Elaine L Wilson

Biosketch / Results /

Elaine L Wilson, Ph.D.

Professor; Co Dir NCI Stem Cell Canc Cell Bio Trng Grant; Co Dir NY Stem Trng Grant Stem Cells; Advsr - Cellular & Molecular Bio Instr. Hstlgy
Departments of Cell Biology (Cell Biology) and Urology (Administration)

Contact Info

Address
550 First Avenue
Floor 6 Room 629
Medical Science Building
New York, NY 10016

212-263-7684, 212-263-7775
212-263-8139
Elaine.Wilson@nyumc.org

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Education

1971 — Dr. Wilson received her Ph.D. in Biochemistry from the University of Cape Town, South Africa, Graduate Education
1974-1975 — Dr. Wilson was a Postdoctoral Fellow in Cell Biology at Rockefeller University New York, NY, PostDoctoral Training

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Research Summary

As stem cell biology and tumorigenesis are closely linked and as stem cells may have a role in the etiology of cancer we are currently defining features of normal prostate stem cells with the goal of determining if these are targets of transformation and if these have similar features to prostate cancer stem cells. We have shown that the proximal region of murine prostatic ducts is enriched in stem cells that express high levels of Sca-1, are quiescent and have high proliferative potential in vitro and in vivo. In addition, single proximal cells give rise to branched ductal structures that contain both basal and luminal cells. Cells from this region have significant regenerative capacity when assayed in an in vivo prostate reconstitution assay in which combinations of prostate cells and embryonic urogenital sinus mesenchyme (inductive mesenchyme for prostatic tissue) are inserted under the renal capsule of recipient animals. Proximal cells also withstand prolonged androgen deprivation, another characteristic of stem cells. Sca-1high prostate regenerating cells also express other antigens characteristic of stem cells such as alpha 6 integrin (~ 96%), and Bcl-2 (~ 80%). High levels of TGF-beta in the proximal region maintain the quiescence of the proximal stem cell niche. As we find that prostate stem cells reside within the population that expresses high levels of Sca-1 we determined the expression of Sca-1 on prostate cancer cells isolated from the prostate tumors of Pten deficient mice. We find these tumor cells express very high levels of Sca-1, indicating that cells expressing high levels of Sca-1 are expanded during tumorigenesis. Tumor cells with self-renewing and tumorigenic capacity reside exclusively in the Sca-1high population and are not present in the Sca-1medium/low and Sca-1negative populations. The data indicate that prostate tumor cells and normal prostate stem cells share common features and that normal stem cells are expanded during tumorigeneiss indicating that they are the likely target of carcinogenesis.

Research Interests

The Biology of Stem Cells<br>

Research Keywords

stem cells, prostate, hematopoiesis, endothelial cells,<br>tumors, growth factors<br><br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration
Peng, Yu-Ching; Levine, Charles M; Zahid, Sarwar; Wilson, E Lynette; Joyner, Alexandra L
2013 Dec;110(51):20611-20616, Proceedings of the National Academy of Sciences of the United States of America
— id: 712482, year: 2013, vol: 110, page: 20611, stat: Journal Article,

TGF-beta and stem cell factor regulate cell proliferation in the proximal stem cell niche
Salm, Sarah; Burger, Patricia E; Wilson, Elaine Lynette
2012 Jun;72(9):998-1005, Prostate
— id: 166811, year: 2012, vol: 72, page: 998, stat: Journal Article,

Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways. L
Blum, Roy; Gupta, Rashmi; Burger, Patricia E; Ontiveros, Christopher S; Salm, Sarah N; Xiong, Xiaozhong; Kamb, Alexander; Wesche, Holger; Marshall, Lisa; Cutler, Gene; Wang, Xiangyun; Zavadil, Jiri; Moscatelli, David; Wilson, E Lynette
2010 ;5(9):?-?, PLoS ONE
— id: 113814, year: 2010, vol: 5, page: ?, stat: Journal Article,

PINing Down the Origin of Prostate Cancer
Moscatelli, David; Wilson, E Lynette
2010 Aug 4;2(43):43ps38-43ps38, Science translational medicine
— id: 111550, year: 2010, vol: 2, page: 43ps38, stat: Journal Article,

Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer
Blum, Roy; Gupta, Rashmi; Burger, Patricia E; Ontiveros, Christopher S; Salm, Sarah N; Xiong, Xiaozhong; Kamb, Alexander; Wesche, Holger; Marshall, Lisa; Cutler, Gene; Wang, Xiangyun; Zavadil, Jiri; Moscatelli, David; Wilson, E Lynette
2009 ;4(5):e5722-e5722, PLoS ONE
— id: 99241, year: 2009, vol: 4, page: e5722, stat: Journal Article,

High Aldehyde Dehydrogenase Activity: A Novel Functional Marker of Murine Prostate Stem/Progenitor Cells
Burger, PE; Gupta, R; Xiong, X; Ontiveros, CS; Salm, SN; Moscatelli, D; Wilson, EL
2009 OCT ;27(9):2220-2228, Stem cells
— id: 102959, year: 2009, vol: 27, page: 2220, stat: Journal Article,

Endothelial cells support the growth of prostate tissue in vivo
Bates, Michael; Kovalenko, Bruce; Wilson, E Lynette; Moscatelli, David
2008 Jun 1;68(8):893-901, Prostate
— id: 79381, year: 2008, vol: 68, page: 893, stat: Journal Article,

Axin2 expression identifies progenitor cells in the murine prostate
Ontiveros, Christopher S; Salm, Sarah N; Wilson, E Lynette
2008 Sep 1;68(12):1263-1272, Prostate
— id: 84018, year: 2008, vol: 68, page: 1263, stat: Journal Article,

Vascular density is highest in the proximal region of the mouse prostate
Wang, Gui-Min; Kovalenko, Bruce; Wilson, E Lynette; Moscatelli, David
2007 Jun 15;67(9):968-975, Prostate
— id: 72722, year: 2007, vol: 67, page: 968, stat: Journal Article,

Proximal prostatic stem cells are programmed to regenerate a proximal-distal ductal axis
Goto, Ken; Salm, Sarah N; Coetzee, Sandra; Xiong, Xiaozhong; Burger, Patricia E; Shapiro, Ellen; Lepor, Herbert; Moscatelli, David; Wilson, E Lynette
2006 Aug;24(8):1859-1868, Stem cells
— id: 72058, year: 2006, vol: 24, page: 1859, stat: Journal Article,

Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue
Burger, Patricia E; Xiong, Xiaozhong; Coetzee, Sandra; Salm, Sarah N; Moscatelli, David; Goto, Ken; Wilson, E Lynette
2005 May 17;102(20):7180-7185, Proceedings of the National Academy of Sciences of the United States of America
— id: 72723, year: 2005, vol: 102, page: 7180, stat: Journal Article,

TGF-{beta} maintains dormancy of prostatic stem cells in the proximal region of ducts
Salm, Sarah N; Burger, Patricia E; Coetzee, Sandra; Goto, Ken; Moscatelli, David; Wilson, E Lynette
2005 Jul;170(1):81-90, Journal of cell biology
— id: 56205, year: 2005, vol: 170, page: 81, stat: Journal Article,

IMMUNOLOCALIZATION OF ESTROGEN RECEPTOR alpha AND beta IN HUMAN FETAL PROSTATE
Shapiro, Ellen; Huang, Hongying; Masch, Rachel J; McFadden, Deborah E; Wilson, E Lynette; Wu, Xue-Ru
2005 Nov;174(5):2051-2053, Journal of urology
— id: 58459, year: 2005, vol: 174, page: 2051, stat: Journal Article,

Stromal/epithelial interactions of murine prostatic cell lines in vivo: a model for benign prostatic hyperplasia and the effect of doxazosin on tissue size
Takao, Tetsuya; Tsujimura, Akira; Coetzee, Sandra; Salm, Sarah N; Lepor, Herbert; Shapiro, Ellen; Moscatelli, David; Wilson, E Lynette
2003 Jan 1;54(1):17-24, Prostate
— id: 35189, year: 2003, vol: 54, page: 17, stat: Journal Article,

Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells
Burger, Patricia E; Coetzee, Sandra; McKeehan, Wallace L; Kan, Mikio; Cook, Perry; Fan, Yong; Suda, Toshio; Hebbel, Robert P; Novitzky, Nicolas; Muller, William A; Wilson, E Lynette
2002 Nov 15;100(10):3527-3535, Blood
— id: 35190, year: 2002, vol: 100, page: 3527, stat: Journal Article,

Basic fibroblast growth factor modulates the expression of glycophorin A and c-kit and inhibits erythroid differentiation in K562 cells
Burger, Patricia E; Lukey, Pauline T; Coetzee, Sandra; Wilson, E Lynette
2002 Jan;190(1):83-91, Journal of cellular physiology
— id: 35193, year: 2002, vol: 190, page: 83, stat: Journal Article,

Androgens modulate the balance between VEGF and angiopoietin expression in prostate epithelial and smooth muscle cells
Richard, Christian; Kim, Gilbert; Koikawa, Yasuhiro; Salm, Sarah N; Tsujimura, Akira; Wilson, E Lynette; Moscatelli, David
2002 Feb 1;50(2):83-91, Prostate
— id: 35192, year: 2002, vol: 50, page: 83, stat: Journal Article,

Differentiation and stromal-induced growth promotion of murine prostatic tumors
Salm, Sarah N; Takao, Tetsuya; Tsujimura, Akira; Coetzee, Sandra; Moscatelli, David; Wilson, E Lynette
2002 May 15;51(3):175-188, Prostate
— id: 35191, year: 2002, vol: 51, page: 175, stat: Journal Article,

Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
Tsujimura, Akira; Koikawa, Yasuhiro; Salm, Sarah; Takao, Tetsuya; Coetzee, Sandra; Moscatelli, David; Shapiro, Ellen; Lepor, Herbert; Sun, Tung-Tien; Wilson, E Lynette
2002 Jun 24;157(7):1257-1265, Journal of cell biology
— id: 32485, year: 2002, vol: 157, page: 1257, stat: Journal Article,

Generation of active TGF-beta by prostatic cell cocultures using novel basal and luminal prostatic epithelial cell lines
Salm SN; Koikawa Y; Ogilvie V; Tsujimura A; Coetzee S; Moscatelli D; Moore E; Lepor H; Shapiro E; Sun TT; Wilson EL
2000 Jul;184(1):70-79, Journal of cellular physiology
— id: 11685, year: 2000, vol: 184, page: 70, stat: Journal Article,

Transforming growth factor-beta is an autocrine mitogen for a novel androgen-responsive murine prostatic smooth muscle cell line, PSMC1
Salm SN; Koikawa Y; Ogilvie V; Tsujimura A; Coetzee S; Moscatelli D; Moore E; Lepor H; Shapiro E; Sun TT; Wilson EL
2000 Dec;185(3):416-424, Journal of cellular physiology
— id: 26907, year: 2000, vol: 185, page: 416, stat: Journal Article,

Endothelial and primitive hematopoietic cell surface markers are co-expressed on a CD34+population that expresses fibroblast growth factor receptors (FGFRs)
Burger, PE; Coetzee, S; Salm, S; Cook, P; Fan, Y; McKeehan, WL; Kan, M; Suda, T; Hebbel, RP; Novitsky, N; Wilson, EL
1999 NOV 15 ;94(10):464A-464A, Blood
— id: 54779, year: 1999, vol: 94, page: 464A, stat: Journal Article,

Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression
Wilhelm OG; Wilhelm S; Escott GM; Lutz V; Magdolen V; Schmitt M; Rifkin DB; Wilson EL; Graeff H; Brunner G
1999 Aug;180(2):225-235, Journal of cellular physiology
— id: 35194, year: 1999, vol: 180, page: 225, stat: Journal Article,

Isolation and characterization of a CD34+ population that expresses fibroblast growth factor receptors
Burger, PE; Coetzee, S; Cook, P; Fan, Y; McKeehan, WL; Kan, M; Suda, T; Mansveldt, E; Novitsky, N; Wilson, EL
1998 NOV 15 ;92(10):56A-56A, Blood
— id: 53626, year: 1998, vol: 92, page: 56A, stat: Journal Article,

bFGF and TGF-beta have antagonistic effects on c-kit expression in K562 cells
Burger, PE; Buhring, HJ; Gowans, A; Wilson, EL
1997 NOV 15 ;90(10):3520-3520, Blood
— id: 53134, year: 1997, vol: 90, page: 3520, stat: Journal Article,

Enhanced expression of fibroblast growth factor receptors (FGF-Rs) on K562 cells during the S/G2/M phase of the cell cycle compared to the G1 phase
Coetzee, S; Hirst, J; McKeehan, WL; Kan, M; Burger, PE; Wilson, EL
1997 NOV 15 ;90(10):1409-1409, Blood
— id: 53145, year: 1997, vol: 90, page: 1409, stat: Journal Article,

Urokinase-type plasminogen activator-deficient mice are predisposed to staphylococcal botryomycosis, pleuritis, and effacement of lymphoid follicles
Shapiro RL; Duquette JG; Nunes I; Roses DF; Harris MN; Wilson EL; Rifkin DB
1997 Jan;150(1):359-369, American journal of pathology
— id: 12426, year: 1997, vol: 150, page: 359, stat: Journal Article,

Inhibition of glycosylphosphatidylinositol (GPI) phospholipase D by suramin-like compounds
Brunner G; Zalkow L; Burgess E; Rifkin DB; Wilson EL; Gruszecka-Kowalik E; Powis G
1996 Sep-Oct;16(5A):2513-2516, Anticancer research
— id: 12546, year: 1996, vol: 16, page: 2513, stat: Journal Article,

Fibroblast growth factors promote a primitive phenotype in K562 cells
Burger, PE; Wilson, EL
1996 NOV 15 ;88(10):3179-3179, Blood
— id: 52696, year: 1996, vol: 88, page: 3179, stat: Journal Article,

The regulation of TGF-beta activity by hematopoietic cells
Coetzee, S; Burger, P; Rifkin, D; Wilson, EL
1996 NOV 15 ;88(10):2150-2150, Blood
— id: 52712, year: 1996, vol: 88, page: 2150, stat: Journal Article,

Elevated intracellular level of basic fibroblast growth factor correlates with stage of chronic lymphocytic leukemia and is associated with resistance to fludarabine
Menzel T; Rahman Z; Calleja E; White K; Wilson EL; Wieder R; Gabrilove J
1996 Feb 1;87(3):1056-1063, Blood
— id: 35195, year: 1996, vol: 87, page: 1056, stat: Journal Article,

Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild-type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals
Shapiro RL; Duquette JG; Roses DF; Nunes I; Harris MN; Kamino H; Wilson EL; Rifkin DB
1996 Aug 1;56(15):3597-3604, Cancer research
— id: 12575, year: 1996, vol: 56, page: 3597, stat: Journal Article,

bFGF and TGF-beta exert antagonistic effects on erythroid differentiation in K562 cells
Burger, PE; Lukey, PT; Wilson, EL
1995 NOV 15 ;86(10):560-560, Blood
— id: 129599, year: 1995, vol: 86, page: 560, stat: Journal Article,

Basic fibroblast growth factor (bFGF) transfected stromal cells promote the growth of Dami leukemic cells
Ogilvie, V; Coetzee, S; Rifkin, D; Quesenberry, P; Wilson, EL
1995 NOV 15 ;86(10):1229-1229, Blood
— id: 53118, year: 1995, vol: 86, page: 1229, stat: Journal Article,

An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures
Brunner G; Metz CN; Nguyen H; Gabrilove J; Patel SR; Davitz MA; Rifkin DB; Wilson EL
1994 Apr 15;83(8):2115-2125, Blood
— id: 56502, year: 1994, vol: 83, page: 2115, stat: Journal Article,

GROWTH-FACTOR REGULATION OF THE GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)-SPECIFIC PHOSPHOLIPASE-D IN BONE-MARROW STROMAL CELLS
BRUNNER, G; GULATI, M; GABRILOVE, JL; RIFKIN, DB; WILSON, EL
1994 NOV 15 ;84(10):A564-A564, Blood
— id: 52291, year: 1994, vol: 84, page: A564, stat: Journal Article,

Basic fibroblast growth factor antagonizes transforming growth factor beta-mediated erythroid differentiation in K562 cells
Burger PE; Dowdle EB; Lukey PT; Wilson EL
1994 Apr 1;83(7):1808-1812, Blood
— id: 57512, year: 1994, vol: 83, page: 1808, stat: Journal Article,

BASIC FIBROBLAST GROWTH-FACTOR DECREASES EXPRESSION OF GLYCOPHORIN-A ON K562 CELLS
BURGER, PE; LUKEY, PT; WILSON EL
1994 NOV 15 ;84(10):A420-A420, Blood
— id: 129598, year: 1994, vol: 84, page: A420, stat: Journal Article,

BASIC FIBROBLAST GROWTH-FACTOR (BFGF) TRANSFECTED STROMAL CELLS SUPPORT SURVIVAL OF MO7E CELLS
COETZEE, S; OGILVIE, V; BRUNNER, G; QUARTO, N; RIFKIN, D; QUESENBERRY, P; WILSON, EL
1994 NOV 15 ;84(10):A279-A279, Blood
— id: 52284, year: 1994, vol: 84, page: A279, stat: Journal Article,

Stem cell factor and basic fibroblast growth factor are synergistic in augmenting committed myeloid progenitor cell growth
Gabrilove JL; White K; Rahman Z; Wilson EL
1994 Feb 15;83(4):907-910, Blood
— id: 57424, year: 1994, vol: 83, page: 907, stat: Journal Article,

Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase D
Metz CN; Brunner G; Choi-Miura NH; Nguyen H; Gabrilove J; Caras IW; Altszuler N; Rifkin DB; Wilson EL; Davitz MA
1994 Apr 1;13(7):1741-1751, EMBO journal
— id: 7885, year: 1994, vol: 13, page: 1741, stat: Journal Article,

Mechanism of action of angiostatic steroids: suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis
Blei F; Wilson EL; Mignatti P; Rifkin DB
1993 Jun;155(3):568-578, Journal of cellular physiology
— id: 8234, year: 1993, vol: 155, page: 568, stat: Journal Article,

Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells
Brunner G; Nguyen H; Gabrilove J; Rifkin DB; Wilson EL
1993 Feb 1;81(3):631-638, Blood
— id: 13270, year: 1993, vol: 81, page: 631, stat: Journal Article,

MOBILIZATION OF BFGF-PROTEOGLYCAN COMPLEXES IN HUMAN BONE-MARROW CULTURES BY A GPI-SPECIFIC PHOSPHOLIPASE-D
BRUNNER, G; NGUYEN, H; RIFKIN, DB; GABRILOVE, J; WILSON, EL
1993 NOV 15 ;82(10):A370-A370, Blood
— id: 52146, year: 1993, vol: 82, page: A370, stat: Journal Article,

Basic fibroblast growth factor promotes the proliferation of human megakaryocyte progenitor cells
Bruno E; Cooper RJ; Wilson EL; Gabrilove JL; Hoffman R
1993 Jul 15;82(2):430-435, Blood
— id: 35196, year: 1993, vol: 82, page: 430, stat: Journal Article,

ROLE OF HEPARAN-SULFATE IN MODULATING HUMAN HEMATOPOIETIC STEM-CELL ATTACHMENT TO CYTOKINES AND EXTRACELLULAR-MATRIX MOLECULES
BRUNO, E; GUSCAR, TK; LUIKART, SD; WILSON, EL; DIXIT, V; LONG, MW; HOFFMAN, R
1993 NOV 15 ;82(10):A21-A21, Blood
— id: 52139, year: 1993, vol: 82, page: A21, stat: Journal Article,

BASIC FIBROBLAST GROWTH-FACTOR ANTAGONIZES TRANSFORMING GROWTH-FACTOR BETA-MEDIATED ERYTHROID-DIFFERENTIATION IN K562 CELLS
BURGER, PE; DOWDLE, EB; WILSON, EL
1993 NOV 15 ;82(10):A99-A99, Blood
— id: 52140, year: 1993, vol: 82, page: A99, stat: Journal Article,

BASIC FIBROBLAST GROWTH-FACTOR STIMULATES PROLIFERATION OF MURINE BONE-MARROW STROMAL CELLS IN THE ABSENCE OF SERUM
COETZEE, S; BRUNNER, G; MOSCATELLI, D; QUESENBERRY, P; WILSON, EL
1993 NOV 15 ;82(10):A496-A496, Blood
— id: 52148, year: 1993, vol: 82, page: A496, stat: Journal Article,

BASIC FIBROBLAST GROWTH-FACTOR AUGMENTS THE GM-CSF-DEPENDENT GROWTH OF MO7 CELLS
COETZEE, S; MOSCATELLI, D; LIUZZO, J; GABRILOVE, J; WILSON, EL
1993 NOV 15 ;82(10):A236-A236, Blood
— id: 52144, year: 1993, vol: 82, page: A236, stat: Journal Article,

Basic fibroblast growth factor counteracts the suppressive effect of transforming growth factor-beta 1 on human myeloid progenitor cells
Gabrilove JL; Wong G; Bollenbacher E; White K; Kojima S; Wilson EL
1993 Feb 15;81(4):909-915, Blood
— id: 35197, year: 1993, vol: 81, page: 909, stat: Journal Article,

PHOSPHOLIPASE-C RELEASE OF BIOLOGICALLY-ACTIVE BASIC FIBROBLAST GROWTH FACTOR-HEPARAN SULFATE PROTEOGLYCAN COMPLEXES FROM HUMAN BONE-MARROW CULTURES
BRUNNER, G; GABRILOVE, J; RIFKIN, DB; WILSON, EL
1992 JAN ;20(1):107-107, Experimental hematology
— id: 52124, year: 1992, vol: 20, page: 107, stat: Journal Article,

RECOMBINANT HUMAN BASIC FIBROBLAST GROWTH-FACTOR AFFECTS THE PROLIFERATION OF HUMAN MEGAKARYOCYTE PROGENITOR CELLS
BRUNO, E; COOPER, RJ; WILSON, EL; GABRILOVE, JL; HOFFMAN, R
1992 JUL ;20(6):823-823, Experimental hematology
— id: 51935, year: 1992, vol: 20, page: 823, stat: Journal Article,

Unusual growth characteristics of human melanoma xenografts in the nude mouse: a model for desmoplasia, dormancy and progression
Gartner MF; Fearns C; Wilson EL; Campbell JA; Dowdle EB
1992 Apr;65(4):487-490, British journal of cancer
— id: 35199, year: 1992, vol: 65, page: 487, stat: Journal Article,

Fibroblast-dependent tumorigenicity of melanoma xenografts in athymic mice
Gartner MF; Wilson EL; Dowdle EB
1992 Jul 9;51(5):788-791, International journal of cancer
— id: 35198, year: 1992, vol: 51, page: 788, stat: Journal Article,

Regulation of proteolytic activity in human bone marrow stromal cells by basic fibroblast growth factor, interleukin-1, and transforming growth factor beta
Hannocks MJ; Oliver L; Gabrilove JL; Wilson EL
1992 Mar 1;79(5):1178-1184, Blood
— id: 13681, year: 1992, vol: 79, page: 1178, stat: Journal Article,

THE REGULATION OF PLASMINOGEN-ACTIVATOR ACTIVITY IN HUMAN BONE-MARROW STROMAL CELLS
HANNOCKS, MJ; RIFKIN, DB; OLIVER, L; GABRILOVE, J; WILSON, EL
1992 JAN ;20(1):108-108, Experimental hematology
— id: 52125, year: 1992, vol: 20, page: 108, stat: Journal Article,

SECRETION OF PLASMINOGEN ACTIVATORS BY NORMAL BONE-MARROW CELLS AND LEUKEMIC MYELOID CELLS
WILSON, EL; JACOBS, P; FRANCIS, GE; OLIVER, L; BURGER, P; DOWDLE, EB
1992 JAN ;6(3):77-79, Fibrinolysis
— id: 52104, year: 1992, vol: 6, page: 77, stat: Journal Article,

ANGIOSTATIC STEROIDS INHIBIT ENDOTHELIAL-CELL PLASMINOGEN-ACTIVATOR ACTIVITY
BLEI, F; WILSON, EL; RIFKIN, DB
1991 APR ;29(4):A137-A137, Pediatric research
— id: 51662, year: 1991, vol: 29, page: A137, stat: Journal Article,

Phospholipase C release of basic fibroblast growth factor from human bone marrow cultures as a biologically active complex with a phosphatidylinositol-anchored heparan sulfate proteoglycan
Brunner G; Gabrilove J; Rifkin DB; Wilson EL
1991 Sep;114(6):1275-1283, Journal of cell biology
— id: 13933, year: 1991, vol: 114, page: 1275, stat: Journal Article,

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse
Ossowski L; Russo-Payne H; Wilson EL
1991 Jan 1;51(1):274-281, Cancer research
— id: 35200, year: 1991, vol: 51, page: 274, stat: Journal Article,

Basic fibroblast growth factor stimulates myelopoiesis in long-term human bone marrow cultures
Wilson EL; Rifkin DB; Kelly F; Hannocks MJ; Gabrilove JL
1991 Mar 1;77(5):954-960, Blood
— id: 57423, year: 1991, vol: 77, page: 954, stat: Journal Article,

Chemotherapy of adult acute nonlymphoblastic leukaemia
Jacobs P; Martell RW; Wilson EL
1990 ;23(1):27-40, Haematologia (Budapest)
— id: 35204, year: 1990, vol: 23, page: 27, stat: Journal Article,

A prospective analysis of prognostic factors in the myelodysplastic syndromes
Knottenbelt E; Jacobs P; Wilson EL
1990 Jan 20;77(2):69-74, South African medical journal
— id: 35202, year: 1990, vol: 77, page: 69, stat: Journal Article,

Long-term culture of human bone marrow stromal cells in the presence of basic fibroblast growth factor
Oliver LJ; Rifkin DB; Gabrilove J; Hannocks MJ; Wilson EL
1990 ;3(3):231-236, Growth factors
— id: 35203, year: 1990, vol: 3, page: 231, stat: Journal Article,

Regulation and secretion of plasminogen activators and their inhibitors in a human leukemic cell line (K562)
Oliver LJ; Keeton M; Wilson EL
1989 Sep;74(4):1321-1327, Blood
— id: 10518, year: 1989, vol: 74, page: 1321, stat: Journal Article,

Abortion
Wilson EL
1989 Summer;7(2):55-58, Health matrix
— id: 35201, year: 1989, vol: 7, page: 55, stat: Journal Article,

Metastasis of a human melanoma cell line in the nude mouse
Wilson EL; Gartner MF; Campbell JA; Dowdle EB
1988 Jan 15;41(1):83-86, International journal of cancer
— id: 35205, year: 1988, vol: 41, page: 83, stat: Journal Article,

Evidence for the involvement of DNA topoisomerase II in neutrophil-granulocyte differentiation
Francis GE; Berney JJ; North PS; Khan Z; Wilson EL; Jacobs P; Ali M
1987 Sep;1(9):653-659, Leukemia
— id: 35207, year: 1987, vol: 1, page: 653, stat: Journal Article,

Growth of a human carcinoma (HEp3) in nude mice: rapid and efficient metastasis
Ossowski L; Russo H; Gartner M; Wilson EL
1987 Nov;133(2):288-296, Journal of cellular physiology
— id: 35206, year: 1987, vol: 133, page: 288, stat: Journal Article,

Differentiation-linked secretion of urokinase and tissue plasminogen activator by normal human hemopoietic cells
Wilson EL; Francis GE
1987 Jun 1;165(6):1609-1623, Journal of experimental medicine
— id: 35208, year: 1987, vol: 165, page: 1609, stat: Journal Article,

The secretion of plasminogen activators by human bone marrow progenitor cells
Wilson EL; Francis GE
1987 ;31(6):181-184, Haematology & blood transfusion
— id: 35209, year: 1987, vol: 31, page: 181, stat: Journal Article,

Hormonal regulation of extracellular plasminogen activators and Mr approximately 54,000 plasminogen activator inhibitor in human neoplastic cell lines, studied with monoclonal antibodies
Andreasen PA; Christensen TH; Huang JY; Nielsen LS; Wilson EL; Dano K
1986 May;45(2-3):137-147, Molecular & cellular endocrinology
— id: 35211, year: 1986, vol: 45, page: 137, stat: Journal Article,

Characterization of seven human melanoma cell lines: melanogenesis and secretion of plasminogen activators
Hoal-Van Helden EG; Wilson EL; Dowdle EB
1986 Aug;54(2):287-295, British journal of cancer
— id: 35210, year: 1986, vol: 54, page: 287, stat: Journal Article,

Plasminogen activator as a prognostic factor in hematological malignancies
Wilson EL; Jacobs P; Oliver L
1985 ;29(2-3):197-199, Haematology & blood transfusion
— id: 35212, year: 1985, vol: 29, page: 197, stat: Journal Article,

The regulation of tissue plasminogen activator activity by human fibroblasts
Hoal EG; Wilson EL; Dowdle EB
1983 Aug;34(1):273-279, Cell
— id: 35213, year: 1983, vol: 34, page: 273, stat: Journal Article,

Secretion of plasminogen activators by human myeloid leukemic cells: modulation and therapeutic correlations
Wilson EL; Jacobs P; Dowdle EB
1983 ;28(3):78-80, Haematology & blood transfusion
— id: 35216, year: 1983, vol: 28, page: 78, stat: Journal Article,

The effects of dexamethasone and tetradecanoyl phorbol acetate on plasminogen activator release by human acute myeloid leukemia cells
Wilson EL; Jacobs P; Dowdle EB
1983 Mar;61(3):561-567, Blood
— id: 35215, year: 1983, vol: 61, page: 561, stat: Journal Article,

The secretion of plasminogen activators by human myeloid leukemic cells in vitro
Wilson EL; Jacobs P; Dowdle EB
1983 Mar;61(3):568-574, Blood
— id: 35214, year: 1983, vol: 61, page: 568, stat: Journal Article,

Plasminogen activating enzyme in cultured glioblastoma cells. An immunofluorescence study with monoclonal antibody
Dano K; Dabelsteen E; Nielsen LS; Kaltoft K; Wilson EL; Zeuthen J
1982 Nov;30(11):1165-1170, Journal of histochemistry & cytochemistry
— id: 35219, year: 1982, vol: 30, page: 1165, stat: Journal Article,

Variable effects of retinoids on two pigmenting human melanoma cell lines
Hoal E; Wilson EL; Dowdle EB
1982 Dec;42(12):5191-5195, Cancer research
— id: 35218, year: 1982, vol: 42, page: 5191, stat: Journal Article,

Purification of zymogen to plasminogen activator from human glioblastoma cells by affinity chromatography with monoclonal antibody
Nielsen LS; Hansen JG; Skriver L; Wilson EL; Kaltoft K; Zeuthen J; Dano K
1982 Dec 7;21(25):6410-6415, Biochemistry
— id: 35217, year: 1982, vol: 21, page: 6410, stat: Journal Article,

Colorimetric assay of urinary 5-hydroxy-3-indoleacetic acid
Shihabi ZK; Wilson EL
1982 Apr;15(2):106-108, Clinical biochemistry
— id: 35220, year: 1982, vol: 15, page: 106, stat: Journal Article,

Challenges in preventive medicine and public health: the health status of refugees from Indochina
Flynn JP; Sorley DL; Wilson EL
1980 May;29(5):60-63, Maryland state medical journal
— id: 35222, year: 1980, vol: 29, page: 60, stat: Journal Article,

Molecular species of plasminogen activators secreted by normal and neoplastic human cells
Wilson EL; Becker ML; Hoal EG; Dowdle EB
1980 Mar;40(3):933-938, Cancer research
— id: 35223, year: 1980, vol: 40, page: 933, stat: Journal Article,

Effects of retinoids on normal and neoplastic human cells cultured in vitro
Wilson EL; Dowdle EB
1980 Dec;40(12):4817-4820, Cancer research
— id: 35221, year: 1980, vol: 40, page: 4817, stat: Journal Article,

Effect of vitamin A on plasminogen activator synthesis by chick embryo fibroblasts
Wilson EL; Reich E
1979 ;23(5):319-323, Haematology & blood transfusion
— id: 35225, year: 1979, vol: 23, page: 319, stat: Journal Article,

Modulation of plasminogen activator synthesis in chick embryo fibroblasts by cyclic nucleotides and phorobol myristate acetate
Wilson EL; Reich E
1979 May;39(5):1579-1586, Cancer research
— id: 35224, year: 1979, vol: 39, page: 1579, stat: Journal Article,

Secretion of plasminogen activator by normal, reactive and neoplastic human tissues cultured in vitro
Wilson EL; Dowdle E
1978 Oct 15;22(4):390-399, International journal of cancer
— id: 35226, year: 1978, vol: 22, page: 390, stat: Journal Article,

Plasminogen activator in chick fibroblasts: induction of synthesis by retinoic acid; synergism with viral transformation and phorbol ester
Wilson EL; Reich E
1978 Oct;15(2):385-392, Cell
— id: 35227, year: 1978, vol: 15, page: 385, stat: Journal Article,

Evaluation of the use of resonant frequencies to characterize physical properties of human long bones
Dhoerty WP; Bovill EG; Wilson EL
1974 Nov;7(6):559-561, Journal of biomechanics
— id: 35228, year: 1974, vol: 7, page: 559, stat: Journal Article,

Beef-liver 5-aminolevulinic acid dehydratase. Purification and properties
Wilson EL; Burger PE; Dowdle EB
1972 Sep 25;29(3):563-571, European journal of biochemistry
— id: 35229, year: 1972, vol: 29, page: 563, stat: Journal Article,

Isolation and purification of ala-dehydratase
Wilson, E L; Dowdle, E B; Burger, P
1971 Sep 25;29(3):178-180, South African medical journal
— id: 35230, year: 1971, vol: 29, page: 178, stat: Journal Article,

Vaginal mucification induced by pituitary prolactin and placental lactogen in mice. A luteotrophic test for protein hormone preparations
Josimovich JB; Wilson EL; Leff A
1970 ;1(4):210-221, Gynecologic investigation
— id: 56386, year: 1970, vol: 1, page: 210, stat: Journal Article,

The clinical laboratory improvement program in New York City. I. Methods of evaluation and results of performance tests
Schaeffer, M; Widelock, D; Blatt, S; Wilson, E
1967 Apr;4(2):72-89, Health laboratory science
— id: 170063, year: 1967, vol: 4, page: 72, stat: Journal Article,