Matthias Stadtfeld

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Matthias Stadtfeld

Assistant Professor;
Departments of Cell Biology (Cell Biology) and Skirball (Skirball)

Contact Info

Address
540 First Ave
Floor 4th Room Lab 1
Skirball Institute
New York, NY 10016

Matthias.Stadtfeld@med.nyu.edu


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Education

2001-2006 — Albert Einstein College of Medicine, Graduate Education

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Research Summary

Pluripotent cells that have the unique ability to form all cell types of the adult body can be derived in two different ways: 1) by explanting early mammalian embryos, thereby giving rise to embryonic stem (ES) cells and 2) by the enforced expression of defined embryonic transcription factors in adult somatic cells, giving rise to induced pluripotent stem (iPS) cells. The latter process is commonly referred to as reprogramming and allows for the comparatively straightforward generation of patient-specific pluripotent stem cells to study, and ultimately possibly treat, degenerative disorders. In addition, iPSC technology represents a tractable experimental approach to study mammalian development. Research in my laboratory uses reprogramming technology to identify mechanisms that control gene expression and determine cellular identity, using the mouse as the main model organism. One major focus of research will be determining the reasons for the occurrence of epigenetic abnormalities that are frequently introduced in specific genomic regions during iPS cell formation. These abnormalities limit the developmental potential of iPS cells and their study will help unraveling the molecular requirements for faithful epigenetic reprogramming. A second major goal will be using pluripotent cells for the in vitro generation of adult-type stem cells that are functionally equivalent to their in vivo counterparts found in the body. We are especially interested in understanding the molecular determinants of blood cell specification and, ultimately, the generation of functional hematopoietic stem cells from ES cells and iPS cells.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming
Apostolou, Effie; Ferrari, Francesco; Walsh, Ryan M; Bar-Nur, Ori; Stadtfeld, Matthias; Cheloufi, Sihem; Stuart, Hannah T; Polo, Jose M; Ohsumi, Toshiro K; Borowsky, Mark L; Kharchenko, Peter V; Park, Peter J; Hochedlinger, Konrad
2013 Jun;12(6):699-712, Cell stem cell
— id: 942602, year: 2013, vol: 12, page: 699, stat: Journal Article,

Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state
Gonzalez, Federico; Georgieva, Daniela; Vanoli, Fabio; Shi, Zhong-Dong; Stadtfeld, Matthias; Ludwig, Thomas; Jasin, Maria; Huangfu, Danwei
2013 Mar;3(3):651-660, Cell reports
— id: 942592, year: 2013, vol: 3, page: 651, stat: Journal Article,

Panning data for gold: the search for master regulators of cell fate
Trapkov, Vanguel; Stadtfeld, Matthias
2013 Jun;10(6):476-477, Nature methods
— id: 366902, year: 2013, vol: 10, page: 476, stat: Journal Article,

Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system
Buckley, Shannon M; Aranda-Orgilles, Beatriz; Strikoudis, Alexandros; Apostolou, Effie; Loizou, Evangelia; Moran-Crusio, Kelly; Farnsworth, Charles L; Koller, Antonius A; Dasgupta, Ramanuj; Silva, Jeffrey C; Stadtfeld, Matthias; Hochedlinger, Konrad; Chen, Emily I; Aifantis, Iannis
2012 Dec;11(6):783-798, Cell stem cell
— id: 202132, year: 2012, vol: 11, page: 783, stat: Journal Article,

A molecular roadmap of reprogramming somatic cells into iPS cells
Polo, Jose M; Anderssen, Endre; Walsh, Ryan M; Schwarz, Benjamin A; Nefzger, Christian M; Lim, Sue Mei; Borkent, Marti; Apostolou, Effie; Alaei, Sara; Cloutier, Jennifer; Bar-Nur, Ori; Cheloufi, Sihem; Stadtfeld, Matthias; Figueroa, Maria Eugenia; Robinton, Daisy; Natesan, Sridaran; Melnick, Ari; Zhu, Jinfang; Ramaswamy, Sridhar; Hochedlinger, Konrad
2012 Dec;151(7):1617-1632, Cell
— id: 215822, year: 2012, vol: 151, page: 1617, stat: Journal Article,

Blood cell fate changes without cell cycle transition
Stadtfeld, Matthias
2012 Sep;11(17):3154-3155, Cell cycle
— id: 178058, year: 2012, vol: 11, page: 3154, stat: Journal Article,

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells
Stadtfeld, Matthias; Apostolou, Effie; Ferrari, Francesco; Choi, Jiho; Walsh, Ryan M; Chen, Taiping; Ooi, Steen S K; Kim, Sang Yong; Bestor, Timothy H; Shioda, Toshi; Park, Peter J; Hochedlinger, Konrad
2012 Apr;44(4):398-405, S1, Nature genetics
— id: 232792, year: 2012, vol: 44, page: 398, stat: Journal Article,

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling
Bertozzi, Cara C; Schmaier, Alec A; Mericko, Patricia; Hess, Paul R; Zou, Zhiying; Chen, Mei; Chen, Chiu-Yu; Xu, Bin; Lu, Min-min; Zhou, Diane; Sebzda, Eric; Santore, Matthew T; Merianos, Demetri J; Stadtfeld, Matthias; Flake, Alan W; Graf, Thomas; Skoda, Radek; Maltzman, Jonathan S; Koretzky, Gary A; Kahn, Mark L
2010 Jul 29;116(4):661-670, Blood
— id: 149095, year: 2010, vol: 116, page: 661, stat: Journal Article,

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
Polo, Jose M; Liu, Susanna; Figueroa, Maria Eugenia; Kulalert, Warakorn; Eminli, Sarah; Tan, Kah Yong; Apostolou, Effie; Stadtfeld, Matthias; Li, Yushan; Shioda, Toshi; Natesan, Sridaran; Wagers, Amy J; Melnick, Ari; Evans, Todd; Hochedlinger, Konrad
2010 Aug;28(8):848-855, Nature biotechnology
— id: 149094, year: 2010, vol: 28, page: 848, stat: Journal Article,

Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture
Singbrant, Sofie; Karlsson, Goran; Ehinger, Mats; Olsson, Karin; Jaako, Pekka; Miharada, Ken-Ichi; Stadtfeld, Matthias; Graf, Thomas; Karlsson, Stefan
2010 Jun 10;115(23):4689-4698, Blood
— id: 149096, year: 2010, vol: 115, page: 4689, stat: Journal Article,

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
Stadtfeld, Matthias; Apostolou, Effie; Akutsu, Hidenori; Fukuda, Atsushi; Follett, Patricia; Natesan, Sridaran; Kono, Tomohiro; Shioda, Toshi; Hochedlinger, Konrad
2010 May 13;465(7295):175-181, Nature
— id: 149097, year: 2010, vol: 465, page: 175, stat: Journal Article,

Induced pluripotency: history, mechanisms, and applications
Stadtfeld, Matthias; Hochedlinger, Konrad
2010 Oct 15;24(20):2239-2263, Genes & development
— id: 149093, year: 2010, vol: 24, page: 2239, stat: Journal Article,

A reprogrammable mouse strain from gene-targeted embryonic stem cells
Stadtfeld, Matthias; Maherali, Nimet; Borkent, Marti; Hochedlinger, Konrad
2010 Jan;7(1):53-55, Nature methods
— id: 149098, year: 2010, vol: 7, page: 53, stat: Journal Article,

Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells
Eminli, Sarah; Foudi, Adlen; Stadtfeld, Matthias; Maherali, Nimet; Ahfeldt, Tim; Mostoslavsky, Gustavo; Hock, Hanno; Hochedlinger, Konrad
2009 Sep;41(9):968-976, Nature genetics
— id: 149099, year: 2009, vol: 41, page: 968, stat: Journal Article,

Induced pluripotent stem cell generation using a single lentiviral stem cell cassette
Sommer, Cesar A; Stadtfeld, Matthias; Murphy, George J; Hochedlinger, Konrad; Kotton, Darrell N; Mostoslavsky, Gustavo
2009 Mar;27(3):543-549, Stem cells
— id: 149102, year: 2009, vol: 27, page: 543, stat: Journal Article,

Without a trace? PiggyBac-ing toward pluripotency
Stadtfeld, Matthias; Hochedlinger, Konrad
2009 May;6(5):329-330, Nature methods
— id: 149101, year: 2009, vol: 6, page: 329, stat: Journal Article,

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
Utikal, Jochen; Polo, Jose M; Stadtfeld, Matthias; Maherali, Nimet; Kulalert, Warakorn; Walsh, Ryan M; Khalil, Adam; Rheinwald, James G; Hochedlinger, Konrad
2009 Aug 27;460(7259):1145-1148, Nature
— id: 149100, year: 2009, vol: 460, page: 1145, stat: Journal Article,

Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions
Varas, Florencio; Stadtfeld, Matthias; de Andres-Aguayo, Luisa; Maherali, Nimet; di Tullio, Alessandro; Pantano, Lorena; Notredame, Cedric; Hochedlinger, Konrad; Graf, Thomas
2009 Feb;27(2):300-306, Stem cells
— id: 149103, year: 2009, vol: 27, page: 300, stat: Journal Article,

Heterogeneity of embryonic and adult stem cells
Graf, Thomas; Stadtfeld, Matthias
2008 Nov 6;3(5):480-483, Cell stem cell
— id: 149105, year: 2008, vol: 3, page: 480, stat: Journal Article,

Reprogramming of pancreatic beta cells into induced pluripotent stem cells
Stadtfeld, Matthias; Brennand, Kristen; Hochedlinger, Konrad
2008 Jun 24;18(12):890-894, Current biology. CB
— id: 149106, year: 2008, vol: 18, page: 890, stat: Journal Article,

Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse
Stadtfeld, Matthias; Maherali, Nimet; Breault, David T; Hochedlinger, Konrad
2008 Mar 6;2(3):230-240, Cell stem cell
— id: 149107, year: 2008, vol: 2, page: 230, stat: Journal Article,

Induced pluripotent stem cells generated without viral integration
Stadtfeld, Matthias; Nagaya, Masaki; Utikal, Jochen; Weir, Gordon; Hochedlinger, Konrad
2008 Nov 7;322(5903):945-949, Science
— id: 149104, year: 2008, vol: 322, page: 945, stat: Journal Article,

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution
Maherali, Nimet; Sridharan, Rupa; Xie, Wei; Utikal, Jochen; Eminli, Sarah; Arnold, Katrin; Stadtfeld, Matthias; Yachechko, Robin; Tchieu, Jason; Jaenisch, Rudolf; Plath, Kathrin; Hochedlinger, Konrad
2007 Jun 7;1(1):55-70, Cell stem cell
— id: 149108, year: 2007, vol: 1, page: 55, stat: Journal Article,

Identification of interventricular septum precursor cells in the mouse embryo
Stadtfeld, Matthias; Ye, Min; Graf, Thomas
2007 Feb 1;302(1):195-207, Developmental biology (Orlando)
— id: 149110, year: 2007, vol: 302, page: 195, stat: Journal Article,

CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation
Zhang, Jinghang; Varas, Florencio; Stadtfeld, Matthias; Heck, Susanne; Faust, Nicole; Graf, Thomas
2007 Mar;35(3):490-499, Experimental hematology
— id: 149109, year: 2007, vol: 35, page: 490, stat: Journal Article,

Determinants of lymphoid-myeloid lineage diversification
Laiosa, Catherine V; Stadtfeld, Matthias; Graf, Thomas
2006 ;24:705-738, Annual review of immunology
— id: 149113, year: 2006, vol: 24, page: 705, stat: Journal Article,

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