Fred T. Valentine

Biosketch / Results /

Fred Valentine

Research Professor, Department of Medicine

Contact Info

Address
462 First Avenue
New York, NY 10016

212/263-6401
Fred.Valentine@nyumc.org


Education

1956-1960 — Dr. Valentine received his M.D. degree from Harvard Medical School, Boston, MA, Medical Education
1960-1962 — Internship Boston City Hospital, Harvard Medical Service, Residency Training
1964-1965 — Residency in Medicine, Boston City Hospital, Harvard Medical Service, Residency Training

Research Summary

Our research involves laboratory and clinical studies of immune responses to malignant melanoma. We have developed a method of inducing cellular immune responses to metastatic melanoma that result in frequent durable complete regressions of disease. We also are interested in immunological and virological aspects of human immunodeficiency virus (HIV) infection. We are investigating HIV-specific cellular immune responses in acute, primary HIV infection and in elite controllers who "spontaneously" control HIV without antiretroviral drugs. We have discovered that individuals treated very early in their HIV infection develop strong CD4 T cell memory responses to HIV antigens, similar but often of smaller magnitude to the memory responses observed in elite controllers. Many individuals treated for one year after the onset of their infection are subsequently able to control their blood levels of HIV for at least 1 to 2 years after stopping their anti-HIV drugs.

Research Interests

Malignant Melanoma, Induction of effective immune responses against metastatic meelanoma Pathogenesis of HIV Disease Immune Responses to HIV Cellular Immunology Vaccine design

Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor
Gornalusse, German G; Mummidi, Srinivas; Gaitan, Alvaro A; Jimenez, Fabio; Ramsuran, Veron; Picton, Anabela; Rogers, Kristen; Manoharan, Muthu Saravanan; Avadhanam, Nymisha; Murthy, Krishna K; Martinez, Hernan; Molano Murillo, Angela; Chykarenko, Zoya A; Hutt, Richard; Daskalakis, Demetre; Shostakovich-Koretskaya, Ludmila; Abdool Karim, Salim; Martin, Jeffrey N; Deeks, Steven G; Hecht, Frederick; Sinclair, Elizabeth; Clark, Robert A; Okulicz, Jason; Valentine, Fred T; Martinson, Neil; Tiemessen, Caroline Tanya; Ndung'u, Thumbi; Hunt, Peter W; He, Weijing; Ahuja, Sunil K. Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Aug 11;112(34):E4762-E4771 (1742172)

Structural Characterization of Two Monoclonal Antibodies Targeting the Fourth Constant Domain in the Bridging Sheet of HIV-1 gp120
Pan, R. ; Chen, Y. ; Vaine, M. ; Wang, S. ; Kelker, H. C. ; Itri, V. R. ; Valentine, F. T. ; Lu, S. ; Kong, X.. Structural Characterization of Two Monoclonal Antibodies Targeting the Fourth Constant Domain in the Bridging Sheet of HIV-1 gp120 [Meeting Abstract]. AIDS research & human retroviruses. 2013 NOV 1;29(11):A61-A62 (657002)

Early Detection of HIV Infection Among Kenyan Infants Using a Reverse Transcriptase Activity Assay
Sivapalasingam, Sumathi; Ahmed, Aabid; Mendillo, Megan; Holzman, Robert; Marshed, Fatuma; Mwamzuka, Musa; Khamadi, Samuel; Mwau, Matilu; Laverty, Maura; Valentine, Fred. Early Detection of HIV Infection Among Kenyan Infants Using a Reverse Transcriptase Activity Assay. Pediatric infectious disease journal. 2012 Jul ;31(7):732-735 (169479)

Sex differences in the incidence of peripheral neuropathy among kenyans initiating antiretroviral therapy
Mehta, Sapna A; Ahmed, Aabid; Laverty, Maura; Holzman, Robert S; Valentine, Fred; Sivapalasingam, Sumathi. Sex differences in the incidence of peripheral neuropathy among kenyans initiating antiretroviral therapy. Clinical infectious diseases. 2011 Sep ;53(5):490-496 (136612)

Susceptibility of Human Th17 Cells to Human Immunodeficiency Virus and Their Perturbation during Infection
El Hed, Aimee; Khaitan, Alka; Kozhaya, Lina; Manel, Nicolas; Daskalakis, Demetre; Borkowsky, William; Valentine, Fred; Littman, Dan R; Unutmaz, Derya. Susceptibility of Human Th17 Cells to Human Immunodeficiency Virus and Their Perturbation during Infection. Journal of infectious diseases. 2010 Mar 15;201(6):843-854 (107380)