Biosketch / Results /

Michael Bruce Whitlow, M.D., Ph.D, Ph.D.

Clinical Associate Professor;
Ronald O. Perelman Department of Dermatology

Clinical Addresses

635 Madison Avenue
New York, NY 10022
Hours: Mon. 9 - 6; Tue. 9 - 6; Wed. 9:30 - 6; Thu. 9 - 6; Fri. 9 - 6
Phone: 212-753-5382

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Medical Specialties

Dermatology

Medical Expertise

Sclerotherapy, Dermatologic Surgery, Aids Associated Dermatology, African American Skin Diseases, General Dermatology

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO/EPO, CIGNA EPO/POS, Cigna PPO, NYS EMPIRE PLAN, UHC EPO, UHC HMO, UHC POS, UHC PPO, UHC TOP TIER

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

1988 — Ab Dermatology - Dermatology
1989 — Ab Dermatology (Clinical & Lab Dermatological Immu)

Education

1984 — Johns Hopkins University, Medical Education
1984-1985 — Francis Scott Key Medical Center (Medical), Internship
1984-1988 — NYU Medical Center, Residency Training

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Research Summary

Our goal is to better understand how the terminal complement proteins damage cell membranes and how cells protect themselves from such complement damage. Complement-induced membrane damage is mediated by the terminal complement proteins C5- C9. When activated, these terminal complement proteins form transmembrane channels in the membrane of nearby cells. We found that complement channels are not formed randomly but within membrane domains. If complement preferentially localizes to membrane domains, a receptor must be within the domains for one or more of the terminal complement proteins. As the initial interaction between the terminal complement proteins and the membrane occurs with C5b6, this complex is the most likely ligand of such a receptor.

We identified these molecules on the erythrocyte surface that the terminal complement proteins bind to: anionic phospholipids, gangliosides, and sialic acid present on glycophorin. We have also shown that the stage of complement channel formation at which this interaction occurs is at the stage of C5b6 binding to the membrane. The focus of our research now is to understand how C5b6 interacts with these anionic molecules and to use this information to develop soluble inhibitors of the terminal complement proteins. This work is clinically important because the terminal complement proteins are a primary focus in the destruction of xenogeneic grafts, i.e., grafts between species. Inhibitors such as the ones we are developing may increase the ability of these xenografts to be used in transplantation.

Research Interests

Interaction Terminal Complement Proteins with Cell Membranes

Research Keywords

complement, inflammation, membrane damage, lipid-protein interaction

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Scleredema diabeticorum
Tran, Kathleen; Boyd, Kevin P; Robinson, Maria R; Whitlow, Michael
2013 Dec;19(12):20718-20718, Dermatology online journal
— id: 806772, year: 2013, vol: 19, page: 20718, stat: Journal Article,

Proliferating trichilemmal cyst with focal calcification
Anolik, Robert; Firoz, Bahar; Walters, Ruth F; Meehan, Shane A; Tsou, Hui C; Whitlow, Michael; Wainwright, Brent
2008 ;14(10):25-25, Dermatology online journal
— id: 95417, year: 2008, vol: 14, page: 25, stat: Journal Article,

Pyoderma gangrenosum
Kim L; Whitlow M
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3753, year: 2001, vol: , page: 184, stat: Chapter,

Aquatic dermatology
Whitlow M
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3678, year: 2001, vol: , page: 16, stat: Chapter,

Interaction between terminal complement proteins C5b-7 and anionic phospholipids
Liu C; Marshall P; Schreibman I; Vu A; Gai W; Whitlow M
1999 Apr 1;93(7):2297-2301, Blood
— id: 56412, year: 1999, vol: 93, page: 2297, stat: Journal Article,

Response of SCC-12F, a human squamous cell carcinoma cell line, to complement attack
Whitlow MB; Klein LM
1997 Jul;109(1):39-45, Journal of investigative dermatology
— id: 7280, year: 1997, vol: 109, page: 39, stat: Journal Article,

Interaction between complement proteins C5b-7 and erythrocyte membrane sialic acid
Marshall P; Hasegawa A; Davidson EA; Nussenzweig V; Whitlow M
1996 Oct 1;184(4):1225-1232, Journal of experimental medicine
— id: 61953, year: 1996, vol: 184, page: 1225, stat: Journal Article,

Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules 1
Lozada C; Levin RI; Huie M; Hirschhorn R; Naime D; Whitlow M; Recht PA; Golden B; Cronstein BN
1995 Aug 29;92(18):8378-8382, Proceedings of the National Academy of Sciences of the United States of America
— id: 7927, year: 1995, vol: 92, page: 8378, stat: Journal Article,

INTERACTION OF THE TERMINAL COMPLEMENT PROTEINS WITH SIALIC-ACID CONTAINING MOLECULES OF THE ERYTHROCYTE
WHITLOW, M; MARSHALL, P
1995 DEC ;105(6):873-873, Journal of investigative dermatology
— id: 52661, year: 1995, vol: 105, page: 873, stat: Journal Article,

New York University therapeutic roundtable: a panel of experts answer questions on the treatment of challenging cases
Shupack JL; Kanof N; Stolman LP; Vogel L; Whitlow M; Cohen DE; Washenik K; Lee MP; Stiller MJ
1994 Jul;54(1):29-33, Cutis
— id: 6750, year: 1994, vol: 54, page: 29, stat: Journal Article,

A synthetic peptide from complement protein C9 binds to CD59 and enhances lysis of human erythrocytes by C5b-9
Tomlinson S; Whitlow MB; Nussenzweig V
1994 Feb 15;152(4):1927-1934, Journal of immunology (1950)
— id: 7888, year: 1994, vol: 152, page: 1927, stat: Journal Article,

RESPONSE OF HUMAN KERATINOCYTES TO COMPLEMENT ATTACK
WHITLOW, MB; KLEIN, LM
1994 OCT ;42(3):A454-A454, Clinical research
— id: 52382, year: 1994, vol: 42, page: A454, stat: Journal Article,

RESPONSE OF HUMAN KERATINOCYTES TO COMPLEMENT ATTACK
KLEIN, LM; WHITLOW, MB
1993 APR ;100(4):574-574, Journal of investigative dermatology
— id: 54250, year: 1993, vol: 100, page: 574, stat: Journal Article,

RESPONSE OF HUMAN KERATINOCYTES TO COMPLEMENT ATTACK
KLEIN, M; WHITLOW, MB
1993 APR ;41(2):A470-A470, Clinical research
— id: 54296, year: 1993, vol: 41, page: A470, stat: Journal Article,

Cells lacking glycan phosphatidylinositol-linked proteins have impaired ability to vesiculate
Whitlow M; Iida K; Marshall P; Silber R; Nussenzweig V
1993 Jan 15;81(2):510-516, Blood
— id: 61955, year: 1993, vol: 81, page: 510, stat: Journal Article,

CELLS LACKING GLYCAN PHOSPHATIDYLINOSITOL-LINKED PROTEINS HAVE IMPAIRED ABILITY TO VESICULATE
WHITLOW, M; IIDA, K; MARSHALL, P; SILBER, R; ROSSE, W; NUSSENZWEIG, V
1992 APR ;40(2):A242-A242, Clinical research
— id: 51986, year: 1992, vol: 40, page: A242, stat: Journal Article,

Preferential expression of human Fc gamma RIIIPMN (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins
Edberg JC; Salmon JE; Whitlow M; Kimberly RP
1991 Jan;87(1):58-67, Journal of clinical investigation
— id: 57475, year: 1991, vol: 87, page: 58, stat: Journal Article,

Membrane vesiculation protects erythrocytes from destruction by complement
Iida K; Whitlow MB; Nussenzweig V
1991 Oct 15;147(8):2638-2642, Journal of immunology (1950)
— id: 8319, year: 1991, vol: 147, page: 2638, stat: Journal Article,

H19, a surface membrane molecule involved in T-cell activation, inhibits channel formation by human complement
Whitlow MB; Iida K; Stefanova I; Bernard A; Nussenzweig V
1990 Mar;126(1):176-184, Cellular immunology
— id: 8318, year: 1990, vol: 126, page: 176, stat: Journal Article,

Secretion by Trypanosoma cruzi of a hemolysin active at low pH
Andrews NW; Whitlow MB
1989 Mar 15;33(3):249-256, Molecular & biochemical parasitology
— id: 10698, year: 1989, vol: 33, page: 249, stat: Journal Article,

Amastigotes of Trypanosoma cruzi escape destruction by the terminal complement components
Iida K; Whitlow MB; Nussenzweig V
1989 Mar 1;169(3):881-891, Journal of experimental medicine
— id: 10718, year: 1989, vol: 169, page: 881, stat: Journal Article,

Trypanosoma cruzi: mechanisms of cell-invasion and intracellular survival
Andrews NW; Schenkman S; Ley V; Whitlow MB; Robbins ES; Nussenzweig V
1988 Nov;83 Suppl 1:452-455, Memorias do Instituto Oswaldo Cruz
— id: 10908, year: 1988, vol: 83 Suppl 1, page: 452, stat: Journal Article,

EFFICIENCY OF CHANNEL FORMATION BY COMPLEMENT AS MEASURED BY PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA ERYTHROCYTES
Whitlow, MB; Iida, K; Nussenzweig, V
1988 Apr;36(3):A704-A704, Clinical research
— id: 31525, year: 1988, vol: 36, page: A704, stat: Journal Article,

EFFICIENCY OF CHANNEL FORMATION BY COMPLEMENT AS MEASURED ON PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA ERYTHROCYTES
Whitlow, MB; Iida, K; Nussenzweig, V
1988 Apr;90(4):617-617, Journal of investigative dermatology
— id: 31535, year: 1988, vol: 90, page: 617, stat: Journal Article,

EFFICIENCY OF CHANNEL FORMATION BY COMPLEMENT ON PAROXYSMAL- NOCTURNAL HEMOGLOBINURIA ERYTHROCYTES
Whitlow, MB; Iida, K; Nussenzweig, V
1988 Mar 25;2(6):A1643-A1643, FASEB journal
— id: 31527, year: 1988, vol: 2, page: A1643, stat: Journal Article,

The relationship between channel size and the number of C9 molecules in the C5b-9 complex
Ramm LE; Whitlow MB; Mayer MM
1985 Apr;134(4):2594-2599, Journal of immunology (1950)
— id: 17056, year: 1985, vol: 134, page: 2594, stat: Journal Article,

Penetration of C8 and C9 in the C5b-9 complex across the erythrocyte membrane into the cytoplasmic space
Whitlow MB; Ramm LE; Mayer MM
1985 Jan 25;260(2):998-1005, Journal of biological chemistry
— id: 17057, year: 1985, vol: 260, page: 998, stat: Journal Article,

Complement lysis of nucleated cells: effect of temperature and puromycin on the number of channels required for cytolysis
Ramm LE; Whitlow MB; Mayer MM
1984 Nov;21(11):1015-1021, Molecular immunology
— id: 17058, year: 1984, vol: 21, page: 1015, stat: Journal Article,

Elimination of complement channels from the plasma membranes of U937, a nucleated mammalian cell line: temperature dependence of the elimination rate
Ramm LE; Whitlow MB; Koski CL; Shin ML; Mayer MM
1983 Sep;131(3):1411-1415, Journal of immunology (1950)
— id: 17059, year: 1983, vol: 131, page: 1411, stat: Journal Article,

Size distribution and stability of the trans-membrane channels formed by complement complex C5b-9
Ramm LE; Whitlow MB; Mayer MM
1983 Feb;20(2):155-160, Molecular immunology
— id: 17060, year: 1983, vol: 20, page: 155, stat: Journal Article,

Size of the transmembrane channels produced by complement proteins C5b-8
Ramm LE; Whitlow MB; Mayer MM
1982 Sep;129(3):1143-1146, Journal of immunology (1950)
— id: 17061, year: 1982, vol: 129, page: 1143, stat: Journal Article,

Transmembrane channel formation by complement: functional analysis of the number of C5b6, C7, C8, and C9 molecules required for a single channel
Ramm LE; Whitlow MB; Mayer MM
1982 Aug;79(15):4751-4755, Proceedings of the National Academy of Sciences of the United States of America
— id: 17062, year: 1982, vol: 79, page: 4751, stat: Journal Article,