Isaac I Wirgin

Biosketch / Results /

Isaac I Wirgin

Associate Professor;
Department of Environmental Medicine

Contact Info

Address
57 Old Forge Road
Floor 2 Room 254B
Sterling Forest
Tuxedo, NY 10987

845-731-3548
845-351-5472
Isaac.Wirgin@nyumc.org

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Education

1987 — City University of New York, New York, NY, Graduate Education

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Research Summary

The Atlantic tomcod, Microgadus tomcod, from the Hudson River provides a unique opportunity to study the molecular aspects of genetic susceptibility to neoplasia in an outbred model organism that 1) exhibits an unusually high prevalence of hepatocellular carcinomas (more than 90% in 2-yr-old fish), 2) is exposed to high levels of environmentally borne chemical carcinogens, and 3) can be used to investigate the effects of controlled laboratory model-chemical exposures on sensitive early-life stages.

We examined the effects of the interactions of genetic variation and exposure to high levels of Hudson River-borne xenobiotics on the structure and expression of carcinogenically relevant genes, such as K-ras, aromatic hydrocarbonreceptor (Ahr) and cytochrome P4501A (CYP1A1). We found activated K-ras in a high percentage of tomcod liver-tumor DNAs, a transcribed genetic polymorphism in the 3' untranslated region of CYP1A1 in Hudson River tomcod that is not observed in cancer-free populations of tomcod.

Currently, we study the functional significance of genetic variation in this model relevant to: 1) the role of K-ras oncogene activation in early neoplastic events and hepatocarcinogenesis progression in tomcod livers, 2) the effects of environmentally relevant polychlorobiphenyl (PCB) promotion on clonal expansion of initiated cells, and 3) the molecular mechanisms of CYP1A1 gene regulation in environmentally exposed tomcod from the Hudson River. We also explore the effects of inter-specific and inter-individual differences in Ahr gene expression levels on CYP1A1 gene expression and transcription inhibition in halogenated aromatic hydrocarbon-exposed fish.

Research Interests

Molecular Mechanisms of Carcinogenesis in Hudson River Tomcod

Research Keywords

chemical carcinogenesis, gene regulation, genetic variability, Hudson River pollution, mitochondrial DNA, oncogene activation

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Coastwide Stock Structure of Winter Flounder Using Nuclear DNA Analyses
Wirgin, Isaac; Maceda, Lorraine; Grunwald, Cheryl; Roy, Nirmal K.; Waldman, John R.
2014 JAN 1;143(1):240-251, Transactions of the American Fisheries Society
— id: 807952, year: 2014, vol: 143, page: 240, stat: Journal Article,

Genetic variants in hormone-related genes and risk of breast cancer
Clendenen, Tess; Zeleniuch-Jacquotte, Anne; Wirgin, Isaac; Koenig, Karen L; Afanasyeva, Yelena; Lundin, Eva; Arslan, Alan A; Axelsson, Tomas; Forsti, Asta; Hallmans, Goran; Hemminki, Kari; Lenner, Per; Roy, Nirmal; Shore, Roy E; Chen, Yu
2013 ;8(7):e69367-e69367 e69367, PLoS one
— id: 495042, year: 2013, vol: 8, page: e69367, stat: Journal Article,

Stock Origins of Subadult and Adult Atlantic Sturgeon, Acipenser oxyrinchus, in a Non-natal Estuary, Long Island Sound
Waldman, John R.; King, Tim; Savoy, Tom; Maceda, Lorraine; Grunwald, Cheryl; Wirgin, Isaac
2013 MAR;36(2):257-267, Estuaries & coasts
— id: 335192, year: 2013, vol: 36, page: 257, stat: Journal Article,

Toxic effects of PCB126 and TCDD on shortnose sturgeon and Atlantic sturgeon
Chambers, R Christopher; Davis, Dawn D; Habeck, Ehren A; Roy, Nirmal K; Wirgin, Isaac
2012 Oct;31(10):2324-2337, Environmental toxicology & chemistry
— id: 179191, year: 2012, vol: 31, page: 2324, stat: Journal Article,

Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer
Lundin, Eva; Wirgin, Isaac; Lukanova, Annekatrin; Afanasyeva, Yelena; Krogh, Vittorio; Axelsson, Tomas; Hemminki, Kari; Clendenen, Tess V; Arslan, Alan A; Ohlson, Nina; Sieri, Sabina; Roy, Nirmal; Koenig, Karen L; Idahl, Annika; Berrino, Franco; Toniolo, Paolo; Hallmans, Goran; Forsti, Asta; Muti, Paola; Lenner, Per; Shore, Roy E; Zeleniuch-Jacquotte, Anne
2012 Oct;36(5):445-452, Cancer epidemiology
— id: 178879, year: 2012, vol: 36, page: 445, stat: Journal Article,

Mixed-stock analysis of wintertime aggregations of striped bass along the Mid-Atlantic coast
Waldman, J.; Maceda, L.; Wirgin, I.
2012 FEB;28(1):1-6, Journal of applied ichthyology
— id: 157625, year: 2012, vol: 28, page: 1, stat: Journal Article,

Stock Origin of Migratory Atlantic Sturgeon in Minas Basin, Inner Bay of Fundy, Canada, Determined by Microsatellite and Mitochondrial DNA Analyses
Wirgin, Isaac; Maceda, Lorraine; Waldman, John R.; Wehrell, Sierra; Dadswell, Michael; King, Tim
2012 ;141(5):1389-1398, Transactions of the American Fisheries Society
— id: 185802, year: 2012, vol: 141, page: 1389, stat: Journal Article,

Characterization and expression of cytochrome P4501A in Atlantic sturgeon and shortnose sturgeon experimentally exposed to coplanar PCB 126 and TCDD
Roy NK; Walker N; Chambers RC; Wirgin I
2011 Mar 30;104(1-2):23-31, Aquatic toxicology
— id: 132243, year: 2011, vol: 104, page: 23, stat: Journal Article,

Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River
Wirgin, Isaac; Roy, Nirmal K; Loftus, Matthew; Chambers, R Christopher; Franks, Diana G; Hahn, Mark E
2011 Mar 11;331(6022):1322-1325, Science
— id: 127231, year: 2011, vol: 331, page: 1322, stat: Journal Article,

DNA methylation in pre-diagnostic serum samples of breast cancer cases: Results of a nested case-control study
Brooks, Jennifer D; Cairns, Paul; Shore, Roy E; Klein, Catherine B; Wirgin, Isaac; Afanasyeva, Yelena; Zeleniuch-Jacquotte, Anne
2010 Dec;34(6):717-723, Cancer epidemiology
— id: 114817, year: 2010, vol: 34, page: 717, stat: Journal Article,

Fine-scale spatial and temporal genetic structure of Atlantic cod off the Atlantic coast of the USA
Kovach, AI; Breton, TS; Berlinsky, DL; Maceda, L; Wirgin, I
2010 MAY ;410(9):177-U195, Marine ecology progress series
— id: 111899, year: 2010, vol: 410, page: 177, stat: Journal Article,

Delineation of discrete population segments of shortnose sturgeon Acipenser brevirostrum based on mitochondrial DNA control region sequence analysis
Wirgin, I; Grunwald, C; Stabile, J; Waldman, JR
2010 JUN ;11(3):689-708, Conservation genetics
— id: 109967, year: 2010, vol: 11, page: 689, stat: Journal Article,

Microarray analysis of polychlorinated biphenyl mixture-induced changes in gene expression among Atlantic tomcod populations displaying differential sensitivity to halogenated aromatic hydrocarbons
Carlson, Erik A; Roy, Nirmal K; Wirgin, Isaac I
2009 Apr;28(4):759-771, Environmental toxicology & chemistry
— id: 120712, year: 2009, vol: 28, page: 759, stat: Journal Article,

Development and Use of Real-Time Reverse Transcription-Polymerase Chain Reaction Assay to Quantify Cytochrome P4501A1 Expression in American Mink
Roy, Nirmal K; Bursian, Steve; Mayack, David T; Wirgin, Isaac
2009 Oct;57(3):608-615, Archives of environmental contamination & toxicology
— id: 94578, year: 2009, vol: 57, page: 608, stat: Journal Article,

Mitochondrial DNA Analysis Indicates Sea Lampreys Are Indigenous to Lake Ontario: Response to Comment
Waldman, J; Daniels, R; Hickerson, M; Wirgin, I
2009 SEP ;138(5):1190-1197, Transactions of the American Fisheries Society
— id: 105455, year: 2009, vol: 138, page: 1190, stat: Journal Article,

Polymorphisms in RAD51, XRCC2, and XRCC3 are not related to breast cancer risk
Brooks, Jennifer; Shore, Roy E; Zeleniuch-Jacquotte, Anne; Currie, Diane; Afanasyeva, Yelena; Koenig, Karen L; Arslan, Alan A; Toniolo, Paolo; Wirgin, Isaac
2008 Apr;17(4):1016-1019, Cancer epidemiology biomarkers & prevention
— id: 80287, year: 2008, vol: 17, page: 1016, stat: Journal Article,

Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer
Clendenen, Tess V; Arslan, Alan A; Koenig, Karen L; Enquist, Kerstin; Wirgin, Isaac; Agren, Asa; Lukanova, Annekatrin; Sjodin, Hubert; Zeleniuch-Jacquotte, Anne; Shore, Roy E; Hallmans, Goran; Toniolo, Paolo; Lundin, Eva
2008 Feb 18;260(1-2):209-215, Cancer letters
— id: 76858, year: 2008, vol: 260, page: 209, stat: Journal Article,

Conservation of Atlantic sturgeon Acipenser oxyrinchus oxyrinchus: delineation of stock structure and distinct population segments
Grunwald, C; Maceda, L; Waldman, J; Stabile, J; Wirgin, I
2008 JUL-AUG ;9(5):1111-1124, Conservation genetics
— id: 86667, year: 2008, vol: 9, page: 1111, stat: Journal Article,

Annual run size and genetic characteristics of Atlantic sturgeon in the Altamaha River, Georgia
Peterson, DL; Schueller, P; DeVries, R; Fleming, J; Grunwald, C; Wirgin, I
2008 MAR ;137(2):393-401, Transactions of the American Fisheries Society
— id: 78717, year: 2008, vol: 137, page: 393, stat: Journal Article,

Polymorphisms in XPC and ERCC2 genes, smoking and breast cancer risk
Shore, Roy E; Zeleniuch-Jacquotte, Anne; Currie, Diane; Mohrenweiser, Harvey; Afanasyeva, Yelena; Koenig, Karen L; Arslan, Alan A; Toniolo, Paolo; Wirgin, Isaac
2008 May 1;122(9):2101-2105, International journal of cancer
— id: 76390, year: 2008, vol: 122, page: 2101, stat: Journal Article,

Sea lamprey Petromyzon marinus: an exception to the rule of homing in anadromous fishes
Waldman, John; Grunwald, Cheryl; Wirgin, Isaac
2008 Dec 23;4(6):659-662, Biology letters
— id: 120710, year: 2008, vol: 4, page: 659, stat: Journal Article,

Molecular analysis as a conservation tool for monitoring the trade of North American sturgeons and paddlefish
Waldman, JR; Doukakis, P; Wirgin, I
2008 JUN ;24(1):20-28, Journal of applied ichthyology
— id: 78392, year: 2008, vol: 24, page: 20, stat: Journal Article,

Genetic evidence for relict Atlantic sturgeon stocks along the mid-Atlantic coast of the USA
Wirgin, I; Grunwald, C; Stabile, J; Waldman, J
2007 NOV ;27(4):1214-1229, North American journal of fisheries management
— id: 75692, year: 2007, vol: 27, page: 1214, stat: Journal Article,

Bioaccumulation and toxicities of aromatic hydrocarbon contaminants at different trophic levels of the Hudson River ecosystem
Wirgin, Isaac I.
Environmental and occupational medicine Philadelphia : Wolters Kluwer/Lippincott Williams & Wilkins, 2007,
— id: 5378, year: 2007, vol: , page: ?, stat: Chapter,

Characterization of the aryl hydrocarbon receptor repressor and a comparison of its expression in Atlantic tomcod from resistant and sensitive populations
Roy, Nirmal K; Courtenay, Simon C; Chambers, R Christopher; Wirgin, Isaac I
2006 Feb;25(2):560-571, Environmental toxicology & chemistry
— id: 64648, year: 2006, vol: 25, page: 560, stat: Journal Article,

Evaluation of the native status of sea lampreys in Lake Champlain based on mitochondrial DNA sequencing analysis
Waldman, JR; Grunwald, C; Wirgin, I
2006 JUL ;135(4):1076-1085, Transactions of the American Fisheries Society
— id: 68667, year: 2006, vol: 135, page: 1076, stat: Journal Article,

Evidence of spatially extensive resistance to PCBs in an anadromous fish of the Hudson River
Yuan, Zhanpeng; Courtenay, Simon; Chambers, R Christopher; Wirgin, Isaac
2006 Jan;114(1):77-84, Environmental health perspectives
— id: 62747, year: 2006, vol: 114, page: 77, stat: Journal Article,

Comparison of hepatic and extra hepatic induction of cytochrome P4501A by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations
Yuan, Zhanpeng; Courtenay, Simon; Wirgin, Isaac
2006 Mar 10;76(3-4):306-320, Aquatic toxicology
— id: 71578, year: 2006, vol: 76, page: 306, stat: Journal Article,

Biomarkers of benzene: Urinary metabolites in relation to individual genotype and personal exposure
Qu, Qingshan; Shore, Roy; Li, Guilan; Su, Lin; Jin, Ximei; Melikian, Asseih A; Roy, Nirmal; Chen, Lung Chi; Wirgin, Isaac; Cohen, Beverly; Yin, Songnian; Li, Yuying; Mu, Ruidong
2005 May 30;153-154:85-95, Chemico-biological interactions
— id: 56002, year: 2005, vol: 153-154, page: 85, stat: Journal Article,

Co-exposure to metals modulates CYP1A mRNA inducibility in Atlantic tomcod Microgadus tomcod from two populations
Sorrentino, C; Roy, N K; Courtenay, S C; Wirgin, I
2005 Nov 10;75(3):238-252, Aquatic toxicology
— id: 64452, year: 2005, vol: 75, page: 238, stat: Journal Article,

Introgression of nuclear DNA (nDNA) alleles of stocked Atlantic coast striped bass with the last remaining native gulf of Mexico population
Wirgin, I; Currie, D; Roy, N; Maceda, L; Waldman, JR
2005 MAY ;25(2):464-474, North American journal of fisheries management
— id: 56196, year: 2005, vol: 25, page: 464, stat: Journal Article,

Range-wide population structure of shortnose sturgeon Acipenser brevirostrum based on sequence analysis of the mitochondrial DNA control region
Wirgin, I; Grunwald, C; Carlson, E; Stabile, J; Peterson, DL; Waldman, J
2005 JUN ;28(3):406-421, Estuaries
— id: 57650, year: 2005, vol: 28, page: 406, stat: Journal Article,

Reduction of cytochrome P4501A with age in Atlantic tomcod from the St. Lawrence Estuary, Canada: relationship with emaciation and possible effect of contamination
Couillard, C M; Wirgin, I I; Lebeuf, M; Legare, B
2004 Jun 24;68(3):233-247, Aquatic toxicology
— id: 44848, year: 2004, vol: 68, page: 233, stat: Journal Article,

Spatial variation in hepatic levels and patterns of PCBs and PCDD/Fs among young-of-the-year and adult Atlantic tomcod (Microgadus tomcod) in the Hudson River estuary
Fernandez, Marc P; Ikonomou, Michael G; Courtenay, Simon C; Wirgin, Isaac I
2004 Feb 15;38(4):976-983, Environmental science & technology
— id: 44849, year: 2004, vol: 38, page: 976, stat: Journal Article,

Origin and movements of young-of-the-year striped bass in the southern Gulf of St. lawrence, New Brunswick
Robinson, M; Courtenay, S; Benfey, T; Maceda, L; Wirgin, I
2004 MAR ;133(2):412-426, Transactions of the American Fisheries Society
— id: 42443, year: 2004, vol: 133, page: 412, stat: Journal Article,

Absence of shared mitochondrial DNA haplotypes between sea lamprey from North American and Spanish rivers
Rodriguez-Munoz, R; Waldman, JR; Grunwald, C; Roy, NK; Wirgin, I
2004 MAR ;64(3):783-787, Journal of fish biology
— id: 42469, year: 2004, vol: 64, page: 783, stat: Journal Article,

B[a]P-DNA binding in early life-stages of Atlantic tomcod: population differences and chromium modulation
Sorrentino, C; Roy, N K; Chambers, R C; Courtenay, S C; Wirgin, I
2004 Aug-Dec;58(2-5):383-388, Marine environmental research
— id: 44847, year: 2004, vol: 58, page: 383, stat: Journal Article,

Mitochondrial DNA analysis indicates sea lampreys are indigenous to Lake Ontario
Waldman, JR; Grunwald, C; Roy, NK; Wirgin, II
2004 JUL ;133(4):950-960, Transactions of the American Fisheries Society
— id: 46569, year: 2004, vol: 133, page: 950, stat: Journal Article,

Development and use of a simple DNA test to distinguish larval redhorse species in the Oconee River, Georgia
Wirgin, I; Currie, DD; Stabile, J; Jennings, CA
2004 FEB ;24(1):293-298, North American journal of fisheries management
— id: 42465, year: 2004, vol: 24, page: 293, stat: Journal Article,

Resistance to contaminants in North American fish populations
Wirgin, Isaac; Waldman, John R
2004 Aug 18;552(1-2):73-100, Mutation research
— id: 44846, year: 2004, vol: 552, page: 73, stat: Journal Article,

Population genetics of shortnose sturgeon Acipenser brevirostrum based on mitochondrial DNA control region sequences
Grunwald, C; Stabile, J; Waldman, J R; Gross, R; Wirgin, I
2002 Oct;11(10):1885-1898, Molecular ecology
— id: 39587, year: 2002, vol: 11, page: 1885, stat: Journal Article,

When the American sea sturgeon swam east
Ludwig, Arne; Debus, Lutz; Lieckfeldt, Dietmar; Wirgin, Isaac; Benecke, Norbert; Jenneckens, Ingo; Williot, Patrick; Waldman, John R; Pitra, Christian
2002 Oct 3;419(6906):447-448, Nature
— id: 44850, year: 2002, vol: 419, page: 447, stat: Journal Article,

Cytochrome P4501A1 is induced by PCB 77 and benzo[a]pyrene treatment but not by exposure to the Hudson River environment in Atlantic tomcod (Microgadus tomcod) post-yolk sac larvae
Roy, Nirmal K; Courtenay, Simon; Maxwell, Grace; Yuan, Zhanpeng; Chambers, R Christopher; Wirgin, Isaac
2002 Mar-Apr;7(2):162-173, Biomarkers
— id: 39620, year: 2002, vol: 7, page: 162, stat: Journal Article,

Impacts of life history and biogeography on the genetic stock structure of Atlantic sturgeon Acipenser oxyrinchus oxyrinchus, Gulf sturgeon A-oxyrinchus desotoi, and shortnose sturgeon A- brevirostrum
Waldman, JR; Grunwald, C; Stabile, J; Wirgin, I
2002 DEC ;18(4-6):509-518, Journal of applied ichthyology
— id: 33274, year: 2002, vol: 18, page: 509, stat: Journal Article,

Comparison of mitochondrial DNA control region sequence and microsatellite DNA analyses in estimating population structure and gene flow rates in Atlantic sturgeon Acipenser oxyrinchus
Wirgin, I; Waldman, J; Stabile, J; Lubinski, B; King, T
2002 DEC ;18(4-6):313-319, Journal of applied ichthyology
— id: 33273, year: 2002, vol: 18, page: 313, stat: Journal Article,

An evaluation of the etiology of reduced CYP1A1 messenger RNA expression in the Atlantic tomcod from the Hudson River, New York, USA, using reverse transcriptase polymerase chain reaction analysis
Roy NK; Courtenay S; Yuan Z; Ikonomou M; Wirgin I
2001 May;20(5):1022-1030, Environmental toxicology & chemistry
— id: 20685, year: 2001, vol: 20, page: 1022, stat: Journal Article,

Morphological and genetic variation among shortnose sturgeon Acipenser brevirostrum from adjacent and distant rivers
Walsh, MG; Bain, MB; Squiers, T; Waldman, JR; Wirgin, I
2001 FEB ;24(1):41-48, Estuaries
— id: 55109, year: 2001, vol: 24, page: 41, stat: Journal Article,

Genetic divergence of robust redhorse Moxostoma robustum (Cypriniformes Catostomidae) from the Oconee River and the Savannah River based on mitochondrial DNA control region sequences
Wirgin, I; Oppermann, T; Stabile, J
2001 MAY 1 ;15(2):526-530, Copeia
— id: 55080, year: 2001, vol: 15, page: 526, stat: Journal Article,

Is hepatic cytochrome P4501A1 expression predictive of hepatic burdens of dioxins, furans, and PCBs in Atlantic tomcod from the Hudson River estuary?
Yuan Z; Wirgin M; Courtenay S; Ikonomou M; Wirgin I
2001 Oct;54(3-4):217-230, Aquatic toxicology
— id: 26711, year: 2001, vol: 54, page: 217, stat: Journal Article,

Isolation of microsatellites in striped bass Morone saxatilis (Teleostei) and their preliminary use in population identification
Roy NK; MacEda L; Wirgin I
2000 Jun;9(6):827-829, Molecular ecology
— id: 11661, year: 2000, vol: 9, page: 827, stat: Journal Article,

Genetic structure of Atlantic sturgeon populations based on mitochondrial DNA control region sequences
Wirgin, I; Waldman, JR; Rosko, J; Gross, R; Collins, MR; Rogers, SG; Stabile, J
2000 MAR ;129(2):476-486, Transactions of the American Fisheries Society
— id: 54551, year: 2000, vol: 129, page: 476, stat: Journal Article,

A comparison of the dose and time response of CYP1A1 mRNA induction in chemically treated Atlantic tomcod from two populations
Courtenay, SC; Grunwald, CM; Kreamer, GL; Fairchild, WL; Arsenault, JT; Ikonomou, M; Wirgin, II
1999 OCT ;47(1):43-69, Aquatic toxicology
— id: 53918, year: 1999, vol: 47, page: 43, stat: Journal Article,

High frequency of K-ras mutations in pink salmon embryos experimentally exposed to Exxon Valdez oil
Roy, NK; Stabile, J; Seeb, JE; Habicht, C; Wirgin, I
1999 ;18(7):1521-1528, Environmental toxicology & chemistry
— id: 637802, year: 1999, vol: 18, page: 1521, stat: Journal Article,

Range-wide stock structure of Atlantic sturgeon Acipenser oxyrinchus oxyrinchus based on sequence analysis of mitochondrial DNA
Wirgin, Isaac I
[Tuxedo NY : Nelson Institute of Environmental Medicine], 1999,
— id: 1222, year: 1999, vol: , page: , stat: ,

Multiple population bottlenecks and DNA diversity in populations of wild striped bass, Morone saxatilis
Waldman, JR; Bender, RE; Wirgin, II
1998 JUL ;96(3):614-620, Fishery bulletin
— id: 53402, year: 1998, vol: 96, page: 614, stat: Journal Article,

Status and restoration options for Atlantic sturgeon in North America
Waldman, JR; Wirgin, II
1998 JUN ;12(3):631-638, Conservation biology
— id: 53435, year: 1998, vol: 12, page: 631, stat: Journal Article,

Altered gene expression and genetic damage in North American fish populations
Wirgin I; Waldman JR
1998 Mar 20;399(2):193-219, Mutation research
— id: 57284, year: 1998, vol: 399, page: 193, stat: Journal Article,

Characterization of the aromatic hydrocarbon receptor gene and its expression in Atlantic tomcod
Roy NK; Wirgin I
1997 Aug 15;344(2):373-386, Archives of biochemistry & biophysics. ABB
— id: 56984, year: 1997, vol: 344, page: 373, stat: Journal Article,

Effects of the antibiotic Baytril (enrofloxacin) on PCB-initiated induction of cytochrome P4501A mRNA in sexually mature Atlantic tomcod (Microgadus tomcod)
Williams, J; Courtenay, SC; Wirgin, II
1997 FEB ;16(2):241-244, Environmental toxicology & chemistry
— id: 53268, year: 1997, vol: 16, page: 241, stat: Journal Article,

An evaluation of introgression of Atlantic coast striped bass mitochondrial DNA in a Gulf of Mexico population using formalin-preserved museum collections
Wirgin I; Maceda L; Stabile J; Mesing C
1997 Oct;6(10):907-916, Molecular ecology
— id: 57351, year: 1997, vol: 6, page: 907, stat: Journal Article,

Mixed-stock analysis of Atlantic coast striped bass (Morone saxatilis) using nuclear DNA and mitochondrial DNA markers
Wirgin, II; Waldman, JR; Maceda, L; Stabile, J; Vecchio, VJ
1997 DEC ;54(12):2814-2826, Canadian journal of fisheries & aquatic sciences
— id: 53542, year: 1997, vol: 54, page: 2814, stat: Journal Article,

Molecular analysis in the conservation of sturgeons and paddlefish
Wirgin, Isaac I.; Stabile, Joseph E.; Waldman, John R.
1997 ;48(1-4):385-398, Environmental biology of fishes
— id: 98800, year: 1997, vol: 48, page: 385, stat: Journal Article,

Genetic divergence between Acipenser oxyrinchus oxyrinchus and A-o-desotoi as assessed by mitochondrial DNA sequencing analysis
Ong, TL; Stabile, J; Wirgin, I; Waldman, JR
1996 MAY 16 ;32(2):464-469, Copeia
— id: 52895, year: 1996, vol: 32, page: 464, stat: Journal Article,

Characterization of CYP1A1 gene regulatory elements in cancer-prone Atlantic tomcod
Roy NK; Konkle B; Wirgin I
1996 Jun;6(3):273-277, Pharmacogenetics
— id: 56890, year: 1996, vol: 6, page: 273, stat: Journal Article,

Stock structure and homing fidelity in Gulf of Mexico sturgeon (Acipenser oxyrinchus desotoi) based on restriction fragment length polymorphism and sequence analyses of mitochondrial DNA
Stabile J; Waldman JR; Parauka F; Wirgin I
1996 Oct;144(2):767-775, Genetics
— id: 12528, year: 1996, vol: 144, page: 767, stat: Journal Article,

Stock composition of the New York Bight Atlantic sturgeon fishery based on analysis of mitochondrial DNA
Waldman, JR; Hart, JT; Wirgin, II
1996 MAY ;125(3):364-371, Transactions of the American Fisheries Society
— id: 52922, year: 1996, vol: 125, page: 364, stat: Journal Article,

Genetic differentiation of three key anadromous fish populations of the Hudson River
Waldman, JR; Nolan, K; Hart, J; Wirgin, II
1996 DEC ;19(4):759-768, Estuaries
— id: 53286, year: 1996, vol: 19, page: 759, stat: Journal Article,

A comparison of cytochrome P4501A (CYP1A) mRNA inducibility in four species of Atlantic coast anadromous fishes
Wirgin, I; Konkle, B; Pedersen, M; Grunwald, C; Williams, J; Courtenay, SC
1996 DEC ;19(4):913-922, Estuaries
— id: 53287, year: 1996, vol: 19, page: 913, stat: Journal Article,

A COMPARISON OF RT-PCR AND NORTHERN BLOT ANALYSIS IN QUANTIFYING METALLOTHIONEIN MESSENGER-RNA LEVELS IN KILLIFISH EXPOSED TO WATERBORNE CADMIUM
KAPLAN, LAE; VANCLEEF, K; WIRGIN, I; CRIVELLO, JF
1995 APR ;39(1-4):137-141, Marine environmental research
— id: 87374, year: 1995, vol: 39, page: 137, stat: Journal Article,

Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod
Roy NK; Kreamer GL; Konkle B; Grunwald C; Wirgin I
1995 Sep 10;322(1):204-213, Archives of biochemistry & biophysics. ABB
— id: 56842, year: 1995, vol: 322, page: 204, stat: Journal Article,

MITOCHONDRIAL-DNA STABILITY AND STRIPED BASS STOCK IDENTIFICATION - COMMENT
WALDMAN, JR; WIRGIN, II
1995 NOV ;124(6):954-956, Transactions of the American Fisheries Society
— id: 52667, year: 1995, vol: 124, page: 954, stat: Journal Article,

MIXED-STOCK ANALYSIS OF STRIPED BASS IN 2 RIVERS OF THE BAY OF FUNDY AS REVEALED BY MITOCHONDRIAL-DNA
WIRGIN, I; JESSOP, B; COURTENAY, S; PEDERSEN, M; MACEDA, S; WALDMAN, JR
1995 MAY ;52(5):961-970, Canadian journal of fisheries & aquatic sciences
— id: 86731, year: 1995, vol: 52, page: 961, stat: Journal Article,

Genetic and molecular ecotoxicology: a research framework
Anderson, S; Sadinski, W; Shugart, L; Brussard, P; Depledge, M; Ford, T; Hose, J; Stegeman, J; Suk, W; Wirgin, I
1994 Dec;102 Suppl 12:3-8, Environmental health perspectives
— id: 132244, year: 1994, vol: 102 Suppl 12, page: 3, stat: Journal Article,

Assessment of within-group variation in CYP1A mRNA inducibility in environmentally exposed and chemically treated Atlantic tomcod
Courtenay S; Williams PJ; Grunwald C; Konkle B; Ong TL; Wirgin II
1994 Dec;102 Suppl 12:85-90, Environmental health perspectives
— id: 6597, year: 1994, vol: 102 Suppl 12, page: 85, stat: Journal Article,

Use of DNA analysis in the management of natural fish populations
Waldman, John R; Wirgin, Isaac
Molecular environmental biology Boca Raton FL : Lewis Publishers, 1994,
— id: 4285, year: 1994, vol: , page: ?, stat: Chapter,

ORIGIN OF THE PRESENT DELAWARE RIVER STRIPED BASS POPULATION AS SHOWN BY ANALYSIS OF MITOCHONDRIAL-DNA
WALDMAN, JR; WIRGIN, II
1994 JAN ;123(1):15-21, Transactions of the American Fisheries Society
— id: 52598, year: 1994, vol: 123, page: 15, stat: Journal Article,

A biomarker approach to assessing xenobiotic exposure in Atlantic tomcod from the North American Atlantic coast
Wirgin II; Grunwald C; Courtenay S; Kreamer GL; Reichert WL; Stein JE
1994 Sep;102(9):764-770, Environmental health perspectives
— id: 8419, year: 1994, vol: 102, page: 764, stat: Journal Article,

WHAT DNA CAN DO FOR YOU
WIRGIN, II; WALDMAN, JR
1994 JUL ;19(7):16-27, Fisheries
— id: 52421, year: 1994, vol: 19, page: 16, stat: Journal Article,

Assessment of environmental degradation by molecular analysis of a sentienel species : Atlantic tomcod
Wirgin, Isaac I; Garte, Seymour J
Molecular environmental biology Boca Raton FL : Lewis Publishers, 1994,
— id: 4286, year: 1994, vol: , page: ?, stat: Chapter,

Racial differences in restriction fragment length polymorphisms and messenger RNA inducibility of the human CYP1A1 gene
Cosma G; Crofts F; Currie D; Wirgin I; Toniolo P; Garte SJ
1993 Jan-Feb;2(1):53-57, Cancer epidemiology biomarkers & prevention
— id: 10391, year: 1993, vol: 2, page: 53, stat: Journal Article,

INDUCTION AND CLEARANCE OF CYTOCHROME P4501A MESSENGER-RNA IN ATLANTIC TOMCOD CAGED IN BLEACHED KRAFT MILL EFFLUENT IN THE MIRAMICHI RIVER
COURTENAY, S; GRUNWALD, C; KREAMER, GL; ALEXANDER, R; WIRGIN, I
1993 DEC ;27(3-4):225-243, Aquatic toxicology
— id: 52592, year: 1993, vol: 27, page: 225, stat: Journal Article,

Glial fibrillary acidic protein (GFAP) indicates in vivo exposure to environmental contaminants: PCBs in the Atlantic tomcod
Evans HL; Little AR; Gong ZL; Duffy JS; Wirgin I; el-Fawal HA
1993 May 28;679:402-406, Annals of the New York Academy of Sciences
— id: 13157, year: 1993, vol: 679, page: 402, stat: Journal Article,

USE OF MITOCHONDRIAL-DNA POLYMORPHISMS TO ESTIMATE THE RELATIVE CONTRIBUTIONS OF THE HUDSON RIVER AND CHESAPEAKE BAY STRIPED BASS STOCKS TO THE MIXED FISHERY ON THE ATLANTIC COAST
WIRGIN, I; MACEDA, L; WALDMAN, JR; CRITTENDEN, RN
1993 SEP ;122(5):669-684, Transactions of the American Fisheries Society
— id: 52153, year: 1993, vol: 122, page: 669, stat: Journal Article,

MITOCHONDRIAL-DNA VARIATION IN STRIPED BASS (MORONE-SAXATILIS) FROM CANADIAN RIVERS
WIRGIN, II; ONG, TL; MACEDA, L; WALDMAN, JR; MOORE, D; COURTENAY, S
1993 JAN ;50(1):80-87, Canadian journal of fisheries & aquatic sciences
— id: 52274, year: 1993, vol: 50, page: 80, stat: Journal Article,

Use of cellular oncogene probes to identify Morone hybrids
Wirgin II; Maceda L; Mesing C
1992 Sep-Oct;83(5):375-382, Journal of heredity
— id: 13463, year: 1992, vol: 83, page: 375, stat: Journal Article,

EFFECTS OF PRIOR EXPOSURE HISTORY ON CYTOCHROME-P4501A MESSENGER-RNA INDUCTION BY PCB CONGENER-77 IN ATLANTIC TOMCOD
WIRGIN, II; KREAMER, GL; GRUNWALD, C; SQUIBB, K; GARTE, SJ; COURTENAY, S
1992 DEC ;34(1-4):103-108, Marine environmental research
— id: 51812, year: 1992, vol: 34, page: 103, stat: Journal Article,

Cytochrome P450IA mRNA expression in feral Hudson River tomcod
Kreamer GL; Squibb K; Gioeli D; Garte SJ; Wirgin I
1991 Jun;55(1):64-78, Environmental research
— id: 14008, year: 1991, vol: 55, page: 64, stat: Journal Article,

DISCRIMINATION AMONG ATLANTIC COAST POPULATIONS OF AMERICAN SHAD (ALOSA-SAPIDISSIMA) USING MITOCHONDRIAL-DNA
Nolan, K; Grossfield, J; Wirgin, I
1991 Sep;48(9):1724-1734, Canadian journal of fisheries & aquatic sciences
— id: 32149, year: 1991, vol: 48, page: 1724, stat: Journal Article,

GENETIC-POLYMORPHISM OF CYTOCHROME P-450IA IN CANCER-PRONE HUDSON RIVER TOMCOD
Wirgin, I; Kreamer, GL; Garte, SJ
1991 Jun;19(3):205-214, Aquatic toxicology
— id: 32169, year: 1991, vol: 19, page: 205, stat: Journal Article,

USE OF DNA FINGERPRINTING IN THE IDENTIFICATION AND MANAGEMENT OF A STRIPED BASS POPULATION IN THE SOUTHEASTERN UNITED-STATES
Wirgin, II; Grunwald, C; Garte, SJ; Mesing, C
1991 May;120(3):273-282, Transactions of the American Fisheries Society
— id: 32163, year: 1991, vol: 120, page: 273, stat: Journal Article,

DEVELOPMENT AND USE OF STRIPED BASS-SPECIFIC RFLP PROBES
WIRGIN, II; MACEDA, L
1991 DEC ;39(1):159-167, Journal of fish biology
— id: 52121, year: 1991, vol: 39, page: 159, stat: Journal Article,

Ha-ras oncogene mutations in cell lines derived from rat tracheal implants exposed in vivo to 7,12-dimethylbenz[a]anthracene
Cosma, G N; Wirgin, I I; Marchok, A C; Garte, S J
1990 ;3(5):258-263, Molecular carcinogenesis
— id: 132246, year: 1990, vol: 3, page: 258, stat: Journal Article,

Genetic diversity at an oncogene locus and in mitochondrial DNA between populations of cancer-prone Atlantic tomcod
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