Fred T. Valentine

Biosketch / Results /

Fred T. Valentine, M.D.

Research Professor;
Departments of Medicine (Medicine) and Microbiology (Microbiology )

Contact Info

Address
550 First Avenue
New Bellevue, Rm 16 S 6 Floor 5 Room 517A
Old Bellevue
New York, NY 10016

212-263-6401
212-263-8264
Fred.Valentine@nyumc.org


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Education

1956-1960 — Dr. Valentine received his M.D. degree from Harvard Medical School, Boston, MA, Medical Education
1960-1962 — Internship Boston City Hospital, Harvard Medical Service, Residency
1964-1965 — Residency in Medicine, Boston City Hospital, Harvard Medical Service, Residency

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Research Summary

Our research involves laboratory and clinical studies of immune responses to malignant melanoma. We have developed a method of inducing cellular immune responses to metastatic melanoma that result in frequent durable complete regressions of disease. We also are interested in immunological and virological aspects of human immunodeficiency virus (HIV) infection. We are investigating HIV-specific cellular immune responses in acute, primary HIV infection and in elite controllers who "spontaneously" control HIV without antiretroviral drugs. We have discovered that individuals treated very early in their HIV infection develop strong CD4 T cell memory responses to HIV antigens, similar but often of smaller magnitude to the memory responses observed in elite controllers. Many individuals treated for one year after the onset of their infection are subsequently able to control their blood levels of HIV for at least 1 to 2 years after stopping their anti-HIV drugs.

Research Interests

Malignant Melanoma, Induction of effective immune responses against metastatic meelanoma Pathogenesis of HIV Disease Immune Responses to HIV Cellular Immunology Vaccine design

Research Keywords

Melanoma, immunotherapy, human immunodecficiency virus (HIV), HIV drugs, HIV vaccines, pathogenesis

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Structural Characterization of Two Monoclonal Antibodies Targeting the Fourth Constant Domain in the Bridging Sheet of HIV-1 gp120
Pan, R. ; Chen, Y. ; Vaine, M. ; Wang, S. ; Kelker, H. C. ; Itri, V. R. ; Valentine, F. T. ; Lu, S. ; Kong, X.
2013 NOV 1;29(11):A61-A62, AIDS research & human retroviruses
— id: 657002, year: 2013, vol: 29, page: A61, stat: Journal Article,

Early Detection of HIV Infection Among Kenyan Infants Using a Reverse Transcriptase Activity Assay
Sivapalasingam, Sumathi; Ahmed, Aabid; Mendillo, Megan; Holzman, Robert; Marshed, Fatuma; Mwamzuka, Musa; Khamadi, Samuel; Mwau, Matilu; Laverty, Maura; Valentine, Fred
2012 Jul;31(7):732-735, Pediatric infectious disease journal
— id: 169479, year: 2012, vol: 31, page: 732, stat: Journal Article,

Sex differences in the incidence of peripheral neuropathy among kenyans initiating antiretroviral therapy
Mehta, Sapna A; Ahmed, Aabid; Laverty, Maura; Holzman, Robert S; Valentine, Fred; Sivapalasingam, Sumathi
2011 Sep;53(5):490-496, Clinical infectious diseases
— id: 136612, year: 2011, vol: 53, page: 490, stat: Journal Article,

Susceptibility of Human Th17 Cells to Human Immunodeficiency Virus and Their Perturbation during Infection
El Hed, Aimee; Khaitan, Alka; Kozhaya, Lina; Manel, Nicolas; Daskalakis, Demetre; Borkowsky, William; Valentine, Fred; Littman, Dan R; Unutmaz, Derya
2010 Mar 15;201(6):843-854, Journal of infectious diseases
— id: 107380, year: 2010, vol: 201, page: 843, stat: Journal Article,

A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein
Kelker, Hanna C; Itri, Vincenza R; Valentine, Fred T
2010 ;5(1):e8555-e8555, PLoS one
— id: 106106, year: 2010, vol: 5, page: e8555, stat: Journal Article,

Implementation of a validated peripheral neuropathy screening tool in patients receiving antiretroviral therapy in mombasa, kenya
Mehta, Sapna A; Ahmed, Aabid; Kariuki, Beatrice W; Said, Swaleh; Omasete, Fanuel; Mendillo, Megan; Laverty, Maura; Holzman, Robert; Valentine, Fred; Sivapalasingam, Sumathi
2010 Sep;83(3):565-570, American journal of tropical medicine & hygiene
— id: 112054, year: 2010, vol: 83, page: 565, stat: Journal Article,

Evidence of dysregulation of dendritic cells in primary HIV infection
Sabado, Rachel Lubong; O'Brien, Meagan; Subedi, Abhignya; Qin, Li; Hu, Nan; Taylor, Elizabeth; Dibben, Oliver; Stacey, Andrea; Fellay, Jacques; Shianna, Kevin V; Siegal, Frederick; Shodell, Michael; Shah, Kokila; Larsson, Marie; Lifson, Jeffrey; Nadas, Arthur; Marmor, Michael; Hutt, Richard; Margolis, David; Garmon, Donald; Markowitz, Martin; Valentine, Fred; Borrow, Persephone; Bhardwaj, Nina
2010 Nov 11;116(19):3839-3852, Blood
— id: 114507, year: 2010, vol: 116, page: 3839, stat: Journal Article,

The Development and Implementation of an Outreach Program to Identify Acute and Recent HIV Infections in New York City
Silvera, Richard; Stein, Dylan; Hutt, Richard; Hagerty, Robert; Daskalakis, Demetre; Valentine, Fred; Marmor, Michael
2010 ;4:76-83, Open AIDS journal
— id: 109049, year: 2010, vol: 4, page: 76, stat: Journal Article,

Measurement of antiretroviral drugs in the lungs of HIV-infected patients
Twigg HL; Schnizlein-Bick CT; Weiden M; Valentine F; Wheat J; Day RB; Rominger H; Zheng L; Collman RG; Coombs RW; Bucy RP; Rezk NL; Kashuba AD
2010 Mar 1;4(2):247-251, HIV therapy
— id: 138270, year: 2010, vol: 4, page: 247, stat: Journal Article,

Implementation of HIV testing at 2 New York City bathhouses: from pilot to clinical service
Daskalakis, Demetre; Silvera, Richard; Bernstein, Kyle; Stein, Dylan; Hagerty, Robert; Hutt, Richard; Maillard, Alith; Borkowsky, William; Aberg, Judith; Valentine, Fred; Marmor, Michael
2009 Jun 1;48(11):1609-1616, Clinical infectious diseases
— id: 98009, year: 2009, vol: 48, page: 1609, stat: Journal Article,

Eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein gp120: A strategy
Kelker, HC; Itri, V; Valentine, FT
2009 DEC ;6(2-3):115-115, Retrovirology
— id: 105704, year: 2009, vol: 6, page: 115, stat: Journal Article,

Monitoring virologic responses to antiretroviral therapy in HIV-infected adults in Kenya: evaluation of a low-cost viral load assay
Sivapalasingam, Sumathi; Wangechi, Beatrice; Marshed, Fatuma; Laverty, Maura; Essajee, Shaffiq; Holzman, Robert S; Valentine, Fred
2009 ;4(8):e6828-e6828, PLoS one
— id: 101963, year: 2009, vol: 4, page: e6828, stat: Journal Article,

Viral commensalism in humans?
Blaser, Martin J; Valentine, Fred T
2008 Jul 1;198(1):1-3, Journal of infectious diseases
— id: 79202, year: 2008, vol: 198, page: 1, stat: Journal Article,

Blood Dendritic Cell Subsets in Early HIV Infection
Sabado, RL; O'Brien, M; Subedi, A; Taylor, E; Hutt, R; Haggerty, R; Marmor, M; Margolis, D; Valentine, F; Borrow, P; Bhardwaj, N
2008 OCT ;24(1):84-85, AIDS research & human retroviruses
— id: 91419, year: 2008, vol: 24, page: 84, stat: Journal Article,

Effect of highly active antiretroviral therapy on viral burden in the lungs of HIV-infected subjects
Twigg Iii, Homer L; Weiden, Michael; Valentine, Fred; Schnizlein-Bick, Carol T; Bassett, Roland; Zheng, Lu; Wheat, Joseph; Day, Richard B; Rominger, Helen; Collman, Ronald G; Fox, Lawrence; Brizz, Barbara; Dragavon, Joan; Coombs, Robert W; Bucy, R Pat
2008 Jan 1;197(1):109-116, Journal of infectious diseases
— id: 78802, year: 2008, vol: 197, page: 109, stat: Journal Article,

Immunological memory after exposure to variola virus, monkeypox virus, and vaccinia virus
Sivapalasingam, Sumathi; Kennedy, Jeffrey S; Borkowsky, William; Valentine, Fred; Zhan, Ming-Xia; Pazoles, Pamela; Paolino, Anna; Ennis, Francis A; Steigbigel, Neal H
2007 Apr 15;195(8):1151-1159, Journal of infectious diseases
— id: 71299, year: 2007, vol: 195, page: 1151, stat: Journal Article,

A Reverse Transcriptase Assay for Early Diagnosis of Infant HIV Infection in Resource-limited Settings
Sivapalasingam, Sumathi; Patel, Usha; Itri, Vincenza; Laverty, Maura; Mandaliya, Kishorchandra; Valentine, Fred; Essajee, Shaffiq
2007 Oct;53(5):355-358, Journal of tropical pediatrics
— id: 72999, year: 2007, vol: 53, page: 355, stat: Journal Article,

Low CD4+ T cell nadir is an independent predictor of lower HIV-specific immune responses in chronically HIV-1-infected subjects receiving highly active antiretroviral therapy
Siddique, M Atif; Hartman, Kelly E; Dragileva, Ella; Dondero, Marla; Gebretsadik, Tebeb; Shintani, Ayumi; Peiperl, Laurence; Valentine, Fred; Kalams, Spyros A
2006 Sep 1;194(5):661-665, Journal of infectious diseases
— id: 78899, year: 2006, vol: 194, page: 661, stat: Journal Article,

Human immunodeficiency virus (HIV) reverse transcriptase activity correlates with HIV RNA load: implications for resource-limited settings
Sivapalasingam, Sumathi; Essajee, Shaffiq; Nyambi, Phillipe N; Itri, Vincenza; Hanna, Bruce; Holzman, Robert; Valentine, Fred
2005 Aug;43(8):3793-3796, Journal of clinical microbiology
— id: 57865, year: 2005, vol: 43, page: 3793, stat: Journal Article,

Activity, safety, and immunological effects of hydroxyurea added to didanosine in antiretroviral-naive and experienced HIV type 1-infected subjects: a randomized, placebo-controlled trial, ACTG 307
Frank, Ian; Bosch, Ronald J; Fiscus, Susan; Valentine, Fred; Flexner, Charles; Segal, Yoninah; Ruan, Ping; Gulick, Roy; Wood, Kenneth; Estep, Scharla; Fox, Lawrence; Nevin, Thomas; Stevens, Michael; Eron, Joseph J Jr
2004 Sep;20(9):916-926, AIDS research & human retroviruses
— id: 78900, year: 2004, vol: 20, page: 916, stat: Journal Article,

Duration of cell-mediated immunity after smallpox vaccination
Sivapalasingam, S.; Borkowsky, W.; Valentine, F.; Holzman, R.; Maslow, M.; Simberkoff, M.; Haren, N.; Maccario, E.; Flannery, J.; Hirsch-Temple, D.; Sathe, S.; Torres, J.; McGibbon, M.; White, M.; Steigbigel, N.
2004 OCT-NOV;44:254-254, Program & abstracts (Interscience Conference on Antimicrobial Agents & Chemotherapy)
— id: 702202, year: 2004, vol: 44, page: 254, stat: Journal Article,

Daily low-dose subcutaneous interleukin-2 added to single- or dual-nucleoside therapy in HIV infection does not protect against CD4+ T-cell decline or improve other indices of immune function: results of a randomized controlled clinical trial (ACTG 248)
Vogler, Mary A; Teppler, Hedy; Gelman, Rebecca; Valentine, Fred; Lederman, Michael M; Pomerantz, Roger J; Pollard, Richard B; Cherng, Deborah Weng; Gonzalez, Charles J; Squires, Kathleen E; Frank, Ian; Mildvan, Donna; Mahon, Laura F; Schock, Barbara
2004 May 1;36(1):576-587, Journal of acquired immune deficiency syndromes. JAIDS
— id: 57853, year: 2004, vol: 36, page: 576, stat: Journal Article,

A controlled Phase II trial assessing three doses of enfuvirtide (T-20) in combination with abacavir, amprenavir, ritonavir and efavirenz in non-nucleoside reverse transcriptase inhibitor-naive HIV-infected adults
Lalezari, Jacob P; DeJesus, Edwin; Northfelt, Donald W; Richmond, Gary; Wolfe, Peter; Haubrich, Richard; Henry, David; Powderly, William; Becker, Stephen; Thompson, Melanie; Valentine, Fred; Wright, David; Carlson, Margrit; Riddler, Sharon; Haas, Frances F; DeMasi, Ralph; Sista, Prokash R; Salgo, Miklos; Delehanty, John
2003 Aug;8(4):279-287, Antiviral therapy
— id: 42276, year: 2003, vol: 8, page: 279, stat: Journal Article,

A phase II clinical study of the long-term safety and antiviral activity of enfuvirtide-based antiretroviral therapy
Lalezari, Jacob P; Eron, Joseph J; Carlson, Margrit; Cohen, Calvin; DeJesus, Edwin; Arduino, Roberto C; Gallant, Joel E; Volberding, Paul; Murphy, Robert L; Valentine, Fred; Nelson, Emily L; Sista, Prakash R; Dusek, Alex; Kilby, J Michael
2003 Mar 28;17(5):691-698, AIDS
— id: 42277, year: 2003, vol: 17, page: 691, stat: Journal Article,

Incomplete immune reconstitution after initiation of highly active antiretroviral therapy in human immunodeficiency virus-infected patients with severe CD4+ cell depletion
Lederman, Howard M; Williams, Paige L; Wu, Julia W; Evans, Thomas G; Cohn, Susan E; McCutchan, J Allen; Koletar, Susan L; Hafner, Richard; Connick, Elizabeth; Valentine, Fred T; McElrath, M Juliana; Roberts, Norbert J Jr; Currier, Judith S
2003 Dec 15;188(12):1794-1803, Journal of infectious diseases
— id: 42275, year: 2003, vol: 188, page: 1794, stat: Journal Article,

Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial
Hammer, Scott M; Vaida, Florin; Bennett, Kara K; Holohan, Mary K; Sheiner, Lewis; Eron, Joseph J; Wheat, Lawrence Joseph; Mitsuyasu, Ronald T; Gulick, Roy M; Valentine, Fred T; Aberg, Judith A; Rogers, Michael D; Karol, Cheryl N; Saah, Alfred J; Lewis, Ronald H; Bessen, Laura J; Brosgart, Carol; DeGruttola, Victor; Mellors, John W
2002 Jul 10;288(2):169-180, JAMA
— id: 32249, year: 2002, vol: 288, page: 169, stat: Journal Article,

The safety, plasma pharmacokinetics, and antiviral activity of subcutaneous enfuvirtide (T-20), a peptide inhibitor of gp41-mediated virus fusion, in HIV-infected adults
Kilby, J Michael; Lalezari, Jacob P; Eron, Joseph J; Carlson, Margrit; Cohen, Calvin; Arduino, Roberto C; Goodgame, Jeffrey C; Gallant, Joel E; Volberding, Paul; Murphy, Robert L; Valentine, Fred; Saag, Michael S; Nelson, Emily L; Sista, Prakash R; Dusek, Alex
2002 Jul 1;18(10):685-693, AIDS research & human retroviruses
— id: 78901, year: 2002, vol: 18, page: 685, stat: Journal Article,

Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure
Skurnick, Joan H; Palumbo, Paul; DeVico, Anthony; Shacklett, Barbara L; Valentine, Fred T; Merges, Michael; Kamin-Lewis, Roberta; Mestecky, Jiri; Denny, Thomas; Lewis, George K; Lloyd, Joan; Praschunus, Robert; Baker, Amanda; Nixon, Douglas F; Stranford, Sharon; Gallo, Robert; Vermund, Sten H; Louria, Donald B
2002 Feb 15;185(4):428-438, Journal of infectious diseases
— id: 29358, year: 2002, vol: 185, page: 428, stat: Journal Article,

Residual human immunodeficiency virus (HIV) Type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years
Gunthard HF; Havlir DV; Fiscus S; Zhang ZQ; Eron J; Mellors J; Gulick R; Frost SD; Brown AJ; Schleif W; Valentine F; Jonas L; Meibohm A; Ignacio CC; Isaacs R; Gamagami R; Emini E; Haase A; Richman DD; Wong JK
2001 May 1;183(9):1318-1327, Journal of infectious diseases
— id: 42278, year: 2001, vol: 183, page: 1318, stat: Journal Article,

Shipment impairs lymphocyte proliferative responses to microbial antigens
Betensky RA; Connick E; Devers J; Landay AL; Nokta M; Plaeger S; Rosenblatt H; Schmitz JL; Valentine F; Wara D; Weinberg A; Lederman HM
2000 Sep;7(5):759-763, Clinical & diagnostic laboratory immunology
— id: 42280, year: 2000, vol: 7, page: 759, stat: Journal Article,

3-year suppression of HIV viremia with indinavir, zidovudine, and lamivudine
Gulick RM; Mellors JW; Havlir D; Eron JJ; Meibohm A; Condra JH; Valentine FT; McMahon D; Gonzalez C; Jonas L; Emini EA; Chodakewitz JA; Isaacs R; Richman DD
2000 Jul 4;133(1):35-39, Annals of internal medicine
— id: 15501, year: 2000, vol: 133, page: 35, stat: Journal Article,

Two double-blinded, randomized, comparative trials of 4 human immunodeficiency virus type 1 (HIV-1) envelope vaccines in HIV-1-infected individuals across a spectrum of disease severity: AIDS Clinical Trials Groups 209 and 214
Schooley RT; Spino C; Kuritzkes D; Walker BD; Valentine FA; Hirsch MS; Cooney E; Friedland G; Kundu S; Merigan TC Jr; McElrath MJ; Collier A; Plaeger S; Mitsuyasu R; Kahn J; Haslett P; Uherova P; deGruttola V; Chiu S; Zhang B; Jones G; Bell D; Ketter N; Twadell T; Chernoff D; Rosandich M
2000 Nov;182(5):1357-1364, Journal of infectious diseases
— id: 42279, year: 2000, vol: 182, page: 1357, stat: Journal Article,

Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258
Gulick RM; McAuliffe V; Holden-Wiltse J; Crumpacker C; Liebes L; Stein DS; Meehan P; Hussey S; Forcht J; Valentine FT
1999 Mar 16;130(6):510-514, Annals of internal medicine
— id: 6055, year: 1999, vol: 130, page: 510, stat: Journal Article,

Delayed-type hypersensitivity to recombinant HIV envelope glycoprotein (rgp160) after immunization with homologous antigen
Katzenstein DA; Kundu S; Spritzler J; Smoller BR; Haszlett P; Valentine F; Merigan TC
1999 Dec 1;22(4):341-347, Journal of acquired immune deficiency syndromes. JAIDS
— id: 42281, year: 1999, vol: 22, page: 341, stat: Journal Article,

Peptide immunogens representing conserved epitopes of gp120 can induce immune responses recognizing gp120 that are not formed by immunization with whole rgp120
Kelker HC; Nardelli B; Itri V; Paolino A; Valentine FT
1998 Feb 1-5;5:94-94, Conference on Retroviruses & Opportunistic Infections
— id: 6010, year: 1998, vol: 5, page: 94, stat: Journal Article,

Lymphocyte-proliferative responses to HIV antigens as a potential measure of immunological reconstitution in HIV disease
Valentine FT; Paolino A; Saito A; Holzman RS
1998 Jun;14 Suppl 2:S161-S166, AIDS research & human retroviruses
— id: 7836, year: 1998, vol: 14 Suppl 2, page: S161, stat: Journal Article,

Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy [see comments]
Gulick RM; Mellors JW; Havlir D; Eron JJ; Gonzalez C; McMahon D; Richman DD; Valentine FT; Jonas L; Meibohm A; Emini EA; Chodakewitz JA
1997 Sep 11;337(11):734-739, New England journal of medicine
— id: 12293, year: 1997, vol: 337, page: 734, stat: Journal Article,

Effect of therapeutic immunization with recombinant gp160 HIV-1 vaccine on HIV-1 proviral DNA and plasma RNA: relationship to cellular immune responses
Kundu SK; Katzenstein D; Valentine FT; Spino C; Efron B; Merigan TC
1997 Aug 1;15(4):269-274, Journal of acquired immune deficiency syndromes & human retrovirology
— id: 15502, year: 1997, vol: 15, page: 269, stat: Journal Article,

Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection - A randomized, double-blind, placebo-controlled trial
DAquila, RT; Hughes, MD; Johnson, VA; Fischl, MA; Sommadossi, JP; Liou, SH; Timpone, J; Myers, M; Basgoz, N; Niu, M; Hirsch, MS; Costanzo, L; Ruben, S; Berzins, B; Martinez, A; Fishman, I; Kazial, K; Cort, SN; Robinson, P; Hall, D; Macy, H; McLaren, C; Rooney, J; Warwick, J; CavailleColl, M; Valentine, F; Booth, D; Soeiro, R; Stein, D; Zingman, B; Schliosberg, J; Polsky, B; Sepkowitz, K; Sharpe, V; Giordano, M; Wanke, C; Gulick, R; Craven, D; Grodman, C; Fife, K; Black, J; Todd, K; Nixon, H; Sperber, K; Gerits, P; Mildvan, D; Nicholas, P; Murphy, RL; Kessler, H; Pulvirenti, J; Squires, K; Saag, M; Weingarten, J; Gnann, J; Havlir, D; Fegan, C; Spector, S; Richman, D; Jacobson, M; Dybeck, K; Joseph, P; Clanon, K; McKenzie, S; Daniel, P; Dayton, D; Leonard, J; Schooley, R; Kuritzkes, D; Ray, G; Putnam, B; Jayaweera, D; PatroneReese, J; Tanner, T; Moebus, J; Reed, N; StJacque, R; Henry, K; Swindells, S; Eron, J; Ragan, D; Horton, J; Lane, T; Frank, I; Norris, A; Pomerantz, R; Hauptman, S; Geiseler, J; Leedom, J; Canchola, F; Olson, C; Deyton, L; Pettinelli, C
1996 JUN 15 ;124(12):1019-1030, Annals of internal medicine
— id: 52887, year: 1996, vol: 124, page: 1019, stat: Journal Article,

Potent and sustained antiretroviral activity of indinavir (IDV), zidovudine (ZDV) and lamivudine (3TC)
Gulick RM; Mellors J; Havlir D; Eron J; Gonzalez C; McMahon D; Richman D; Valentine F; Rooney J; Jonas L; Meibohm A; Emini E; Chodakewitz J
1996 Jul 7-12;11:19-19, International conference on AIDS
— id: 6004, year: 1996, vol: 11, page: 19, stat: Journal Article,

A randomized, placebo-controlled study of the immunogenicity of human immunodeficiency virus (HIV) rgp160 vaccine in HIV-infected subjects with > or = 400/mm3 CD4 T lymphocytes (AIDS Clinical Trials Group Protocol 137)
Valentine FT; Kundu S; Haslett PA; Katzenstein D; Beckett L; Spino C; Borucki B; Vasquez M; Smith G; Korvick J; Kagan J; Merigan TC
1996 Jun;173(6):1336-1346, Journal of infectious diseases
— id: 8016, year: 1996, vol: 173, page: 1336, stat: Journal Article,

CD4+ blood lymphocytes are rapidly killed in vitro by contact with autologous human immunodeficiency virus-infected cells
Nardelli B; Gonzalez CJ; Schechter M; Valentine FT
1995 Aug 1;92(16):7312-7316, Proceedings of the National Academy of Sciences of the United States of America
— id: 6850, year: 1995, vol: 92, page: 7312, stat: Journal Article,

The ability of CD8 cells to suppress HIV replication is affected by their stat of activation
Schnoll S; Hennesey NP; Valentine F
1995 Jan 29-Feb 2;2:86-86, National Conference on Human Retroviruses & Related Infections
— id: 5996, year: 1995, vol: 2, page: 86, stat: Journal Article,

Analysis of potential risk factors associated with the development of pancreatitis in phase I patients with AIDS or AIDS-related complex receiving didanosine [see comments]
Grasela TH; Walawander CA; Beltangady M; Knupp CA; Martin RR; Dunkle LM; Barbhaiya RH; Pittman KA; Dolin R; Valentine FT; et al
1994 Jun;169(6):1250-1255, Journal of infectious diseases
— id: 15503, year: 1994, vol: 169, page: 1250, stat: Journal Article,

Within-subject variation in CD4 lymphocyte count in asymptomatic human immunodeficiency virus infection: implications for patient monitoring
Hughes MD; Stein DS; Gundacker HM; Valentine FT; Phair JP; Volberding PA
1994 Jan;169(1):28-36, Journal of infectious diseases
— id: 15504, year: 1994, vol: 169, page: 28, stat: Journal Article,

PHASE-II DOSE-RANGING TRIAL OF FOSCARNET SALVAGE THERAPY FOR CYTOMEGALOVIRUS RETINITIS IN AIDS PATIENTS INTOLERANT OF OR RESISTANT TO GANCICLOVIR (ACTG PROTOCOL 093)
JACOBSON, MA; WULFSOHN, M; FEINBERG, JE; DAVIS, R; POWER, M; OWENS, S; CAUSEY, D; HEATHCHIOZZI, ME; MURPHY, RL; CHEUNG, TW; DIETERICH, DT; SPECTOR, SA; MCKINLEY, GF; PARENTI, DM; CRUMPACKER, C; NISHIMOTO, B; LEEDOM, JM; KRAMER, F; COHEN, C; LOFTUS, J; KESSLER, HA; POTTAGE, JC; BENSON, CA; PHAIR, JP; GERITS, P; CHUSID, E; SACKS, HS; FRIEDBERG, D; CURRANKRIKORIAN, K; VALENTINE, FT; MENG, TC; FREEMAN, WR; MEIXNER, L; RICHMAN, D; ODONNELL, JJ; KIMBRELL, C; BOGGIO, K; LARSON, J; WHITMORE, PV; SIMON, GL; LELACHEUR, S; FIFE, K; ZWICKL, B; RELUE, J; STEIGBIGEL, RT; FUHRER, J; DONLON, W; BURK, RA; PORTMORE, AC; WEISSBACH, NE; HOOTON, TM; HOLZWORTH, P; DAVISON, S; COLLIER, AC; POWDERLY, WG; KLEBERT, M; ROYAL, M; SEYFRIED, W; SQUIRES, KC; WEISS, W; BARBACCI, M; BECKER, RL; JABS, D; BARTLETT, JG; PARA, MF; JONES, M; NEIDIG, JL; FASS, RJ; VANDERHORST, C; KYLSTRA, J; RAASCH, R; BLOODGOOD, K; WOLITZ, R; KIRK, S; ROLFE, L; PATRONEREESE, J; BARTLETT, JA; WASKIN, HA; WILLIAMS, DK; SHIP, KW; KAHL, P; ASSAYKEEN, T; KAROL, C; MARTINMUNLEY, S; SUMNER, P
1994 APR ;8(4):451-459, AIDS
— id: 52528, year: 1994, vol: 8, page: 451, stat: Journal Article,

Immunogenic and antigenic properties of an HIV-1 gp120-derived multiple chain peptide
Kelker HC; Schlesinger D; Valentine FT
1994 Apr 15;152(8):4139-4148, Journal of immunology
— id: 6419, year: 1994, vol: 152, page: 4139, stat: Journal Article,

Didanosine: long-term follow-up of patients in a phase 1 study
Lambert JS; Seidlin M; Valentine FT; Reichman RC; Dolin R
1993 Feb;16 Suppl 1:S40-S45, Clinical infectious diseases
— id: 15505, year: 1993, vol: 16 Suppl 1, page: S40, stat: Journal Article,

Relationship between dideoxyinosine exposure, CD4 counts, and p24 antigen levels in human immunodeficiency virus infection. A phase I trial
Drusano GL; Yuen GJ; Lambert JS; Seidlin M; Dolin R; Valentine FT
1992 Apr 1;116(7):562-566, Annals of internal medicine
— id: 15507, year: 1992, vol: 116, page: 562, stat: Journal Article,

Impact of bioavailability on determination of the maximal tolerated dose of 2',3'-dideoxyinosine in phase I trials
Drusano GL; Yuen GJ; Morse G; Cooley TP; Seidlin M; Lambert JS; Liebman HA; Valentine FT; Dolin R
1992 Jun;36(6):1280-1283, Antimicrobial agents & chemotherapy
— id: 15506, year: 1992, vol: 36, page: 1280, stat: Journal Article,

Lymphocytes from some long-term seronegative heterosexual partners of HIV-infected individuals proliferate in response to HIV antigens
Kelker HC; Seidlin M; Vogler M; Valentine FT
1992 Aug;8(8):1355-1359, AIDS research & human retroviruses
— id: 13495, year: 1992, vol: 8, page: 1355, stat: Journal Article,

Extended follow-up of peripheral neuropathy in patients with AIDS and AIDS-related complex treated with dideoxyinosine
Kieburtz KD; Seidlin M; Lambert JS; Dolin R; Reichman R; Valentine F
1992 ;5(1):60-64, Journal of acquired immune deficiency syndrome
— id: 42282, year: 1992, vol: 5, page: 60, stat: Journal Article,

ADRENALECTOMY FAILS TO ABOLISH CORTICOTROPIN-RELEASING FACTOR (CRF)-INDUCED IMMUNOSUPPRESSION IN HUMANS AS WELL AS RATS
NABRISKI, D; SHAPIRO, M; SAPERSTEIN, A; SHENKMAN, L; VALENTINE, FT; YAO, JS; ROSENZWEIG, S; HUTCHINSON, B; AUDYHA, T; HOLLANDER, CS
1992 APR ;40(2):A373-A373, Clinical research
— id: 52005, year: 1992, vol: 40, page: A373, stat: Journal Article,

Population pharmacokinetic analysis of didanosine (2',3'-dideoxyinosine) plasma concentrations obtained in phase I clinical trials in patients with AIDS or AIDS-related complex
Pai SM; Shukla UA; Grasela TH; Knupp CA; Dolin R; Valentine FT; McLaren C; Liebman HA; Martin RR; Pittman KA; et al
1992 Mar;32(3):242-247, Journal of clinical pharmacology
— id: 15508, year: 1992, vol: 32, page: 242, stat: Journal Article,

Effects of therapy with didanosine on hematologic parameters in patients with advanced human immunodeficiency virus disease
Schacter LP; Rozencweig M; Beltangady M; Allan JD; Canetta R; Cooley TP; Dolin R; Kelley S; Lambert J; Liebman HA; Messina M; Nicaise C; Seidlin M; Valentine FT; Yarchoan R; Smaldone LF
1992 Dec 15;80(12):2969-2976, Blood
— id: 42283, year: 1992, vol: 80, page: 2969, stat: Journal Article,

Pancreatitis and pancreatic dysfunction in patients taking dideoxyinosine
Seidlin M; Lambert JS; Dolin R; Valentine FT
1992 Aug;6(8):831-835, AIDS
— id: 13502, year: 1992, vol: 6, page: 831, stat: Journal Article,

Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex
Knupp CA; Shyu WC; Dolin R; Valentine FT; McLaren C; Martin RR; Pittman KA; Barbhaiya RH
1991 May;49(5):523-535, Clinical pharmacology & therapeutics
— id: 15509, year: 1991, vol: 49, page: 523, stat: Journal Article,

HYPERICIN - A HEXAHYDROXYL, DIMETHYL-NAPHTHODIANTHRONE WITH ACTIVITY AGAINST HIV INVITRO AND AGAINST MURINE RETROVIRUSES INVIVO
VALENTINE, FT
1991 FEB 14 ;4(3):317-317, Journal of acquired immune deficiency syndromes & human retrovirology
— id: 51726, year: 1991, vol: 4, page: 317, stat: Journal Article,

Toxicity of combined ganciclovir and zidovudine for cytomegalovirus disease associated with AIDS. An AIDS Clinical Trials Group Study
Hochster, H; Dieterich, D; Bozzette, S; Reichman, R C; Connor, J D; Liebes, L; Sonke, R L; Spector, S A; Valentine, F; Pettinelli, C
1990 Jul 15;113(2):111-117, Annals of internal medicine
— id: 101812, year: 1990, vol: 113, page: 111, stat: Journal Article,

A review of the flow cytometry quality control program of the national institutes of health AIDS program
Kidd, PG; Gelman, R; Paxton, H; McKay, J; Waxdal, M; Valentine, F
1990 ;10(1):8-11, Clinical immunology newsletter
— id: 584152, year: 1990, vol: 10, page: 8, stat: Journal Article,

2',3'-dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. A phase I trial [see comments]
Lambert JS; Seidlin M; Reichman RC; Plank CS; Laverty M; Morse GD; Knupp C; McLaren C; Pettinelli C; Valentine FT; et al
1990 May 10;322(19):1333-1340, New England journal of medicine
— id: 15511, year: 1990, vol: 322, page: 1333, stat: Journal Article,

Pathogenesis of the immunological deficiencies caused by infection with the human immunodeficiency virus
Valentine FT
1990 Jun;17(3):321-334, Seminars in oncology
— id: 8240, year: 1990, vol: 17, page: 321, stat: Journal Article,

Immunological and virological surrogate markers in the evaluation of therapies for HIV infection
Valentine FT; Jacobson MA
1990 ;4 Suppl 1:S201-S206, AIDS
— id: 15512, year: 1990, vol: 4 Suppl 1, page: S201, stat: Journal Article,

Phase I study of 2',3'-dideoxyinosine: experience with 19 patients at New York University Medical Center
Valentine FT; Seidlin M; Hochster H; Laverty M
1990 Jul-Aug;12 Suppl 5:S534-S539, Reviews of infectious diseases
— id: 15510, year: 1990, vol: 12 Suppl 5, page: S534, stat: Journal Article,

Phase I/II trial of thymostimulin in opportunistic infections of the acquired immune deficiency syndrome
Chachoua A; Green MD; Valentine F; Muggia FM
1989 ;7(3):225-229, Cancer investigation
— id: 10760, year: 1989, vol: 7, page: 225, stat: Journal Article,

Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin
Lavie G; Valentine F; Levin B; Mazur Y; Gallo G; Lavie D; Weiner D; Meruelo D
1989 Aug;86(15):5963-5967, Proceedings of the National Academy of Sciences of the United States of America
— id: 10542, year: 1989, vol: 86, page: 5963, stat: Journal Article,

Results of the flow cytometry ACTG quality control program: analysis and findings
Paxton, H; Kidd, P; Landay, A; Giorgi, J; Flomenberg, N; Walker, E; Valentine, F; Fahey, J; Gelman, R
1989 Jul;52(1):68-84, Clinical immunology & immunopathology
— id: 135032, year: 1989, vol: 52, page: 68, stat: Journal Article,

Prevalence of HIV infection in New York call girls
Seidlin M; Krasinski K; Bebenroth D; Itri V; Paolino AM; Valentine F
1988 ;1(2):150-154, Journal of acquired immune deficiency syndrome
— id: 11246, year: 1988, vol: 1, page: 150, stat: Journal Article,

Detection of HIV antigen and specific antibodies to HIV core and envelope proteins in sera of patients with HIV infection
Cao YZ; Valentine F; Hojvat S; Allain JP; Rubinstein P; Mirabile M; Czelusniak S; Leuther M; Baker L; Friedman-Kien AE
1987 Aug;70(2):575-578, Blood
— id: 14776, year: 1987, vol: 70, page: 575, stat: Journal Article,

Immunophenotype of human melanoma cells in different metastases
Bystryn JC; Bernstein P; Liu P; Valentine F
1985 Nov;45(11 Pt 2):5603-5607, Cancer research
— id: 16255, year: 1985, vol: 45, page: 5603, stat: Journal Article,

Cryptococcal pericarditis in an intravenous drug abuser
Schuster M; Valentine F; Holzman R
1985 Oct;152(4):842-842, Journal of infectious diseases
— id: 63235, year: 1985, vol: 152, page: 842, stat: Journal Article,

METASTATIC MELANOMA-CELLS BEAR ANTIGENS THAT MAY BE RECOGNIZED INVIVO BY THE PATIENTS LYMPHOCYTES
Valentine, FT
1985 ;11(8):821-821, Journal of dermatologic surgery & oncology
— id: 30863, year: 1985, vol: 11, page: 821, stat: Journal Article,

Reduced Langerhans' cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome
Belsito DV; Sanchez MR; Baer RL; Valentine F; Thorbecke GJ
1984 May 17;310(20):1279-1282, New England journal of medicine
— id: 8829, year: 1984, vol: 310, page: 1279, stat: Journal Article,

REDUCED LANGERHANS CELL IA-ANTIGEN AND ATPASE ACTIVITY IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)
BELSITO, D; SANCHEZ, M; BAER, R; VALENTINE, F; THORBECKE, GJ
1984 ;82(4):398-398, Journal of investigative dermatology
— id: 40815, year: 1984, vol: 82, page: 398, stat: Journal Article,

REDUCED LANGERHANS CELL IA-ANTIGEN AND ATPASE ACTIVITY IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)
BELSITO, D; SANCHEZ, M; BAER, R; VALENTINE, F; THORBECKE, GJ
1984 ;32(2):A570-A570, Clinical research
— id: 40835, year: 1984, vol: 32, page: A570, stat: Journal Article,

STRATEGIES TO CIRCUMVENT ANTIGENETIC HETEROGENEITY RESTRICTING THE SPECIFIC IMMUNOTHERAPY OF MELANOMA
BYSTRYN, JC; BERNSTEIN, P; VALENTINE, F
1984 ;32(2):A481-A481, Clinical research
— id: 40828, year: 1984, vol: 32, page: A481, stat: Journal Article,

MAPPING OF CELL-SURFACE MELANOMA-ASSOCIATED ANTIGENS IN DIFFERENT INDIVIDUALS AND IN DIFFERENT METASTASES IN THE SAME INDIVIDUAL
BYSTRYN, JC; LIU, P; VALENTINE, F; BERNSTEIN, P
1984 ;57(3):344-344, Yale journal of biology & medicine
— id: 40771, year: 1984, vol: 57, page: 344, stat: Journal Article,

Acquired immune deficiency syndrome possibly related to transfusion in an adult without known disease-risk factors
Gordon SM; Valentine FT; Holzman RS; Holliday RA; Baggott B; Chinitz LA; Brick PD
1984 Jun;149(6):1030-1032, Journal of infectious diseases
— id: 15513, year: 1984, vol: 149, page: 1030, stat: Journal Article,

HUMAN-TUMOR CLONOGENIC-ASSAY - CHEMOSENSITIVITY TESTING IN SOFT AGAR AND CLINICAL CORRELATION IN MALIGNANT-MELANOMA
CUMPS, E; BOWEN, J; HARRIS, M; ROSES, D; GOLOMB, F; VALENTINE, F; MUGGIA, F; LEVIN, M
1983 ;31(2):A405-A405, Clinical research
— id: 40682, year: 1983, vol: 31, page: A405, stat: Journal Article,

SURFACE-PROPERTIES OF MELANOMA-CELLS IN DIFFERENT METASTASES IN THE SAME INDIVIDUAL
LIU, P; VALENTINE, F; BYSTRYN, JC
1983 ;31(2):A265-A265, Clinical research
— id: 40543, year: 1983, vol: 31, page: A265, stat: Journal Article,

Cytotoxicity of natural killer cells: correlation with emperipolesis and surface enzymes
Burns ER; Zucker-Franklin D; Valentine F
1982 Jul;47(1):99-107, Laboratory investigation
— id: 61762, year: 1982, vol: 47, page: 99, stat: Journal Article,

EFFECTS INVIVO OF AUTOLOGOUS LYMPHOKINES(LK) ON INJECTED AND ON NON-INJECTED METASTATIC NODULES OF HUMAN-MALIGNANT MELANOMA
Valentine, F; Golomb, F; Fazzini, E
1982 ;4(4):375-375, International journal of immunopharmacology
— id: 30533, year: 1982, vol: 4, page: 375, stat: Journal Article,

Characterization of the cell population mediating cytotoxicity and emperipolesis in human malignant melanomas
Burns ER; Zucker-Franklin D; Valentine F
1981 ;94:366-371, Transactions of the Association of American Physicians
— id: 61770, year: 1981, vol: 94, page: 366, stat: Journal Article,

CHARACTERIZATION OF THE CELL-POPULATION MEDIATING CYTO-TOXICITY AND EMPERIPOLESIS IN HUMAN-MALIGNANT MELANOMA
BURNS, ER; ZUCKERFRANKLIN, D; VALENTINE, F
1981 ;29(2):A580-A580, Clinical research
— id: 40228, year: 1981, vol: 29, page: A580, stat: Journal Article,

Interaction of mononuclear leukocytes with malignant melanoma
Fujinami N; Zucker-Franklin D; Valentine F
1981 Jul;45(1):28-37, Laboratory investigation
— id: 61768, year: 1981, vol: 45, page: 28, stat: Journal Article,

The proliferative response of human lymphocytes to antigen is suppressed preferentially by lymphocytes precultured with the same antigen
Borkowsky W; Valentine FT
1979 May;122(5):1867-1873, Journal of immunology
— id: 14599, year: 1979, vol: 122, page: 1867, stat: Journal Article,

Activated lymphocytes depress phagocytosis of latex particles by human monocyte-macrophages
Al-Ibrahim MS; Valentine FT; Lawrence HS
1978 Dec;41(2):217-230, Cellular immunology
— id: 15514, year: 1978, vol: 41, page: 217, stat: Journal Article,

A micromethod for evaluating the phagocytic activity of human macrophages by ingestion of radio-labelled polystyrene particles
Al-Ibrahim MS; Chandra R; Kishore R; Valentine FT; Lawrence HS
1976 Mar;10(2-3):207-218, Journal of immunological methods
— id: 15516, year: 1976, vol: 10, page: 207, stat: Journal Article,

MICRO-ASSAY FOR MACROPHAGE ACTIVATION IN MAN
Alibrahim, MS; Valentine, FT; Lawrence, HS
1976 ;24(3):A444-A444, Clinical research
— id: 28758, year: 1976, vol: 24, page: A444, stat: Journal Article,

Leucocyte dialysates require precommitted, antigen-reactive cells to augment lymphocyte proliferation
Cohen L; Holzman RS; Valentine FT; Lawrence HS
Transfer factor: basic properties and clinical applications New York, Academic Press, 1976,
— id: 2535, year: 1976, vol: , page: 61, stat: Chapter,

Requirement of precommitted cells as targets for the augmentation of lymphocyte proliferation by leukocyte dialysates
Cohen L; Holzman RS; Valentine FT; Lawrence HS
1976 Apr 1;143(4):791-804, Journal of experimental medicine
— id: 15515, year: 1976, vol: 143, page: 791, stat: Journal Article,

PRECOMMITTED ANTIGEN RESPONSIVE CELLS ARE REQUIRED FOR AUGMENTATION OF LYMPHOCYTE-PROLIFERATION BY LEUKOCYTE DIALYSATES
Cohen, L; Holzman, RS; Valentine, FT; Lawrence, HS
1976 ;24(4):A604-A604, Clinical research
— id: 28729, year: 1976, vol: 24, page: A604, stat: Journal Article,

Transfer factor: is it related to immune RNA
Valentine FT
Immune RNA in neoplasia New York, Academic Press, 1976,
— id: 2534, year: 1976, vol: , page: 75, stat: Chapter,

LYMPHOCYTE STIMULATION BY HERPES-SIMPLEX ANTIGENS IN RECURRENT HERPES INFECTIONS
Valentine, FT
1975 ;51(10):1193-1193, Bulletin of the New York Academy of Medicine
— id: 28636, year: 1975, vol: 51, page: 1193, stat: Journal Article,

In vitro properties of leukocyte dialysates containing transfer factor
Ascher MS; Schneider WJ; Valentine FT; Lawrence HS
1974 Apr;71(4):1178-1182, Proceedings of the National Academy of Sciences of the United States of America
— id: 15518, year: 1974, vol: 71, page: 1178, stat: Journal Article,

Effects of dialyzable transfer factor in patients with breast cancer
Oettgen HF; Old LJ; Farrow JH; Valentine FT; Lawrence HS; Thomas L
1974 Jun;71(6):2319-2323, Proceedings of the National Academy of Sciences of the United States of America
— id: 15517, year: 1974, vol: 71, page: 2319, stat: Journal Article,

Soluble factors produced by lymphocytes
Valentine FT
1974 ;221:317-323, Annals of the New York Academy of Sciences
— id: 15519, year: 1974, vol: 221, page: 317, stat: Journal Article,

Preparation and properties of cloning inhibitory factor. I. Inhibition of HeLa cell cloning by stimulated lymphocytes and their culture supernatants
Holzman RS; Lebowitz AS; Valentine FT; Lawrence HS
1973 Aug;8(2):249-258, Cellular immunology
— id: 15521, year: 1973, vol: 8, page: 249, stat: Journal Article,

Preparation and properties of cloning inhibitory factor. II. Factors affecting its production and assay
Holzman RS; Valentine FT; Lawrence HS
1973 Aug;8(2):259-269, Cellular immunology
— id: 15520, year: 1973, vol: 8, page: 259, stat: Journal Article,

Cell-mediated immunity
Valentine, F T; Lawrence, H S
1971 ;17:51-93, Advances in internal medicine
— id: 15522, year: 1971, vol: 17, page: 51, stat: Journal Article,

Transfer factor and other mediators of cellular immunity
Lawrence HS; Valentine FT
1970 Sep;60(3):437-452, American journal of pathology
— id: 15523, year: 1970, vol: 60, page: 437, stat: Journal Article,

Transfer factor in delayed hypersensitivity
Lawrence HS; Valentine FT
1970 Feb 13;169(1):269-287, Annals of the New York Academy of Sciences
— id: 15524, year: 1970, vol: 169, page: 269, stat: Journal Article,

Cellular immunity in vitro. Clonal proliferation of antigen-stimulated lymphocytes
Marshall WH; Valentine FT; Lawrence HS
1969 Aug 1;130(2):327-343, Journal of experimental medicine
— id: 15526, year: 1969, vol: 130, page: 327, stat: Journal Article,

Lymphocyte stimulation: transfer of cellular hypersensitivity to antigen in vitro
Valentine FT; Lawrence HS
1969 Sep 5;165(897):1014-1016, Science
— id: 15525, year: 1969, vol: 165, page: 1014, stat: Journal Article,