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Bo Shopsin

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Bo Shopsin, M.D., Ph.D.

Assistant Professor;
Departments of Medicine (ID&Immun Div), Microbiology (Microbiology ) and Molecular Pathogenesis

Clinical Addresses

530 FIRST AVENUE
SUITE 7G
NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-263-7778
Fax: 212-263-3528


Additional Clinical Addresses

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Medical Specialties

Infectious Diseases

Clinical Responsibilities

Infectious Diseases consultation service; Bellevue and NYU Hospital Centers

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Board Certification

2005 — Ab Internal Medicine - Internal Medicine
2006 — Ab Internal Medicine (Infectious Disease)

Education

2001 — New York University School of Medicine, Medical Education
2001-2004 — New York University (Internal Medicine), Residency Training
2004-2006 — New York University (Infectious Diseases), Clinical Fellowships

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Research Summary

The long-term goals of research conducted in our laboratory are to understand the molecular basis underlying the adaptive changes in Staphylococcus aureus that take place during infection. An integrated approach is used that incorporates new technologies to detect low abundance variants in pooled bacterial populations, traditional bacterial and evolutionary genetics, and molecular population genetic analysis. A special focus of these studies is on the identification of within-host variation in the agr locus, a global regulator of virulence in S. aureus. agr mutants are attenuated for virulence in animal models of infection, and the majority of clinical isolates have a functional agr locus. However, agr-defective strains are frequently recovered from patients with a variety of hospital-acquired infections, suggesting that the occurrence of these strains may be favored under certain in vivo conditions. This work is motivated by practical questions in infectious diseases (such as the best use of antimicrobials that target agr and virulence), as well as more basic yet closely intertwined questions, such as how to explain the alterations that are responsible for adaptive changes at different stages of S. aureus infections.

The Shopsin lab is located in the Smilow Research Building, 522 First Ave., Room 1004.
Link to Shopsin Lab Group web page

Research Keywords

Staphyloocccus aureus; microbial pathogenesis, quorum sensing, colonization, transmission, mucosal immunity

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo
Alonzo Iii, Francis; Benson, Meredith A; Chen, John; Novick, Richard P; Shopsin, Bo; Torres, Victor J
2012 Jan;83(2):423-435, Molecular microbiology
— id: 149802, year: 2012, vol: 83, page: 423, stat: Journal Article,

Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner
Benson, Meredith A; Lilo, Sarit; Wasserman, Gregory A; Thoendel, Matthew; Smith, Amanda; Horswill, Alexander R; Fraser, John; Novick, Richard P; Shopsin, Bo; Torres, Victor J
2011 Aug;81(3):659-675, Molecular microbiology
— id: 137439, year: 2011, vol: 81, page: 659, stat: Journal Article,

Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis
Dumont, Ashley L; Nygaard, Tyler K; Watkins, Robert L; Smith, Amanda; Kozhaya, Lina; Kreiswirth, Barry N; Shopsin, Bo; Unutmaz, Derya; Voyich, Jovanka M; Torres, Victor J
2011 Feb;79(3):814-825, Molecular microbiology
— id: 120726, year: 2011, vol: 79, page: 814, stat: Journal Article,

Mutations in agr do not persist in natural populations of methicillin-resistant Staphylococcus aureus
Shopsin, Bo; Eaton, Christian; Wasserman, Gregory A; Mathema, Barun; Adhikari, Rajan P; Agolory, Simon; Altman, Deena R; Holzman, Robert S; Kreiswirth, Barry N; Novick, Richard P
2010 Nov 15;202(10):1593-1599, Journal of infectious diseases
— id: 113948, year: 2010, vol: 202, page: 1593, stat: Journal Article,

Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains
Shopsin, Bo; Drlica-Wagner, Alex; Mathema, Barun; Adhikari, Rajan P; Kreiswirth, Barry N; Novick, Richard P
2008 Oct 15;198(8):1171-1174, Journal of infectious diseases
— id: 93361, year: 2008, vol: 198, page: 1171, stat: Journal Article,

agr function in clinical Staphylococcus aureus isolates
Traber, Katrina E; Lee, Elsie; Benson, Sarah; Corrigan, Rebecca; Cantera, Mariela; Shopsin, Bo; Novick, Richard P
2008 Aug;154(Pt 8):2265-2274, Microbiology
— id: 87805, year: 2008, vol: 154, page: 2265, stat: Journal Article,

Are the new quinolones appropriate treatment for community-acquired methicillin-resistant Staphylococcus aureus?
Shopsin, Bo; Zhao, Xilin; Kreiswirth, Barry N; Tillotson, Glenn S; Drlica, Karl
2004 Aug;24(1):32-34, International journal of antimicrobial agents
— id: 46140, year: 2004, vol: 24, page: 32, stat: Journal Article,

Prevalence of agr specificity groups among Staphylococcus aureus strains colonizing children and their guardians
Shopsin, B; Mathema, B; Alcabes, P; Said-Salim, B; Lina, G; Matsuka, A; Martinez, J; Kreiswirth, B N
2003 Jan;41(1):456-459, Journal of clinical microbiology
— id: 39333, year: 2003, vol: 41, page: 456, stat: Journal Article,

Molecular epidemiology of methicillin-resistant Staphylococcus aureus
Shopsin, B; Kreiswirth, B N
2001 Mar-Apr;7(2):323-326, Emerging infectious diseases
— id: 104950, year: 2001, vol: 7, page: 323, stat: Journal Article,

Molecular epidemiology and tuberculosis control [In Process Citation]
Bifani PJ; Shopsin B; Alcabes P; Mathema B; Kreiswirth BN; Liu Z; Driscoll J; Frothingham R; Musser JM
2000 Jul 19;284(3):305-307, JAMA
— id: 11599, year: 2000, vol: 284, page: 305, stat: Journal Article,

Molecular characterization of Mycobacterium tuberculosis H37Rv/Ra variants: distinguishing the mycobacterial laboratory strain
Bifani, P; Moghazeh, S; Shopsin, B; Driscoll, J; Ravikovitch, A; Kreiswirth, B N
2000 Sep;38(9):3200-3204, Journal of clinical microbiology
— id: 104945, year: 2000, vol: 38, page: 3200, stat: Journal Article,

Prevalence of methicillin-resistant and methicillin-susceptible Staphylococcus aureus in the community
Shopsin B; Mathema B; Martinez J; Ha E; Campo ML; Fierman A; Krasinski K; Kornblum J; Alcabes P; Waddington M; Riehman M; Kreiswirth BN
2000 Jul;182(1):359-362, Journal of infectious diseases
— id: 11617, year: 2000, vol: 182, page: 359, stat: Journal Article,

Use of coagulase gene (coa) repeat region nucleotide sequences for typing of methicillin-resistant Staphylococcus aureus strains
Shopsin, B; Gomez, M; Waddington, M; Riehman, M; Kreiswirth, B N
2000 Sep;38(9):3453-3456, Journal of clinical microbiology
— id: 104946, year: 2000, vol: 38, page: 3453, stat: Journal Article,

Resistance rather than virulence selects for the clonal spread of methicillin-resistant Staphylococcus aureus: implications for MRSA transmission
Shopsin, B; Mathema, B; Zhao, X; Martinez, J; Kornblum, J; Kreiswirth, B N
2000 Fall;6(3):239-244, Microbial drug resistance : MDR : mechanisms, epidemiology, & disease
— id: 104947, year: 2000, vol: 6, page: 239, stat: Journal Article,

Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology [see comments]
Bifani PJ; Mathema B; Liu Z; Moghazeh SL; Shopsin B; Tempalski B; Driscol J; Frothingham R; Musser JM; Alcabes P; Kreiswirth BN
1999 Dec 22-29;282(24):2321-2327, JAMA
— id: 11889, year: 1999, vol: 282, page: 2321, stat: Journal Article,

Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains
Shopsin, B; Gomez, M; Montgomery, S O; Smith, D H; Waddington, M; Dodge, D E; Bost, D A; Riehman, M; Naidich, S; Kreiswirth, B N
1999 Nov;37(11):3556-3563, Journal of clinical microbiology
— id: 104943, year: 1999, vol: 37, page: 3556, stat: Journal Article,

Molecular epidemiology of methicillin-resistant Staphylococcus aureus in 12 New York hospitals. MRSA Collaborative Study Group
Roberts, R B; de Lencastre, A; Eisner, W; Severina, E P; Shopsin, B; Kreiswirth, B N; Tomasz, A
1998 Jul;178(1):164-171, Journal of infectious diseases
— id: 105017, year: 1998, vol: 178, page: 164, stat: Journal Article,

The in vitro generation of post-Golgi vesicles carrying viral envelope glycoproteins requires an ARF-like GTP-binding protein and a protein kinase C associated with the Golgi apparatus
Simon JP; Ivanov IE; Shopsin B; Hersh D; Adesnik M; Sabatini DD
1996 Jul 12;271(28):16952-16961, Journal of biological chemistry
— id: 7048, year: 1996, vol: 271, page: 16952, stat: Journal Article,

Regulation of post-Golgi vesicle production in an in vitro system
Simon JP; Ivanov IE; Ren M; Zeng J; Shopsin B; Hersh D; Tempst P; Erdjument-Bromage H; Lui M; De Lemos-Chiarandini C; et al
1995 ;60:179-195, Cold Spring Harbor symposia on quantitative biology
— id: 12818, year: 1995, vol: 60, page: 179, stat: Journal Article,

A PKC-like activity is involved in the release of post Golgi vesicles
Simon, J.-P.; Shopsin, B.; Hersh, D.; Ivanov, I. E.; Adesnik, M.; Sabatini, D. D.
1995 ;6(SUPPL.):397A-397A, Molecular biology of the cell
— id: 104644, year: 1995, vol: 6, page: 397A, stat: Journal Article,