaling in 3XTG-ad mice
Scholtzova H.; Goni F.; Sun Y.; Hatos L.; Pan J.; Kascsak R.; Mehta P.; Spinner D.; Wisniewski T.
2011 ;7(4 SUPPL 1):S665-S665, Alzheimer's and dementia
— id: 136959, year: 2011, vol: 7, page: S665, stat: Journal Article,

Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome
Wegiel, Jerzy; Kaczmarski, Wojciech; Barua, Madhabi; Kuchna, Izabela; Nowicki, Krzysztof; Wang, Kuo-Chiang; Wegiel, Jarek; Yang, Shuang Ma; Frackowiak, Janusz; Mazur-Kolecka, Bozena; Silverman, Wayne P; Reisberg, Barry; Monteiro, Isabel; de Leon, Mony; Wisniewski, Thomas; Dalton, Arthur; Lai, Florence; Hwang, Yu-Wen; Adayev, Tatyana; Liu, Fei; Iqbal, Khalid; Iqbal, Inge-Grundke; Gong, Cheng-Xin
2011 Jan;70(1):36-50, Journal of neuropathology & experimental neurology
— id: 134289, year: 2011, vol: 70, page: 36, stat: Journal Article,

Specific anti-prp mucosal and systemic response in white tail deer vaccinated with attenuated salmonella expressing deer prp
Wisniewski T.; Mathiason C.; Wong V.; Hayes-Klug J.; Nalls A.; Anderson K.; Estevez V.; Yim L.; Brown D.; Chabalgoity J.A.; Hoover E.; Goni F.
2011 ;7(4 SUPPL 1):S687-S688, Alzheimer's and dementia
— id: 136958, year: 2011, vol: 7, page: S687, stat: Journal Article,

Blocking the Apolipoprotein E/Amyloid-beta Interaction Reduces Fibrillar Vascular Amyloid Deposition and Cerebral Microhemorrhages in TgSwDI Mice
Yang, Jing; Ji, Yong; Mehta, Pankaj; Bates, Kristyn A; Sun, Yanjie; Wisniewski, Thomas
2011 Jan 1;24(2):269-285, Journal of Alzheimer's disease
— id: 130902, year: 2011, vol: 24, page: 269, stat: Journal Article,

Detection of amyloid plaques targeted by USPIO-Abeta1-42 in Alzheimer's disease transgenic mice using magnetic resonance microimaging
Yang, Jing; Zaim Wadghiri, Youssef; Minh Hoang, Dung; Tsui, Wai; Sun, Yanjie; Chung, Erika; Li, Yongsheng; Wang, Andrew; de Leon, Mony; Wisniewski, Thomas
2011 Apr 15;55(4):1600-1609, Neuroimage
— id: 128789, year: 2011, vol: 55, page: 1600, stat: Journal Article,

Synergistic effects of bifunctional antibodies against beta3 integrin on dissolution of platelet thrombus
Zhang, W; Dang, S; Wisniewski, T
2011 18 Nov 2011;118(21):-, Blood
— id: 169670, year: 2011, vol: 118, page: , stat: Journal Article,

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an alzheimer's disease model mouse
Chung, Erika; Ji, Yong; Sun, Yanjie; Kascsak, Richard J; Kascsak, Regina B; Mehta, Pankaj D; Strittmatter, Stephen M; Wisniewski, Thomas
2010 ;11:130-130, BMC neuroscience
— id: 114049, year: 2010, vol: 11, page: 130, stat: Journal Article,

Immunomodulation targeting abnormal protein conformation reduces pathology in a mouse model of Alzheimer's disease
Goni, Fernando; Prelli, Frances; Ji, Yong; Scholtzova, Henrieta; Yang, Jing; Sun, Yanjie; Liang, Feng-Xia; Kascsak, Regina; Kascsak, Richard; Mehta, Pankaj; Wisniewski, Thomas
2010 ;5(10):e13391-e13391, PLoS one
— id: 114051, year: 2010, vol: 5, page: e13391, stat: Journal Article,

Synthesis and immunological activities of novel agonists of toll-like receptor 9
Struthers, Mary; Bett, Andrew J; Wisniewski, Thomas; Dubey, Sheri A; Precopio, Melissa; Jiang, Weiwen; Sun, Zhenhua; Wang, Hao; Nowak, Ireneusz; Putta, Mallikarjuna R; Yu, Dong; Tang, Jimmy X; Kandimalla, Ekambar R; Agrawal, Sudhir; Casimiro, Danilo R
2010 ;263(1):105-113, Cellular immunology
— id: 458852, year: 2010, vol: 263, page: 105, stat: Journal Article,

The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
Wegiel, Jerzy; Kuchna, Izabela; Nowicki, Krzysztof; Imaki, Humi; Wegiel, Jarek; Marchi, Elaine; Ma, Shuang Yong; Chauhan, Abha; Chauhan, Ved; Bobrowicz, Teresa Wierzba; de Leon, Mony; Louis, Leslie A Saint; Cohen, Ira L; London, Eric; Brown, W Ted; Wisniewski, Thomas
2010 Jun;119(6):755-770, Acta neuropathologica
— id: 119248, year: 2010, vol: 119, page: 755, stat: Journal Article,

Type, topography, and sequelae of neuropathological changes: Shaping clinical phenotype of autism
Wegiel, Jerzy; Wisniewski, Thomas; Chauhan, Abha; Chauhan, Ved; Kuchna, Izabela; Nowicki, Krzysztof; Imaki, Humi; Wegiel, Jarek; Ma, Shuang Yong; Bobrowicz, Teresa Wierzba; Cohen, Ira L; London, Eric; Brown, W. Ted
Autism: Oxidative stress, inflammation, and immune abnormalities Boca Raton, FL : CRC Press, 2010,
— id: 5288, year: 2010, vol: , page: 279, stat: Chapter,

Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist
Wisniewski, T; Bayne, E; Flanagan, J; Shao, Q; Wnek, R; Matheravidathu, S; Fischer, P; Forrest, M J; Peterson, L; Song, X; Yang, L; Demartino, J A; Struthers, M
2010 Jan;352(1-2):101-110, Journal of immunological methods
— id: 878062, year: 2010, vol: 352, page: 101, stat: Journal Article,

Immunotherapeutic approaches for Alzheimer's disease in transgenic mouse models
Wisniewski, Thomas; Boutajangout, Allal
2010 Mar;214(2-3):201-218, Brain structure & function
— id: 108917, year: 2010, vol: 214, page: 201, stat: Journal Article,

Vaccination as a therapeutic approach to Alzheimer's disease
Wisniewski, Thomas; Boutajangout, Allal
2010 Jan;77(1):17-31, Mount Sinai journal of medicine
— id: 106502, year: 2010, vol: 77, page: 17, stat: Journal Article,

Immunomodulation for prion and prion-related diseases
Wisniewski, Thomas; Goni, Fernando
2010 Dec;9(12):1441-1452, Expert review of vaccines
— id: 114848, year: 2010, vol: 9, page: 1441, stat: Journal Article,

Murine models of Alzheimer's disease and their use in developing immunotherapies
Wisniewski, Thomas; Sigurdsson, Einar M
2010 Oct;1802(10):847-859, Biochimica & biophysica acta
— id: 112199, year: 2010, vol: 1802, page: 847, stat: Journal Article,

Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus
Zhang, Wei; Li, Yong-Sheng; Nardi, Michael A; Dang, Suying; Yang, Jing; Ji, Yong; Li, Zongdong; Karpatkin, Simon; Wisniewski, Thomas
2010 Sep 30;116(13):2336-2344, Blood
— id: 114164, year: 2010, vol: 116, page: 2336, stat: Journal Article,

Memantine Lowers beta-Amyloid Levels and Improves Cognitive Performance: Evidence from Preclinical Studies
Banerjee, P; Lahiri, DK; Tanila, H; Wisniewski, T; LaFerla, F
2009 APR 15 ;65(8):65S-65S, Biological psychiatry
— id: 97976, year: 2009, vol: 65, page: 65S, stat: Journal Article,

Diminished Amyloid-beta Burden in Tg2576 Mice Following a Prophylactic Oral Immunization with a Salmonella-Based Amyloid-beta Derivative Vaccine
Boutajangout, Allal; Goni, Fernando; Knudsen, Elin; Schreiber, Fernanda; Asuni, Ayodeji; Quartermain, David; Frangione, Blas; Chabalgoity, Alejandro; Wisniewski, Thomas; Sigurdsson, Einar M
2009 Jan 1;18(4):961-972, Journal of Alzheimer's disease
— id: 107413, year: 2009, vol: 18, page: 961, stat: Journal Article,

Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha-synuclein, or polyglutamine repeats for induction of an immune response thereto
Frangione, Blas; Wisniewski, Thomas; Sigurdsson, Einar M
2009 ;27(7):957-964, Official gazette of the United States Patent & Trademark Office. Patents
— id: 97983, year: 2009, vol: 27, page: 957, stat: Journal Article,

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease
Mosconi, Lisa; Mistur, Rachel; Switalski, Remigiusz; Tsui, Wai Hon; Glodzik, Lidia; Li, Yi; Pirraglia, Elizabeth; De Santi, Susan; Reisberg, Barry; Wisniewski, Thomas; de Leon, Mony J
2009 May;36(5):811-822, European journal of nuclear medicine & molecular imaging
— id: 91500, year: 2009, vol: 36, page: 811, stat: Journal Article,

Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo
Sadowski, Martin J; Pankiewicz, Joanna; Prelli, Frances; Scholtzova, Henrieta; Spinner, Daryl S; Kascsak, Regina B; Kascsak, Richard J; Wisniewski, Thomas
2009 May;34(2):267-278, Neurobiology of disease
— id: 101114, year: 2009, vol: 34, page: 267, stat: Journal Article,

Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's disease-related pathology
Scholtzova, Henrieta; Kascsak, Richard J; Bates, Kristyn A; Boutajangout, Allal; Kerr, Daniel J; Meeker, Harry C; Mehta, Pankaj D; Spinner, Daryl S; Wisniewski, Thomas
2009 Feb 11;29(6):1846-1854, Journal of neuroscience
— id: 92200, year: 2009, vol: 29, page: 1846, stat: Journal Article,

Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives
Trouche, Stephanie G; Asuni, Ayodeji; Rouland, Sylvie; Wisniewski, Thomas; Frangione, Blas; Verdier, Jean-Michel; Sigurdsson, Einar M; Mestre-Frances, Nadine
2009 Feb 11;27(7):957-964, Vaccine
— id: 91348, year: 2009, vol: 27, page: 957, stat: Journal Article,

AD vaccines: conclusions and future directions
Wisniewski, Thomas
2009 Apr;8(2):160-166, CNS & neurological disorders drug targets
— id: 100596, year: 2009, vol: 8, page: 160, stat: Journal Article,

An entorhinal cortex sulcal pattern is associated with Alzheimer's disease
Zhan, Jiong; Brys, Miroslaw; Glodzik, Lidia; Tsui, Wai; Javier, Elizabeth; Wegiel, Jerzy; Kuchna, Izabela; Pirraglia, Elizabeth; Li, Yi; Mosconi, Lisa; Saint Louis, Leslie A; Switalski, Remigiusz; De Santi, Susan; Kim, Byeong C; Wisniewski, Thomas; Reisberg, Barry; Bobinski, Matthew; de Leon, Mony J
2009 Mar;30(3):874-882, Human brain mapping
— id: 76758, year: 2009, vol: 30, page: 874, stat: Journal Article,

Enhanced accumulation of AB neurons in autism
Brown, WT; Kuchna, I; Nowicki, K; Wegiel, J; Wisniewski, T; Wegiel, J
2008 ;52(3):659-659, Journal of intellectual disability research : JIDR
— id: 97623, year: 2008, vol: 52, page: 659, stat: Journal Article,

Prominent Neuroleptic Sensitivity in a Case of Early-onset Alzheimer Disease due to Presenilin-1 G206A Mutation
Cercy, Steven P; Sadowski, Martin J; Wisniewski, Thomas
2008 Sep;21(3):190-195, Cognitive & behavioral neurology
— id: 83107, year: 2008, vol: 21, page: 190, stat: Journal Article,

5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease
Firuzi, Omidreza; Zhuo, Jiamin; Chinnici, Cinzia M; Wisniewski, Thomas; Pratico, Domenico
2008 Apr;22(4):1169-1178, FASEB journal
— id: 135343, year: 2008, vol: 22, page: 1169, stat: Journal Article,

Synthetic immunogenic but non amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits
Frangione, Blas; Wisniewski, Thomas; Sigurdsson, Einar M
2008 ;27(7):957-964, Official gazette of the United States Patent & Trademark Office. Patents
— id: 97982, year: 2008, vol: 27, page: 957, stat: Journal Article,

A novel human disease with abnormal prion protein sensitive to protease
Gambetti, Pierluigi; Dong, Zhiqian; Yuan, Jue; Xiao, Xiangzhu; Zheng, Mengjie; Alshekhlee, Amer; Castellani, Rudy; Cohen, Mark; Barria, Marcelo A; Gonzalez-Romero, D; Belay, Ermias D; Schonberger, Lawrence B; Marder, Karen; Harris, Carrie; Burke, James R; Montine, Thomas; Wisniewski, Thomas; Dickson, Dennis W; Soto, Claudio; Hulette, Christine M; Mastrianni, James A; Kong, Qingzhong; Zou, Wen-Quan
2008 Jun;63(6):697-708, Annals of neurology
— id: 79464, year: 2008, vol: 63, page: 697, stat: Journal Article,

High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice
Goni, F; Prelli, F; Schreiber, F; Scholtzova, H; Chung, E; Kascsak, R; Brown, D R; Sigurdsson, E M; Chabalgoity, J A; Wisniewski, T
2008 May 15;153(3):679-686, Neuroscience
— id: 99013, year: 2008, vol: 153, page: 679, stat: Journal Article,

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
Klyubin, Igor; Betts, Vicki; Welzel, Alfred T; Blennow, Kaj; Zetterberg, Henrik; Wallin, Anders; Lemere, Cynthia A; Cullen, William K; Peng, Ying; Wisniewski, Thomas; Selkoe, Dennis J; Anwyl, Roger; Walsh, Dominic M; Rowan, Michael J
2008 Apr 16;28(16):4231-4237, Journal of neuroscience
— id: 78679, year: 2008, vol: 28, page: 4231, stat: Journal Article,

Prion Diseases
Sadowski M; Verma A; Wisniewski T
Neurology in clinical practice Philadelphia, PA : Butterworth-Heinemann/Elsevier, 2008,
— id: 4960, year: 2008, vol: , page: 1567, stat: Chapter,

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging
Scholtzova, Henrieta; Wadghiri, Youssef Z; Douadi, Moustafa; Sigurdsson, Einar M; Li, Yong-Sheng; Quartermain, David; Banerjee, Pradeep; Wisniewski, Thomas
2008 Sep;86(12):2784-2791, Journal of neuroscience research
— id: 79463, year: 2008, vol: 86, page: 2784, stat: Journal Article,

A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice
Sigurdsson, Einar M; Wadghiri, Youssef Z; Mosconi, Lisa; Blind, Jeffrey A; Knudsen, Elin; Asuni, Ayodeji; Scholtzova, Henrieta; Tsui, Wai H; Li, Yongsheng; Sadowski, Martin; Turnbull, Daniel H; de Leon, Mony J; Wisniewski, Thomas
2008 Jun;29(6):836-847, Neurobiology of aging
— id: 71031, year: 2008, vol: 29, page: 836, stat: Journal Article,

Accelerated prion disease pathogenesis in Toll-like receptor 4 (TLR4) signaling-mutant mice
Spinner, Daryl S; Cho, In Soo; Park, Seung Yong; Kim, Jae Il; Meeker, Harry C; Ye, Xuemin; Lafauci, Giuseppe; Kerr, Daniel J; Flory, Michael J; Kim, Bo Sook; Kascsak, Regina B; Wisniewski, Thomas; Levis, William R; Schuller-Levis, Georgia B; Carp, Richard I; Park, Eunkyue; Kascsak, Richard J
2008 Nov;82(21):10701-10708, Journal of virology
— id: 83108, year: 2008, vol: 82, page: 10701, stat: Journal Article,

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
Wegiel, Jerzy; Dowjat, Karol; Kaczmarski, Wojciech; Kuchna, Izabela; Nowicki, Krzysztof; Frackowiak, Janusz; Mazur Kolecka, Bozena; Wegiel, Jarek; Silverman, Wayne P; Reisberg, Barry; Deleon, Mony; Wisniewski, Thomas; Gong, Cheng-Xin; Liu, Fei; Adayev, Tatyana; Chen-Hwang, Mo-Chou; Hwang, Yu-Wen
2008 Oct;116(4):391-407, Acta neuropathologica
— id: 80400, year: 2008, vol: 116, page: 391, stat: Journal Article,

Amyloid-beta immunisation for Alzheimer's disease
Wisniewski, Thomas; Konietzko, Uwe
2008 Sep;7(9):805-811, Lancet neurology
— id: 81584, year: 2008, vol: 7, page: 805, stat: Journal Article,

Preventing beta-amyloid fibrillization and deposition: beta-sheet breakers and pathological chaperone inhibitors
Wisniewski, Thomas; Sadowski, Martin
2008 ;9 Suppl 2:S5-S5, BMC neuroscience
— id: 91501, year: 2008, vol: 9 Suppl 2, page: S5, stat: Journal Article,

A blood test for prion: disease associated prion aggregate is detected in the blood of infected but asymptomatic animals
Chang, Binggong; Cheng, Xin; Yin, Shaoman; Pan, Tao; Zhang, Hongtao; Wong, Poki; Kang, Shin-Chung; Xiao, Fan; Yan, Huimin; Li, Chaoyang; Wolfe, Lisa L; Miller, Michael W; Wisniewski, Thomas; Greene, Mark I; Sy, Man-Sun
2007 Jan;14(1):36-43, Clinical & vaccine immunology
— id: 69182, year: 2007, vol: 14, page: 36, stat: Journal Article,

Styryl-Based Compounds as Potential in vivo Imaging Agents for beta-Amyloid Plaques
Li, Qian; Min, Jaeki; Ahn, Young-Hoon; Namm, Joshua; Kim, Eun Min; Lui, Rowena; Kim, Hye Yun; Ji, Yong; Wu, Hueizhi; Wisniewski, Thomas; Chang, Young-Tae
2007 Aug 20;8(14):1679-1687, Chembiochem : a European journal of chemical biology
— id: 73943, year: 2007, vol: 8, page: 1679, stat: Journal Article,

Ligand binding and calcium influx induce distinct ectodomain/gamma -secretase processing pathways of EPHB2 receptor
Litterst, Claudia; Georgakopoulos, Anastasios; Shioi, Junichi; Ghersi, Enrico; Wisniewski, Thomas; Wang, Rong; Ludwig, Andreas; Robakis, Nikolaos K
2007 Jun 1;282(22):16155-16163, Journal of biological chemistry
— id: 71396, year: 2007, vol: 282, page: 16155, stat: Journal Article,

Diaryl substituted pyrazoles as potent CCR2 receptor antagonists
Pinkerton, Anthony B; Huang, Dehua; Cube, Rowena V; Hutchinson, John H; Struthers, Mary; Ayala, Julia M; Vicario, Pasquale P; Patel, Sima R; Wisniewski, Thomas; DeMartino, Julie A; Vernier, Jean-Michel
2007 Feb;17(3):807-813, Bioorganic & medicinal chemistry letters
— id: 458862, year: 2007, vol: 17, page: 807, stat: Journal Article,

Disease modifying approaches for Alzheimer's pathology
Sadowski, Marcin; Wisniewski, Thomas
2007 ;13(19):1943-1954, Current pharmaceutical design
— id: 73005, year: 2007, vol: 13, page: 1943, stat: Journal Article,

Therapeutic monoclonal antibodies for prion exposure prophylaxis
Sadowski, MJ; Pankiewicz, J; Prelli, F; Scholtzova, H; Spinner, D; Kascsak, RB; Kascsak, RJ; Wisniewski, T
2007 ;68(12):A141-A142, Neurology
— id: 97601, year: 2007, vol: 68, page: A141, stat: Journal Article,

CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils
Spinner, Daryl S; Kascsak, Regina B; Lafauci, Giuseppe; Meeker, Harry C; Ye, Xuemin; Flory, Michael J; Kim, Jae Il; Schuller-Levis, Georgia B; Levis, William R; Wisniewski, Thomas; Carp, Richard I; Kascsak, Richard J
2007 Jun;81(6):1374-1385, Journal of leukocyte biology
— id: 71030, year: 2007, vol: 81, page: 1374, stat: Journal Article,

Mechanistic Insights into Prion Curing by Novel Anti-Prion Compounds
Webb, Sarah; Lekishvili, Tamuna; Loeschner, Corinna; Sellarajah, Shane; Prelli, Frances; Wisniewski, Thomas; Gilbert, Ian H; Brown, David R
2007 ;81(19):10729-10741, Journal of virology
— id: 73169, year: 2007, vol: 81, page: 10729, stat: Journal Article,

Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration
Wegiel, Jerzy; Kuchna, Izabela; Nowicki, Krzysztof; Frackowiak, Janusz; Mazur-Kolecka, Bozena; Imaki, Humi; Wegiel, Jarek; Mehta, Pankaj D; Silverman, Wayne P; Reisberg, Barry; Deleon, Mony; Wisniewski, Thomas; Pirttilla, Tuula; Frey, Harry; Lehtimaki, Terho; Kivimaki, Tarmo; Visser, Frank E; Kamphorst, Wouter; Potempska, Anna; Bolton, David; Currie, Julia R; Miller, David L
2007 Apr;113(4):389-402, Acta neuropathologica
— id: 71032, year: 2007, vol: 113, page: 389, stat: Journal Article,

Is vaccination against transmissible spongiform encephalopathy feasible?
Wisniewski, T; Chabalgoity, J A; Goni, F
2007 Apr;26(1):243-251, Revue scientifique et technique (International Office of Epizootics)
— id: 73007, year: 2007, vol: 26, page: 243, stat: Journal Article,

Mucosal vaccination can prevent prion infection via an oral route
Wisniewski, T; Prelli, F; Scholtzova, H; Wu, H; Chung, E; Chabalgoity, JA; Sigurdsson, E; Sadowski, M; Goni, F
2007 ;68(12):A348-A348, Neurology
— id: 97602, year: 2007, vol: 68, page: A348, stat: Journal Article,

Therapeutic approaches for prion and Alzheimer's diseases
Wisniewski, Thomas; Sigurdsson, Einar M
2007 Aug;274(15):3784-3798, FEBS journal
— id: 73006, year: 2007, vol: 274, page: 3784, stat: Journal Article,

Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages
Asuni, Ayodeji A; Boutajangout, Allal; Scholtzova, Henrieta; Knudsen, Elin; Li, Yong Sheng; Quartermain, David; Frangione, Blas; Wisniewski, Thomas; Sigurdsson, Einar M
2006 Nov;24(9):2530-2542, European journal of neuroscience
— id: 69181, year: 2006, vol: 24, page: 2530, stat: Journal Article,

Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology
Leal, Maria C; Dorfman, Veronica B; Gamba, Agata Fernandez; Frangione, Blas; Wisniewski, Thomas; Castano, Eduardo M; Sigurdsson, Einar M; Morelli, Laura
2006 Oct;65(10):976-987, Journal of neuropathology & experimental neurology
— id: 68945, year: 2006, vol: 65, page: 976, stat: Journal Article,

Clearance and prevention of prion infection in cell culture by anti-PrP antibodies
Pankiewicz, Joanna; Prelli, Frances; Sy, Man-Sun; Kascsak, Richard J; Kascsak, Regina B; Spinner, Daryl S; Carp, Richard I; Meeker, Harry C; Sadowski, Marcin; Wisniewski, Thomas
2006 May;23(10):2635-2647, European journal of neuroscience
— id: 65120, year: 2006, vol: 23, page: 2635, stat: Journal Article,

Apolipoproteins in different amyloidoses
Sadowski M; Wisniewski T
Protein misfolding, aggregation, and conformational diseases. Part A. Protein aggretation and conformational diseases New York : Springer, 2006,
— id: 4979, year: 2006, vol: , page: 329, stat: Chapter,

Characterization of therapeutically effective monoclonal antibodies against prion protein
Sadowski, M; Pankiewicz, J; Prelli, F; Sy, MS; Kascsak, RJ; Kascsak, RB; Spinner, DS; Carp, RI; Meeker, HC; Wisniewski, T
2006 ;66(5):A258-A258, Neurology
— id: 97603, year: 2006, vol: 66, page: A258, stat: Journal Article,

Inhibition the apolipoprotein E/amyloid-beta interaction as a novel therapeutic approach for Alzheimer's disease
Sadowski, M; Pankiewicz, J; Scholtzova, H; Wen, P; Mehta, P; Quartermain, D; Wisniewski, T
2006 ;66(5):A379-A379, Neurology
— id: 97604, year: 2006, vol: 66, page: A379, stat: Journal Article,

Blocking the apolipoprotein E/amyloid-{beta} interaction as a potential therapeutic approach for Alzheimer's disease
Sadowski, Martin J; Pankiewicz, Joanna; Scholtzova, Henrieta; Mehta, Pankaj D; Prelli, Frances; Quartermain, David; Wisniewski, Thomas
2006 Dec 5;103(49):18787-18792, Proceedings of the National Academy of Sciences of the United States of America
— id: 69282, year: 2006, vol: 103, page: 18787, stat: Journal Article,

Assessing the effects of memantine in APP/PS1 transgenic mice by behavioural studies and ex vivo imaging of amyloid plaques using gadolinium labelled amyloid beta peptides and mu MRI
Scholtzova, H; Wadghiri, YZ; Sigurdsson, EM; Douadi, M; Li, Y; Quartermain, D; Banerjee, PK; Wisniewski, T
2006 SEP ;16(11):S483-S483, European neuropsychopharmacology
— id: 69190, year: 2006, vol: 16, page: S483, stat: Journal Article,

Characterization and non-invasive imaging of lens b-amyloid in the Tg2576 mouse model of Alzheimer's disease
Goldstein, LE; Moir, R; Arnett, E; Sadowski, M; Tanzi, R; Wisniewski, T; Klunk, W; Clark, J; Chylack, LT
2005 ;46(Suppl. S):2905-A379, Investigative ophthalmology & visual science. IOVS
— id: 97605, year: 2005, vol: 46, page: 2905, stat: Journal Article,

Mucosal vaccination delays or prevents prion infection via an oral route
Goni, F; Knudsen, E; Schreiber, F; Scholtzova, H; Pankiewicz, J; Carp, R; Meeker, H C; Rubenstein, R; Brown, D R; Sy, M-S; Chabalgoity, J A; Sigurdsson, E M; Wisniewski, T
2005 ;133(2):413-421, Neuroscience
— id: 75837, year: 2005, vol: 133, page: 413, stat: Journal Article,

An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates
Pan, Tao; Chang, Binggong; Wong, Poki; Li, Chaoyang; Li, Ruliang; Kang, Shin-Chung; Robinson, John D; Thompsett, Andrew R; Tein, Po; Yin, Shaoman; Barnard, Geoff; McConnell, Ian; Brown, David R; Wisniewski, Thomas; Sy, Man-Sun
2005 Oct;79(19):12355-12364, Journal of virology
— id: 64338, year: 2005, vol: 79, page: 12355, stat: Journal Article,

Biochemical fingerprints of prion infection: accumulations of aberrant full-length and N-terminally truncated PrP species are common features in mouse prion disease
Pan, Tao; Wong, Poki; Chang, Binggong; Li, Chaoyang; Li, Ruliang; Kang, Shin-Chung; Wisniewski, Thomas; Sy, Man-Sun
2005 Jan;79(2):934-943, Journal of virology
— id: 64339, year: 2005, vol: 79, page: 934, stat: Journal Article,

Anti-PrP monoclonal antibodies for prevention of prion infection
Pankiewicz, J; Prelli, F; Sadowski, M; Scholtzova, H; Kascsak, R; Kascsak, R; Carp, RI; Meeker, CH; Sy, MS; Wisniewski, T
2005 ;64(6):A249-A250, Neurology
— id: 97606, year: 2005, vol: 64, page: A249, stat: Journal Article,

MRI approaches for specific targeting of PrPSc in the spleen of prion infected presymptomatic subjects
Sadowski, M; Wadghiri, ZY; Brown, D; Scholtzova, H; Pankiewicz, J; Turnbull, DH; Wisniewski, T
2005 ;64(6):A409-A410, Neurology
— id: 97607, year: 2005, vol: 64, page: A409, stat: Journal Article,

Therapeutics and prion disease: can immunisation or drugs be effective?
Sassoon, J; Sadowski, M; Wisniewski, T; Brown, D R
2005 Apr;5(4):361-366, Mini reviews in medicinal chemistry
— id: 878052, year: 2005, vol: 5, page: 361, stat: Journal Article,

Promising developments in prion immunotherapy
Sigurdsson, Einar M; Wisniewski, Thomas
2005 Oct;4(5):607-610, Expert review of vaccines
— id: 62131, year: 2005, vol: 4, page: 607, stat: Journal Article,

Magnetic resonance imaging of amyloid plaques in transgenic mice
Wadghiri, Youssef Zaim; Sigurdsson, Einar M; Wisniewski, Thomas; Turnbull, Daniel H
2005 ;299:365-379, Methods in molecular biology
— id: 56371, year: 2005, vol: 299, page: 365, stat: Journal Article,

Is amyloid-beta-peptide immunization clinically effective in patients with Alzheimer's disease?
Wisniewski, Thomas
2005 Dec;1(2):84-85, Nature clinical practice. Neurology
— id: 68666, year: 2005, vol: 1, page: 84, stat: Journal Article,

Immunological and anti-chaperone therapeutic approaches for Alzheimer disease
Wisniewski, Thomas; Frangione, Blas
2005 Jan;15(1):72-77, Brain pathology
— id: 51394, year: 2005, vol: 15, page: 72, stat: Journal Article,

Antibody mediated modulation of A beta induced neurotoxicity in cell culture
Asuni, AA; Knudsen, E; Frangione, B; Wisniewski, T; Sigurdsson, EM
2004 JUL ;25(10):S581-S582, Neurobiology of aging
— id: 47745, year: 2004, vol: 25, page: S581, stat: Journal Article,

A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations
Dowjat, Wieslaw K; Kuchna, Izabela; Wisniewski, Thomas; Wegiel, Jerzy
2004 Feb;6(1):31-43, Journal of Alzheimer's disease
— id: 45287, year: 2004, vol: 6, page: 31, stat: Journal Article,

Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits
Frangione, Blas; Wisniewski, Thomas; Sigurdsson, Einar M
2004 ;1280(5):S30-S31, Official gazette of the United States Patent & Trademark Office. Patents
— id: 97981, year: 2004, vol: 1280, page: S30, stat: Journal Article,

An animal model of vascular amyloidosis
Ghiso, Jorge; Wisniewski, Thomas
2004 Sep;7(9):902-904, Nature neuroscience
— id: 44510, year: 2004, vol: 7, page: 902, stat: Journal Article,

MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease
Helpern, Joseph A; Lee, Sang-Pil; Falangola, Maria F; Dyakin, Victor V; Bogart, Adam; Ardekani, Babak; Duff, Karen; Branch, Craig; Wisniewski, Thomas; de Leon, Mony J; Wolf, Oliver; O'Shea, Jacqueline; Nixon, Ralph A
2004 Apr;51(4):794-798, Magnetic resonance in medicine
— id: 42285, year: 2004, vol: 51, page: 794, stat: Journal Article,

Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice
Kang, Shin-Chung; Brown, David R; Whiteman, Matthew; Li, Ruliang; Pan, Tao; Perry, George; Wisniewski, Thomas; Sy, Man-Sun; Wong, Boon-Seng
2004 May;203(1):603-608, Journal of pathology
— id: 42679, year: 2004, vol: 203, page: 603, stat: Journal Article,

Intraneuronal amyloid beta immunoreactivity is not a predictor of fibrillar plaque formation or neurofibrillary degeneration
Kuchna, I; Nowicki, K; Imaki, H; Wang, KC; Mehta, PD; Silverman, WP; Reisberg, B; de Leon, M; Wisniewski, T; Pirttila, T; Frey, H; Lehtimaki, T; Kivimaki, T; Visser, FE; Kamphorst, W; Currie, JR; Miller, DL; Wegiel, J
2004 JUL ;25(10):S407-S408, Neurobiology of aging
— id: 47737, year: 2004, vol: 25, page: S407, stat: Journal Article,

Epitope scanning reveals gain and loss of strain specific antibody binding epitopes associated with the conversion of normal cellular prion to scrapie prion
Pan, Tao; Li, Ruliang; Kang, Shin-Cheng; Wong, Boon-Seng; Wisniewski, Thomas; Sy, Man-Sun
2004 Sep;90(5):1205-1217, Journal of neurochemistry
— id: 45286, year: 2004, vol: 90, page: 1205, stat: Journal Article,

Monoclonal antibodies for the treatment of prion infection
Pankiewicz, J; Prelli, F; Scholtzova, H; Sadowski, M; Sigurdsson, EM; Goni, F; Kascsak, R; Kascsak, R; Carp, RI; Meeker, HC; Sy, MS; Wisniewski, T
2004 JUL ;25(10):S456-S456, Neurobiology of aging
— id: 47740, year: 2004, vol: 25, page: S456, stat: Journal Article,

Prion diseases
Sadowski M; Verma A; Wisniewski T
Neurology in clinical practice Philadelphia : Butterworth-Heinemann, 2004,
— id: 3167, year: 2004, vol: , page: 1613, stat: Chapter,

100 questions and answers about Alzheimer's disease
Sadowski M; Wisniewski T
Boston : Jones & Bartlett, 2004,
— id: 763, year: 2004, vol: , page: , stat: ,

Blocking the apolipoprotein E/beta-amyloid interaction by synthetic peptide mitigates beta-amyloid toxicity and fibril formation in vitro and in vivo
Sadowski, M; Pankiewicz, J; Scholtzova, H; Li, Y; Sigurdsson, EM; Wisniewski, T
2004 AUG ;13(3):237-237, Protein science
— id: 55684, year: 2004, vol: 13, page: 237, stat: Journal Article,

In vivo imaging of prion amyloid deposits
Sadowski, M; Pankiewicz, J; Scholtzova, H; Tsai, J; Carp, RI; Meeker, HC; Debnath, M; Mathis, CA; Shao, L; Klunk, WE; Gan, WB; Wisniewski, T
2004 JUL ;25(10):S280-S281, Neurobiology of aging
— id: 47732, year: 2004, vol: 25, page: S280, stat: Journal Article,

Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice
Sadowski, Marcin; Pankiewicz, Joanna; Scholtzova, Henrieta; Ji, Yong; Quartermain, David; Jensen, Catrin H; Duff, Karen; Nixon, Ralph A; Gruen, Rand J; Wisniewski, Thomas
2004 May;63(5):418-428, Journal of neuropathology & experimental neurology
— id: 44514, year: 2004, vol: 63, page: 418, stat: Journal Article,

Links between the pathology of Alzheimer's disease and vascular dementia
Sadowski, Marcin; Pankiewicz, Joanna; Scholtzova, Henrieta; Li, Yong-sheng; Quartermain, David; Duff, Karen; Wisniewski, Thomas
2004 Jul;29(6):1257-1266, Neurochemical research
— id: 46031, year: 2004, vol: 29, page: 1257, stat: Journal Article,

Blocking the chaperoning effect of apolipoprotein E reduces beta-amyloid load in Alzheimer's disease transgenic mice
Sadowski, Marcin; Pankiewicz, Joanna; Scholtzova, Henrieta; Ripellino, James A.; Schmidt, Stephen D.; Mathews, Paul W.; Sigurdsson, Einar M.; Wisniewski, Thomas
2004 ;62(7, Suppl. 5):A522-A447, Neurology
— id: 97610, year: 2004, vol: 62, page: A522, stat: Journal Article,

A Synthetic Peptide Blocking the Apolipoprotein E/{beta}-Amyloid Binding Mitigates {beta}-Amyloid Toxicity and Fibril Formation in Vitro and Reduces {beta}-Amyloid Plaques in Transgenic Mice
Sadowski, Marcin; Pankiewicz, Joanna; Scholtzova, Henrieta; Ripellino, James A; Li, Yongsheng; Schmidt, Stephen D; Mathews, Paul M; Fryer, John D; Holtzman, David M; Sigurdsson, Einar M; Wisniewski, Thomas
2004 Sep;165(3):937-948, American journal of pathology
— id: 44511, year: 2004, vol: 165, page: 937, stat: Journal Article,

Detection of prion amyloid deposits in vivo
Sadowski, Marcin; Pankiewicz, Joanna; Scholtzova, Henrieta; Tsai, Julia; Carp, Richard I.; Meeker, Cliff H.; Gan, Wen-Biao; Klunk, William E.; Mathis, Chester A.; Shao, Li; Debnath, Manik; Wisniewski, Thomas
2004 ;62(7, Suppl. 5):A446-A447, Neurology
— id: 97609, year: 2004, vol: 62, page: A446, stat: Journal Article,

Targeting prion amyloid deposits in vivo
Sadowski, Marcin; Pankiewicz, Joanna; Scholtzova, Henrieta; Tsai, Julia; Li, Yongsheng; Carp, Richard I; Meeker, Harry C; Gambetti, Pierluigi; Debnath, Manik; Mathis, Chester A; Shao, Li; Gan, Wen-Biao; Klunk, William E; Wisniewski, Thomas
2004 Jul;63(7):775-784, Journal of neuropathology & experimental neurology
— id: 44512, year: 2004, vol: 63, page: 775, stat: Journal Article,

Vaccines for conformational disorders
Sadowski, Marcin; Wisniewski, Thomas
2004 ;3(3):279-290, Expert review of vaccines
— id: 97608, year: 2004, vol: 3, page: 279, stat: Journal Article,

Age-associated behavioral, metabolic, and structural changes in wild-type littermates of Alzheimer's transgenic mice
Scholtzova, H; Pankiewicz, J; Sadowski, M; Quartermain, D; Jensen, CH; Duff, K; Nixon, RA; Helpern, JH; Gruen, RJ; Wisniewski, T
2004 JUL ;25(10):S225-S226, Neurobiology of aging
— id: 47726, year: 2004, vol: 25, page: S225, stat: Journal Article,

In vivo magnetic resonance of amyloid plaques in Alzheimer's disease model mice
Sigurdsson, E; Wadghiri, YZ; Sadowski, M; Elliott, JI; Li, YS; Scholtzova, H; Tang, CY; Aguinaldo, G; Duff, K; Turnbull, DH; Wisniewski, T
The living brain and Alzheimer's disease Berlin : Springer, 2004,
— id: 4970, year: 2004, vol: , page: 47, stat: Chapter,

An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives
Sigurdsson, Einar M; Knudsen, Elin; Asuni, Ayodeji; Fitzer-Attas, Cheryl; Sage, Daniel; Quartermain, David; Goni, Fernando; Frangione, Blas; Wisniewski, Thomas
2004 Jul 14;24(28):6277-6282, Journal of neuroscience
— id: 44513, year: 2004, vol: 24, page: 6277, stat: Journal Article,

Modest immune response elicited by A beta derivatives in TG2576 mice improves cognition
Sigurdsson, EM; Knudsen, E; Asuni, A; Sage, D; Goni, F; Quartermam, D; Frangione, B; Wisniewski, T
2004 JUL ;25(10):S576-S576, Neurobiology of aging
— id: 47744, year: 2004, vol: 25, page: S576, stat: Journal Article,

In vivo magnetic resonance imaging of amyloid plaques in mice with a non-toxic A beta derivative
Sigurdsson, EM; Wadghiri, YZ; Blind, JA; Knudsen, E; Asuni, A; Sadowski, M; Turnbull, DH; Wisniewski, T
2004 JUL ;25(10):S57-S57, Neurobiology of aging
— id: 47715, year: 2004, vol: 25, page: S57, stat: Journal Article,

Detection of Alzheimer's amyloid lesions in transgenic mice by magnetic resonance imaging
Sigurdsson, EM; Wadghiri, YZ; Li, YS; Elliott, JI; Tang, CY; Aguilnaldo, G; Duff, K; Pappolla, M; Watanabe, M; Scholtzova, H; Turnbull, DH; Wisniewski, T
2004 FEB ;25(2):251-251, Neurobiology of aging
— id: 42486, year: 2004, vol: 25, page: 251, stat: Journal Article,

Age-associated neurofibrillary degeneration and neuronal loss in people free of beta-amyloidosis
Wegiel, J; Kuchna, I; Nowicki, K; Badmaev, E; Wisniewski, T; de Leon, M; Reisberg, B; Pirttila, T; Silverman, WP
2004 JUL ;25(10):S10-S10, Neurobiology of aging
— id: 47707, year: 2004, vol: 25, page: S10, stat: Journal Article,

Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain
Wegiel, Jerzy; Kuchna, Izabela; Nowicki, Krzysztof; Frackowiak, Janusz; Dowjat, Karol; Silverman, Wayne P; Reisberg, Barry; DeLeon, Mony; Wisniewski, Thomas; Adayev, Tatyana; Chen-Hwang, Mo-Chou; Hwang, Yu-Wen
2004 Jun 4;1010(1-2):69-80, Brain research
— id: 44515, year: 2004, vol: 1010, page: 69, stat: Journal Article,

Imaging and therapeutic approaches for beta-sheet structures in prion and Alzheimer's diseases
Wisniewski, T; Pankiewicz, J; Scholtzova, H; Fernando, G; Chabalgoity, JA; Ji, Y; Wadghiri, YZ; Gan, WB; Tang, CY; Turnbull, DH; Mathis, CA; Kascsak, R; Klunk, WE; Carp, RI; Frangione, B; Sigurdsson, EM; Sadowski, M
2004 ;25(2):S30-S31, Neurobiology of aging
— id: 97595, year: 2004, vol: 25, page: S30, stat: Journal Article,

Reduction of beta-amyloid load in Alzheimer's disease transgenic mice by competitive blocking of beta-amyloid binding to apolipoprotein E
Wisniewski, T; Pankiewicz, J; Scholtzova, H; Schmidt, SD; Mathews, PM; Sigurdsson, EM; Sadowski, M
2004 JUL ;25(10):S583-S583, Neurobiology of aging
— id: 47746, year: 2004, vol: 25, page: S583, stat: Journal Article,

In vivo imaging of amyloid plaques in AD and prion disease model mice
Wisniewski, T; Sigurdsson, EM; Wadghiri, YZ; Carp, R; Tang, CY; Turnbull, DH; Mathis, C; Klunk, WE; Gan, WB; Sadowski, M
2004 APR ;25(12):S29-S29, Neurobiology of aging
— id: 42446, year: 2004, vol: 25, page: S29, stat: Journal Article,

Prion protein ubiquitination in scrapie infection
Wong, BS; Kang, SC; Brown, DR; Whiteman, M; Li, R; Pan, T; Perry, G; Wisniewski, T; Sy, MS
2004 FEB ;88(5):55-55, Journal of neurochemistry
— id: 42488, year: 2004, vol: 88, page: 55, stat: Journal Article,

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients
Ji, Y; Gong, Y; Gan, W; Beach, T; Holtzman, D M; Wisniewski, T
2003 ;122(2):305-315, Neuroscience
— id: 46270, year: 2003, vol: 122, page: 305, stat: Journal Article,

Immunization with amyloid - beta derivatives improves cognition while provoking a weak antibody response
Knudsen, E. L.; Wisniewski, T.; Quartermain, D.; Sage, D.; Scholtzova, H.; Frangione, B.; Sigurdsson, E. M.
2003 ;2003(5):Abstract No. 133.10-S31, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97630, year: 2003, vol: 2003, page: Abstract No. 133.10, stat: Journal Article,

Global ischemia exacerbates Alzheimer's disease related pathology in transgenic mice
Pankiewicz, J.; Scholtzova, H.; Sadowski, M.; Ferris, S.; Li, Y. S.; Quartermain, D.; Duff, K.; Wisniewski, T.
2003 ;2003(7, Suppl. 5):Abstract No. 534.7-S583, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97611, year: 2003, vol: 2003, page: Abstract No. 534.7, stat: Journal Article,

Inhibition of apolipoprotein E binding to amyloid - beta decreases fibril formation and deposition in vitro and in vivo
Sadowski, M.; Ji, Y.; Scholtzova, H.; Pankiewicz, J.; Sigurdsson, E. M.; Wisniewski, T.
2003 ;2003(5 Supplement 1):Abstract No. 666.6-118, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97615, year: 2003, vol: 2003, page: Abstract No. 666.6, stat: Journal Article,

Blocking apolipoprotein E/beta-amyloid interaction as a therapeutic approach for Alzheimer's disease
Sadowski, Marcin; Ji, Yong; Scholtzova, Henrieta; Sigurdsson, Einar M.; Wisniewski, Thomas
2003 ;60(5 Supplement 1):A68-118, Neurology
— id: 97613, year: 2003, vol: 60, page: A68, stat: Journal Article,

MRI approaches for the detection of prion disease pathology
Sadowski, Marcin; Tang, Cheuk Ying; Aguinaldo, Gilbert; Carp, Richard; Wadghiri, Youssef Zaim; Turnbull, Daniel H.; Wisniewski, Thomas
2003 ;60(5 Supplement 1):A250-118, Neurology
— id: 97614, year: 2003, vol: 60, page: A250, stat: Journal Article,

In vivo micro magnetic resonance imaging signal changes in scrapie infected mice
Sadowski, Marcin; Tang, Cheuk Ying; Aguinaldo, Juan Gilberto; Carp, Richard; Meeker, Harry C; Wisniewski, Thomas
2003 Jul 10;345(1):1-4, Neuroscience letters
— id: 38796, year: 2003, vol: 345, page: 1, stat: Journal Article,

Immunological therapeutic and imaging approaches for prion disease
Sadowski, Marcin; Wisniewski, Thomas
2003 ;3(2):113-118, Current medicinal chemistry: Immunology, endocrine & metabolic agents
— id: 97612, year: 2003, vol: 3, page: 113, stat: Journal Article,

Mice expressing presenilin - 1 mutations demonstrate age - related neuronal loss
Scholtzova, H.; Pankiewicz, J.; Sadowski, M.; Li, Y. S.; Quartermain, D.; Wen, P. H.; Elder, G.; Duff, K.; Wisniewski, T.
2003 ;2003(5 Supplement 1):Abstract No. 729.8-118, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97616, year: 2003, vol: 2003, page: Abstract No. 729.8, stat: Journal Article,

Copper modulates prion infectivity
Sigurdsson, E. M.; Brown, D.; Alim, M. A.; Scholtzova, H.; Carp, R.; Meeker, H. C.; Prelli, F.; Frangione, B.; Wisniewski, T.
2003 ;2003(47):Abstract No. 631.2-46202, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97631, year: 2003, vol: 2003, page: Abstract No. 631.2, stat: Journal Article,

Copper chelation delays the onset of prion disease
Sigurdsson, Einar M; Brown, David R; Alim, Muhammad A; Scholtzova, Henrieta; Carp, Richard; Meeker, Harry C; Prelli, Frances; Frangione, Blas; Wisniewski, Thomas
2003 Nov 21;278(47):46199-46202, Journal of biological chemistry
— id: 48185, year: 2003, vol: 278, page: 46199, stat: Journal Article,

Anti-prion antibodies for prophylaxis following prion exposure in mice
Sigurdsson, Einar M; Sy, Man-Sun; Li, Ruliang; Scholtzova, Henrieta; Kascsak, Richard J; Kascsak, Regina; Carp, Richard; Meeker, Harry C; Frangione, Blas; Wisniewski, Thomas
2003 Jan 23;336(3):185-187, Neuroscience letters
— id: 34146, year: 2003, vol: 336, page: 185, stat: Journal Article,

Ex - vivo magnetic resonance imaging of beta - amyloid plaques in transgenic AD mice
Tang, C.; Hajianpour, A.; Aguinaldo, G.; Ho, L.; Pasinetti, G.; Hof, P. R.; Perl, D. P.; Sadowski, M.; Wisniewski, T.
2003 ;2003(5 Supplement 1):Abstract No. 862.3-118, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97617, year: 2003, vol: 2003, page: Abstract No. 862.3, stat: Journal Article,

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging
Wadghiri, Youssef Zaim; Sigurdsson, Einar M; Sadowski, Marcin; Elliott, James I; Li, Yongsheng; Scholtzova, Henrieta; Tang, Cheuk Ying; Aguinaldo, Gilbert; Pappolla, Miguel; Duff, Karen; Wisniewski, Thomas; Turnbull, Daniel H
2003 Aug;50(2):293-302, Magnetic resonance in medicine
— id: 38795, year: 2003, vol: 50, page: 293, stat: Journal Article,

Redistribution of minibrain kinase in aging and neurodegeneration
Wegiel, J; Kuchna, I; Nowicki, K; Dowiat, K; Reisberg, B; deLeon, M; Wisniewski, T; Chen-Hwang, M; Hwang, Y
2003 MAY ;62(5):546-546, Journal of neuropathology & experimental neurology
— id: 38568, year: 2003, vol: 62, page: 546, stat: Journal Article,

The neuropathology of Alzheimer dementia
Weigel J; Wisniewski T; Reisberg B; Silverman W
Dementia : presentations, differential diagnosis, and nosology Baltimore MD : Johns Hopkins Press, 2003,
— id: 4978, year: 2003, vol: , page: 89, stat: Chapter,

in vivo magnetic resonance imaging of amyloid plaques in AD model mice
Wisniewski, T.; Sigurdsson, E. M.; Wadghiri, Y. Z.; Sadowski, M.; Scholtzova, H.; Tang, C. Y.; Aguilnaldo, G.; Duff, K.; Turnbull, D. H.
2003 ;2003(2):Abstract No. 203.7-302, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97618, year: 2003, vol: 2003, page: Abstract No. 203.7, stat: Journal Article,

Immunization approaches for the treatment of prion disease
Wisniewski, Thomas; Sy, Man-Sun; Sadowski, Marcin; Kascsak, Richard J.; Kascsak, Regina; Carp, Richard; Goni, Fernando; Sigurdsson, Einar
2003 ;60(5 Supplement 1):A250-302, Neurology
— id: 97619, year: 2003, vol: 60, page: A250, stat: Journal Article,

Mapping the antigenicity of copper-treated cellular prion protein with the scrapie isoform
Wong, B-S; Li, R; Sassoon, J; Kang, S-C; Liu, T; Pan, T; Greenspan, N S; Wisniewski, T; Brown, D R; Sy, M-S
2003 Jun;60(6):1224-1234, Cellular & molecular life sciences: CMLS
— id: 878042, year: 2003, vol: 60, page: 1224, stat: Journal Article,

Prion protein ubiquitination and proteasomal dysfunction in scrapie infection
Wong, BS; Whiteman, M; Sassoon, J; Kang, SC; Li, R; Pan, T; Smith, MA; Perry, G; Brown, DR; Wisniewski, T; Sy, MS
2003 DEC ;87(2):92-92, Journal of neurochemistry
— id: 98218, year: 2003, vol: 87, page: 92, stat: Journal Article,

Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment
de Leon, M J; Segal, S; Tarshish, C Y; DeSanti, S; Zinkowski, R; Mehta, P D; Convit, A; Caraos, C; Rusinek, H; Tsui, W; Saint Louis, L A; DeBernardis, J; Kerkman, D; Qadri, F; Gary, A; Lesbre, P; Wisniewski, T; Poirier, J; Davies, P
2002 Nov 29;333(3):183-186, Neuroscience letters
— id: 39372, year: 2002, vol: 333, page: 183, stat: Journal Article,

A safer vaccine for Alzheimer's disease?
Frangione, B; Wisniewski, T; Sigurdsson, EM
2002 Jul-Aug;23(1):1579-, Neurobiology of aging
— id: 32430, year: 2002, vol: 23, page: 1579, stat: Journal Article,

Rapid labeling of neuronal structures in post-mortem human brain by ballistic delivery of lipophilic dyes
Grutzendler, J; Gong, YD; Gan, WB; Wisniewski, T
2002 Jul-Aug;23(1):1762-, Neurobiology of aging
— id: 32435, year: 2002, vol: 23, page: 1762, stat: Journal Article,

Apolipoprotein E expression modulates neuronal spine density in an isotype specific manner in transgenic mice
Ji, Y; Gong, YD; Gan, WB; Wisniewski, T
2002 Jul-Aug;23(1):1472-, Neurobiology of aging
— id: 32426, year: 2002, vol: 23, page: 1472, stat: Journal Article,

Slower rates of Alzheimer's disease-related neuronal loss in the entorhinal cortex in Down's syndrome compared to sporadic Alzheimer's disease
Kuchna, I; Wegiel, J; Silverman, W; Pirttila, T; Visser, F; Wisniewski, T; Reisberg, B
2002 Jul-Aug;23(1):1763-, Neurobiology of aging
— id: 32436, year: 2002, vol: 23, page: 1763, stat: Journal Article,

Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions
Mackic, Jasmina B; Bading, James; Ghiso, Jorge; Walker, Larry; Wisniewski, Thomas; Frangione, Blas; Zlokovic, Berislav V
2002 Jun;38(6):303-313, Vascular pharmacology
— id: 42006, year: 2002, vol: 38, page: 303, stat: Journal Article,

Presenilin-1-dependent gamma-secretase cleavage of E-cadherin controls adherens junction disassembly
Marambaud, P; Shioi, J; Serban, G; Georgakopoulos, A; Sarner, S; Nagy, V; Baki, L; Wen, P; Efthimiopoulos, S; Wisniewski, T; Robakis, N
2002 Jul-Aug;23(1):802-, Neurobiology of aging
— id: 32418, year: 2002, vol: 23, page: 802, stat: Journal Article,

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
Marambaud, Philippe; Shioi, Junichi; Serban, Geo; Georgakopoulos, Anastasios; Sarner, Shula; Nagy, Vanja; Baki, Lia; Wen, Paul; Efthimiopoulos, Spiros; Shao, Zhiping; Wisniewski, Thomas; Robakis, Nikolaos K
2002 Apr 15;21(8):1948-1956, EMBO journal
— id: 39675, year: 2002, vol: 21, page: 1948, stat: Journal Article,

Intraneuronal Abeta42 accumulation in Down syndrome brain
Mori, Chica; Spooner, Edward T; Wisniewsk, Krystyna E; Wisniewski, Thomas M; Yamaguch, Haruyasu; Saido, Takaom C; Tolan, Dean R; Selkoe, Dennis J; Lemere, Cynthia A
2002 Jun;9(2):88-102, Amyloid
— id: 32919, year: 2002, vol: 9, page: 88, stat: Journal Article,

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging
Poduslo, JF; Wengenack, T; Curran, GV; Macura, S; Borowski, B; Jack, C; Wisniewski, T; Sigurdsson, E
2002 ;23(1):1550-329, Neurobiology of aging
— id: 97596, year: 2002, vol: 23, page: 1550, stat: Journal Article,

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging
Poduslo, JF; Wengenack, TM; Curran, GL; Wisniewski, T; Sigurdsson, EM; Macura, SI; Borowski, BJ; Jack, CR
2002 Jun;81(7):61-61, Journal of neurochemistry
— id: 32368, year: 2002, vol: 81, page: 61, stat: Journal Article,

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging
Poduslo, Joseph F; Wengenack, Thomas M; Curran, Geoffry L; Wisniewski, Thomas; Sigurdsson, Einar M; Macura, Slobodon I; Borowski, Bret J; Jack, Clifford R Jr
2002 Nov;11(2):315-329, Neurobiology of disease
— id: 62132, year: 2002, vol: 11, page: 315, stat: Journal Article,

SAFETY OF POTENTIAL VACCINES FOR ALZHEIMER'S DISEASE
Scholtzova, H.; Wisniewski, T.; Ahlawat, S.; Watanabe, M.; Quartermain, D.; Frangione, B.; Sigurdsson, E. M.
2002 ;2002(6):Abstract No. 227.1-46202, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97632, year: 2002, vol: 2002, page: Abstract No. 227.1, stat: Journal Article,

Unique cleavage site of E-cadherin by presenilin-associated gamma-secretase
Shioi, J; Marambaud, P; Shao, ZP; Robakis, NK; Wisniewski, TM
2002 Jul-Aug;23(1):779-, Neurobiology of aging
— id: 32417, year: 2002, vol: 23, page: 779, stat: Journal Article,

VACCINATION DELAYS THE ONSET OF PRION DISEASE IN MICE
Sigurdsson, E. M.; Brown, D. R.; Daniels, M.; Kascsak, R. J.; Kascsak, R.; Carp, R.; Meeker, H. C.; Watanabe, M.; Scholtzova, H.; Frangione, B.; Wisniewski, T.
2002 ;2002(6):Abstract No. 692.15-413, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97633, year: 2002, vol: 2002, page: Abstract No. 692.15, stat: Journal Article,

Immunization delays the onset of prion disease in mice
Sigurdsson, Einar M; Brown, David R; Daniels, Maki; Kascsak, Richard J; Kascsak, Regina; Carp, Richard; Meeker, Harry C; Frangione, Blas; Wisniewski, Thomas
2002 Jul;161(1):13-17, American journal of pathology
— id: 32479, year: 2002, vol: 161, page: 13, stat: Journal Article,

A safer vaccine for Alzheimer's disease?
Sigurdsson, Einar M; Wisniewski, Thomas; Frangione, Blas
2002 Nov-Dec;23(6):1001-1008, Neurobiology of aging
— id: 32918, year: 2002, vol: 23, page: 1001, stat: Journal Article,

Infectivity of amyloid diseases
Sigurdsson, Einar M; Wisniewski, Thomas; Frangione, Blas
2002 Sep;8(9):411-413, Trends in molecular medicine
— id: 32920, year: 2002, vol: 8, page: 411, stat: Journal Article,

Immunization for Alzheimer's disease
Sigurdsson, EM; Frangione, B; Wisniewski, T
2002 Jun;56(2):135-142, Drug development research
— id: 32447, year: 2002, vol: 56, page: 135, stat: Journal Article,

In vivo detection of Alzheimer's amyloid by magnetic resonance imaging
Sigurdsson, EM; Wadghiri, YZ; Li, Q; Scholtzova, H; Tang, CY; Aguilnaldo, JG; Duff, K; Pappolla, M; Elliott, JI; Watanabe, M; Turnbull, DH; Wisniewski, T
2002 Jul-Aug;23(1):1307-, Neurobiology of aging
— id: 32425, year: 2002, vol: 23, page: 1307, stat: Journal Article,

Therapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease
Wang, Z H; Ji, Y; Shan, W; Zeng, B; Raksadawan, N; Pastores, G M; Wisniewski, T; Kolodny, E H
2002 ;113(3):629-640, Neuroscience
— id: 39612, year: 2002, vol: 113, page: 629, stat: Journal Article,

Intraneuronal accumulation of N-terminally truncated amyloid beta
Wegiel, J; Kuchna, I; Miller, D; Mehta, P; Wegiel, J; Wisniewski, T; Reisberg, B; Silverman, W
2002 May;61(5):164-, Journal of neuropathology & experimental neurology
— id: 28188, year: 2002, vol: 61, page: 164, stat: Journal Article,

Vascular fibrosis and calcification in the hippocampus in aging, Alzheimer disease, and Down syndrome
Wegiel, J; Kuchna, I; Wisniewski, T; de Leon, M J; Reisberg, B; Pirttila, T; Kivimaki, T; Lehtimaki, T
2002 Apr;103(4):333-343, Acta neuropathologica
— id: 34298, year: 2002, vol: 103, page: 333, stat: Journal Article,

Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice
Wen, Paul H; Shao, Xiang; Shao, Zhiping; Hof, Patrick R; Wisniewski, Thomas; Kelley, Kevin; Friedrich, Victor L Jr; Ho, Lap; Pasinetti, Giulio M; Shioi, Junichi; Robakis, Nikolaos K; Elder, Gregory A
2002 Jun;10(1):8-19, Neurobiology of disease
— id: 47187, year: 2002, vol: 10, page: 8, stat: Journal Article,

Prion related diseases
Wisniewski T; Sigurdsson E
2002;:- [Web site], 2002-, Emedicine
— id: 150918, year: 2002, vol: , page: , stat: Web Site,

PASSIVE IMMUNIZATION WITH ANTI - PrP ANTIBODIES PROLONGS PRION INCUBATION PERIOD
Wisniewski, T.; Sy, M. S.; Li, R.; Scholtzova, H.; Kascsak, R. J.; Kascsak, R.; Carp, R.; Meeker, H. C.; Frangione, B.; Sigurdsson, E. M.
2002 ;2002(6):Abstract No. 692.16-413, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97634, year: 2002, vol: 2002, page: Abstract No. 692.16, stat: Journal Article,

Therapeutics in Alzheimer's and prion diseases
Wisniewski, T; Brown, D R; Sigurdsson, E M
2002 Aug;30(4):574-578, Transactions (Biochemical Society (Great Britain))
— id: 32922, year: 2002, vol: 30, page: 574, stat: Journal Article,

Vaccination delays the onset of prion disease in mice
Wisniewski, T; Scholtzova, H; Watanabe, M; Ji, Y; Frangione, B; Sigurdsson, EM; Brown, DR; Daniels, M; Kasesak, RJ; Kascsak, R
2002 Jul-Aug;23(1):496-, Neurobiology of aging
— id: 32412, year: 2002, vol: 23, page: 496, stat: Journal Article,

Immunization treatment approaches in Alzheimer's and prion diseases
Wisniewski, Thomas; Sigurdsson, Einar M
2002 Sep;2(5):400-404, Current neurology & neuroscience reports
— id: 32923, year: 2002, vol: 2, page: 400, stat: Journal Article,

Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie
Aucouturier P; Geissmann F; Damotte D; Saborio GP; Meeker HC; Kascsak R; Kascsak R; Carp RI; Wisniewski T
2001 Sep;108(5):703-708, Journal of clinical investigation
— id: 23495, year: 2001, vol: 108, page: 703, stat: Journal Article,

Infected splenic dendritic cells are sufficient for scrapie neuroinvasion in RAG-1(0/0) mice
Aucouturier, P; Geissmann, F; Carnaud, C; Kascsak, R; Wisniewski, T; Carp, RI
2001 MAR 8 ;15(5):A1011-A1011, FASEB journal
— id: 55091, year: 2001, vol: 15, page: A1011, stat: Journal Article,

Neuronal degeneration and loss in nigro-striatal system in Alzheimer disease, Down syndrome, and Parkinson disease
Badmaev, E; Wegiel, J; Nowicki, K; Kuchna, I; Tarnawski, M; Wrzolek, M; Pirttila, T; Kivimaki, T; Lehtimaki, T; Reisberg, B; de Leon, M; Wisniewski, T; Silverman, W
2001 MAY ;60(5):545-545, Journal of neuropathology & experimental neurology
— id: 55072, year: 2001, vol: 60, page: 545, stat: Journal Article,

Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments
Dowjat WK; Wisniewski H; Wisniewski T
2001 ;103(1):1-8, Neuroscience
— id: 23494, year: 2001, vol: 103, page: 1, stat: Journal Article,

In vivo detection of neuropathology in an animal model of Alzheimer's disease by magnetic resonance imaging
Helpern, J. A.; Wisniewski, T.; Duff, K.; Dyakin, V.; de Leon, M.; Ardekani, B.; Wolf, O.; Branch, C.; O'Shea, J.; Wegiel, J.; Nixon, R. A.
2001 ;27(1):1217-343, Abstracts (Society for Neuroscience)
— id: 97624, year: 2001, vol: 27, page: 1217, stat: Journal Article,

Introduction
Iqbal, Khalid; Wisniewski, Thomas
2001 ;3(1):3-3 Apr, Journal of Alzheimer's disease
— id: 68944, year: 2001, vol: 3, page: 3, stat: Journal Article,

Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice
Ji Y; Permanne B; Sigurdsson EM; Holtzman DM; Wisniewski T
2001 Feb;3(1):23-30, Journal of Alzheimer's disease
— id: 32921, year: 2001, vol: 3, page: 23, stat: Journal Article,

[Familial Alzheimer's disease connected with mutation in presenilin gene 1 (P117L)]
Kulczycki, J; Bertrand, E; Lojkowska, W; Dowjat, W; Wisniewski, T; Lyczywek-Zwierz, M
2001 Mar-Apr;35(2):213-224, Neurologia i neurochirurgia polska
— id: 97589, year: 2001, vol: 35, page: 213, stat: Journal Article,

Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide
Poeggeler B; Miravalle L; Zagorski MG; Wisniewski T; Chyan YJ; Zhang Y; Shao H; Bryant-Thomas T; Vidal R; Frangione B; Ghiso J; Pappolla MA
2001 Dec 11;40(49):14995-15001, Biochemistry
— id: 42012, year: 2001, vol: 40, page: 14995, stat: Journal Article,

Effect of the presenilin 1 P117L FAD linked mutation on hippocampal morphology transgenic mice
Sadowski, M; Wen, PH; Elder, GA; Robakis, NK; Wisniewski, T
2001 MAY ;60(5):543-543, Journal of neuropathology & experimental neurology
— id: 55071, year: 2001, vol: 60, page: 543, stat: Journal Article,

Apolipoprotein E mediated uptake of amyloid by astrocytes in vitro
Shao, CY; Ji, Y; Wisniewski, T
2001 MAY ;60(5):505-505, Journal of neuropathology & experimental neurology
— id: 55066, year: 2001, vol: 60, page: 505, stat: Journal Article,

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
Sigurdsson EM; Scholtzova H; Mehta PD; Frangione B; Wisniewski T
2001 Aug;159(2):439-447, American journal of pathology
— id: 23485, year: 2001, vol: 159, page: 439, stat: Journal Article,

Immunization with a soluble and non-toxic amyloid-beta derivative substantially impedes Alzheimer's disease associated pathology in transgenic mice
Sigurdsson, E. M.; Schwaninger, J.; Scholtzova, H.; Mehta, P. D.; Ji, Y.; Ahlawat, S.; Sparks, C. M.; Quartermain, D.; Frangione, B.; Wisniewski, T.
2001 ;27(2):1807-447, Abstracts (Society for Neuroscience)
— id: 97635, year: 2001, vol: 27, page: 1807, stat: Journal Article,

Fibrillar amyloid-beta affects neurofibrillary changes but only in neurons already involved in neurofibrillary degeneration
Wegiel J; Bobinski M; Tarnawski M; Dziewiatkowski J; Popovitch E; Miller DC; Wisniewski T; Golomb J; de Leon MJ; Reisberg B
2001 Jun;101(6):585-590, Acta neuropathologica
— id: 34299, year: 2001, vol: 101, page: 585, stat: Journal Article,

Henry M. Wisniewski M.D. Ph.D
Wisniewski T
2001 Feb;3(1):7-22, Journal of Alzheimer's disease
— id: 39452, year: 2001, vol: 3, page: 7, stat: Journal Article,

Conformation as a therapeutic target in the prionoses and other neurodegenerative conditions
Wisniewski T; Sigurdsson EM; Aucouturier P; Frangione B
Molecular pathology of the prions Totowa NJ: Humana Press, 2001,
— id: 2638, year: 2001, vol: , page: ?, stat: Chapter,

Conformation as therapeutic target in the prionoses and other neurodegenerative conditions
Wisniewski, T; Sigurdsson, E M; Aucouturier, P; Frangione, B
2001 ;59:223-236, Methods in molecular medicine
— id: 156282, year: 2001, vol: 59, page: 223, stat: Journal Article,

Prion diseases and the immune system
Aucouturier P; Carp RI; Carnaud C; Wisniewski T
2000 Aug;96(2):79-85, Clinical immunology
— id: 11590, year: 2000, vol: 96, page: 79, stat: Journal Article,

Short analytical review: Prion diseases and the immune system
Aucouturier, P; Carp, RI; Carnaud, C; Wisniewski, T
2000 ;96(2):79-85, Clinical immunology & immunopathology
— id: 637172, year: 2000, vol: 96, page: 79, stat: Journal Article,

Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E
Golabek AA; Kida E; Walus M; Perez C; Wisniewski T; Soto C
2000 Aug;79(2):1008-1015, Biophysical journal
— id: 34320, year: 2000, vol: 79, page: 1008, stat: Journal Article,

On the biological activity of vitamin E
Kayden, H J; Wisniewski, T
2000 Jul;72(1):201-203, American journal of clinical nutrition
— id: 101158, year: 2000, vol: 72, page: 201, stat: Journal Article,

In vivo A beta related neurotoxicity is dependent on the expression of apolipoprotein E
Shao, CY; Ji, Y; Mackey, B; Holtzman, DM; Wisniewski, T
2000 MAY ;59(5):425-425, Journal of neuropathology & experimental neurology
— id: 54611, year: 2000, vol: 59, page: 425, stat: Journal Article,

In vivo reversal of amyloid-beta lesions in rat brain
Sigurdsson EM; Permanne B; Soto C; Wisniewski T; Frangione B
2000 Jan;59(1):11-17, Journal of neuropathology & experimental neurology
— id: 8565, year: 2000, vol: 59, page: 11, stat: Journal Article,

Reversion of prion protein conformational changes by synthetic beta-sheet breaker peptides
Soto C; Kascsak RJ; Saborio GP; Aucouturier P; Wisniewski T; Prelli F; Kascsak R; Mendez E; Harris DA; Ironside J; Tagliavini F; Carp RI; Frangione B
2000 Jan 15;355(9199):192-197, Lancet
— id: 8575, year: 2000, vol: 355, page: 192, stat: Journal Article,

Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease
Stoltzner SE; Grenfell TJ; Mori C; Wisniewski KE; Wisniewski TM; Selkoe DJ; Lemere CA
2000 Feb;156(2):489-499, American journal of pathology
— id: 32243, year: 2000, vol: 156, page: 489, stat: Journal Article,

Shift from fibrillar to nonfibrillar A beta deposits in the neocortex of subjects with Alzheimer disease
Wegiel, J; Bobinski, M; Tarnawski, M; Popovitch, E; Lach, B; Reisberg, B; Miller, DC; Wisniewski, T; de Leon, MJ
2000 MAY ;59(5):421-421, Journal of neuropathology & experimental neurology
— id: 54608, year: 2000, vol: 59, page: 421, stat: Journal Article,

"Prion biology and diseases" by Stanley B. Prusiner
Wisniewski T; Frangione B
2000 ;342:983-983, New England journal of medicine
— id: 97679, year: 2000, vol: 342, page: 983, stat: Journal Article,

Abtracts from XI Conference of Polish Association of Neuropathologists, Warszawa, May 13-15, 1999
Adamczewska-Goncerzewicz, Z; Biczysko, W; Dorszczewska, J; Marszalek, M; Florek, E; Michalak, S; Bertand, E; Kulczycki, J; Wisniewski, T; Wegiel, J; Lewandowska, E; Lojkowska, W; Dymecki, J
1999 ;37(4):293-307, Folia neuropathologica
— id: 97625, year: 1999, vol: 37, page: 293, stat: Journal Article,

Prion diseases and the immune system
Aucouturier P; Frangione B; Wisniewski T
1999 Feb;150(2):75-78, Annales de medecine interne
— id: 8496, year: 1999, vol: 150, page: 75, stat: Journal Article,

Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt-Jakob disease
Aucouturier P; Kascsak RJ; Frangione B; Wisniewski T
1999 Oct 15;274(1):33-36, Neuroscience letters
— id: 9501, year: 1999, vol: 274, page: 33, stat: Journal Article,

Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt-Jakob disease
Aucouturier, Pierre; Kascsak, Richard J.; Quartermain, David; Frangione, Blas; Wisniewski, Thomas
1999 ;25(1-2):1854-78, Abstracts (Society for Neuroscience)
— id: 97636, year: 1999, vol: 25, page: 1854, stat: Journal Article,

Familial Alzheimer's disease with an usually early onset and severity of disease
Bertrand, E.; Kulczycki, J.; Wisniewski, Th.; Wegiel, J.; Lewandowska, E.; Lojkowska, W.; Dymecki, J.
1999 ;435(3):374-307, Virchows archive
— id: 97626, year: 1999, vol: 435, page: 374, stat: Journal Article,

Localization of alpha-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders
Copp RP; Wisniewski T; Hentati F; Larnaout A; Ben Hamida M; Kayden HJ
1999 Mar 20;822(1-2):80-87, Brain research
— id: 6064, year: 1999, vol: 822, page: 80, stat: Journal Article,

Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations
Dowjat WK; Wisniewski T; Efthimiopoulos S; Wisniewski HM
1999 May 28;267(2):141-144, Neuroscience letters
— id: 34318, year: 1999, vol: 267, page: 141, stat: Journal Article,

Expression of PS1 mutations linked to familial Alzheimer's disease inhibits neuritic outgrowth
Dowjat, WK; Wisniewski, T; Efthimiopoulos, S; Wisniewski, HM
1999 MAY ;58(5):558-558, Journal of neuropathology & experimental neurology
— id: 54055, year: 1999, vol: 58, page: 558, stat: Journal Article,

Abeta40 and Abeta42 clearance in a transgenic mouse model expressing human apoE3 and apoE4
Permanne, B.; Ji, Yong; Holtzman, D. M.; Frangione, B.; Wisniewski, T.
1999 ;25(1-2):1058-78, Abstracts (Society for Neuroscience)
— id: 97637, year: 1999, vol: 25, page: 1058, stat: Journal Article,

Melatonin abolishes the pro-aggregatory effects of apoE4 on the Alzheimer beta-protein
Poeggeler, B.; Chyan, Y.-J.; Bryant, T.; Wisniewski, T.; Frangione, B.; Ghiso, J.; Pappolla, M.
1999 ;25(1-2):1805-78, Abstracts (Society for Neuroscience)
— id: 97638, year: 1999, vol: 25, page: 1805, stat: Journal Article,

ApoE-epsilon 4 allele: Relationship to plasma amyloid beta and ApoE levels in normal elderly
Pomara, N; Shao, B; Wisniewski, T; Mehta, PD
1999 APR 15 ;45(8):274-49, Biological psychiatry
— id: 98321, year: 1999, vol: 45, page: 274, stat: Journal Article,

In vivo disassembly of cerebral amyloid-beta (Abeta) deposits in rat brain
Sigurdsson, E. M.; Permanne, B.; Soto, C.; Wisniewski, T.; Frangione, B.
1999 ;25(1-2):1805-78, Abstracts (Society for Neuroscience)
— id: 97639, year: 1999, vol: 25, page: 1805, stat: Journal Article,

Amyloid: chemical and molecular considerations
Wisniewski T; Frangione B
An atlas of Alzheimer's disease New York : Parthenon Publishing, 1999,
— id: 4977, year: 1999, vol: , page: 109, stat: Chapter,

Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy
Askanas V; Engel WK; Yang CC; Alvarez RB; Lee VM; Wisniewski T
1998 Apr;152(4):889-895, American journal of pathology
— id: 7491, year: 1998, vol: 152, page: 889, stat: Journal Article,

Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles
Efthimiopoulos, S; Floor, E; Georgakopoulos, A; Shioi, J; Cui, W; Yasothornsrikul, S; Hook, V Y; Wisniewski, T; Buee, L; Robakis, N K
1998 Dec;71(6):2365-2372, Journal of neurochemistry
— id: 878022, year: 1998, vol: 71, page: 2365, stat: Journal Article,

HB-GAM, a novel amyloid associated protein, is present in prion related disorders and other cerebral amyloidoses
Lalowski M; Baumann M; Rauvala H; Frangione B; Wisniewski T
Progress in Alzheimer's and Parkinson's diseases New York : Plenum, 1998,
— id: 4982, year: 1998, vol: , page: 121, stat: Chapter,

Decreases in plasma A beta 1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 allele
Pomara N; Shao B; Wisniewski T; Mehta PD
1998 Dec;23(12):1563-1566, Neurochemical research
— id: 7747, year: 1998, vol: 23, page: 1563, stat: Journal Article,

Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L)
Wegiel J; Wisniewski HM; Kuchna I; Tarnawski M; Badmajew E; Popovitch E; Kulczycki J; Dowjat WK; Wisniewski T
1998 Sep;57(9):831-838, Journal of neuropathology & experimental neurology
— id: 7843, year: 1998, vol: 57, page: 831, stat: Journal Article,

Brain structure specific enhancement of amyloidosis beta in a novel presenilin-1 mutation (P117L)
Wegiel, J; Wisniewski, HM; Kuchna, I; Tarnawski, M; Badmajew, E; Kulczycki, J; Dowjat, KW; Wisniewski, T
1998 ;57(5):172-80, Journal of neuropathology & experimental neurology
— id: 97620, year: 1998, vol: 57, page: 172, stat: Journal Article,

Pathogenesis of amyloid-beta plaques : activated microglia the cause of fibrillar amyloid formation and neuropil degeneration
Wisniewski HM; Wegiel J; Wisniewski T
1998 ;1:30-34, Neuroscience news
— id: 97676, year: 1998, vol: 1, page: 30, stat: Journal Article,

Compound heterozygous genotype is associated with protracted juvenile neuronal ceroid lipofuscinosis
Wisniewski KE; Zhong N; Kaczmarski W; Kaczmarski A; Kida E; Brown WT; Schwarz KO; Lazzarini AM; Rubin AJ; Stenroos ES; Johnson WG; Wisniewski TM
1998 Jan;43(1):106-110, Annals of neurology
— id: 7858, year: 1998, vol: 43, page: 106, stat: Journal Article,

The prionoses and other conformational disorders
Wisniewski T; Aucouturier P; Soto C; Frangione B
1998 Sep;5(3):212-224, Amyloid
— id: 7855, year: 1998, vol: 5, page: 212, stat: Journal Article,

A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years
Wisniewski T; Dowjat WK; Buxbaum JD; Khorkova O; Efthimiopoulos S; Kulczycki J; Lojkowska W; Wegiel J; Wisniewski HM; Frangione B
1998 Jan 26;9(2):217-221, Neuroreport
— id: 7856, year: 1998, vol: 9, page: 217, stat: Journal Article,

Alpha B-crystallin is associated with intermediate filaments in astrocytoma cells
Wisniewski T; Goldman JE
1998 Mar;23(3):385-392, Neurochemical research
— id: 7857, year: 1998, vol: 23, page: 385, stat: Journal Article,

A novel Polish presenilin-1 mutation (P117L) associated with a very early onset of familial Alzheimer's disease
Wisniewski, T; Dowjat, WK; Buxbaum, JD; Kulczycki, J; Lojkowska, W; Wegiel, J; Wisniewski, HM; Frangione, B
1998 ;50(4):P04107-221, Neurology
— id: 97627, year: 1998, vol: 50, page: P04107, stat: Journal Article,

Biology of A beta amyloid in Alzheimer's disease (vol 4, pg 313, 1997)
Wisniewski, T; Ghiso, J; Frangione, B
1998 ;5(1):65-65, Neurobiology of disease
— id: 97597, year: 1998, vol: 5, page: 65, stat: Journal Article,

Alzheimer's soluble amyloid beta is a normal component of human urine
Ghiso J; Calero M; Matsubara E; Governale S; Chuba J; Beavis R; Wisniewski T; Frangione B
1997 May 12;408(1):105-108, FEBS letters
— id: 7153, year: 1997, vol: 408, page: 105, stat: Journal Article,

C for T substitution at codon 108: The first identified silent mutation in the transthyretin gene
Palha, JA; Moreira, P; Wisniewski, T; Frangione, B; Saraiva, MJ
1997 ;4(1):52-53, Amyloid
— id: 97594, year: 1997, vol: 4, page: 52, stat: Journal Article,

Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants
Permanne B; Perez C; Soto C; Frangione B; Wisniewski T
1997 Nov 26;240(3):715-720, Biochemical & biophysical research communications
— id: 9505, year: 1997, vol: 240, page: 715, stat: Journal Article,

Soluble amyloid beta/apolipoprotein E complexes in the Alzheimer brain
Permanne, B.; Perez, C.; Soto, C.; Frangione, B.; Wisniewski, T.
1997 ;23(1-2):538-53, Abstracts (Society for Neuroscience)
— id: 97640, year: 1997, vol: 23, page: 538, stat: Journal Article,

Presenilin-1 is associated with Alzheimer's disease amyloid
Wisniewski T; Dowjat WK; Permanne B; Palha J; Kumar A; Gallo G; Frangione B
1997 Aug;151(2):601-610, American journal of pathology
— id: 7282, year: 1997, vol: 151, page: 601, stat: Journal Article,

Biology of A beta amyloid in Alzheimer's disease
Wisniewski T; Ghiso J; Frangione B
1997 ;4(5):313-328, Neurobiology of disease
— id: 7854, year: 1997, vol: 4, page: 313, stat: Journal Article,

A novel presenilin-1 mutation at codon 117 (P117L) in a Polish familial Alzheimer's disease kindred
Wisniewski, T.; Dowjat, K.; Kulczycki, J.; Wisniewski, H. M.; Wegiel, J.; Frangione, B.
1997 ;23(1-2):825-80, Abstracts (Society for Neuroscience)
— id: 97621, year: 1997, vol: 23, page: 825, stat: Journal Article,

The four genes linked to Alzheimer's Disease are expressed in neuritic plaques
Wisniewski, T.; Lalowski, M.; Dowjat, K.; Frangione, B.
1997 ;45(3):238A-80, Journal of investigative medicine
— id: 97622, year: 1997, vol: 45, page: 238A, stat: Journal Article,

Micropreparative gel electrophoresis of low-molecular-weight peptides: purification of highly insoluble amyloid peptide fragments
Baumann M; Golabek A; Lalowski M; Wisniewski T
1996 May 1;236(2):191-198, Analytical biochemistry
— id: 12618, year: 1996, vol: 236, page: 191, stat: Journal Article,

C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type
Baumann MH; Wisniewski T; Levy E; Plant GT; Ghiso J
1996 Feb 6;219(1):238-242, Biochemical & biophysical research communications
— id: 6886, year: 1996, vol: 219, page: 238, stat: Journal Article,

Medical conditions in Alzheimer's disease patients with 4/4 isotype of apolipoprotein E
Boksay, I.; Tchernkov, K.; Myint, Z.; Reisberg, B.; Wisniewski, T.
1996 ;17(4 SUPPL.):S125-S126, Neurobiology of aging
— id: 97598, year: 1996, vol: 17, page: S125, stat: Journal Article,

Chaperoning amyloid in Alzheimer's disease: the art of avoiding sticky situations?
Frangione B; Castano EM; Prelli F; Soto C; Ghiso J; Wisniewski T
Apolipoprotein E and Alzheimer's disease Berlin : Springer, 1996,
— id: 4976, year: 1996, vol: , page: 151, stat: Chapter,

Apolipoprotein E and amyloidogenesis
Frangione B; Castano EM; Wisniewski T; Ghiso J; Prelli F; Vidal R
1996 ;199:132-41; discussion 141, CIBA Foundation symposium
— id: 9396, year: 1996, vol: 199, page: 132, stat: Journal Article,

Familial meningocerebrovascular amyloidosis, Hungarian type, with mutant transthyretin (TTR Asp18Gly)
Garzuly, F; Vidal, R; Wisniewski, T; Brittig, F; Budka, H
1996 Dec;47(6):1562-1567, Neurology
— id: 878032, year: 1996, vol: 47, page: 1562, stat: Journal Article,

The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation
Golabek AA; Soto C; Vogel T; Wisniewski T
1996 May 3;271(18):10602-10606, Journal of biological chemistry
— id: 6997, year: 1996, vol: 271, page: 10602, stat: Journal Article,

Binding between apolipoprotein E and amyloid beta is dependent on secondary structure
Golabek, A. A.; Soto, C.; Wisniewski, T.
1996 ;17(4 SUPPL.):S174-S126, Neurobiology of aging
— id: 97599, year: 1996, vol: 17, page: S174, stat: Journal Article,

The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation
Golabek, AA; Soto, C; Wisniewski, T
1996 MAY ;55(5):150-150, Journal of neuropathology & experimental neurology
— id: 52926, year: 1996, vol: 55, page: 150, stat: Journal Article,

The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid
Lalowski M; Golabek A; Lemere CA; Selkoe DJ; Wisniewski HM; Beavis RC; Frangione B; Wisniewski T
1996 Dec 27;271(52):33623-33631, Journal of biological chemistry
— id: 9507, year: 1996, vol: 271, page: 33623, stat: Journal Article,

Amyloid beta peptides in cerebellar preamyloid and cortical neuritic plaques of Down's syndrome patients
Lalowski, M.; Golabek, A.; Lemere, C. A.; Selkoe, D. J.; Kolodny, E.; Frangione, B.; Wisniewski, T.
1996 ;22(1-3):1208-145, Abstracts (Society for Neuroscience)
— id: 97641, year: 1996, vol: 22, page: 1208, stat: Journal Article,

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation
Lemere CA; Blusztajn JK; Yamaguchi H; Wisniewski T; Saido TC; Selkoe DJ
1996 Feb;3(1):16-32, Neurobiology of disease
— id: 34319, year: 1996, vol: 3, page: 16, stat: Journal Article,

Alzheimer's soluble amyloid beta is a normal component of urine
Matsubara, E.; Governale, S.; Calero, M.; Wisniewski, T.; Frangione, B.; Ghiso, J.
1996 ;22(1-3):1170-33631, Abstracts (Society for Neuroscience)
— id: 97642, year: 1996, vol: 22, page: 1170, stat: Journal Article,

Transthyretin gene in Alzheimer's disease patients
Palha JA; Moreira P; Wisniewski T; Frangione B; Saraiva MJ
1996 Feb 9;204(3):212-214, Neuroscience letters
— id: 9511, year: 1996, vol: 204, page: 212, stat: Journal Article,

Alzheimer's beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro
Soto C; Golabek A; Wisniewski T; Castano EM
1996 Feb 29;7(3):721-725, Neuroreport
— id: 7091, year: 1996, vol: 7, page: 721, stat: Journal Article,

Meningocerebrovascular amyloidosis associated with a novel transthyretin mis-sense mutation at codon 18 (TTRD 18G) [see comments]
Vidal R; Garzuly F; Budka H; Lalowski M; Linke RP; Brittig F; Frangione B; Wisniewski T
1996 Feb;148(2):361-366, American journal of pathology
— id: 6970, year: 1996, vol: 148, page: 361, stat: Journal Article,

Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant
Vidal R; Ghiso J; Wisniewski T; Frangione B
1996 Sep 9;393(1):19-23, FEBS letters
— id: 7919, year: 1996, vol: 393, page: 19, stat: Journal Article,

Apolipoprotein E, Amyloidosis and Alzheimer's disease
Wisniewski T; Frangione B
1996 ;10:171-183, Dementia (Osaka, Japan)
— id: 97675, year: 1996, vol: 10, page: 171, stat: Journal Article,

Molecular biology of brain aging and neurodegenerative disorders
Wisniewski T; Frangione B
1996 ;56(1):267-279, Acta neurobiologiae experimentalis
— id: 9513, year: 1996, vol: 56, page: 267, stat: Journal Article,

HB-GAM is a cytokine present in Alzheimer's and Down's syndrome lesions
Wisniewski T; Lalowski M; Baumann M; Rauvala H; Raulo E; Nolo R; Frangione B
1996 Jan 31;7(2):667-671, Neuroreport
— id: 6974, year: 1996, vol: 7, page: 667, stat: Journal Article,

Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs
Wisniewski T; Lalowski M; Bobik M; Russell M; Strosznajder J; Frangione B
1996 Jan 15;313 ( Pt 2):575-580, Biochemical journal
— id: 6975, year: 1996, vol: 313 ( Pt 2), page: 575, stat: Journal Article,

Presenilin fragments in cerebro-spinal fluid and brain tissue
Wisniewski, T.; Dowjat, W.; Golabek, A.; Miller, D.; Frangione, B.
1996 ;22(1-3):727-671, Abstracts (Society for Neuroscience)
— id: 97643, year: 1996, vol: 22, page: 727, stat: Journal Article,

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E
Castano EM; Prelli F; Wisniewski T; Golabek A; Kumar RA; Soto C; Frangione B
1995 Mar 1;306 ( Pt 2):599-604, Biochemical journal
— id: 8000, year: 1995, vol: 306 ( Pt 2), page: 599, stat: Journal Article,

Amyloids, genes and chaperones
Frangione B; Wisniewski T; Castano E; Ghiso J
Research advances in Alzheimer's disease and related disorders New York : Wiley, 1995,
— id: 4974, year: 1995, vol: , page: 563, stat: Chapter,

Familial cerebral amyloid angiopathy (British type) with nonneuritic amyloid plaque formation may be due to a novel amyloid protein
Ghiso J; Plant GT; Revesz T; Wisniewski T; Frangione B
1995 Mar;129(1):74-75, Journal of the neurological sciences
— id: 7904, year: 1995, vol: 129, page: 74, stat: Journal Article,

Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid
Golabek A; Marques MA; Lalowski M; Wisniewski T
1995 May 19;191(1-2):79-82, Neuroscience letters
— id: 6629, year: 1995, vol: 191, page: 79, stat: Journal Article,

Amyloid A beta-1-42 does not lead to senile plaques in the canine aging model of Alzheimer's disease
Lalowski, M.; Strosznajder, J.; Russel, M.; Bobik, M.; Frangione, B.; Wisniewski, T.
1995 ;55(SUPPL.):42-75, Acta neurobiologiae experimentalis
— id: 97644, year: 1995, vol: 55, page: 42, stat: Journal Article,

AMYLOID A-BETA-1-42 DOES NOT LEAD TO ALZHEIMERS LESIONS IN AGED DOGS
LALOWSKI, M; GOLABEK, A; BOBIK, M; RUSSELL, M; FRANGIONE, B; WISNIEWSKI, T
1995 ;54(3):432-432, Journal of neuropathology & experimental neurology
— id: 97645, year: 1995, vol: 54, page: 432, stat: Journal Article,

Early onset Alzheimer's disease in a South American pedigree from Argentina
Mangone CA; Castano EM; Levy E; Abiusi G; Wisniewski T; Marques MR; Faccio E; Gorelick PB; Frangione B; Sica RE
1995 Jan;91(1):6-13, Acta neurologica Scandinavica
— id: 9521, year: 1995, vol: 91, page: 6, stat: Journal Article,

COLLOID INCLUSIONS OF PARKINSONS-DISEASE - FURTHER IMMUNOHISTOCHEMICAL CHARACTERIZATION WITH SPECIAL REFERENCE TO LEWY BODIES
OGBURN, J; SAMBAMURTI, K; WISNIEWSKI, T; FRANGIONE, B; DUDLEY, A; PAPPOLLA, M
1995 MAY ;54(3):445-445, Journal of neuropathology & experimental neurology
— id: 87308, year: 1995, vol: 54, page: 445, stat: Journal Article,

Neurology for non-neurologists
Weinreb, Herman J.; Chou, James C.-Y.; Wisniewski, Thomas; Golomb, Jamie; Hiesiger, Emile M.; Sussman, Norman; Rapoport, David; Henry, Katherine; Krishna, Ranga; Kricheff, Irvin I.; Stiller, Keith
[Irvington, NY] : Pass the Boards, c1995,
— id: 512, year: 1995, vol: , page: , stat: ,

Amyloidosis in Alzheimer's disease
Wisniewski T; Frangione B
1995 Aug 12;346(8972):441-441, Lancet
— id: 7908, year: 1995, vol: 346, page: 441, stat: Journal Article,

Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis
Wisniewski T; Golabek AA; Kida E; Wisniewski KE; Frangione B
1995 Aug;147(2):238-244, American journal of pathology
— id: 6878, year: 1995, vol: 147, page: 238, stat: Journal Article,

Is Alzheimer's disease an apolipoprotein E amyloidosis?
Wisniewski T; Lalowski M; Golabek A; Vogel T; Frangione B
1995 Apr 15;345(8955):956-958, Lancet
— id: 6779, year: 1995, vol: 345, page: 956, stat: Journal Article,

The influence of apolipoprotein E isotypes on Alzheimer's disease pathology in 40 cases of Down's syndrome
Wisniewski T; Morelli L; Wegiel J; Levy E; Wisniewski HM; Frangione B
1995 Jan;37(1):136-138, Annals of neurology
— id: 9519, year: 1995, vol: 37, page: 136, stat: Journal Article,

S182 protein in Alzheimer's disease neuritic plaques
Wisniewski T; Palha JA; Ghiso J; Frangione B
1995 Nov 18;346(8986):1366-1366, Lancet
— id: 7909, year: 1995, vol: 346, page: 1366, stat: Journal Article,

The origin of A-beta in plaques and vessels in aging and Alzheimer disease
Wisniewski, H. M.; Wegiel, J.; Frackowiak, J.; Wisniewski, T.
1995 ;55(SUPPL.):42-221, Acta neurobiologiae experimentalis
— id: 97628, year: 1995, vol: 55, page: 42, stat: Journal Article,

APOLIPOPROTEIN-E AMYLOID IN ALZHEIMERS PLAQUE
WISNIEWSKI, T; GOLABEK, A; LALOWSKI, M; VOGEL, T; FRANGIONE, B
1995 ;54(3):411-411, Journal of neuropathology & experimental neurology
— id: 97647, year: 1995, vol: 54, page: 411, stat: Journal Article,

APOLIPOPROTEIN-E IN ALZHEIMERS-DISEASE
WISNIEWSKI, T; GOLABEK, A; LALOWSKI, M; VOGEL, T; FRANGIONE, B
1995 ;38(2):324-324, Annals of neurology
— id: 97646, year: 1995, vol: 38, page: 324, stat: Journal Article,

The blood brain barrier regulates transport of Alzheimer's amyloid ? and apolipoproteins E and J
Zlokovic B; Mackic J; Martel C; Wisniewski T; Frangione B; Ghiso J
Research advances in Alzheimer's disease and related disorders New York : Wiley, 1995,
— id: 4975, year: 1995, vol: , page: 585, stat: Chapter,

Chaperoning Alzheimer's amyloids
Frangione B; Wisniewski T; Ghiso J
1994 ;15 Suppl 2:S97-S99, Neurobiology of aging
— id: 6619, year: 1994, vol: 15 Suppl 2, page: S97, stat: Journal Article,

Potential role of apolipoprotein-E in fibrillogenesis
Gallo G; Wisniewski T; Choi-Miura NH; Ghiso J; Frangione B
1994 Sep;145(3):526-530, American journal of pathology
— id: 9401, year: 1994, vol: 145, page: 526, stat: Journal Article,

Unifying features of systemic and cerebral amyloidosis
Ghiso J; Wisniewski T; Frangione B
1994 Feb;8(1):49-64, Molecular neurobiology
— id: 9403, year: 1994, vol: 8, page: 49, stat: Journal Article,

Binding of soluble beta-amyloid in vitro and in vivo
Golabek, A.; Marques, M.; Koji, I.; Ghiso, J.; Herbert, J.; Frangione, B.; Wisniewski, T.
1994 ;20(1-2):1643-64, Abstracts (Society for Neuroscience)
— id: 97648, year: 1994, vol: 20, page: 1643, stat: Journal Article,

Regional differences in apolipoprotein E immunoreactivity in diffuse plaques in Alzheimer's disease brain
Kida, E; Golabek, A A; Wisniewski, T; Wisniewski, K E
1994 Feb 14;167(1-2):73-76, Neuroscience letters
— id: 97586, year: 1994, vol: 167, page: 73, stat: Journal Article,

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3
Sanan DA; Weisgraber KH; Russell SJ; Mahley RW; Huang D; Saunders A; Schmechel D; Wisniewski T; Frangione B; Roses AD; et al
1994 Aug;94(2):860-869, Journal of clinical investigation
— id: 9523, year: 1994, vol: 94, page: 860, stat: Journal Article,

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro
Wisniewski T; Castano EM; Golabek A; Vogel T; Frangione B
1994 Nov;145(5):1030-1035, American journal of pathology
— id: 6777, year: 1994, vol: 145, page: 1030, stat: Journal Article,

Alzheimer's disease and soluble A beta
Wisniewski T; Ghiso J; Frangione B
1994 Mar-Apr;15(2):143-152, Neurobiology of aging
— id: 6778, year: 1994, vol: 15, page: 143, stat: Journal Article,

The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient
Wisniewski T; Lalowski M; Levy E; Marques MR; Frangione B
1994 Feb;35(2):245-246, Annals of neurology
— id: 9525, year: 1994, vol: 35, page: 245, stat: Journal Article,

Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta
Zlokovic BV; Martel CL; Mackic JB; Matsubara E; Wisniewski T; McComb JG; Frangione B; Ghiso J
1994 Dec 15;205(2):1431-1437, Biochemical & biophysical research communications
— id: 9399, year: 1994, vol: 205, page: 1431, stat: Journal Article,

Transport of Alzheimer's amyloid beta and apolipoproteins E and J at the blood-brain barrier
Zlokovic, B. V.; Mackic, J. B.; Martell, C. J.; Wisniewski, T.; Frangione, B.; Ghiso, J.
1994 ;20(1-2):1642-1437, Abstracts (Society for Neuroscience)
— id: 97649, year: 1994, vol: 20, page: 1642, stat: Journal Article,

THE BLOOD-BRAIN-BARRIER REGULATES TRANSPORT OF ALZHEIMERS AMYLOID-BETA AND APOLIPOPROTEIN-E AND APOLIPOPROTEIN-J
ZLOKOVIC, BV; MACKIC, JB; MARTELL, CL; WISNIEWSKI, T; FRANGIONE, B; GHISO, J
1994 JUL ;15(7):S80-S80, Neurobiology of aging
— id: 52407, year: 1994, vol: 15, page: S80, stat: Journal Article,

Alzheimer's disease and amyloid
Frangione B; Wisniewski T; Ghiso J
Amyloid and amyloidosis 1993 New York : Parthenon, 1993,
— id: 5144, year: 1993, vol: , page: 310, stat: Chapter,

Alzheimer's disease and Dutch variant: Opposing faces of a single coin
Frangione, Blas; Wisniewski, Thomas; Tagliavini, Fabrizio; Bugiani, Orso; Ghiso, Jorge
Alzheimer's disease : advances in clinical and basic research New York : Wiley, 1993,
— id: 4969, year: 1993, vol: , page: 387, stat: Chapter,

The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
Ghiso J; Matsubara E; Koudinov A; Choi-Miura NH; Tomita M; Wisniewski T; Frangione B
1993 Jul 1;293(Pt 1):27-30, Biochemical journal
— id: 8397, year: 1993, vol: 293, page: 27, stat: Journal Article,

Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease
Ghiso J; Wisniewski T; Vidal R; Rostagno A; Frangione B
1993 ;1:19-20, Parkinson/Alzheimer digest
— id: 101632, year: 1993, vol: 1, page: 19, stat: Journal Article,

The cerebrospinal fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (APO J), an inhibitor of the complement membrane attack complex
Ghiso, Jorge; Matsubara, Etsuro; Koudinov, Alexei; Wisniewski, Thomas; Frangione, Blas
1993 ;19(1-3):19-S80, Abstracts (Society for Neuroscience)
— id: 97650, year: 1993, vol: 19, page: 19, stat: Journal Article,

Gelsolin immunoreactivity in corneal amyloid, wound healing, and macular and granular dystrophies
Rodrigues MM; Rajagopalan S; Jones K; Nirankari V; Wisniewski T; Frangione B; Gorevic PD
1993 May 15;115(5):644-652, American journal of ophthalmology
— id: 9528, year: 1993, vol: 115, page: 644, stat: Journal Article,

Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro
Wisniewski T; Castano E; Ghiso J; Frangione B
1993 Oct;34(4):631-633, Annals of neurology
— id: 6554, year: 1993, vol: 34, page: 631, stat: Journal Article,

Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid
Wisniewski T; Golabek A; Matsubara E; Ghiso J; Frangione B
1993 Apr 30;192(2):359-365, Biochemical & biophysical research communications
— id: 9408, year: 1993, vol: 192, page: 359, stat: Journal Article,

ALZHEIMERS AMYLOID BETA-SUBUNIT IS PRESENT IN PREAMYLOID DEPOSITS AND IN CSF
WISNIEWSKI, T; WEGIEL, J; WISNIEWSKI, HM; FRANGIONE, B
1993 ;43(4):A422-A422, Neurology
— id: 97629, year: 1993, vol: 43, page: A422, stat: Journal Article,

Apolipoprotein E and Alzheimer's beta-amyloid fibril formation
Wisniewski, Thomas; Golabek, Adam; Ghiso, Jorge; Frangione, Blas
1993 ;19(1-3):1034-633, Abstracts (Society for Neuroscience)
— id: 97651, year: 1993, vol: 19, page: 1034, stat: Journal Article,

The adult and a new late adult forms of neuronal ceroid lipofuscinosis
Constantinidis J; Wisniewski KE; Wisniewski TM
1992 ;83(5):461-468, Acta neuropathologica
— id: 23491, year: 1992, vol: 83, page: 461, stat: Journal Article,

ACCELERATED INSTRUCTIVE FIBRILLOGENESIS IN THE DUTCH VARIANT OF ALZHEIMER'S DISEASE
FRANGIONE B; WISNIEWSKI T; GHISO J
1992 ;43(16 PART E):200-A422, Journal of cellular biochemistry. Supplement
— id: 97652, year: 1992, vol: 43, page: 200, stat: Journal Article,

ACCELERATED INSTRUCTIVE FIBRILLOGENESIS IN THE DUTCH VARIANT OF ALZHEIMER'S DISEASE AND THE ROLE OF PATHOLOGICAL CHAPERONES IN AMYLOID FORMATION
FRANGIONE B; WISNIEWSKI T; GHISO J
1992 ;13(SUPPL. 1):S73-S80, Neurobiology of aging
— id: 97600, year: 1992, vol: 13, page: S73, stat: Journal Article,

Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease
Ghiso J; Wisniewski T; Vidal R; Rostagno A; Frangione B
1992 Mar 1;282(Pt 2):517-522, Biochemical journal
— id: 9414, year: 1992, vol: 282, page: 517, stat: Journal Article,

Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions
Iwaki, T; Wisniewski, T; Iwaki, A; Corbin, E; Tomokane, N; Tateishi, J; Goldman, J E
1992 Feb;140(2):345-356, American journal of pathology
— id: 97585, year: 1992, vol: 140, page: 345, stat: Journal Article,

Pituitary apoplexy
Post K; Onesti S; Wisniewski T
Intracerebral hematomas New York : Raven Press, 1992,
— id: 4973, year: 1992, vol: , page: ?, stat: Chapter,

Amyloid-like fibrils formed in vitro from prion protein segments
Tagliavini, F.; Prelli, F.; Verga, L.; Giaccone, G.; Salmona, M.; Passerini, F.; Wisniewski, T.; Ghetti, B.; Bugiani, O.; Frangione, B.
1992 ;18(1-2):1251-522, Abstracts (Society for Neuroscience)
— id: 97653, year: 1992, vol: 18, page: 1251, stat: Journal Article,

Aberrant aggregation of a normal amyloid precursor protein fragment
Wisniewski T; Frangione B
1992 ;3:66-66, Neuroscience facts
— id: 97678, year: 1992, vol: 3, page: 66, stat: Journal Article,

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid
Wisniewski T; Frangione B
1992 Feb 3;135(2):235-238, Neuroscience letters
— id: 8466, year: 1992, vol: 135, page: 235, stat: Journal Article,

Molecular biology of Alzheimer's amyloid--Dutch variant
Wisniewski T; Frangione B
1992 Spring;6(1):75-86, Molecular neurobiology
— id: 9540, year: 1992, vol: 6, page: 75, stat: Journal Article,

ACCELERATED FIBRILLOGENESIS IN THE DUTCH VARIANT OF ALZHEIMER'S DISEASE
WISNIEWSKI T; GHISO J; FRANGIONE B
1992 ;42(4 SUPPL. 3):304-238, Neurology
— id: 97654, year: 1992, vol: 42, page: 304, stat: Journal Article,

I corpi di Lewy immunoreagiscono con gli anticorpi dell'amiloide di tipo finnico omologo alla gelsolina
Wisniewski T; Haltia M; Ghiso J; Frangione B
1992 ;2:59-60, Update on Parkinson
— id: 102366, year: 1992, vol: 2, page: 59, stat: Journal Article,

Lewy bodies and gelsolin
Wisniewski T; Haltia M; Ghiso J; Frangione B
1992 ;1:6-8, Parkinson/Alzheimer digest
— id: 97677, year: 1992, vol: 1, page: 6, stat: Journal Article,

Alzheimer's disease and the cerebral amyloidoses
Wisniewski, Thomas M; Wisniewski, Henryk M
Neurodevelopment, aging and cognition Cambridge, MA, US: Birkhauser; US, 1992,
— id: 5416, year: 1992, vol: , page: 157, stat: Chapter,

Inherited amyloids of the nervous system
Castano EM; Wisniewski T; Frangione B
1991 Oct;1(3):448-454, Current opinion in neurobiology
— id: 9542, year: 1991, vol: 1, page: 448, stat: Journal Article,

The dominant form of the pigmentary orthochromatic leukodystrophy
Constantinidis J; Wisniewski TM
1991 ;82(6):483-487, Acta neuropathologica
— id: 23492, year: 1991, vol: 82, page: 483, stat: Journal Article,

Familial amyloidosis - Finish type - and its relationship to Lewy bodies in Parkinson's and Diffuse Lewy Body disease
Frangione B; Haltia M; Levy E; Ghiso J; Kiuru S; Prelli F; Wisniewski T
Proceedings of the XIth International Congress of Neuropathology, September 2-8, 1990, Kyoto, Japan [Tokyo] : Japanese Society of Neuropathology, 1991,
— id: 4980, year: 1991, vol: , page: 150, stat: Chapter,

Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies
Haltia M; Ghiso J; Wisniewski T; Kiuru S; Miller D; Frangione B
1991 Jul-Aug;12(4):313-316, Neurobiology of aging
— id: 9421, year: 1991, vol: 12, page: 313, stat: Journal Article,

Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation
Wisniewski T; Ghiso J; Frangione B
1991 Nov 14;180(3):1528-1528, Biochemical & biophysical research communications
— id: 9418, year: 1991, vol: 180, page: 1528, stat: Journal Article,

Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation [published erratum appears in Biochem Biophys Res Commun 1991 Nov 14;180(3):1528]
Wisniewski T; Ghiso J; Frangione B
1991 Sep 30;179(3):1247-1254, Biochemical & biophysical research communications
— id: 9419, year: 1991, vol: 179, page: 1247, stat: Journal Article,

LEWY BODIES ARE IMMUNOREACTIVE WITH ANTIBODIES RAISED TO GELSOLIN AMYLOID
WISNIEWSKI T; HALTIA M; GHISO J; FRANGIONE B
1991 ;41(3 SUPPL. 1):177-316, Neurology
— id: 97655, year: 1991, vol: 41, page: 177, stat: Journal Article,

Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type
Wisniewski T; Haltia M; Ghiso J; Frangione B
1991 May;138(5):1077-1083, American journal of pathology
— id: 9422, year: 1991, vol: 138, page: 1077, stat: Journal Article,

Beta-protein immunoreactivity in brains of patients with neuronal ceroid lipofuscinosis: ultrastructural and biochemical demonstration
Kitaguchi T; Wisniewski KE; Maslinski S; Maslinska D; Wisniewski TM; Kim KS
1990 May 4;112(2-3):155-160, Neuroscience letters
— id: 23493, year: 1990, vol: 112, page: 155, stat: Journal Article,

Clinical versus subclinical pituitary apoplexy: presentation, surgical management, and outcome in 21 patients
Onesti, S T; Wisniewski, T; Post, K D
1990 Jun;26(6):980-986, Neurosurgery
— id: 97582, year: 1990, vol: 26, page: 980, stat: Journal Article,

Pituitary hemorrhage into a Rathke's cleft cyst
Onesti, S T; Wisniewski, T; Post, K D
1990 Oct;27(4):644-646, Neurosurgery
— id: 97583, year: 1990, vol: 27, page: 644, stat: Journal Article,

Intracerebral solitary plasmacytoma
Wisniewski, T; Sisti, M; Inhirami, G; Knowles, D M; Powers, J M
1990 Nov;27(5):826-9; discussion 829, Neurosurgery
— id: 97584, year: 1990, vol: 27, page: 826, stat: Journal Article,

Partial purification of neurofilament subunits from bovine brains and studies on neurofilament assembly
Moon, H M; Wisniewski, T; Merz, P; De Martini, J; Wisniewski, H M
1981 Jun;89(3):560-567, Journal of cell biology
— id: 97581, year: 1981, vol: 89, page: 560, stat: Journal Article,