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Timothy Shepherd

Assistant Professor, Department of Radiology

Contact Info

Address
660 First Avenue
New York, NY 10016

212/263-8487

Research Interests

I am seeking to understand the how the structural and functional organization of medial temporal lobe structures and cerebral cortex are affected by diseases, such as epilepsy and Alzheimer?s disease. My approach is to use ex vivo MRI microscopy, advanced coil technology and ultra-high-field MRI of clinical patients to study human cerebral cortex and medial temporal lobe structures in normal and diseased states. The thesis of this research is that early changes to the functional organization of these structures can be detected by emerging MRI techniques during the preclinical stages of disease. This translational research focus could have an important impact on the contributions of neuroradiology to clinical management of patients, while also altering our fundamental understanding of local neuronal network organization in important brain substructures, such as the hippocampus.

Optimized, Minimal Specific Absorption Rate MRI for High-Resolution Imaging in Patients with Implanted Deep Brain Stimulation Electrodes
Franceschi, A M; Wiggins, G C; Mogilner, A Y; Shepherd, T; Chung, S; Lui, Y W. Optimized, Minimal Specific Absorption Rate MRI for High-Resolution Imaging in Patients with Implanted Deep Brain Stimulation Electrodes. AJNR. American journal of neuroradiology. 2016 Jul 14;:?-? (2180022)

Clinical visual readings of brain region-specific hypometabolism in cognitive impairment patients is independent of attenuation correction method for integrated PET/MR
Franceschi, A; Raad, R; Abballe, V; Nelson, A; Jackson, K; Babb, J; Koesters, T; Fenchel, M; Zhan, Y; Hermosillo, G; Shepherd, T; Friedman, K. Clinical visual readings of brain region-specific hypometabolism in cognitive impairment patients is independent of attenuation correction method for integrated PET/MR [Meeting Abstract]. Journal of nuclear medicine. 2016 May 2016;57(no):- (2187942)

New Clinically Feasible 3T MRI Protocol to Discriminate Internal Brain Stem Anatomy
Hoch, M J; Chung, S; Ben-Eliezer, N; Bruno, M T; Fatterpekar, G M; Shepherd, T M. New Clinically Feasible 3T MRI Protocol to Discriminate Internal Brain Stem Anatomy. AJNR. American journal of neuroradiology. 2016 Feb 11;37(6):1058-1065 (2009812)

Track density imaging of hypertrophic olivary degeneration from multiple sclerosis plaque
Hoch, Michael J; Chung, Sohae; Fatterpekar, Girish M; Kister, Ilya; Shepherd, Timothy M. Track density imaging of hypertrophic olivary degeneration from multiple sclerosis plaque. BJR case reports. 2016 April 13;?:?-? (2071332)

In vivo quantification of demyelination and recovery using compartment-specific diffusion MRI metrics validated by electron microscopy
Jelescu, Ileana O; Zurek, Magdalena; Winters, Kerryanne V; Veraart, Jelle; Rajaratnam, Anjali; Kim, Nathanael S; Babb, James S; Shepherd, Timothy M; Novikov, Dmitry S; Kim, Sungheon G; Fieremans, Els. In vivo quantification of demyelination and recovery using compartment-specific diffusion MRI metrics validated by electron microscopy. Neuroimage. 2016 Feb 11;132:104-114 (1949552)