Vivienne C Greenstein

Biosketch / Results /

Vivienne Greenstein

Research Professor, Department of Ophthalmology

Contact Info

Address
462 First Avenue
New York, NY 10016

212/263-1191
Vivienne.Greenstein@nyumc.org

Research Summary

The visual system can adapt to lights and can function over a wide range of light levels. It accomplishes this by adjusting its light sensitivity relative to the ambient level of light. The mechanisms underlying light adaptation are largely retinal in origin. We concentrate our research, using psychophysical and noninvasive electrophysiological techniques, on studying the sites, i.e., the retinal levels involved, and the mechanisms of light adaptation. The information gained from these studies in the normal visual system is then used to test hypotheses about how disease affects the visual system.

We have just completed a study of patients with an inherited retinal degenerative disease characterized by increased sensitivity of the short-wavelength-sensitive (S) cone system. Our purpose was to test the hypothesis that the retinas of patients with this syndrome have more S-cones than those patients with normal retinas. To conduct this research, the results of noninvasive electrophysiological techniques, i.e., electroretinogram responses, were compared to results obtained using psychophysical techniques. The data which were analyzed within the context of a model of the S-cone system were consistent with the presence of more S-cones and S-cone ganglion cells and with a decrease in the L- and M-cone input to each S-cone ganglion cell.

Research Interests

Tests of Models of Retinal Disease and Adaptation

New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11
Xie, Yajing Angela; Lee, Winston; Cai, Carolyn; Gambin, Tomasz; Noupuu, Kalev; Sujirakul, Tharikarn; Ayuso, Carmen; Jhangiani, Shalini; Muzny, Donna; Boerwinkle, Eric; Gibbs, Richard; Greenstein, Vivienne C; Lupski, James R; Tsang, Stephen H; Allikmets, Rando. New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11. Human molecular genetics. 2014 Jun 10;23(21):5774-5780 (1033622)

Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa
Acton, Jennifer H; Greenberg, Jonathan P; Greenstein, Vivienne C; Marsiglia, Marcela; Tabacaru, Mirela; Theodore Smith, R; Tsang, Stephen H. Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa. Experimental eye research. 2013 May 10;113:41-48 (848322)

Fundus-driven perimetry (microperimetry) compared to conventional static automated perimetry: similarities, differences, and clinical applications
Acton, Jennifer H; Greenstein, Vivienne C. Fundus-driven perimetry (microperimetry) compared to conventional static automated perimetry: similarities, differences, and clinical applications. Canadian journal of ophthalmology = Journal canadien d'ophtalmologie. 2013 Sep 2;48(5):358-363 (848312)

Comparison between MP-1 and Humphrey visual field defects in glaucoma and retinitis pigmentosa
Acton, Jennifer H; Smith, R Theodore; Greenberg, Jonathan P; Greenstein, Vivienne C. Comparison between MP-1 and Humphrey visual field defects in glaucoma and retinitis pigmentosa. Optometry & vision science. 2012 Jul ;89(7):1050-1058 (848262)

Relationship between retinal layer thickness and the visual field in early age-related macular degeneration
Acton, Jennifer H; Smith, R Theodore; Hood, Donald C; Greenstein, Vivienne C. Relationship between retinal layer thickness and the visual field in early age-related macular degeneration. Investigative ophthalmology & visual science. IOVS. 2012 Nov 9;53(12):7618-7624 (848222)