Biosketch / Results /

Timothy Shepherd

Assistant Professor, Department of Radiology

Contact Info

Address
660 First Avenue
New York, NY 10016

212-263-8487

Research Summary

I am seeking to understand the how the structural and functional organization of medial temporal lobe structures and cerebral cortex are affected by diseases, such as epilepsy and Alzheimer?s disease. My approach is to use ex vivo MRI microscopy, advanced coil technology and ultra-high-field MRI of clinical patients to study human cerebral cortex and medial temporal lobe structures in normal and diseased states. The thesis of this research is that early changes to the functional organization of these structures can be detected by emerging MRI techniques during the preclinical stages of disease. This translational research focus could have an important impact on the contributions of neuroradiology to clinical management of patients, while also altering our fundamental understanding of local neuronal network organization in important brain substructures, such as the hippocampus.


Electrical stimulation and monitoring devices of the CNS: An imaging review
Patel, Sohil H; Halpern, Casey H; Shepherd, Timothy M; Timpone, Vincent M. Electrical stimulation and monitoring devices of the CNS: An imaging review. Journal of neuroradiology = Journal de neuroradiologie. 2017 Feb 6;:?-? (2437552)

Comparison of white matter microstructure based on cerebral amyloid deposition in healthy aging and mild cognitive impairment: A multimodal PET/MR study
Dong, J W; Jelescu, I O; Ades-Aron, B; Novikov, D; Friedman, K; Ding, Y -S; Galvin, J E; Shepherd, T; Fieremans, E. Comparison of white matter microstructure based on cerebral amyloid deposition in healthy aging and mild cognitive impairment: A multimodal PET/MR study [Meeting Abstract]. Molecular imaging & biology. 2016 December;Conference:(World):S113-S114 (2415672)

Palliative CT-Guided Cordotomy for Medically Intractable Pain in Patients with Cancer
Shepherd, T M; Hoch, M J; Cohen, B A; Bruno, M T; Fieremans, E; Rosen, G; Pacione, D; Mogilner, A Y. Palliative CT-Guided Cordotomy for Medically Intractable Pain in Patients with Cancer. AJNR. American journal of neuroradiology. 2016 Nov 3;38(2):387-390 (2296992)

Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction
Kister, I; Johnson, E; Raz, E; Babb, J; Loh, J; Shepherd, T M. Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. Multiple sclerosis & related disorders. 2016 Sep;9:62-67 (2254562)

FUNCTIONAL SUBCLONE PROFILING FOR PREDICTION OF TREATMENT-INDUCED INTRA-TUMOR POPULATION SHIFTS AND DISCOVERY OF RATIONAL DRUG COMBINATIONS IN HUMAN GLIOBLASTOMA
Reinartz, Roman; Wang, Shanshan; Kebir, Sied; Silver, Daniel J; Anja, Wieland; Zheng, Tong; Kupper, Marius; Rauschenbach, Laurel; Fimmers, Rolf; Shepherd, Timothy; Trageser, Daniel; Till, Andreas; Schafer, Niklas; Glas, Martin; Hillmer, Axel M; Cichon, Sven; Smith, Amy; Pietsch, Torsten; Liu, Ying; Reynolds, Brent A; Yachnis, Anthony T; Pincus, David W; Simon, Matthias; Brustle, Oliver; Steindler, Dennis A; Scheffler, Bjorn. FUNCTIONAL SUBCLONE PROFILING FOR PREDICTION OF TREATMENT-INDUCED INTRA-TUMOR POPULATION SHIFTS AND DISCOVERY OF RATIONAL DRUG COMBINATIONS IN HUMAN GLIOBLASTOMA. Clinical cancer research. 2016 Aug 12;23(2):562-574 (2219182)