Biosketch / Results /

Sreeramaiah Veeranna

Assistant Professor, Department of Psychiatry

Contact Info



— Univ of Bagalore, Medical Education
— 1991-1992 Research Associate, University of Illinois, Chicago, PostDoctoral Training
— 1992-1996 Visiting Fellow, Lab. Neurochemistry NINDS, NIH, Bethesda, MD, PostDoctoral Training
— 1999-2000 Research Fellow, Lab. Neurochemistry NINDS, NIH, Bethesda, MD, PostDoctoral Training
— 1996-1999 Visiting Associate, Lab. Neurochemistry NINDS, NIH, Bethesda, MD, PostDoctoral Training

Research Summary

My interests include the molecular mechanisms underlying cell signaling and neur odegeneration, with special reference to cytoskeletal phosphorylation. Aberrant phosphorylation of the cytoskeleton is a pathological hallmark of sever al neurodegenerative disorders. Currently we are investigating the following as pects of protein phosphorylation in the brain: kinases and phosphatases responsi ble for neurofilament phosphorylation in health and disease (using primary and t ransformed cells in culture, mouse models and autopsy tissues from human patient s); factors that trigger and govern cytoskeletal phosphorylation through signali ng cascades and their spatial and temporal regulation during neuronal developmen t and aging; implications of domain-specific phosphorylation of cytoskeletal pro teins for modulating neuronal cytoskeletal assembly, interactions, transport and turnover.

Neurofilaments at a glance
Yuan, Aidong; Rao, Mala V; Veeranna; Nixon, Ralph A
2012-10-12; 0021-9533,Journal of cell science - id: 179149, year: 2012 Journal Article

Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments
Veeranna; Yang, Dun-Sheng; Lee, Ju-Hyun; Vinod, K Yaragudri; Stavrides, Philip; Amin, Niranjana D; Pant, Harish C; Nixon, Ralph A
2014-07-31; 0197-4580,Neurobiology of aging - id: 1085962, year: 2011 Journal Article

Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases
Veeranna; Lee, Ju-Hyun; Pareek, Tej K; Jaffee, Howard; Boland, Barry; Vinod, K Yaragudri; Amin, Niranjana; Kulkarni, Ashok B; Pant, Harish C; Nixon, Ralph A
2014-07-31; 0022-3042,Journal of neurochemistry - id: 1085952, year: 2008 Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects
Hirasawa M; Ohshima T; Takahashi S; Longenecker G; Honjo Y; Veeranna; Pant HC; Mikoshiba K; Brady RO; Kulkarni AB
2012-02-05; 0027-8424,Proceedings of the National Academy of Sciences of the United States of America (PNAS) - id: 61274, year: 2004 Journal Article

Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
Veeranna; Kaji T; Boland B; Odrljin T; Mohan P; Basavarajappa BS; Peterhoff C; Cataldo A; Rudnicki A; Amin N; Li BS; Pant HC; Hungund BL; Arancio O; Nixon RA
2012-02-05; 0002-9440,American journal of pathology - id: 46128, year: 2004 Comparative Study; Journal Article