Biosketch / Results /

A Veeranna, Ph.D.

Assistant Professor;
Department of Psychiatry

Contact Info

Address
140 Old Orangeburg Road
Orangeburg, NY 10962

845-398-2172
A.Veeranna@nyumc.org

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Education

— Univ of Bagalore, Medical Education
— 1991-1992 Research Associate, University of Illinois, Chicago, PostDoctoral Training
— 1992-1996 Visiting Fellow, Lab. Neurochemistry NINDS, NIH, Bethesda, MD, PostDoctoral Training
— 1999-2000 Research Fellow, Lab. Neurochemistry NINDS, NIH, Bethesda, MD, PostDoctoral Training
— 1996-1999 Visiting Associate, Lab. Neurochemistry NINDS, NIH, Bethesda, MD, PostDoctoral Training

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Research Summary

My interests include the molecular mechanisms underlying cell signaling and neur odegeneration, with special reference to cytoskeletal phosphorylation. Aberrant phosphorylation of the cytoskeleton is a pathological hallmark of sever al neurodegenerative disorders. Currently we are investigating the following as pects of protein phosphorylation in the brain: kinases and phosphatases responsi ble for neurofilament phosphorylation in health and disease (using primary and t ransformed cells in culture, mouse models and autopsy tissues from human patient s); factors that trigger and govern cytoskeletal phosphorylation through signali ng cascades and their spatial and temporal regulation during neuronal developmen t and aging; implications of domain-specific phosphorylation of cytoskeletal pro teins for modulating neuronal cytoskeletal assembly, interactions, transport and turnover.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Neurofilaments at a glance
Yuan, Aidong; Rao, Mala V; Veeranna; Nixon, Ralph A
2012 Jul;125(Pt 14):3257-3263, Journal of cell science
— id: 179149, year: 2012, vol: 125, page: 3257, stat: Journal Article,

Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments
Veeranna; Yang, Dun-Sheng; Lee, Ju-Hyun; Vinod, K Yaragudri; Stavrides, Philip; Amin, Niranjana D; Pant, Harish C; Nixon, Ralph A
2011 Nov;32(11):2016-2029, Neurobiology of aging
— id: 1085962, year: 2011, vol: 32, page: 2016, stat: Journal Article,

Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases
Veeranna; Lee, Ju-Hyun; Pareek, Tej K; Jaffee, Howard; Boland, Barry; Vinod, K Yaragudri; Amin, Niranjana; Kulkarni, Ashok B; Pant, Harish C; Nixon, Ralph A
2008 Oct;107(1):35-49, Journal of neurochemistry
— id: 1085952, year: 2008, vol: 107, page: 35, stat: Journal Article,

Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects
Hirasawa M; Ohshima T; Takahashi S; Longenecker G; Honjo Y; Veeranna; Pant HC; Mikoshiba K; Brady RO; Kulkarni AB
2004 Apr 20;101(16):6249-6254, Proceedings of the National Academy of Sciences of the United States of America
— id: 61274, year: 2004, vol: 101, page: 6249, stat: Journal Article,

Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
Veeranna; Kaji T; Boland B; Odrljin T; Mohan P; Basavarajappa BS; Peterhoff C; Cataldo A; Rudnicki A; Amin N; Li BS; Pant HC; Hungund BL; Arancio O; Nixon RA
2004 Oct;165(3):795-805, American journal of pathology
— id: 46128, year: 2004, vol: 165, page: 795, stat: Journal Article,

Calpain mediates calcium-induced activation of the ERK 1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: Relevance to Alzheimer's disease
Veeranna; Kaji, T; Boland, B; Odrljin, T; Mohan, P; Basavarajappa, BS; Peterhoff, C; Cataldo, AM; Rudnicki, A; Li, BS; Pant, HC; Hungund, BL; Arancio, O; Nixon, RA
2004 JUL ;25(10):S173-S173, Neurobiology of aging
— id: 47723, year: 2004, vol: 25, page: S173, stat: Journal Article,

Cdk5 is a key factor in tau aggregation and tangle formation in vivo
Noble W; Olm V; Takata K; Casey E; Mary O; Meyerson J; Gaynor K; LaFrancois J; Wang L; Kondo T; Davies P; Burns M; Veeranna; Nixon R; Dickson D; Matsuoka Y; Ahlijanian M; Lau LF; Duff K
2003 May 22;38(4):555-565, Neuron
— id: 60993, year: 2003, vol: 38, page: 555, stat: Journal Article,

Phosphorylation of the head domain of neurofilament protein (NF-M): a factor regulating topographic phosphorylation of NF-M tail domain KSP sites in neurons
Zheng YL; Li BS; Veeranna; Pant HC
2003 Jun 27;278(26):24026-24032, Journal of biological chemistry
— id: 61275, year: 2003, vol: 278, page: 24026, stat: Journal Article,

Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway
Sharma P; Veeranna; Sharma M; Amin ND; Sihag RK; Grant P; Ahn N; Kulkarni AB; Pant HC
2002 Jan 4;277(1):528-534, Journal of biological chemistry
— id: 48163, year: 2002, vol: 277, page: 528, stat: Journal Article,

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain
Ohshima T; Ogawa M; Veeranna; Hirasawa M; Longenecker G; Ishiguro K; Pant HC; Brady RO; Kulkarni AB; Mikoshiba K
2001 Feb 27;98(5):2764-2769, Proceedings of the National Academy of Sciences of the United States of America
— id: 24252, year: 2001, vol: 98, page: 2764, stat: Journal Article,

Neuronal cyclin-dependent kinase 5 activity is critical for survival
Tanaka T; Veeranna; Ohshima T; Rajan P; Amin ND; Cho A; Sreenath T; Pant HC; Brady RO; Kulkarni AB
2001 Jan 15;21(2):550-558, Journal of neuroscience
— id: 24253, year: 2001, vol: 21, page: 550, stat: Journal Article,

Regulation of axonal neurofilament phosphorylation
Pant HC; Veeranna; Grant P
2000 ;36(2):133-150, Current topics in cellular regulation
— id: 24254, year: 2000, vol: 36, page: 133, stat: Journal Article,

Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain
Veeranna; Shetty KT; Takahashi M; Grant P; Pant HC
2000 Mar 29;76(2):229-236, Brain research. Molecular brain research
— id: 24255, year: 2000, vol: 76, page: 229, stat: Journal Article,

Calcium influx and membrane depolarization induce phosphorylation of neurofilament (NF-M) KSP repeats in PC12 cells
Li BS; Veeranna; Grant P; Pant HC
1999 Jun 18;70(1):84-91, Brain research. Molecular brain research
— id: 24256, year: 1999, vol: 70, page: 84, stat: Journal Article,

Activation of mitogen-activated protein kinases (Erk1 and Erk2) cascade results in phosphorylation of NF-M tail domains in transfected NIH 3T3 cells
Li BS; Veeranna; Gu J; Grant P; Pant HC
1999 May;262(1):211-217, European journal of biochemistry
— id: 24257, year: 1999, vol: 262, page: 211, stat: Journal Article,

Phosphorylation Activity in the Alzheimer's Disease and Normal Brain is Modulated by Microtubule-Associated Protein, Tau In Vitro
Pant MK; Veeranna; Amin ND; Amin N; Pant HC
1999 ;1:169-182, Journal of Alzheimer's disease
— id: 24774, year: 1999, vol: 1, page: 169, stat: Journal Article,

Characterization of serine and threonine phosphorylation sites in beta-elimination/ethanethiol addition-modified proteins by electrospray tandem mass spectrometry and database searching
Jaffe H; Veeranna; Pant HC
1998 Nov 17;37(46):16211-16224, Biochemistry
— id: 24258, year: 1998, vol: 37, page: 16211, stat: Journal Article,

Characterization of the phosphorylation sites of human high molecular weight neurofilament protein by electrospray ionization tandem mass spectrometry and database searching
Jaffe H; Veeranna; Shetty KT; Pant HC
1998 Mar 17;37(11):3931-3940, Biochemistry
— id: 24260, year: 1998, vol: 37, page: 3931, stat: Journal Article,

Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M
Veeranna; Amin ND; Ahn NG; Jaffe H; Winters CA; Grant P; Pant HC
1998 Jun 1;18(11):4008-4021, Journal of neuroscience
— id: 24259, year: 1998, vol: 18, page: 4008, stat: Journal Article,

Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)
Pant AC; Veeranna; Pant HC; Amin N
1997 Aug 15;765(2):259-266, Brain research
— id: 24261, year: 1997, vol: 765, page: 259, stat: Journal Article,

Expression of p67 (Munc-18), Cdk5, P-NFH and syntaxin during development of the rat cerebellum
Veeranna; Grant P; Pant HC
1997 ;19(2):172-183, Developmental neuroscience
— id: 24262, year: 1997, vol: 19, page: 172, stat: Journal Article,

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death
Ohshima T; Ward JM; Huh CG; Longenecker G; Veeranna; Pant HC; Brady RO; Martin LJ; Kulkarni AB
1996 Oct 1;93(20):11173-11178, Proceedings of the National Academy of Sciences of the United States of America
— id: 24263, year: 1996, vol: 93, page: 11173, stat: Journal Article,

Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by Munc-18
Veeranna; Shetty KT; Amin N; Grant P; Albers RW; Pant HC
1996 May;21(5):629-636, Neurochemical research
— id: 24264, year: 1996, vol: 21, page: 629, stat: Journal Article,

Neurofilament phosphorylation
Pant HC; Veeranna
1995 Sep-Oct;73(9-10):575-592, Biochemistry & cell biology
— id: 24265, year: 1995, vol: 73, page: 575, stat: Journal Article,

Neuronal cyclin-dependent kinase-5 phosphorylation sites in neurofilament protein (NF-H) are dephosphorylated by protein phosphatase 2A
Veeranna; Shetty KT; Link WT; Jaffe H; Wang J; Pant HC
1995 Jun;64(6):2681-2690, Journal of neurochemistry
— id: 24266, year: 1995, vol: 64, page: 2681, stat: Journal Article,

Brain and spinal cord kappa opiate receptors and pharmacological responses to U-50,488H in rats of differing ages
Bhargava HN; Matwyshyn GA; Reddy PL; Veeranna
1994 May;48(1):87-91, Pharmacology biochemistry & behavior
— id: 24267, year: 1994, vol: 48, page: 87, stat: Journal Article,

Effect of morphine tolerance and abstinence on the binding of [3H]naltrexone to discrete brain regions and spinal cord of the rat
Reddy PL; Veeranna; Matwyshyn GA; Thorat SN; Bhargava HN
1994 Mar;25(2):355-361, General pharmacology
— id: 24268, year: 1994, vol: 25, page: 355, stat: Journal Article,

Effects of naltrexone on the binding of [3H]D-Ala2, MePhe4, Gly-ol5-enkephalin to brain regions and spinal cord and pharmacological responses to morphine in the rat
Bhargava HN; Matwyshyn GA; Reddy PL; Veeranna
1993 Nov;24(6):1351-1357, General pharmacology
— id: 24269, year: 1993, vol: 24, page: 1351, stat: Journal Article,

Evidence for the behavioral supersensitivity of dopamine D2 receptors without receptor up-regulation in morphine-abstinent rats
Reddy PL; Veeranna; Thorat SN; Bhargava HN
1993 Apr 2;607(1-2):293-300, Brain research
— id: 24272, year: 1993, vol: 607, page: 293, stat: Journal Article,

Biochemical and behavioral studies on the interaction between mu- and kappa-opiate agonists in mice
Thorat SN; Veeranna; Reddy PL; Bhargava HN
1993 Jul 2;615(2):191-198, Brain research
— id: 24270, year: 1993, vol: 615, page: 191, stat: Journal Article,

Effect of chronic administration of U-50,488H, a kappa-opioid receptor agonist, on central dopamine D2 receptors of the rat
Veeranna; Reddy PL; Bhargava HN
1993 Apr 22;235(1):23-30, European journal of pharmacology
— id: 24271, year: 1993, vol: 235, page: 23, stat: Journal Article,

Phosphatase activity against neurofilament proteins from bovine spinal cord: effect of aluminium and neuropsychoactive drugs
Shetty KT; Veeranna; Guru SC
1992 Mar 16;137(1):83-86, Neuroscience letters
— id: 24273, year: 1992, vol: 137, page: 83, stat: Journal Article,

Phosphoserine phosphatase of human brain: partial purification, characterization, regional distribution, and effect of certain modulators including psychoactive drugs
Veeranna; Shetty KT
1990 Dec;15(12):1203-1210, Neurochemical research
— id: 24274, year: 1990, vol: 15, page: 1203, stat: Journal Article,