Biosketch / Results /

Timothy Shepherd

Assistant Professor, Department of Radiology

Contact Info

Address
660 First Avenue
New York, NY 10016

212/263-8487

Research Summary

I am seeking to understand the how the structural and functional organization of medial temporal lobe structures and cerebral cortex are affected by diseases, such as epilepsy and Alzheimer?s disease. My approach is to use ex vivo MRI microscopy, advanced coil technology and ultra-high-field MRI of clinical patients to study human cerebral cortex and medial temporal lobe structures in normal and diseased states. The thesis of this research is that early changes to the functional organization of these structures can be detected by emerging MRI techniques during the preclinical stages of disease. This translational research focus could have an important impact on the contributions of neuroradiology to clinical management of patients, while also altering our fundamental understanding of local neuronal network organization in important brain substructures, such as the hippocampus.


Palliative CT-Guided Cordotomy for Medically Intractable Pain in Patients with Cancer
Shepherd, T M; Hoch, M J; Cohen, B A; Bruno, M T; Fieremans, E; Rosen, G; Pacione, D; Mogilner, A Y. Palliative CT-Guided Cordotomy for Medically Intractable Pain in Patients with Cancer. AJNR. American journal of neuroradiology. 2016 Nov 3;:?-? (2296992)

Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction
Kister, I; Johnson, E; Raz, E; Babb, J; Loh, J; Shepherd, T M. Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. Multiple sclerosis & related disorders. 2016 Sep;9:62-67 (2254562)

FUNCTIONAL SUBCLONE PROFILING FOR PREDICTION OF TREATMENT-INDUCED INTRA-TUMOR POPULATION SHIFTS AND DISCOVERY OF RATIONAL DRUG COMBINATIONS IN HUMAN GLIOBLASTOMA
Reinartz, Roman; Wang, Shanshan; Kebir, Sied; Silver, Daniel J; Anja, Wieland; Zheng, Tong; Kupper, Marius; Rauschenbach, Laurel; Fimmers, Rolf; Shepherd, Timothy; Trageser, Daniel; Till, Andreas; Schafer, Niklas; Glas, Martin; Hillmer, Axel M; Cichon, Sven; Smith, Amy; Pietsch, Torsten; Liu, Ying; Reynolds, Brent A; Yachnis, Anthony T; Pincus, David W; Simon, Matthias; Brustle, Oliver; Steindler, Dennis A; Scheffler, Bjorn. FUNCTIONAL SUBCLONE PROFILING FOR PREDICTION OF TREATMENT-INDUCED INTRA-TUMOR POPULATION SHIFTS AND DISCOVERY OF RATIONAL DRUG COMBINATIONS IN HUMAN GLIOBLASTOMA. Clinical cancer research. 2016 Aug 12;23(2):562-574 (2219182)

Optimized, Minimal Specific Absorption Rate MRI for High-Resolution Imaging in Patients with Implanted Deep Brain Stimulation Electrodes
Franceschi, A M; Wiggins, G C; Mogilner, A Y; Shepherd, T; Chung, S; Lui, Y W. Optimized, Minimal Specific Absorption Rate MRI for High-Resolution Imaging in Patients with Implanted Deep Brain Stimulation Electrodes. AJNR. American journal of neuroradiology. 2016 Jul 14;:?-? (2180022)

Dixon sequence with superimposed model-based bone compartment provides highly accurate PET/MR attenuation correction of the brain
Koesters, Thomas; Friedman, Kent Parks; Fenchel, Matthias; Zhan, Yiqiang; Hermosillo, Gerardo; Babb, James; Jelescu, Ileana O; Faul, David; Boada, Fernando E; Shepherd, Timothy M. Dixon sequence with superimposed model-based bone compartment provides highly accurate PET/MR attenuation correction of the brain. Journal of nuclear medicine. 2016 Jun;57(6):918-924 (1933112)