Edwin C Weiss, M.D.

Cardiac troponin T is not increased in patients with hypothyroidism
Ness-Abramof, R; Nabriski, D A; Shapiro, M S; Tripto-Shkolnik, L; Katz, B; Weiss, E; Shenkman, L
2009 Feb;39(2):117-120, Internal medicine journal
Patients with hypothyroidism often have increased creatine kinase (CK) levels. It is possible that there is increased production of CK, but other mechanisms, such as an increased cell membrane permeability or decreased enzyme clearance were also proposed. Recently, troponins T and I have been extensively studied because of their cardiac specificity. Cardiac troponins are sensitive and specific markers of cardiac injury. The objective of the study was to measure cardiac troponin T (cTnT) levels in patients with hypothyroidism. Twenty-five patients with primary hypothyroidism were evaluated (thyroid-stimulating hormone (TSH) >30 mU/L and low FT(4)). In all patients thyrotropin (TSH), free thyroxine (FT(4)), CK, CK-MB and cTnT were measured.There were 3 men and 22 women with a mean age of 47.5 +/- 12.4 years. TSH levels ranged from 31 to 75 mIU/L and mean FT(4) levels were 4.5 +/- 1.9 pmol/L. CK was normal in 11 patients and increased in 14. CK levels ranged between 86 and 1221 U/L (normal levels <170 in women, <195 in men) with a mean of 322 U/L +/- 279. CK-MB was increased in 4 patients (16%) and normal in 21. All 25 patients had normal cTnT levels, < 0.01 ng/mL (normal levels 0-0.1 microg/L). Increase in CK and its MB fraction are common in patients with hypothyroidism but cTnT levels are not, even in patients with increased CK-MB. Therefore, cTnT is a reliable marker of cardiac injury even in the hypothyroid patient
— id: 146850, year: 2009, vol: 39, page: 117, stat: Journal Article,

Prevalence and evaluation of B12 deficiency in patients with autoimmune thyroid disease
Ness-Abramof, Rosane; Nabriski, Dan A; Braverman, Lewis E; Shilo, Lotan; Weiss, Eliahu; Reshef, Tamar; Shapiro, Menachem S; Shenkman, Louis
2006 Sep;332(3):119-122, American journal of the medical sciences
BACKGROUND: Patients with autoimmune thyroid disease (AITD) have a higher prevalence of pernicious anemia compared with the general population. Clinical signs of B12 deficiency may be subtle and missed, particularly in patients with known autoimmune disease. We assessed the prevalence of vitamin B12 deficiency in patients with AITD and whether their evaluation may be simplified by measuring fasting gastrin levels. METHODS: Serum B12 levels was measured in 115 patients with AITD (7 men and 108 women), with a mean age of 47 +/- 15 years. In patients with low serum B12 levels (< or =133 pmol/L), fasting serum gastrin and parietal cell antibodies (PCA) were measured. RESULTS: Thirty-two patients (28%) with AITD had low B12 levels. Fasting serum gastrin was measured in 26 and was higher than normal in 8 patients. PCA were also measured in 27 patients with B12 deficiency and were positive in 8 patients. Five patients with high gastrin levels underwent gastroscopy with biopsy, and atrophic gastritis was diagnosed in all. The prevalence of pernicious anemia as assessed by high serum gastrin levels in patients with low B12 was 31%. CONCLUSIONS: Patients with AITD have a high prevalence of B12 deficiency and particularly of pernicious anemia. The evaluation of B12 deficiency can be simplified by measuring fasting serum gastrin and, if elevated, referring the patient for gastroscopy
— id: 146840, year: 2006, vol: 332, page: 119, stat: Journal Article,

Overnight dexamethasone suppression test: a reliable screen for Cushing's syndrome in the obese
Ness-Abramof, Rosane; Nabriski, Dan; Apovian, Caroline M; Niven, Mark; Weiss, Eliahu; Shapiro, Menachem S; Shenkman, Louis
2002 Dec;10(12):1217-1221, Obesity research
OBJECTIVE: Reevaluation of the validity of the 1-mg overnight dexamethasone suppression test (ODST) as a screening test for Cushing's syndrome in obese patients. RESEARCH METHODS AND PROCEDURES: Eighty-six obese patients (body mass index, 30 to 53 kg/m(2)) that were referred to a general endocrine outpatient clinic for evaluation of simple obesity, diabetes mellitus, hypertension, polycystic ovary disease, or pituitary tumor. One milligram dexamethasone was administered orally at 11:00 PM, and serum cortisol levels were measured the following morning between 8:00 AM and 9:00 AM. Suppression of serum cortisol to <80 nM (3 micro g/dL) was chosen as the cut-off point for normal suppression. Patients with serum cortisol levels > or =80 nM were evaluated for Cushing's syndrome. RESULTS: Suppression of morning cortisol levels to <80 nM occurred in 79 of the 86 obese patients. Seven patients had serum cortisol levels higher than 80 nM; five were eventually diagnosed with Cushing's syndrome and two were considered false positive results in view of normal 24-hour free urinary cortisol and normal suppression on a low dose dexamethasone suppression test (0.5 mg of dexamethasone every 6 hours for 2 days). We found a false positive rate of 2.3% for the ODST using a cut-off serum cortisol of 80 nM. DISCUSSION: The ODST is a valid screening test for Cushing's syndrome in the obese population. The false positive rate was 2.3%, even when using a strict cut-off serum cortisol of 80 nM. Abnormal cortisol suppression in obese patients should be investigated and not be considered false positive results
— id: 146829, year: 2002, vol: 10, page: 1217, stat: Journal Article,

Massive thyroid hormone overdose: kinetics, clinical manifestations and management
Shilo, Lotan; Kovatz, Susy; Hadari, Ruth; Weiss, Eli; Nabriski, Dan; Shenkman, Louis
2002 Apr;4(4):298-299, Israel Medical Association journal
— id: 146827, year: 2002, vol: 4, page: 298, stat: Journal Article,

Highlights of January '97 - March '97 television placements
Chu, Benjamin; Colvin, Stephen B.; Llinas, Rudolfo R.; Menche, David; Weiss, Edwin
1997,
— id: 726, year: 1997, vol: , page: , stat: ,

False positive signal-averaged electrocardiogram produced by atrial flutter
Schrem SS; Nachamie M; Weiss E
1990 Sep;120(3):698-699, American heart journal
— id: 64555, year: 1990, vol: 120, page: 698, stat: Journal Article,

Right atrial papillary fibroelastoma: diagnosis by transthoracic and transesophageal echocardiography and percutaneous transvenous biopsy
Schwinger ME; Katz E; Rotterdam H; Slater J; Weiss EC; Kronzon I
1989 Nov;118(5 Pt 1):1047-1050, American heart journal
— id: 10431, year: 1989, vol: 118, page: 1047, stat: Journal Article,

The usefulness of echocardiography in a long term health care facility
Kronzon, I; Freedberg, R S; Khan, B; Cohen, M L; Berger, A; Weiss, E C
1988 Jul;88(7):357-359, New York state journal of medicine
— id: 100110, year: 1988, vol: 88, page: 357, stat: Journal Article,

Anesthetic and supportive management during experimental pulsatile flow perfusion studies in calves
Short, C E; Harvey, R C; Fisher, F E; Cunningham, J N Jr; Rose, D M; Gelbfish, J; Weiss, E; Grossi, E
1987 Feb;37(1):94-99, Laboratory animal science
The purpose of this study was to determine the factors influencing successful experimental cardiopulmonary bypass studies using pulsatile flow perfusion and the medications and methodology necessary to produce successful bypass in calves. In six calves showing no cardiopulmonary pathology prior to bypass procedures, successful anesthesia and surgical intervention was accomplished. Animals were maintained on 5 hours of pulsatile flow bypass perfusion. Successful recovery from the procedures was accomplished. In two calves with pre-existing pulmonary pathology, anesthetic and surgical intervention was accomplished with the utilization of extensive anesthetic management and cardiac supportive medications until the animals could be initiated into 5 hours of pulsatile flow bypass perfusion, in spite of major pulmonary dysfunction. In these two animals, attempts to resuscitate upon termination of pulsatile flow perfusion were unsuccessful due to pre-existing excessive lesions in the lungs. This study shows a contrast between complete success of a pulsatile flow system in normal subjects versus the ultimate failure in experimental animals with pre-existing pulmonary pathology. The inability of experimental calves with a diseased lung to resume spontaneous cardiopulmonary function after the challenges of thoracic intervention indicates the unsuitability of animals with marked pre-existing pulmonary disease status for use in cardiopulmonary bypass studies
— id: 126724, year: 1987, vol: 37, page: 94, stat: Journal Article,

ECHOCARDIOGRAPHY IN PARADOXIC PULSE
KRONZON, I; WINER, H; WEISS, E; BERGER, A
1981 ;80(3):376-376, Chest
— id: 40194, year: 1981, vol: 80, page: 376, stat: Journal Article,

Disappearance of hepatitis B surface antigen during an unusual case of fulminant hepatitis B
Tabor E; Krugman S; Weiss EC; Gerety RJ
1981 ;8(4):277-282, Journal of medical virology
A 30-year-old surgical resident was admitted to the hospital with symptoms of acute hepatitis; two days later he became comatose. Hepatitis B surface antigen had been detected in his serum two days prior to admission, but it was not detected at any time thereafter. Hepatitis B e antigen, antibody to hepatitis B core antigen, and antibody to hepatitis B surface antigen were detected using sensitive radioimmunoassays at admission. Titers of antibody to hepatitis B core antigen increased over the next five weeks. Clearance of hepatitis B e antigen and subsequent appearance of antibody to hepatitis B e antigen accompanied clinical improvement and recovery. This unusual case documents that hepatitis B surface antigen can become undetectable during the course of fulminant hepatitis B and indicates the importance of tests for other serologic markers of hepatitis B virus in the evaluation of hepatitis B surface antigen-negative fulminant hepatitis
— id: 32956, year: 1981, vol: 8, page: 277, stat: Journal Article,

Case report: echocardiographic observations in patients with Friedreich's ataxia
Weiss, E; Kronzon, I; Winer, H E; Berger, A R
1981 Nov-Dec;282(3):136-140, American journal of the medical sciences
Echocardiography was performed on 11 patients with Friedreich's Ataxia. Eight of 11 had asymmetric septal hypertrophy and systolic anterior motion of the anterior leaflet of the mitral valve at rest or after inhalation of amyl nitrite. Two patients had concentric left ventricular hypertrophy. In view of this high incidence of hypertrophic cardiomyopathy, echocardiography is suggested as part of the routine evaluation of the patient with Friedreich's Ataxia
— id: 100144, year: 1981, vol: 282, page: 136, stat: Journal Article,

The not-so-benign Miller Fisher syndrome: a variant of the Guilain-Barre syndrome
Blau, I; Casson, I; Lieberman, A; Weiss, E
1980 Jun;37(6):384-385, Archives of neurology
Two patients with Fisher's syndrome of ophthalmoplegia, ataxia, and areflexia experienced severe weakness and respiratory distress. Both patients required tracheostomy and assisted ventilation, but both made a complete recovery. Fisher's syndrome is generally considered to be a benign variant of acute infectious polyneuropathy (the Guillain-Barre syndrome). Our two patients demonstrate that the condition is not always benign
— id: 141170, year: 1980, vol: 37, page: 384, stat: Journal Article,

Echocardiographic observations of paradoxic pulse without pericardial disease
Kronzon, I; Winer, H E; Weiss, E C; Berger, A R
1980 Sep;78(3):474-479, Chest
Echocardiograms were obtained in 10 normal patients and in 11 patients with respiratory insufficiency due to chronic obstructive lung disease (8) and to thoracic poliomyelitis (3). Only the eight patients with obstructive lung disease had paradoxic pulse. No patient had pericardial disease. The left ventricular internal dimension, stroke volume, and the mitral valve E-F slope and D-E excursion were measured. The inspiratory to expiratory ratio of each measurement was significantly lower in patients with obstructive lung disease than in normal subjects. The patients with thoracic poliomyelitis demonstrated almost no respiratory change in these measurements. The magnitude of the change in the measured factors probably relates to the degree of negativity of intrathoracic pressure during respiration. The inspiratory reduction of mitral valve motion and left ventricular internal dimension is not specific to tamponade but may be seen in patients who exhibit paradoxic pulse due to other conditions
— id: 100148, year: 1980, vol: 78, page: 474, stat: Journal Article,

CHANGES IN LEFT-VENTRICULAR DIMENSION DURING POSITIVE PRESSURE RESPIRATION
Weiss, E; Kronzon, I; Winer, HE; Berger, A
1979 ;27(2):A494-A494, Clinical research
— id: 30127, year: 1979, vol: 27, page: A494, stat: Journal Article,

ECHOCARDIOGRAPHY IN PARADOXICAL PULSE WITHOUT PERICARDIAL-EFFUSION
KRONZON, I; WEISS, E; WINER, HE; BERGER, A
1977 ;56(4):67-67, Circulation
— id: 39933, year: 1977, vol: 56, page: 67, stat: Journal Article,

Chest wall stimulation for temporary suppression of competitive rhythms due to permanent pacemaker malfunction
Deutsch PG; Weiss EC
1976 Mar-Apr;271(2):221-224, American journal of the medical sciences
Chest wall stimulation by electrical stimuli was employed to suppress permanent demand (ventricular-inhibited) pacemakers in two patients with competitive ventricular rhythms. The stimuli were nor perceived by either patient, and were continued until surgical intervention was effected. In selected patients with permanent pacemaker malfunction, chest wall stimulation may be appropriate and necessary initial therapy until definitive correction is performed
— id: 21652, year: 1976, vol: 271, page: 221, stat: Journal Article,

Unusually rapid atrial rate in a patient with thyrotoxicosis and atrial flutter
Deutsch PG; Kronzon I; Weiss EC
1975 Mar;67(3):350-351, Chest
— id: 21654, year: 1975, vol: 67, page: 350, stat: Journal Article,

Experimental neurinoma in tissue culture
Cravioto, H; Palekar, L; Weiss, E; Bennett, K
1972 ;21(2):154-164, Acta neuropathologica
— id: 118110, year: 1972, vol: 21, page: 154, stat: Journal Article,