Edward Y Skolnik

Biosketch / Results /

Edward Y Skolnik, M.D.

Norman S. Wikler Professor of Medicine; Professor; Director Division of Nephrology
Departments of Medicine (Skirball), Biochemistry and Molecular Pharmacology and Molecular Pathogenesis
NYU Langone Medical Center Nephrology Faculty Group Practice

Clinical Addresses

530 FIRST AVENUE, SK-9N
NEW YORK, NY 10016
Hours: Wed. 4 - 6; Fri. 9 - 6
Handicap Access: yes
Phone: 212-263-5851
Fax: 212-263-5711

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Medical Specialties

Nephrology

Medical Expertise

Autosomal Dominant Polycystic Kidney Disease, Transplant Nephrology, Hypertension, General Nephrology, Hemodialysis, Acute and Chronic Kidney Disease/Renal Failure, Glomerular Disease & Glomerulonephritis, Hereditary Kidney Diseases, Fluid & Electrolyte Disorders

Insurance

AETNA HMO, AETNA MEDICARE, AFFINITY, AFFINITY EXCHANGE- ESSENTIAL, CIGNA EPO/POS, Cigna HMO, Cigna PPO, Empire BC/BS, Empire BCBS EPO, Empire BCBS HMO, Empire BCBS MediBlue (Medicare), Empire BCBS PPO, FIDELIS CHLD HLTH, FIDELIS EXCHANGE, FIDELIS FAM HLTH, FIDELIS MEDICARE, Fidelis Medicaid, HealthNet, Local 1199, Medicaid, Medicare, Multiplan, NY MEDICAID, Oxford Freedom Plan, Oxford Liberty, Oxford Medicare, Tricare, UHC COMMUNITY & STATE PLAN, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UNITED EXCHANGE- COMPASS, United Healthcare

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

1985 — Ab Internal Medicine - Internal Medicine
1988 — Ab Internal Medicine (Nephrology)

Education

1982 — SUNY Health Sciences Center at Brooklyn - Downstate Medical, Medical Education
1982-1985 — Mount Sinai Medical Center (Medicine), Residency Training
1986-1988 — New York Presbyterian - Weill Cornell Medical Center (Nephrology), Clinical Fellowships

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Research Summary

The Ca2+-activated K+ channel, KCa3.1, is required for Ca2+ influx and the subsequent activation of B and T cells. Inhibitors of KCa3.1 are in development to treat autoimmune diseases and transplant rejection, underscoring the importance in understanding how these channels are regulated. We recently identified several new signaling molecules that are critical for regulating KCa3.1 channel activity in human CD4+ T cells. We found that: 1) the lipid phophatidylinositol 3 phosphate (PI3P) is required for KCa3.1 channel activity and that the PI3P phosphatase, myotubularin related protein 6 (MTMR6) negatively regulates KCa3.1 by dephosphorylating PI3P; 2) Nucleoside Diphosphate Kinase Beta (NDPK-B), a mammalian histidine kinase, is required for KCa3.1 channel activation by phosphorylating histidine (H) 358 in the carboxyl terminus of KCa3.1; and 3) the histidine phosphatase protein histidine phosphatase-1 (PHPT-1) directly binds and dephosphorylates H358 on KCa3.1 leading to KCa3.1 channel inhibition. These findings provide one of the best examples whereby a mammalian histidine kinase and histidine phosphatase regulates a biological process in mammals. Moreover, these studies identify for the first time that NDPK-B is required for activation of a subset of human CD4+ T cells and that MTMR6 and PHPT-1 function to inhibit activation of these cells. We are currently working to understand the mechanism(s) whereby NDPK-B, PHPT-1, and MTMR6 are regulated in CD4+ T cells. These studies should uncover novel pathways that regulate T cell activation and may identify new mechanisms whereby aberrant activation of these pathways can contribute to autoimmune diseases.

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the presence of innumerous fluid-filled cysts in the kidneys and is a common cause of renal failure. Net fluid secretion into renal cysts is driven by transepithelial Cl- secretion mediated by apical cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels and is an important factor in kidney enlargement. Our recent studies demonstrated that KCa3.1 also plays a critical role in the regulation of CFTR-mediated Cl- secretion and cyst formation in normal human kidney epithelia (NHK) cells and epithelial cells derived from the cysts of ADPKD kidneys. Moreover, we found that treatment of various mouse models of polycystic kidney disease with the KCa3.1 inhibitor, TRAM34, significantly decreased the formation of cysts in these animals. We currently exploring the use of KCa3.1 inhibitors as a potential new therapy to treat patients with ADPKD.

Research Interests

Signal Transduction Mechanisms

Research Keywords

diabetes, insulin receptor, phosphorylation, signaling pathway, tyrosine kinase receptor

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Regulation of the epithelial Ca2+ channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B and PHPT1
Cai, Xinjiang; Srivastava, Shekhar; Surindran, Sheena; Li, Zhai; Skolnik, Edward Y
2014 Apr;25(8):1244-1250, Molecular biology of the cell
— id: 881682, year: 2014, vol: 25, page: 1244, stat: Journal Article,

Nucleoside Diphosphate Kinase B Regulates Angiogenesis Through Modulation of Vascular Endothelial Growth Factor Receptor Type 2 and Endothelial Adherens Junction Proteins
Feng, Yuxi; Gross, Shalini; Wolf, Nadine M; Butenschon, Vicki M; Qiu, Yi; Devraj, Kavi; Liebner, Stefan; Kroll, Jens; Skolnik, Edward Y; Hammes, Hans-Peter; Wieland, Thomas
2014 Aug;:857-867, Arteriosclerosis, thrombosis, & vascular biology
— id: 1142632, year: 2014, vol: , page: 857, stat: Journal Article,

Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis
Maekawa, Masashi; Terasaka, Shimpei; Mochizuki, Yasuhiro; Kawai, Katsuhisa; Ikeda, Yuka; Araki, Nobukazu; Skolnik, Edward Y; Taguchi, Tomohiko; Arai, Hiroyuki
2014 Mar;111(11):E978-E987, Proceedings of the National Academy of Sciences of the United States of America
— id: 882922, year: 2014, vol: 111, page: E978, stat: Journal Article,

Ion channels and transporters in lymphocyte function and immunity
Feske, Stefan; Skolnik, Edward Y; Prakriya, Murali
2012 Jul;12(7):532-547, Nature reviews. Immunology
— id: 170426, year: 2012, vol: 12, page: 532, stat: Journal Article,

Phosphatidylinositol-3-Kinase C2beta and TRIM27 Function To Positively and Negatively Regulate IgE Receptor Activation of Mast Cells
Srivastava, Shekhar; Cai, Xinjiang; Li, Zhai; Sun, Yi; Skolnik, Edward Y
2012 Aug;32(15):3132-3139, Molecular & cellular biology
— id: 175807, year: 2012, vol: 32, page: 3132, stat: Journal Article,

Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A(2) receptor antibody-positive membranous nephropathy
Surindran, Sheena; Ayalon, Rivka; Hasan, Nazia; Beck, Laurence H Jr; Salant, David J; Barisoni, Laura; Skolnik, Edward Y; Beara-Lasic, Lada
2012 Apr;5(2):162-165, Clinical kidney journal
— id: 220982, year: 2012, vol: 5, page: 162, stat: Journal Article,

Cyclosporine versus tacrolimus maintenance therapy in renal transplant
Alghamdi, Saad; Nabi, Zahid; Skolnik, Edward; Alkorbi, Lutfi; Albaqumi, Mamdouh
2011 Jun;9(3):170-174, Experimental & clinical transplantation
— id: 136484, year: 2011, vol: 9, page: 170, stat: Journal Article,

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2beta
Cai, Xinjiang; Srivastava, Shekhar; Sun, Yi; Li, Zhai; Wu, Haiyan; Zuvela-Jelaska, Ljiljana; Li, Jun; Salamon, Rachel S; Backer, Jonathan M; Skolnik, Edward Y
2011 Dec 13;108(50):20072-20077, Proceedings of the National Academy of Sciences of the United States of America
— id: 146256, year: 2011, vol: 108, page: 20072, stat: Journal Article,

Kidney function: glomerular filtration rate measurement with MR renography in patients with cirrhosis
Vivier, Pierre-Hugues; Storey, Pippa; Rusinek, Henry; Zhang, Jeff L; Yamamoto, Akira; Tantillo, Kristopher; Khan, Umer; Lim, Ruth P; Babb, James S; John, Devon; Teperman, Lewis W; Chandarana, Hersh; Friedman, Kent; Benstein, Judith A; Skolnik, Edward Y; Lee, Vivian S
2011 May;259(2):462-470, Radiology
— id: 134249, year: 2011, vol: 259, page: 462, stat: Journal Article,

The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy
Zhdanova, Olga; Srivastava, Shekhar; Di, Lie; Li, Zhai; Tchelebi, Leila; Dworkin, Sara; Johnstone, Duncan B; Zavadil, Jiri; Chong, Mark M; Littman, Dan R; Holzman, Lawrence B; Barisoni, Laura; Skolnik, Edward Y
2011 Oct;80(7):719-730, Kidney international
— id: 137467, year: 2011, vol: 80, page: 719, stat: Journal Article,

A Pilot Clinical Study to Evaluate Changes in Urine Osmolality and Urine cAMP in Response to Acute and Chronic Water Loading in Autosomal Dominant Polycystic Kidney Disease
Barash, Irina; Ponda, Manish P; Goldfarb, David S; Skolnik, Edward Y
2010 Apr;5(4):693-697, Clinical journal of the American Society of Nephrology : CJASN
— id: 107297, year: 2010, vol: 5, page: 693, stat: Journal Article,

Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis
Di, Lie; Srivastava, Shekhar; Zhdanova, Olga; Ding, Yi; Li, Zhai; Wulff, Heike; Lafaille, Maria; Skolnik, Edward Y
2010 Jan 26;107(4):1541-1546, Proceedings of the National Academy of Sciences of the United States of America
— id: 106594, year: 2010, vol: 107, page: 1541, stat: Journal Article,

Nucleoside diphosphate kinase B knock-out mice have impaired activation of the K+ channel KCa3.1, resulting in defective T cell activation
Di, Lie; Srivastava, Shekhar; Zhdanova, Olga; Sun, Yi; Li, Zhai; Skolnik, Edward Y
2010 Dec 10;285(50):38765-38771, Journal of biological chemistry
— id: 116205, year: 2010, vol: 285, page: 38765, stat: Journal Article,

Moderate kidney disease inhibits atherosclerosis regression
Ponda, Manish P; Barash, Irina; Feig, Jonathan E; Fisher, Edward A; Skolnik, Edward Y
2010 May;210(1):57-62, Atherosclerosis
— id: 109717, year: 2010, vol: 210, page: 57, stat: Journal Article,

GLOMERULAR FILTRATION RATE IN CIRRHOTIC PATIENTS BY MR RENOGRAPHY
Vivier, Pierre-Hugues; Storey, Pippa; Rusinek, Henry; Zhang, Jeff L.; Yamamoto, Akira; Tantillo, Kristopher; Lim, Ruth P.; Khan, Umer A.; Babb, James; John, Devon G.; Teperman, Lewis W.; Friedman, Kent P.; Benstein, Judith; Skolnik, Edward; Lee, Vivian S.
2010 OCT ;52(4):963A-964A, Hepatology
— id: 130850, year: 2010, vol: 52, page: 963A, stat: Journal Article,

The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells
Srivastava, Shekhar; Di, Lie; Zhdanova, Olga; Li, Zhai; Vardhana, Santosha; Wan, Qi; Yan, Ying; Varma, Rajat; Backer, Jonathan; Wulff, Heike; Dustin, Michael L; Skolnik, Edward Y
2009 Sep;20(17):3783-3791, Molecular biology of the cell
— id: 101953, year: 2009, vol: 20, page: 3783, stat: Journal Article,

KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease
Albaqumi, Mamdouh; Srivastava, Shekhar; Li, Zhai; Zhdnova, Olga; Wulff, Heike; Itani, Omar; Wallace, Darren P; Skolnik, Edward Y
2008 Sep;74(6):740-749, Kidney international
— id: 91969, year: 2008, vol: 74, page: 740, stat: Journal Article,

Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1
Srivastava, Shekhar; Zhdanova, Olga; Di, Lie; Li, Zhai; Albaqumi, Mamdouh; Wulff, Heike; Skolnik, Edward Y
2008 Sep 23;105(38):14442-14446, Proceedings of the National Academy of Sciences of the United States of America
— id: 83550, year: 2008, vol: 105, page: 14442, stat: Journal Article,

Histidine phosphorylation of the Ca2+-activated K+ channel KCa3.1 by nucleoside diphosphate kinase B (NDPK-B) is required for KCa3.1 channel activation and the reactivation of CD4 T lymphocytes
Srivastava, S; Li, Z; Ko, K; Choudhury, P; Albaqumi, M; Johnson, AK; Yan, Y; Backer, J; Unutmaz, D; Coetzee, WA; Skolnik, EY
2007 JAN ;108(11):200A-200A, Biophysical journal
— id: 71388, year: 2007, vol: 108, page: 200A, stat: Journal Article,

Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain
Choudhury, Papiya; Srivastava, Shekhar; Li, Zhai; Ko, Kyung; Albaqumi, Mamdouh; Narayan, Kartik; Coetzee, William A; Lemmon, Mark A; Skolnik, Edward Y
2006 Oct 20;281(42):31762-31769, Journal of biological chemistry
— id: 70220, year: 2006, vol: 281, page: 31762, stat: Journal Article,

Phosphatidylinositol 3-Phosphate Indirectly Activates KCa3.1 via 14 Amino Acids in the Carboxy Terminus of KCa3.1
Srivastava, Shekhar; Choudhury, Papiya; Li, Zhai; Liu, Gongxin; Nadkarni, Vivek; Ko, Kyung; Coetzee, William A; Skolnik, Edward Y
2006 Jan;17(1):146-154, Molecular biology of the cell
— id: 59246, year: 2006, vol: 17, page: 146, stat: Journal Article,

Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells
Srivastava, Shekhar; Ko, Kyung; Choudhury, Papiya; Li, Zhai; Johnson, Amanda K; Nadkarni, Vivek; Unutmaz, Derya; Coetzee, William A; Skolnik, Edward Y
2006 Aug;26(15):5595-5602, Molecular & cellular biology
— id: 68660, year: 2006, vol: 26, page: 5595, stat: Journal Article,

Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells
Srivastava, Shekhar; Li, Zhai; Ko, Kyung; Choudhury, Papiya; Albaqumi, Mamdouh; Johnson, Amanda K; Yan, Ying; Backer, Jonathan M; Unutmaz, Derya; Coetzee, William A; Skolnik, Edward Y
2006 Dec 8;24(5):665-675, Molecular cell
— id: 69707, year: 2006, vol: 24, page: 665, stat: Journal Article,

Quantitative phosphotyrosine proteomics of EphB2 signaling by stable isotope labeling with amino acids in cell culture (SILAC)
Zhang, Guoan; Spellman, Daniel S; Skolnik, Edward Y; Neubert, Thomas A
2006 Mar;5(3):581-588, Journal of proteome research
— id: 76652, year: 2006, vol: 5, page: 581, stat: Journal Article,

p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
Zohn, Irene E; Li, Yingqiu; Skolnik, Edward Y; Anderson, Kathryn V; Han, Jiahuai; Niswander, Lee
2006 Jun 2;125(5):957-969, Cell
— id: 94744, year: 2006, vol: 125, page: 957, stat: Journal Article,

The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1
Srivastava, Shekhar; Li, Zhai; Lin, Lin; Liu, GongXin; Ko, Kyung; Coetzee, William A; Skolnik, Edward Y
2005 May;25(9):3630-3638, Molecular & cellular biology
— id: 55912, year: 2005, vol: 25, page: 3630, stat: Journal Article,

Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans
Dang, Hope; Li, Zhai; Skolnik, Edward Y; Fares, Hanna
2004 Jan;15(1):189-196, Molecular biology of the cell
— id: 44994, year: 2004, vol: 15, page: 189, stat: Journal Article,

Myotubularins (MTMs) are lipid phosphatases that negatively regulate the Ca2+-activated K+ channel (KCa3.1)
Lin, L; Li, Z; Coetzee, WA; Skolnik, EY
2004 OCT 26 ;110(17):62-62, Circulation
— id: 55935, year: 2004, vol: 110, page: 62, stat: Journal Article,

A potential role for integrin beta 6-mediated activation of TGF-beta in the progression of chronic renal disease
Cardinale, CJ; Ko, K; Dworkin, LD; Shaw, AS; Skolnik, EY
2003 NOV ;14(2):373A-373A, Journal of the American Society of Nephrology
— id: 42504, year: 2003, vol: 14, page: 373A, stat: Journal Article,

The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required for T cell-independent II antigen responses
Fournier, Emanuel; Isakoff, Steven J; Ko, Kyung; Cardinale, Christopher J; Inghirami, Giorgio G; Li, Zhai; Curotto de Lafaille, Maria A; Skolnik, Edward Y
2003 Oct;13(21):1858-1866, Current biology. CB
— id: 159188, year: 2003, vol: 13, page: 1858, stat: Journal Article,

Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans
Xue, Yingzi; Fares, Hanna; Grant, Barth; Li, Zhai; Rose, Ann M; Clark, Scott G; Skolnik, Edward Y
2003 Sep 5;278(36):34380-34386, Journal of biological chemistry
— id: 39208, year: 2003, vol: 278, page: 34380, stat: Journal Article,

Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1
Saxena, Anjana; Morozov, Pavel; Frank, Dale; Musalo, Raymond; Lemmon, Mark A; Skolnik, Edward Y; Tycko, Benjamin
2002 Dec 20;277(51):49935-49944, Journal of biological chemistry
— id: 68910, year: 2002, vol: 277, page: 49935, stat: Journal Article,

Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
Shen, B; Liu, H; Skolnik, E Y; Manley, J L
2001 Jul;98(15):8596-8601, Proceedings of the National Academy of Sciences of the United States of America
— id: 163352, year: 2001, vol: 98, page: 8596, stat: Journal Article,

Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)
Xue Y; Wang X; Li Z; Gotoh N; Chapman D; Skolnik EY
2001 May;128(9):1559-1572, Development
— id: 21213, year: 2001, vol: 128, page: 1559, stat: Journal Article,

Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation
Becker E; Huynh-Do U; Holland S; Pawson T; Daniel TO; Skolnik EY
2000 Mar;20(5):1537-1545, Molecular & cellular biology
— id: 8546, year: 2000, vol: 20, page: 1537, stat: Journal Article,

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains
Ferguson, K M; Kavran, J M; Sankaran, V G; Fournier, E; Isakoff, S J; Skolnik, E Y; Lemmon, M A
2000 Aug;6(2):373-384, Molecular cell
— id: 634662, year: 2000, vol: 6, page: 373, stat: Journal Article,

The Ste20 kinase misshapen regulates both photoreceptor axon targeting and dorsal closure, acting downstream of distinct signals
Su YC; Maurel-Zaffran C; Treisman JE; Skolnik EY
2000 Jul;20(13):4736-4744, Molecular & cellular biology
— id: 11663, year: 2000, vol: 20, page: 4736, stat: Journal Article,

A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase
Liu H; Su YC; Becker E; Treisman J; Skolnik EY
1999 Jan 28;9(2):101-104, Current biology. CB
— id: 6050, year: 1999, vol: 9, page: 101, stat: Journal Article,

Cell-type-specific activation of c-Jun N-terminal kinase by salicylates
Schwenger P; Alpert D; Skolnik EY; Vilcek J
1999 Apr;179(1):109-114, Journal of cellular physiology
— id: 7444, year: 1999, vol: 179, page: 109, stat: Journal Article,

Analysis of the inhibitory action of p38 MAP kinase on TNF-induced IkappaB phosphorylation and degradation
Alpert, Deborah; Schwenger, Paul; Skolnik, Edward Y; Han, Jiahuai; Vilcek, Jan
1998 May 17-21;18(5):A51-A51, Journal of interferon & cytokine research
— id: 15935, year: 1998, vol: 18, page: A51, stat: Journal Article,

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast
Isakoff SJ; Cardozo T; Andreev J; Li Z; Ferguson KM; Abagyan R; Lemmon MA; Aronheim A; Skolnik EY
1998 Sep 15;17(18):5374-5387, EMBO journal
— id: 7615, year: 1998, vol: 17, page: 5374, stat: Journal Article,

Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains
Kavran, J M; Klein, D E; Lee, A; Falasca, M; Isakoff, S J; Skolnik, E Y; Lemmon, M A
1998 Nov;273(46):30497-30508, Journal of biological chemistry
— id: 163493, year: 1998, vol: 273, page: 30497, stat: Journal Article,

Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation
Schwenger P; Alpert D; Skolnik EY; Vilcek J
1998 Jan;18(1):78-84, Molecular & cellular biology
— id: 7974, year: 1998, vol: 18, page: 78, stat: Journal Article,

Negative regulation of TNF-induced I kappa B phosphorylation and degradation by p38 map kinase
Schwenger, P; Alpert, D; Skolnik, EY; Vilcek, J
1998 SEP ;9(3):370-370, European cytokine network
— id: 53661, year: 1998, vol: 9, page: 370, stat: Journal Article,

Differential effects of sodium salicylate on T
Schwenger, Paul; Alpert, Deborah; Skolnik, Edward Y; Vilcek, Jan
1998 May 17-21;18(5):A58-A58, Journal of interferon & cytokine research
— id: 15934, year: 1998, vol: 18, page: A58, stat: Journal Article,

The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway
Su YC; Treisman JE; Skolnik EY
1998 Aug 1;12(15):2371-2380, Genes & development
— id: 7813, year: 1998, vol: 12, page: 2371, stat: Journal Article,

Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation
Schwenger P; Bellosta P; Vietor I; Basilico C; Skolnik EY; Vilcek J
1997 Apr 1;94(7):2869-2873, Proceedings of the National Academy of Sciences of the United States of America
— id: 57523, year: 1997, vol: 94, page: 2869, stat: Journal Article,

Salicylate inhibits TNF-induced NF-kappa B activation by interfering with I kappa B phosphorylation and degradation: The role of p38 MAP kinase
Schwenger, P; Alpert, D; Skolnik, EY; Vilcek, J
1997 DEC 1 ;17(23):108-108, Journal of leukocyte biology
— id: 53151, year: 1997, vol: 17, page: 108, stat: Journal Article,

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
Su YC; Han J; Xu S; Cobb M; Skolnik EY
1997 Mar 17;16(6):1279-1290, EMBO journal
— id: 12352, year: 1997, vol: 16, page: 1279, stat: Journal Article,

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1
Galisteo ML; Chernoff J; Su YC; Skolnik EY; Schlessinger J
1996 Aug 30;271(35):20997-21000, Journal of biological chemistry
— id: 6996, year: 1996, vol: 271, page: 20997, stat: Journal Article,

Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivo
Isakoff SJ; Yu YP; Su YC; Blaikie P; Yajnik V; Rose E; Weidner KM; Sachs M; Margolis B; Skolnik EY
1996 Feb 23;271(8):3959-3962, Journal of biological chemistry
— id: 6919, year: 1996, vol: 271, page: 3959, stat: Journal Article,

Finally, some signaling molecules find a home in yeast
Isakoff, SJ; Wang, YL; Skolnik, EY
1996 MAY ;14(5):578-578, Nature biotechnology
— id: 52919, year: 1996, vol: 14, page: 578, stat: Journal Article,

Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase activation by sodium salicylate
Schwenger P; Skolnik EY; Vilcek J
1996 Apr 5;271(14):8089-8094, Journal of biological chemistry
— id: 6961, year: 1996, vol: 271, page: 8089, stat: Journal Article,

Inhibition of insulin receptor signaling by TNF: potential role in obesity and non-insulin-dependent diabetes mellitus
Skolnik EY; Marcusohn J
1996 Aug;7(2):161-173, Cytokine & growth factor reviews
— id: 12560, year: 1996, vol: 7, page: 161, stat: Journal Article,

Identification of a new STE20 related kinase that binds Nck and activates the SAPK/JNK cascade by interacting with MEKK1
Su, YC; Han, JH; Xu, SC; Cobb, M; Skolnik, EY
1996 DEC ;7(3):2112-2112, Molecular biology of the cell
— id: 53359, year: 1996, vol: 7, page: 2112, stat: Journal Article,

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake
Isakoff SJ; Taha C; Rose E; Marcusohn J; Klip A; Skolnik EY
1995 Oct 24;92(22):10247-10251, Proceedings of the National Academy of Sciences of the United States of America
— id: 56823, year: 1995, vol: 92, page: 10247, stat: Journal Article,

The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes
Marcusohn J; Isakoff SJ; Rose E; Symons M; Skolnik EY
1995 Nov 1;5(11):1296-1302, Current biology. CB
— id: 56831, year: 1995, vol: 5, page: 1296, stat: Journal Article,

Use of tyrosine-phosphorylated proteins to screen bacterial expression libraries for SH2 domains
Margolis B; Skolnik EY; Schlessinger J
1995 ;255:360-369, Methods in enzymology
— id: 6843, year: 1995, vol: 255, page: 360, stat: Journal Article,

Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin
Pruett W; Yuan Y; Rose E; Batzer AG; Harada N; Skolnik EY
1995 Mar;15(3):1778-1785, Molecular & cellular biology
— id: 6717, year: 1995, vol: 15, page: 1778, stat: Journal Article,

The insulin-dependent biosynthesis of GLUT1 and GLUT3 glucose transporters in L6 muscle cells is mediated by distinct pathways. Roles of p21ras and pp70 S6 kinase
Taha, C; Mitsumoto, Y; Liu, Z; Skolnik, E Y; Klip, A
1995 Oct;270(42):24678-24681, Journal of biological chemistry
— id: 163490, year: 1995, vol: 270, page: 24678, stat: Journal Article,

PARTICIPATION OF THE GRBB2-RAS SIGNALING PATHWAY IN THE STIMULATION OF GLUCOSE-TRANSPORTER EXPRESSION BY INSULIN IN L6 MUSCLE-CELLS
TAHA, C; MITSUMOTO, Y; LIU, Z; SKOLNIK, EY; KLIP, A
1995 MAR 10 ;9(4):A977-A977, FASEB journal
— id: 87393, year: 1995, vol: 9, page: A977, stat: Journal Article,

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
Batzer AG; Rotin D; Urena JM; Skolnik EY; Schlessinger J
1994 Aug;14(8):5192-5201, Molecular & cellular biology
— id: 12942, year: 1994, vol: 14, page: 5192, stat: Journal Article,

Activation of Ras by receptor tyrosine kinases
Margolis B; Skolnik EY
1994 Dec;5(6):1288-1299, Journal of the American Society of Nephrology
— id: 56681, year: 1994, vol: 5, page: 1288, stat: Journal Article,

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
Hu P; Mondino A; Skolnik EY; Schlessinger J
1993 Dec;13(12):7677-7688, Molecular & cellular biology
— id: 6407, year: 1993, vol: 13, page: 7677, stat: Journal Article,

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells
Lee CH; Li W; Nishimura R; Zhou M; Batzer AG; Myers MG Jr; White MF; Schlessinger J; Skolnik EY
1993 Dec 15;90(24):11713-11717, Proceedings of the National Academy of Sciences of the United States of America
— id: 56554, year: 1993, vol: 90, page: 11713, stat: Journal Article,

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
Li N; Batzer A; Daly R; Yajnik V; Skolnik E; Chardin P; Bar-Sagi D; Margolis B; Schlessinger J
1993 May 6;363(6424):85-88, Nature
— id: 57448, year: 1993, vol: 363, page: 85, stat: Journal Article,

The function of GRB2 in linking the insulin receptor to Ras signaling pathways
Skolnik EY; Batzer A; Li N; Lee CH; Lowenstein E; Mohammadi M; Margolis B; Schlessinger J
1993 Jun 25;260(5116):1953-1955, Science
— id: 13127, year: 1993, vol: 260, page: 1953, stat: Journal Article,

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling
Skolnik EY; Lee CH; Batzer A; Vicentini LM; Zhou M; Daly R; Myers MJ Jr; Backer JM; Ullrich A; White MF; et al
1993 May;12(5):1929-1936, EMBO journal
— id: 13171, year: 1993, vol: 12, page: 1929, stat: Journal Article,

PHOSPHATIDYLINOSITOL 3'-KINASE IS ACTIVATED BY ASSOCIATION WITH IRS-1 DURING INSULIN STIMULATION
BACKER, JM; MYERS, MG; SHOELSON, SE; CHIN, DJ; SUN, XJ; MIRALPEIX, M; HU, P; MARGOLIS, B; SKOLNIK, EY; SCHLESSINGER, J; WHITE, MF
1992 SEP ;11(9):3469-3479, EMBO journal
— id: 51914, year: 1992, vol: 11, page: 3469, stat: Journal Article,

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
Hu P; Margolis B; Skolnik EY; Lammers R; Ullrich A; Schlessinger J
1992 Mar;12(3):981-990, Molecular & cellular biology
— id: 13684, year: 1992, vol: 12, page: 981, stat: Journal Article,

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors
Li W; Hu P; Skolnik EY; Ullrich A; Schlessinger J
1992 Dec;12(12):5824-5833, Molecular & cellular biology
— id: 13360, year: 1992, vol: 12, page: 5824, stat: Journal Article,

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
Lowenstein EJ; Daly RJ; Batzer AG; Li W; Margolis B; Lammers R; Ullrich A; Skolnik EY; Bar-Sagi D; Schlessinger J
1992 Aug 7;70(3):431-442, Cell
— id: 13480, year: 1992, vol: 70, page: 431, stat: Journal Article,

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains
Margolis B; Silvennoinen O; Comoglio F; Roonprapunt C; Skolnik E; Ullrich A; Schlessinger J
1992 Oct 1;89(19):8894-8898, Proceedings of the National Academy of Sciences of the United States of America
— id: 13415, year: 1992, vol: 89, page: 8894, stat: Journal Article,

THE HUMAN GENE ENCODING PHOSPHATIDYLINOSITOL-3 KINASE ASSOCIATED P85-ALPHA IS AT CHROMOSOME REGION 5Q12-13
CANNIZZARO, LA; SKOLNIK, EY; MARGOLIS, B; CROCE, CM; SCHLESINGER, J; HUEBNER, K
1991 JUL 15 ;51(14):3818-3820, Cancer research
— id: 51577, year: 1991, vol: 51, page: 3818, stat: Journal Article,

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
Skolnik EY; Margolis B; Mohammadi M; Lowenstein E; Fischer R; Drepps A; Ullrich A; Schlessinger J
1991 Apr 5;65(1):83-90, Cell
— id: 57500, year: 1991, vol: 65, page: 83, stat: Journal Article,