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Timothy Shepherd

Assistant Professor, Department of Radiology
Radiology

Contact Info

Address
660 First Avenue
New York, NY 10016

212/263-8487

Research Interests

I am seeking to understand the how the structural and functional organization of medial temporal lobe structures and cerebral cortex are affected by diseases, such as epilepsy and Alzheimer?s disease. My approach is to use ex vivo MRI microscopy, advanced coil technology and ultra-high-field MRI of clinical patients to study human cerebral cortex and medial temporal lobe structures in normal and diseased states. The thesis of this research is that early changes to the functional organization of these structures can be detected by emerging MRI techniques during the preclinical stages of disease. This translational research focus could have an important impact on the contributions of neuroradiology to clinical management of patients, while also altering our fundamental understanding of local neuronal network organization in important brain substructures, such as the hippocampus.

Dixon sequence with superimposed model-based bone compartment provides highly accurate PET/MR attenuation correction of the brain
Koesters, Thomas; Friedman, Kent Parks; Fenchel, Matthias; Zhan, Yiqiang; Hermosillo, Gerardo; Babb, James; Jelescu, Ileana O; Faul, David; Boada, Fernando E; Shepherd, Timothy M. Dixon sequence with superimposed model-based bone compartment provides highly accurate PET/MR attenuation correction of the brain. Journal of nuclear medicine. 2016 Feb;:?-? (1933112)

Accelerated and motion-robust in vivo T mapping from radially undersampled data using bloch-simulation-based iterative reconstruction
Ben-Eliezer, Noam; Sodickson, Daniel K; Shepherd, Timothy; Wiggins, Graham C; Block, Kai Tobias. Accelerated and motion-robust in vivo T mapping from radially undersampled data using bloch-simulation-based iterative reconstruction. Magnetic resonance in medicine. 2015 Apr;:?-? (1543012)

Correlation of white matter damage with amyloid and hippocampal atrophy in normal aging and amnestic Mild Cognitive Impairment (aMCI): an MR-PET study.
Jelescu, Ileana; Shepherd, Timothy; Novikov, Dmitry; Ding, Yu-Shin; Koesters, Thomas; Friedman, Kent; Galvin, James; Fieremans, Els. Correlation of white matter damage with amyloid and hippocampal atrophy in normal aging and amnestic Mild Cognitive Impairment (aMCI): an MR-PET study. [Meeting Abstract]. Journal of nuclear medicine. 2015 MAY 1;56(3):?-? (1734812)

Teaching NeuroImages: NMDA encephalomyelitis with MRI abnormalities isolated to ventral spinal cord gray matter
Zubkov, Sarah; Aggarwal Joshi, Puja; Shepherd, Timothy M; Kothare, Sanjeev V. Teaching NeuroImages: NMDA encephalomyelitis with MRI abnormalities isolated to ventral spinal cord gray matter. Neurology. 2015 Aug;85(6):e55-e56 (1720962)

Disabling amnestic syndrome following stereotactic laser ablation of a hypothalamic hamartoma in a patient with a prior temporal lobectomy
Zubkov, Sarah; Del Bene, Victor A; MacAllister, William S; Shepherd, Timothy M; Devinsky, Orrin. Disabling amnestic syndrome following stereotactic laser ablation of a hypothalamic hamartoma in a patient with a prior temporal lobectomy. Epilepsy & behavior case reports. 2015 ;4:60-62 (1732292)