Terry Gordon

Biosketch / Results /

Terry Gordon

Professor, Department of Environmental Medicine
Environmental Medicine

Contact Info

Address
57 Old Forge Rd.
Tuxedo, NY 10987

845/731-3536
Terry.Gordon@nyumc.org

Education

1975-1977 — M.S. (Toxicology), University of Michigan, Graduate Education
1978-1981 — Ph.D. (Toxicology), MIT, Graduate Education
1983-1985 — UCSF, PostDoctoral Training

Research Summary



Genetic Susceptibility: Our research program utilizes both human and animal experimental models to study the genetic susceptibility underlying the adverse pulmonary and cardiac effects of environmental and occupational air pollutants. We perform these studies in collaboration with several investigators at NYU School of Medicine and other academic centers. One primary focus of ongoing studies is to examine the cellular, molecular, and humoral interactions which lead to pollutant-induced pulmonary injury. The most important aim of my susceptibility work examines the contribution of genetic susceptibility to the adverse effects of inhaled pollutants. We examine the role of genetic host factors in murine models of disease using both classic mouse genetic and computational genomics approaches. Ongoing genetic studies examine the relative contribution of ozone, age, beryllium, hyperbaric oxygen, and nanoparticles to adverse effects. Our overall goal is to examine not only the pathways involved in the progression of pulmonary disease but also the role of endogenous mediators in the development of tolerance associated with chronic exposure to environmental and occupational agents.



Particulate Matter: Ambient PM produces significant adverse cardiopulmonary effects. Our lab examines the role of coarse, fine, and ultrafine PM both in vitro and in vivo. Over the last few years, we have collected ambient PM in several cities in the U.S., Germany, and China (the latter both during and after the 2008 Olympics). Ongoing studies focus on the differential toxicity of PM on the basis of particle size, season, composition, and urban/rural location.




Research Interests

1. Adverse effects of ambient particulate matter 2. Genetic susceptibility of lung disease produced by environmental and occupational agents

Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung
Anderson, Donald S; Patchin, Esther S; Silva, Rona M; Uyeminami, Dale L; Sharmah, Arjun; Guo, Ting; Das, Gautom K; Brown, Jared M; Shannahan, Jonathan; Gordon, Terry; Chen, Lung Chi; Pinkerton, Kent E; Van Winkle, Laura S
2015-04-06; 1096-0929,Toxicological sciences - id: 1520502, year: 2015 Journal Article

Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications
Mirowsky, J; Gordon, T
2015-04-01; 1559-0631,Journal of exposure science & environmental epidemiology - id: 1515422, year: 2015

In vitro and in vivo toxicity of urban and rural particulate matter from California
Mirowsky, Jaime E.; Jin, Lan; Thurston, George; Lighthall, David; Tyner, Tim; Horton, Lori; Galdanes, Karen; Chillrud, Steven; Ross, James; Pinkerton, Kent E.; Chen, Lung Chi; Lippmann, Morton; Gordon, Terry
2015-04-10; 1352-2310,Atmospheric environment (Oxford) - id: 1522182, year: 2015

Hookah use among adolescents in the United States: results of a national survey
Amrock, Stephen M; Gordon, Terry; Zelikoff, Judith T; Weitzman, Michael
2014-01-20; 1462-2203,Nicotine & tobacco research - id: 741352, year: 2014 Journal Article

Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract
Asgharian, B; Price, O T; Oldham, M; Chen, Lung-Chi; Saunders, E L; Gordon, T; Mikheev, V B; Minard, K R; Teeguarden, J G
2015-01-07; 0895-8378,Inhalation toxicology - id: 1423642, year: 2014 Journal Article