Biosketch / Results /
Vivienne GreensteinResearch Professor, Department of Ophthalmology
462 First Avenue
New York, NY 10016
Research SummaryThe visual system can adapt to lights and can function over a wide range of light levels. It accomplishes this by adjusting its light sensitivity relative to the ambient level of light. The mechanisms underlying light adaptation are largely retinal in origin. We concentrate our research, using psychophysical and noninvasive electrophysiological techniques, on studying the sites, i.e., the retinal levels involved, and the mechanisms of light adaptation. The information gained from these studies in the normal visual system is then used to test hypotheses about how disease affects the visual system.
We have just completed a study of patients with an inherited retinal degenerative disease characterized by increased sensitivity of the short-wavelength-sensitive (S) cone system. Our purpose was to test the hypothesis that the retinas of patients with this syndrome have more S-cones than those patients with normal retinas. To conduct this research, the results of noninvasive electrophysiological techniques, i.e., electroretinogram responses, were compared to results obtained using psychophysical techniques. The data which were analyzed within the context of a model of the S-cone system were consistent with the presence of more S-cones and S-cone ganglion cells and with a decrease in the L- and M-cone input to each S-cone ganglion cell.
Research InterestsTests of Models of Retinal Disease and Adaptation
New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11
Xie, Yajing Angela; Lee, Winston; Cai, Carolyn; Gambin, Tomasz; Noupuu, Kalev; Sujirakul, Tharikarn; Ayuso, Carmen; Jhangiani, Shalini; Muzny, Donna; Boerwinkle, Eric; Gibbs, Richard; Greenstein, Vivienne C; Lupski, James R; Tsang, Stephen H; Allikmets, Rando
2014-06-14; 0964-6906,Human molecular genetics - id: 1033622, year: 2014 JOURNAL ARTICLE
Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa
Acton, Jennifer H; Greenberg, Jonathan P; Greenstein, Vivienne C; Marsiglia, Marcela; Tabacaru, Mirela; Theodore Smith, R; Tsang, Stephen H
2014-03-22; 0014-4835,Experimental eye research - id: 848322, year: 2013 Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Fundus-driven perimetry (microperimetry) compared to conventional static automated perimetry: similarities, differences, and clinical applications
Acton, Jennifer H; Greenstein, Vivienne C
2014-03-22; 0008-4182,Canadian journal of ophthalmology = Journal canadien d'ophtalmologie - id: 848312, year: 2013 Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Review
A study of factors affecting the human cone photoreceptor density measured by adaptive optics scanning laser ophthalmoscope
Park, Sung Pyo; Chung, Jae Keun; Greenstein, Vivienne; Tsang, Stephen H; Chang, Stanley
2014-03-22; 0014-4835,Experimental eye research - id: 848342, year: 2013 Journal Article
Comparison between MP-1 and Humphrey visual field defects in glaucoma and retinitis pigmentosa
Acton, Jennifer H; Smith, R Theodore; Greenberg, Jonathan P; Greenstein, Vivienne C
2014-03-22; 1040-5488,Optometry & vision science - id: 848262, year: 2012 Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't