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Terry GordonProfessor, Department of Environmental Medicine
57 Old Forge Rd.
Tuxedo, NY 10987
Genetic Susceptibility: Our research program utilizes both human and animal experimental models to study the genetic susceptibility underlying the adverse pulmonary and cardiac effects of environmental and occupational air pollutants. We perform these studies in collaboration with several investigators at NYU School of Medicine and other academic centers. One primary focus of ongoing studies is to examine the cellular, molecular, and humoral interactions which lead to pollutant-induced pulmonary injury. The most important aim of my susceptibility work examines the contribution of genetic susceptibility to the adverse effects of inhaled pollutants. We examine the role of genetic host factors in murine models of disease using both classic mouse genetic and computational genomics approaches. Ongoing genetic studies examine the relative contribution of ozone, age, beryllium, hyperbaric oxygen, and nanoparticles to adverse effects. Our overall goal is to examine not only the pathways involved in the progression of pulmonary disease but also the role of endogenous mediators in the development of tolerance associated with chronic exposure to environmental and occupational agents.
Particulate Matter: Ambient PM produces significant adverse cardiopulmonary effects. Our lab examines the role of coarse, fine, and ultrafine PM both in vitro and in vivo. Over the last few years, we have collected ambient PM in several cities in the U.S., Germany, and China (the latter both during and after the 2008 Olympics). Ongoing studies focus on the differential toxicity of PM on the basis of particle size, season, composition, and urban/rural location.
Research Keywordsadverse effects of ambient particulate matter, genetic susceptibility of lung disease produced by environmental and occupational agents
Secondhand hookah smoke: an occupational hazard for hookah bar employees
Zhou, Sherry; Behrooz, Leili; Weitzman, Michael; Pan, Grace; Vilcassim, Ruzmyn; Mirowsky, Jaime E; Breysee, Patrick; Rule, Ana; Gordon, Terry. Secondhand hookah smoke: an occupational hazard for hookah bar employees. Tobacco control. 2017 Jan;26(1):40-45 (1929612)
Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time
Silva, Rona M; Anderson, Donald S; Peake, Janice; Edwards, Patricia C; Patchin, Esther S; Guo, Ting; Gordon, Terry; Chen, Lung Chi; Sun, Xiaolin; Van Winkle, Laura S; Pinkerton, Kent E. Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time. Toxicology pathology. 2016 Jul;44(5):673-686 (2059132)
Perception and reality of particulate matter exposure in New York City taxi drivers
Gany, Francesca; Bari, Sehrish; Prasad, Lakshmi; Leng, Jennifer; Lee, Trevor; Thurston, George D; Gordon, Terry; Acharya, Sudha; Zelikoff, Judith T. Perception and reality of particulate matter exposure in New York City taxi drivers. Journal of exposure science & environmental epidemiology. 2016 May 11;:?-? (2107712)
Frontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages
Lauterstein, Dana E; Tijerina, Pamella B; Corbett, Kevin; Akgol Oksuz, Betul; Shen, Steven S; Gordon, Terry; Klein, Catherine B; Zelikoff, Judith T. Frontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages. International journal of environmental research & public health. 2016 Apr 12;13(4):417-417 (2078432)
"Particulate Air Pollution and Clinical Cardiovascular Disease Risk Factors"
Shanley, Ryan P; Hayes, Richard B; Cromar, Kevin R; Ito, Kazuhiko; Gordon, Terry; Ahn, Jiyoung. "Particulate Air Pollution and Clinical Cardiovascular Disease Risk Factors". Epidemiology. 2016 Mar;27(2):291-298 (1856952)