Jane Skok

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Jane Skok, Ph.D.

Professor; Co-Dir Path Grand Rounds & Seminars
Department of Pathology (Pathology)

Contact Info

550 First Ave
New York, NY 10016


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Research Interests

Nuclear Organisation of immunoglobulin genes

Research Documents

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All data from NYU Health Sciences Library Faculty Bibliography — -


beta-Catenin induces T-cell transformation by promoting genomic instability
Dose, Marei; Emmanuel, Akinola Olumide; Chaumeil, Julie; Zhang, Jiangwen; Sun, Tianjiao; Germar, Kristine; Aghajani, Katayoun; Davis, Elizabeth M; Keerthivasan, Shilpa; Bredemeyer, Andrea L; Sleckman, Barry P; Rosen, Steven T; Skok, Jane A; Le Beau, Michelle M; Georgopoulos, Katia; Gounari, Fotini
2014 Jan;111(1):391-396, Proceedings of the National Academy of Sciences of the United States of America
— id: 781772, year: 2014, vol: 111, page: 391, stat: Journal Article,

Interpreting 4C-Seq data: how far can we go?
Raviram, Ramya; Rocha, Pedro P; Bonneau, Richard; Skok, Jane A
2014 Oct;6(5):455-457, Epigenomics
— id: 1360082, year: 2014, vol: 6, page: 455, stat: Journal Article,

Taking a break from the lab: can it really be done?
Skok, Jane A
2014 Dec;24(12):725-726, Trends in cell biology
— id: 1369332, year: 2014, vol: 24, page: 725, stat: Journal Article,

Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers
Chaumeil, Julie; Micsinai, Mariann; Ntziachristos, Panagiotis; Deriano, Ludovic; Wang, Joy M-H; Ji, Yanhong; Nora, Elphege P; Rodesch, Matthew J; Jeddeloh, Jeffrey A; Aifantis, Iannis; Kluger, Yuval; Schatz, David G; Skok, Jane A
2013 Feb;3(2):359-370, Cell reports
— id: 242262, year: 2013, vol: 3, page: 359, stat: Journal Article,

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage
Chaumeil, Julie; Micsinai, Mariann; Ntziachristos, Panagiotis; Roth, David B; Aifantis, Iannis; Kluger, Yuval; Deriano, Ludovic; Skok, Jane A
2013 Jul;4:2231-2231, Nature communications
— id: 463612, year: 2013, vol: 4, page: 2231, stat: Journal Article,

Combined immunofluorescence and DNA FISH on 3D-preserved interphase nuclei to study changes in 3D nuclear organization
Chaumeil, Julie; Micsinai, Mariann; Skok, Jane A
2013 ;(72):e50087-e50087 e50087, Journal of visualized experiments : JoVE
— id: 255212, year: 2013, vol: , page: e50087, stat: Journal Article,

A New Take on V(D)J Recombination: Transcription Driven Nuclear and Chromatin Reorganization in Rag-Mediated Cleavage
Chaumeil, Julie; Skok, Jane A
2013 ;4:423-423, Frontiers in immunology
— id: 986692, year: 2013, vol: 4, page: 423, stat: Journal Article,

Molecular biology. Finding the right partner in a 3D genome
Rocha, Pedro P; Chaumeil, Julie; Skok, Jane A
2013 Dec;342(6164):1333-1334, Science
— id: 722322, year: 2013, vol: 342, page: 1333, stat: Journal Article,

Response to Casellas et al
Rocha, Pedro P; Micsinai, Mariann; Kluger, Yuval; Skok, Jane A
2013 Aug;51(3):277-278, Molecular cell
— id: 495012, year: 2013, vol: 51, page: 277, stat: Journal Article,

The origin of recurrent translocations in recombining lymphocytes: a balance between break frequency and nuclear proximity
Rocha, Pedro P; Skok, Jane A
2013 Mar;:365-371, Current opinion in cell biology
— id: 255472, year: 2013, vol: , page: 365, stat: Journal Article,

Viral infection alters subnuclear localization of PD-1 and CD62L loci in LCMV-specific CD8 T-cells (P6369)
Sacristan, Catarina; Youngblood, Ben; Xu, Jean; Lu, Peiyuan; McGary, Katelyn; Hewitt, Susannah; Skok, Jane; Boss, Jerry; Ahmed, Rafi; Dustin, Michael
2013 MAY 1;190:-, Journal of immunology (1950)
— id: 540672, year: 2013, vol: 190, page: , stat: Journal Article,

Equal opportunity for all
Chaumeil, Julie; Skok, Jane A
2012 ;31(7):1627-1629, EMBO journal
— id: 163574, year: 2012, vol: 31, page: 1627, stat: Journal Article,

The role of CTCF in regulating V(D)J recombination
Chaumeil, Julie; Skok, Jane A
2012 Apr;24(2):153-159, Current opinion in immunology
— id: 163575, year: 2012, vol: 24, page: 153, stat: Journal Article,

IL-7 Functionally Segregates the Pro-B Cell Stage by Regulating Transcription of Recombination Mediators across Cell Cycle
Johnson, Kristen; Chaumeil, Julie; Micsinai, Mariann; Wang, Joy M H; Ramsey, Laura B; Baracho, Gisele V; Rickert, Robert C; Strino, Francesco; Kluger, Yuval; Farrar, Michael A; Skok, Jane A
2012 Jun;188(12):6084-6092, Journal of immunology (1950)
— id: 169249, year: 2012, vol: 188, page: 6084, stat: Journal Article,

Close Proximity to Igh Is a Contributing Factor to AID-Mediated Translocations
Rocha, Pedro P; Micsinai, Mariann; Kim, Junghyun Rachel; Hewitt, Susannah L; Souza, Patricia P; Trimarchi, Thomas; Strino, Francesco; Parisi, Fabio; Kluger, Yuval; Skok, Jane A
2012 Sep;47(6):873-885, Molecular cell
— id: 179081, year: 2012, vol: 47, page: 873, stat: Journal Article,

RUNX Transcription Factor-Mediated Association of Cd4 and Cd8 Enables Coordinate Gene Regulation
Collins, Amelie; Hewitt, Susannah L; Chaumeil, Julie; Sellars, Maclean; Micsinai, Mariann; Allinne, Jeanne; Parisi, Fabio; Nora, Elphege P; Bolland, Dan J; Corcoran, Anne E; Kluger, Yuval; Bosselut, Remy; Ellmeier, Wilfried; Chong, Mark M W; Littman, Dan R; Skok, Jane A
2011 Mar 25;34(3):303-314, Immunity
— id: 129323, year: 2011, vol: 34, page: 303, stat: Journal Article,

The RAG2 C terminus suppresses genomic instability and lymphomagenesis
Deriano, Ludovic; Chaumeil, Julie; Coussens, Marc; Multani, Asha; Chou, YiFan; Alekseyenko, Alexander V; Chang, Sandy; Skok, Jane A; Roth, David B
2011 Mar 3;471(7336):119-123, Nature
— id: 128877, year: 2011, vol: 471, page: 119, stat: Journal Article,

Control of RAG cleavage activity contributes to maintaining genome stability during V(D)J recombination
Hewitt, S; Arnal, S; Deriano, L; Roth, D; Skok, J
2011 18 Nov 2011;118(21):-, Blood
— id: 169667, year: 2011, vol: 118, page: , stat: Journal Article,

A multifunctional element in the mouse Igkappa locus that specifies repertoire and Ig loci subnuclear location
Xiang, Yougui; Zhou, Xiaorong; Hewitt, Susannah L; Skok, Jane A; Garrard, William T
2011 May 1;186(9):5356-5366, Journal of immunology (1950)
— id: 133891, year: 2011, vol: 186, page: 5356, stat: Journal Article,

It takes two: Communication between homologous alleles preserves genomic stability during V(D)J recombination
Brandt, Vicky L; Hewitt, Susannah L; Skok, Jane A
2010 Jan;1(1):23-29, Nucleus (Austin, Tex.)
— id: 138156, year: 2010, vol: 1, page: 23, stat: Journal Article,

Chromosome dynamics and the regulation of V(D)J recombination
Hewitt, Susannah L; Chaumeil, Julie; Skok, Jane A
2010 Sep;237(1):43-54, Immunological reviews
— id: 111975, year: 2010, vol: 237, page: 43, stat: Journal Article,

Epigenetic regulation of V(D)J recombination
Johnson, Kristen; Chaumeil, Julie; Skok, Jane A
2010 Sep 20;48(1):221-243, Essays in biochemistry
— id: 112204, year: 2010, vol: 48, page: 221, stat: Journal Article,

V(D)J recombination: a paradigm for studying chromosome interactions in mammalian cells
Skok, Jane A
2010 Apr;2(2):175-177, Epigenomics
— id: 255482, year: 2010, vol: 2, page: 175, stat: Journal Article,

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci
Hewitt, Susannah L; Yin, Bu; Ji, Yanhong; Chaumeil, Julie; Marszalek, Katarzyna; Tenthorey, Jeannette; Salvagiotto, Giorgia; Steinel, Natalie; Ramsey, Laura B; Ghysdael, Jacques; Farrar, Michael A; Sleckman, Barry P; Schatz, David G; Busslinger, Meinrad; Bassing, Craig H; Skok, Jane A
2009 Jun;10(6):655-664, Nature immunology
— id: 99020, year: 2009, vol: 10, page: 655, stat: Journal Article,

Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells
Hewitt, Susannah L; Farmer, Deborah; Marszalek, Katarzyna; Cadera, Emily; Liang, Hong-Erh; Xu, Yang; Schlissel, Mark S; Skok, Jane A
2008 Apr;9(4):396-404, Nature immunology
— id: 78360, year: 2008, vol: 9, page: 396, stat: Journal Article,

Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
Johnson, Kristen; Hashimshony, Tamar; Sawai, Catherine M; Pongubala, Jagan M R; Skok, Jane A; Aifantis, Iannis; Singh, Harinder
2008 Mar;28(3):335-345, Immunity
— id: 81074, year: 2008, vol: 28, page: 335, stat: Journal Article,

Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1
Karnowski, Alexander; Cao, Chun; Matthias, Gabriele; Carotta, Sebastian; Corcoran, Lynn M; Martensson, Inga-Lill; Skok, Jane A; Matthias, Patrick
2008 ;3(10):e3568-e3568, PLoS one
— id: 105353, year: 2008, vol: 3, page: e3568, stat: Journal Article,

Jane Skok: choreography of allelic exclusion.
Skok, Jane
2008 Jul 7;205(7):1514-1515, Journal of experimental medicine
— id: 81075, year: 2008, vol: 205, page: 1514, stat: Journal Article,

Dynamic changes in accessibility, nuclear positioning, recombination, and transcription at the Ig kappa locus
Fitzsimmons, Sean P; Bernstein, Ralph M; Max, Edward E; Skok, Jane A; Shapiro, Marjorie A
2007 Oct 15;179(8):5264-5273, Journal of immunology (1950)
— id: 81073, year: 2007, vol: 179, page: 5264, stat: Journal Article,

Transcriptional regulation in early B cell development
Fuxa, Martin; Skok, Jane A
2007 Apr;19(2):129-136, Current opinion in immunology
— id: 70842, year: 2007, vol: 19, page: 129, stat: Journal Article,

Yin Yang 1 is a critical regulator of B-cell development
Liu, Huifei; Schmidt-Supprian, Marc; Shi, Yujiang; Hobeika, Elias; Barteneva, Natasha; Jumaa, Hassan; Pelanda, Roberta; Reth, Michael; Skok, Jane; Rajewsky, Klaus; Shi, Yang
2007 May 15;21(10):1179-1189, Genes & development
— id: 81072, year: 2007, vol: 21, page: 1179, stat: Journal Article,

Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes
Skok, Jane A; Gisler, Ramiro; Novatchkova, Maria; Farmer, Deborah; de Laat, Wouter; Busslinger, Meinrad
2007 Apr;8(4):378-387, Nature immunology
— id: 70841, year: 2007, vol: 8, page: 378, stat: Journal Article,

Epigenetic ontogeny of the Igk locus during B cell development
Goldmit, Maya; Ji, Yanhong; Skok, Jane; Roldan, Esther; Jung, Steffen; Cedar, Howard; Bergman, Yehudit
2005 Feb;6(2):198-203, Nature immunology
— id: 70844, year: 2005, vol: 6, page: 198, stat: Journal Article,

The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription
Parker, Mathew J; Licence, Steve; Erlandsson, Lena; Galler, Gunther R; Chakalova, Lyubomira; Osborne, Cameron S; Morgan, Geoff; Fraser, Peter; Jumaa, Hassan; Winkler, Thomas H; Skok, Jane; Martensson, Inga-Lill
2005 Nov 16;24(22):3895-3905, EMBO journal
— id: 70843, year: 2005, vol: 24, page: 3895, stat: Journal Article,

Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene
Roldan, Esther; Fuxa, Martin; Chong, Winnie; Martinez, Dolores; Novatchkova, Maria; Busslinger, Meinrad; Skok, Jane A
2005 Jan;6(1):31-41, Nature immunology
— id: 70845, year: 2005, vol: 6, page: 31, stat: Journal Article,

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene
Fuxa, Martin; Skok, Jane; Souabni, Abdallah; Salvagiotto, Giorgia; Roldan, Esther; Busslinger, Meinrad
2004 Feb 15;18(4):411-422, Genes & development
— id: 70846, year: 2004, vol: 18, page: 411, stat: Journal Article,

C-terminal SRC kinase controls acute inflammation and granulocyte adhesion
Thomas, Richard M; Schmedt, Christian; Novelli, Marco; Choi, B Ken; Skok, Jane; Tarakhovsky, Alexander; Roes, Jurgen
2004 Feb;20(2):181-191, Immunity
— id: 70847, year: 2004, vol: 20, page: 181, stat: Journal Article,

Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development
Kosak, Steven T; Skok, Jane A; Medina, Kay L; Riblet, Roy; Le Beau, Michelle M; Fisher, Amanda G; Singh, Harinder
2002 Apr 5;296(5565):158-162, Science
— id: 70848, year: 2002, vol: 296, page: 158, stat: Journal Article,

Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool
Siepmann, K; Skok, J; van Essen, D; Harnett, M; Gray, D
2001 Mar;102(3):263-272, Immunology
— id: 81071, year: 2001, vol: 102, page: 263, stat: Journal Article,

Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes
Skok, J A; Brown, K E; Azuara, V; Caparros, M L; Baxter, J; Takacs, K; Dillon, N; Gray, D; Perry, R P; Merkenschlager, M; Fisher, A G
2001 Sep;2(9):848-854, Nature immunology
— id: 70849, year: 2001, vol: 2, page: 848, stat: Journal Article,

Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development
Skok, J; Poudrier, J; Gray, D
1999 Oct 15;163(8):4284-4291, Journal of immunology (1950)
— id: 81070, year: 1999, vol: 163,